TREA

Project 2: Integrin Signaling and Physical Forces

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Information

  • Research Project
  • 8234227
  • ApplicationId
    8234227
  • Core Project Number
    P01GM098412
  • Full Project Number
    1P01GM098412-01
  • Serial Number
    98412
  • FOA Number
    PAR-10-266
  • Sub Project Id
    6465
  • Project Start Date
    9/30/2011 - 12 years ago
  • Project End Date
    8/31/2016 - 7 years ago
  • Program Officer Name
  • Budget Start Date
    9/30/2011 - 12 years ago
  • Budget End Date
    8/31/2012 - 11 years ago
  • Fiscal Year
    2011
  • Support Year
    1
  • Suffix
  • Award Notice Date
    9/16/2011 - 12 years ago
Organizations
Information

Project 2: Integrin Signaling and Physical Forces

This project is innovative in both the questions to be addressed and many of the tools to be employed. Mechanotransduction by integrin-dependent adhesions is a major area of current interest but detailed molecular mechanisms are pooriy understood. What stands out compared to ether studies is that we propose to study these phenomena in the context of high resolution analysis of cytoskeletal and receptor dynamics. This combination is highly nevel and offers major opportunities for deeper molecular understanding of what is, in essence, a dynamic phenomenon. Additionally, numerous technical innovations will be combined in this study. These include analysis of mutants of integrins and cytoskeletal proteins, a state of the art, high resolution EM technique, novel materials, nevel biosensors, and nevel imaging and data analysis methods. The application therefore contains mulfiple innovative aspects that take it far beyond current work.

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    P01
  • Administering IC
    GM
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
    274590
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NIGMS:274590\
  • Funding Mechanism
    Research Projects
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    SANFORD-BURNHAM MEDICAL RESEARCH INSTIT
  • Organization Department
  • Organization DUNS
    020520466
  • Organization City
    LA JOLLA
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    065103209
  • Organization District
    UNITED STATES