Claims
- 1. The clonal cell line MMQ, said MMQ cell line being on deposit and identified in the American Type Culture Collection as CRL 10609 and characterized by the presence of dopamine receptors and the secretion of only the prolactin hormone.
- 2. The cell line of claim 1 wherein said MMQ cell line is derived from the pituitary tumor 7315a, said pituitary tumor being characterized by secreting both prolactin and adrenocorticotrophin and having an absence of functional dopamine receptors.
- 3. The clonal cell line of claim 1 wherein the functional dopamine receptors are capable of being negatively coupled to adenylate cyclase by a GTP-binding protein.
- 4. The cell line of claim 1 further comprising functional somatostatin receptors.
- 5. The cell line of claim 1 further comprising functional vasoactive intestinal polypeptide receptors.
CROSS-REFERENCE TO RELATED APPLICATION
This is a continuation-in-part of application Ser. No. 07/160,751 filed on Feb. 26, 1988 abandoned.
This application is a C-I-P of co-pending application, Ser. No. 07/160,757, filed Feb. 26, 1988, the subject matter of which is incorporated by reference as though cited in full.
Government Interests
The present invention was made with the assistance of the U.S. Government funding (NIH Grant CA07353 and CA38228). The U.S. Government may have some rights in the invention.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4725549 |
Cooke et al. |
Feb 1988 |
|
Non-Patent Literature Citations (2)
Entry |
Judd, et al.; Endocrinology, vol. 123, No. 5, pp. 2341-2350; 1988. |
Lamberts, et al.; Endocrinology, vol. 114, No. 6, pp. 2349-2353; 1984. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
160757 |
Feb 1988 |
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