Claims
- 1. A prolinal derivative of the formula: ##STR75## wherein A represents an alkylene group of from 1 to 8 carbon atom(s) or an alkenylene group of from 2 to 8 carbon atoms or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents a hydrogen atom, a phenyl group, a benzyl group, an alkyl group of from 1 to 8 carbon atom(s) or a cycloalkyl group of from 3 to 7 carbon atoms, B represents a single bond or an alkylene group of from 1 to 8 carbon atom(s) unsubstituted or substituted by a phenyl group or a benzyl group, D represents a heterocyclic ring selected from the group consisting of imidazole, pyrimidine, pyrazine, quinazoline and phenazine rings, which ring represented by D may be partially or fully saturated and wherein said heterocyclic ring represented by D is unsubstituted or substituted by from one to three of a halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group.
- 2. A prolinal derivatives of the formula: ##STR76## wherein A represents an alkylene group of from 1 to 8 carbon atom(s) or an alkenylene group of from 2 to 8 carbon atoms or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents a hydrogen atom, a phenyl group, a benzyl group, an alkyl group of from 1 to 8 carbon atom(s) or a cycloalkyl group of from 3 to 7 carbon atoms, B represents a single bond or an alkylene group of from 1 to 8 carbon atom(s) unsubstituted or substituted by a phenyl group or a benzyl group, D represents a heterocyclic ring selected from the group consisting of imidazole, pyrimidine, pyrazine, quinazoline and phenazine rings, which ring represented by D may be partially or fully saturated and wherein said heterocyclic ring represented by D is unsubstituted or substituted by from one to three of a halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group.
- 3. A pharmaceutical composition for treating amnesia which comprises an effective amount of a prolinal derivative of the formula (I) depicted in claim 1 and a pharmaceutically acceptable carrier and/or coating.
- 4. The method for treating amnesia which comprises administering a therapeutically effective amount of a prolinal derivative of the formula (I) depicted in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
61-275375 |
Nov 1986 |
JPX |
|
62-228452 |
Sep 1987 |
JPX |
|
Parent Case Info
This is a divisional of application Ser. No. 07/533,648 filed Jun. 5, 1990, now U.S. Pat. No. 5,100,904, which is a divisional of prior application Ser. No. 07/123,410 filed Nov. 20, 1987 (now U.S. Pat. No. 4,956,380).
Foreign Referenced Citations (6)
Number |
Date |
Country |
0080822 |
Jun 1983 |
EPX |
0154353 |
Sep 1985 |
EPX |
0172458 |
Feb 1986 |
EPX |
0201741 |
Nov 1986 |
EPX |
0201742 |
Nov 1986 |
EPX |
0201743 |
Nov 1986 |
EPX |
Non-Patent Literature Citations (4)
Entry |
Protein Nucleic Acid & Enzyme, 25(6), pp. 513-523 (1980). |
Nippon Nogeikagaku Kaishi 59(11), pp. 1147-1153 (1984). |
Japanese Patent Application No. 61-183297 Aug. 15, 1986. |
Chemical Abstracts, vol. 105, No. 23, Dec. 8, 1986, abstract 209396q. |
Divisions (2)
|
Number |
Date |
Country |
Parent |
533648 |
Jun 1990 |
|
Parent |
123410 |
Nov 1987 |
|