Claims
- 1. A prolonged release microcapsule for injection, which comprises particles containing a water-soluble drug, the particles being dispersed in a spherical microcapsule matrix composed of a copolymer of lactic acid and glycolic acid having a comonomer ratio within the range of about 100/0 to 50/50 and an average molecular weight within the range of about 5,000 to 200,000, the spherical microcapsule matrix having an average diameter of 2 to 200 .mu.m, and an excipient selected from the group consisting of mannitol, sorbitol, lactose and glucose, which particles are produced by in-water drying.
- 2. A microcapsule as claimed in claim 1, wherein the water-soluble drug is a biologically active polypeptide.
- 3. A microcapsule as claimed in claim 1, wherein the water-soluble drug is a non-polypeptidic drug.
- 4. A microcapsule as claimed in claim 1, wherein the excipient is mannitol.
- 5. An injectable preparation comprising a therapeutically effective amount of a prolonged release microcapsule which comprises particles containing a water-soluble drug, the particles being dispersed in a spherical microcapsule matrix composed of a copolymer of lactic acid and glycolic acid having a comonomer ratio within the range of about 100/0 to 50/50 and an average molecular weight within the range of about 5,000 to 200,000, the spherical microcapsule matrix having an average diameter of 2 to 200 .mu.m, and an excipient selected from the group consisting of mannitol, sorbitol, lactose and glucose, which particles are produced by in-water drying.
- 6. An injectable preparation as claimed in claim 5, wherein the water-soluble drug is a biologically active polypeptide.
- 7. An injectable preparation as claimed in claim 5, wherein the water-soluble drug is a non-polypeptidic drug.
- 8. An injectable preparation as claimed in claim 5, wherein the excipient is mannitol.
Priority Claims (1)
Number |
Date |
Country |
Kind |
58-207760 |
Nov 1983 |
JPX |
|
Parent Case Info
This application is a continuation of U.S. application Ser. No. 07/748,423 filed Aug. 22, 1991, now abandoned; which is a divisional of U.S. application Ser. No. 07/469,784 filed Jan. 24, 1990 [now U.S. Pat. No. 5,061,492]; which is a divisional of U.S. application Ser. No. 07/103,117 filed Sep. 30, 1987 [now U.S. Pat. No. 4,917,893]; which is a divisional of U.S. application Ser. No. 06/940,614 filed Dec. 11, 1986 [now U.S. Pat. No. 4,711,782]; which is a divisional of U.S. application Ser. No. 06/667,096 filed Nov. 1, 1984 [now U.S. Pat. No. 4,652,441].
US Referenced Citations (22)
Foreign Referenced Citations (5)
Number |
Date |
Country |
0052510 |
May 1982 |
EPX |
0058481 |
Aug 1982 |
EPX |
2491351 |
Sep 1982 |
FRX |
42-13703 |
Mar 1967 |
JPX |
2088314 |
Sep 1982 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines, and Other Biologicals," Journal of Bioengineering, vol. 1, pp. 25-32, 1976. |
The Pharmacopoeia of Japan, Tenth Edition, 1981, pp. 16-21. |
Journal of the Chemical Society of Japan, vol. 72, 1969, pp. 493-499 (with translation). |
Divisions (4)
|
Number |
Date |
Country |
Parent |
469784 |
Jan 1990 |
|
Parent |
103117 |
Sep 1987 |
|
Parent |
940614 |
Dec 1986 |
|
Parent |
667096 |
Nov 1984 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
748423 |
Aug 1991 |
|