Patent Application
20230172210
The present invention is included in the field of herbicidal formulations of the chemical compound promethrin (N2,N4-diisopropyl-6-methylthio-1,3,5-triazine-2,4-diamine) especially in form of microemulsion at low concentrations.
The object of the present invention is the provision of an herbicidal composition of the active ingredient promethrin in low concentration in form of a micro-emulsion that unexpectedly requires a lower dose of application of the active ingredient per unit of cultivation area to which it is applied achieving equal or better benefits than concentrated commercial formulations thereof.
It is common to find in the agrochemical market the herbicide promethrin marketed as a 50% concentrated suspension (Gesagard % 50 concentrated suspension, Prometrex FW 50% SC, among others).
In general, commercial presentations for the control of promethrin as soluble liquid in equivalents in grams of active ingredient per kg or liter of presentation are commercialized in 480; as wettable powder 500 and as suspension concentrated 500 (see commercial presentations of promethrin on the website https://www-ecured.cu/Prometrina).
The Merck Index 2000 indicates as the first patents related to the product promethrin, patents CH 337019, U.S. Pat. No. 2,909,420, FR1372089 and U.S. Pat. No. 3,207,756, among others.
Patents FR1372089 and U.S. Pat. No. 3,207,756 refer to methods of synthesis of promethrin, where compositions of said herbicide are not disclosed.
The first patent for promethrin CH 337019 revealed the formulation of the active ingredient using xylene, cyclohexanone, surfactants, fatty acids. However, all the formulations disclosed in said patent are to generate emulsifiable concentrates and the examples are directed to wettable powders, there are no formulations of the microemulsion type in the same at concentrations that demonstrate that they can be applied at a lower dose on the crops having an effect at least the same as a concentrated composition.
U.S. Pat. No. 2,909,420 refers to compositions for inhibiting the growth of plants that comprise promethrin among its active ingredients; however, no microemulsions of promethrin are disclosed in said patent.
The present invention contemplates a composition of promethrin in form of a microemulsion comprising from 15 to 20% by volume by weight of promethrin, a non-polar solvent or solvent mixture comprising from 47 to 58% w/v, a polar solvent or mixture of polar solvent comprising from 2 to 21% w/v, an anionic surfactant 60% or 70% w/w comprising from 2.4 to 4.33% w/v, an adjuvant from 0 to 4.70% w/v, and a mixture of nonionic surfactants from 9.66 to 21.00% w/v.
In the above microemulsion composition of promethrin according to one of your preferences, the non-polar solvent or solvent mixture comprises xylene and/or cyclohexanone and/or ethyl acetate and/or dimethylamide of natural fatty acids such as coconut acids with 8 to 10 carbon atoms.
In the developed microemulsion composition of promethrin, the polar solvent or solvent mixture comprises water and/or propylene glycol.
In the composition of promethrin in form of a microemulsion according to one of the preferences, the 60% or 70% w/w anionic surfactant is calcium dodecylbenzenesulfonate.
In the microemulsion composition of promethrin according to another preference, the mixture of nonionic surfactant comprises castor oil ethoxylated with 36 moles of ethylene oxide and/or tristyryl phenol ethoxylated with 20 moles of ethylene oxide and/or tridecyl alcohol ethoxylated with 6 moles of ethylene oxide and/or polyalkylene glycol ether polymer.
In the microemulsion composition of promethrin according to a variant thereof, the adjuvant is a soybean oil fatty acid methyl ester.
In the composition of promethrin in form of a microemulsion according to any of the proposed variants, the concentration of promethrin is 18.5% w/v.
One of the preferred variants of the microemulsion composition of promethrin comprises the following component ratio: 18.5% w/v of promethrin, 39% w/v of xylene, 16.5% w/v of cyclohexanone, 2% w/v of ethyl acetate, 2% w/v of soybean oil fatty acid methyl ester, 4.33% w/v of isotridecyl alcohol ethoxylated with 6 moles of ethylene oxide, 4.33% w/v of calcium dodecylbenzenesulfonate (60% w/w), 4.33% w/v of castor oil ethoxylated with 36 moles of ethylene oxide, 1.0% w/v of tristyryl phenol ethoxylated with 20 moles of ethylene oxide and 5% w/v of propylene glycol.
Another preferred variant of the microemulsion composition of promethrin comprises the following component ratio: 18.5% w/v of promethrin, 43% w/v of xylene, 17% w/v of cyclohexanone, 2% w/v of ethyl acetate, 0% w/v of soybean oil fatty acid methyl ester, 4.33% w/v of tridecyl alcohol ethoxylated with 6 moles of ethylene oxide, 4.33% w/v of calcium dodecylbenzenesulfonate (60% w/w), 4.33% w/v of castor oil ethoxylated with 36 moles of ethylene oxide, 1.0% w/v of tristyryl phenol ethoxylated with 20 moles of ethylene oxide and 2% w/v of propylene glycol.
Among the variants of the composition of promethrin in form of a microemulsion there is also one that comprises the following ratio of components: 18.5% w/v of promethrin, 46.6% w/v of xylene, 3.5% of water, 4.70% w/v of soybean oil fatty acid methyl ester, 2.40% w/v of calcium dodecylbenzenesulfonate (60% w/w), 4.70% w/v of polymeric polyalkylene glycol ether, 12.20% w/v of tristyryl phenol ethoxylated with 20 moles of ethylene oxide and 2.80% w/v of propylene glycol.
Another variant of the microemulsion composition of promethrin according to the present document comprises the following component ratio: 18.5% w/v of promethrin, 47% w/v of xylene, 3.50% w/v of water, 2% w/v of soybean oil fatty acid methyl ester, 5.0% w/v of polymeric polyalkylene glycol ether, 16.0% w/v of triestyryl phenol ethoxylated with 20 moles of ethylene oxide and 21.0% w/v of propylene glycol.
Another variant of the composition of promethrin in form of a microemulsion according to the present embodiment comprises the following ratio of components: 18.5% w/v of promethrin, 47.70% w/v of xylene, 2.00% w/v of water, 3.70% w/v of soybean oil fatty acid methyl ester, 1.50% w/v of tridecyl alcohol ethoxylated with 6 moles of ethylene oxide, 2.40% w/v of calcium dodecylbenzenesulfonate (70% w/w), 4.70% w/v of polymeric polyalkylene glycol ether, and 12.2% w/v of tristyryl phenol ethoxylated with 20 moles of ethylene oxide.
An embodiment of the composition of promethrin in form of a microemulsion according to the present description comprises the following component ratio 18.5% w/v of promethrin, 49.0% w/v of coconut fatty acid dimethylamide of 8-10 carbon atoms, 1.00% w/v of soybean oil fatty acid methyl ester, 1.5% w/v of propylene glycol, 15.00% w/v of triestyryl phenol ethoxylated with 20 moles of ethylene oxide, 3.30% w/v of calcium dodecylbenzenesulfonate (70% w/w), 6.00% w/v of polymeric polyalkylene glycol ether, and 2.00% w/v of water.
The composition of promethrin in form of a microemulsion in other variants comprises the following component ratio: 18.5% w/v of promethrin, 48.0% w/v of coconut fatty acid dimethylamide of 8-10 carbon atoms, 2.00% w/v of soybean oil fatty acid methyl ester, 2.5% w/v of propylene glycol, 16.00% w/v of triestyryl phenol ethoxylated with 20 moles of ethylene oxide, 2.50% w/v of calcium dodecylbenzenesulfonate (70% w/w), 5.00% w/v of polymeric polyalkylene glycol ether, and 2.50% w/v of water.
Among the variants of the composition of promethrin in form of a microemulsion according to the present document, there is one that comprises the following component ratio: 15.0% w/v of promethrin, 40% w/v of xylene, 17.80% w/v of cyclohexanone, 2.00% w/v of ethyl acetate, 2.00% w/v of soybean oil fatty acid methyl ester, 4.33% w/v of tridecyl alcohol ethoxylated with 6 moles of ethylene oxide, 4.33% w/v of calcium dodecylbenzenesulfonate (60% w/w), 4.33% w/v of castor oil ethoxylated with 36 moles of ethylene oxide, 1.0% w/v detriestiril phenol ethoxylated with 20 moles of ethylene oxide and 5% w/v of propylene glycol.
Also preferred is the composition of promethrin in form of a microemulsion according to the present application, which comprises the following component ratio: 20.00% w/v of promethrin, 39% w/v of xylene, 15% w/v of cyclohexanone, 2% w/v of ethyl acetate, 2% w/v of soybean oil fatty acid methyl ester, 4.33% w/v of tridecyl alcohol ethoxylated with 6 moles of ethylene oxide, 4.33% w/v of calcium dodecylbenzenesulfonate (60% w/w), 4.33% w/v of castor oil ethoxylated with 36 moles of ethylene oxide, 1.0% w/v of triestryl phenol ethoxylated with 20 moles of ethylene oxide and 5% w/v of propylene glycol.
In another variant of the invention, the composition of promethrin in form of a microemulsion is combined with 2,4-D and/or glyphosate compositions before dilution with water in application broths.
In this last variant of the invention, the described composition of promethrin in form of a microemulsion comprises compositions with a concentration of 18.5% w/v, 15% w/v and 20% w/v; the glyphosate composition comprises glyphosate potassium salt 54% w/v and the 2.4-D composition comprises 2.4-D 30% w/v of microemulsion.
In this previously described variant of the promethrin composition in form of a microemulsion, the ratio of the combination of promethrin composition:glyphosate composition in a binary mixture is 58.3:41.7 v/v.
In this previously described variant of the promethrin composition in form of a microemulsion, the ratio of the combination of promethrin composition:2.4-D composition in a binary mixture is 72.9:27.1 v/v.
Finally, in this previously described variant of the promethrin composition in form of a microemulsion, the ratio of the combination of promethrin composition:glyphosate composition:2.4-D composition in a ternary mixture is 47.9:34.2:17.9 v/v.
The present invention relates to promethrin compositions in form of a microemulsion with a concentration of the active ingredient between 15 and 20% w/v.
Technical grade promethrin is a solid that is marketed at a concentration of 96%-98% w/w with a very low solubility in water of 33 ppm (mg/L) at 20° C.
The microemulsion compositions are formulations containing very small emulsified oily drops which originate a clear formulation that is thermodynamically stable in a wide range of temperatures because the droplets have a very small size that varies in a range of 0.01 μm to 0.05 μm in diameter. Therefore, unlike other emulsion systems, wherein over time oily droplets can slowly melt causing phase separation, in microemulsion formulations this does not occur.
Microemulsions are made up of immiscible liquids and appropriate amounts of surfactant and co-surfactant.
The present microemulsion formulation of promethrin is composed of immiscible liquids comprising an organic solvent of non-polar formulation comprising a mixture of xylene-ethyl acetate or mixture of xylene-cyclohexanone-ethyl acetate (very poorly soluble in water) or a natural fatty acid dimethylamide such as coconut acids with 8 to 10 carbon atoms marketed as Genagen 4166 and as a polar solvent insoluble with the above organic solvent but soluble in water comprising water or propylene glycol or a propylene glycol-water mixture.
Among the surfactants for the promethrin microemulsion of the present embodiment, the following are preferred: as nonionic surfactant, castor oil ethoxylated with 36 moles of ethylene oxide, for example, that sold under the name Emulsogen EL 360; tristyryl phenol ethoxylated with 20 moles of ethylene oxide with low VOC content for example the one sold under the name Emulsogen TS 200; tridecyl alcohol ethoxylated with 6 moles of ethylene oxide, for example, the one sold under the name Genapol X060. Anionic surfactant is preferred to 60% or 70% w/w of calcium dodecylbenzenesulfonate (FS Ca) in isobutanol.
Polyalkylene glycol ether polymer is also used as a nonionic surfactant, for example, marketed under the name Atlas G5002 L.
The promethrin microemulsion also contains fatty acid methyl esters such as soybean oil as adjuvants; adjuvants give them an anti-evaporation and adherent power to agricultural applications; this property is essential to avoid the separation of active phases into the mixing tank at the time of applying agrochemicals. Based on the above components, the following microemulsions were prepared where the amounts in % w/v are described in the following tables:
In all the previous formulations, the technical grade drug was added in order to obtain the desired weight-by-volume concentrations.
The above microemulsion formulations showed excellent stability, suitably passing the emulsion tests in water without component separation, as demonstrated in the table presented at the end of the present description.
With the previous microemulsion formulations, the following tests were performed:
1) Comparative Test of Herbicides in Sunflower Preemergence (Wide Leaf) with Promethrin 18.5% ME
Trial design: Complete random blocks with plots 3 m wide by 10 m long.
a. Crop: Paradise Sunflower 1000 CL Plus planted
b. Site: La Dulce (Necochea district) Province of Buenos Aires.
c. Soil Moisture: Good soil moisture but very little stubble coverage
d. Characteristics of the application: The application was made the day after sowing. A 35 lb CO2 constant pressure manual backpack was used with 11002 tablets and an application volume of 140 L/ha.
The tailwind was of 20 km/h, relative humidity of 39% and 32° C. of room temperature.
e. Weeds present: The lot was clean at the time of application due to a control carried out with glyphosate 35 days before. But the presence of Sonchus oleraceus SONOL “cerraja” and Euphorbia dentata “Lecheron” was known in a certain sector.
f. Measured variables: 35 days after application and 76 days after application, visual control evaluations were performed for each weed present. The data were subjected to an analysis of variance and the means were compared with the Fisher test (DMS) with a p<0.05.
g. Results
The selectivity of all the doses on the sunflower was very notable. No morphological symptoms of phytotoxicity were seen. Lecheron controls were very good for all doses evaluated (Table 1). In dose 1 only a few isolated plants remained and the best treatment for this species was with dose 4.
Different letters between columns indicate significant differences between treatments.
SONOL controls are shown in Table 2. In general the control was not good for this herbicide. The control increased slightly as the dose was increased but none of the treatments reached 80% control. So it should be mixed with another active ingredient to control this weed.
Different letters between columns indicate significant differences between treatments.
Trial design: Plots of 10 m×4 m, with 3 replicates per treatment.
Work Report:
a. CROP: Application after sowing of the Sunflower crop, prior to the emergence of annual grass weeds, from predecessor Soybean campaign *14-*15. Lot for direct sowing. An early application against weeds from the harvest of the mentioned glyphosate-based crop. Treatments applied on Sep. 27, 2015 (sowing delayed with respect to the usual one for the region due to excess water in the lot under study).
b. SITE: Freyre, District of San Justo, Province of Cordoba, soil use class IVw, environment class 2.
c. CLIMATE CHARACTERISTICS: Lot with signs of excess water during the 14-15 season. Good environmental conditions during the fallow period, as well as a good history of previous weed controls, given the well-known seed bank of the site, the lot used at this stage is a site having good aptitude for the evaluation of the product in question. Ambient temperatures and humidity above the historical values for the months being surveyed.
Rainfalls and evapotranspiration of Freyre Site Historical series vs. campaign 15-16 is showed in Graph 1 of
d. WEED MONITORING: The initial survey was carried out by going across the lot of 60 hectares in total on a biweekly basis, walking it in the form of X and making the reading in a radius of 2 meters per sample, for a total of approximately 1 sample every 10 hectares.
At the time of application, the lot was clean of weeds, 2 days after sowing. Then, sampling was made 15 and 30 days after application, then registering the emergence of controllable seedlings (species and quantity).
e. EMERGENCES REGISTERED AND ASSESSMENT OF APPLICATION
Lolium multiflorum
Eleusine indica
Setaria sp.
Setaria sp.
Amaranthus quitensis
Gomphrena pulchella
Individuals present per square meter, average value of three repetitions of each treatment
f. Statistical Analysis
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
Different letters indicate significant differences (p≤0.05)
General Comments:
The product evaluated under this study had an adequate performance compared to the chemical control, directly dependent on the test dose and the biological features of each weed species being present. Its concentration and formulation features improve the handling of the final product compared to the chemical control.
Although the agronomic recommendation for this chemical molecule in use for grass species particularly indicates the convenience of accompaniments at varying doses of acetochlor to make control more robust, its herbicidal ability in the present study was clearly shown, both for the grasses as for broadleaf weeds present at the site.
3) Evaluation of Promethrin 18.5% Micro Emulsion in Preemergence Treatments on the Sunflower Crop on a Complete Coverage Basis, Evaluated in the Control of Annual Grass Weeds being Commonly Present in the Pampas Region, Susceptible to the Chemical Molecules Under Study.
Trial design: Plots of 10 m×4 m, with 3 repetitions per treatment.
Treatments Proposed:
Work Report:
a. CROP: Application after sowing of the Sunflower crop, prior to the emergence of annual grass weeds, from predecessor Soybean of the first campaign “15-” 16. Lot for direct sowing, with serious flooding problems after the intense rainfalls of April 2016. An early application against weeds from the harvest of the mentioned crop based on Glyphosate. Treatments applied on Aug. 29, 2016.
b. SITE: Nelson, La Capital District, Province of Santa Fe, soil use class IIIwe, environment class 2.
c. CLIMATE CHARACTERISTICS: Lot with serious water excesses during the pre-harvest season 15-16, which did not fully resolve during the fallow period. Good history of previous weed controls despite abundant seed bank on site.
Ambient temperatures and humidity above the historical values for the months being surveyed.
d. WEED MONITORING: The initial survey was carried out by going across the lot of 60 hectares in total on a biweekly basis, walking it in the form of X and making the reading in a radius of 2 meters per sample, for a total of approximately 1 sample every 10 hectares.
At the time of application, the lot was clean of weeds, 2 days after sowing. Then, sampling was made 15 and 30 days after application, then registering the emergence of controllable seedlings (species and quantity).
e. EMERGENCES REGISTERED AND ASSESSMENT OF APPLICATION
Lolium multiflorum
Eleusine indica
Sorghum halepense (riz)
Sorghum halepense (sem)
Individuals present per square meter, average value of three repetitions of each treatment
f. Statistical analysis:
Means with a common letter are not significantly different (p>0.05)
Variable N Ra Ra Aj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra RaAj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra RaAj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra Ra Aj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra Ra Aj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra Ra Aj CV
Means with a common letter are not significantly different (p>0.05)
Variable N Ra Ra Aj CV
Means with a common letter are not significantly different (p>0.05)
General Comments:
The environmental conditions of good soil moisture caused weed species to appear in the control row in accordance with the expected, despite the prevailing low temperatures post-application of the treatments.
The product evaluated in this study presented an adequate performance compared to the chemical control, directly dependent on the test dose and the biological features of each weed species present.
Although the agronomic recommendation for this chemical molecule in its use for grass species in particular indicates the convenience of accompaniments at varying doses of acetochlor to make control more robust, its herbicidal ability in the present study was evidently shown and with statistical significance in most cases, on the species covered in this work.
Objective:
To determine the efficacy of the herbicide promethrin 18.5% ME for the control of broadleaf weeds in a sunflower crop.
Experimental Conditions:
Identification of pests to be controlled.
Table 2: Weed species evaluated
Portulaca oleracea
Cyperus rotundus, Digitaria
sanguinalis, Sonchus
oleraceus, Conyza
bonariensis, Polygonum
aviculare, Chenopodium album
Euphorbia serpeas
Conyza bonariensis,
Amaranthus hybridus, Eleusine
Oxalis corniculata
indica, Gamochaeta spicata,
Lamium amplexicaule,
Cyperus rotundas
Portulaca oleracea
Amaranthus hybridus
Eleusine indica, Echinochloa
crusgalli, Ipomoea purpurea,
Sonchus oleraceus
Conyza bonariensis, Chloris
Ipomea grandifolia
Gamochaeta spicata, Lamium
amplexicaule
Weeds evaluated (present in more than 70% of the plots) Other species present in the weed community
Geographical locality and agro-ecological features.
Experimental Design:
In a randomized complete block design with four replications, plots three meters wide by seven meters long were marked with matched controls of one meter and the treatments described below were applied:
Form of Application
Herbicides being evaluated were sprayed on a complete coverage basis using an application volume of 120 l ha−1. To this end, a CO2 spraying backpack and four TTI 110-015 flat fan tablets were provided. In all cases the working pressure was 2 bar and the distance between peaks was 0.52 m. No unusual weather events occurred that may have had an impact on the study quality.
Evaluation, Data and Measurements Recording:
Method, timing and frequency of evaluation
Phytotoxicity:
At 15, 30 and 45 DDA, the phytotoxicity generated by the herbicides on the sunflower crop was evaluated visually and with a percentage scale from 0% to 100%.
Efficacy:
The control efficacy of treatments on weeds present at 15, 30 and 45 days after application (DDA) was evaluated. The control percentage of the herbicides was determined considering the seedlings emerged in the plot with respect to the seedlings emerged in the matched control.
Statistical Analysis:
Analysis of variance (ANOVA) was carried out using treatments and replicates of the test as classification variables, and the control exercised on weeds as a dependent variable. The means were compared using the Fisher test for p<0.05. The statistical program used was InfoStat (2016).
Results:
Balcarce
Portulaca oleracea
Conclusion:
Cyperus esculentus
Eleusine indica
Euphorbia serpens
Oxalis corniculatus
Conclusion:
Margarita
Amaranthus hybridus and Sonchus oleraceus
Ipomea grandifolia
Localities:
Balcarce, Buenos Aires, Argentina.
Cavanagh, Córdoba, Argentina.
Margarita, Santa Fe, Argentina.
Objective:
To determine the efficacy of the herbicide promethrin 18.5% ME for the control of weeds in the sunflower crop.
Experimental Conditions:
Portulaca oleracea
Chenopodium album, Brassica
napus, Polygonum aviculare,
Viola avenis, Conyza
bonariensis, Carduus nutans,
Digitaria sanguinalis,
Cyperus esculentus
Amarantlms hybridus
Conyza bonariensis,
Echinochloa crus-galli,
Portulaca oleracea
Gamochaeta spicata, Lamium
amplexicaule, Gamochaeta
spicata, Eulisine indica
Amaranthus hybridus
Conyza bonariensis, Portulaca
oleracea, Catula australis,
Lamium amplexicaule,
Gamochaeta spicata
The meteorological data in Balcarce, Cavanagh and Margarita from November 2018 to January 2019 is showed in
Design of the Experiment/Size of the Plot/Number of Repetitions/Choice of Treatments
In a randomized complete block design with four replications, the present trial was carried out on plots three meter wide by seven meter long, with matched controls of one meter.
Application Data:
Form of Application:
The evaluated herbicides were sprayed on a complete coverage basis using an application volume of 110 l ha−1. To this end, a CO2 spraying backpack and four TTI 110-015 flat fan tablets were provided. In all cases the working pressure was 2 bar and the distance between peaks was 0.52 m. No unusual weather events occurred that may have had an impact on the study quality.
Evaluation, Data and Measurements Recording:
Method, Timing and Frequency of Evaluation
Phytotoxicity
At 15, 30 and 45 days after application (DDA), the phytotoxicity generated by herbicides on the sunflower crop was evaluated visually and with a percentage scale from 0% to 100%.
Efficacy:
The efficacy of control of the treatments on the weeds present at 15, 30 and 45 days after application (DDA) was evaluated. To this end, the present symptomatology on weeds was considered (Table 8).
Statistical Analysis:
Analysis of variance (ANOVA) was performed using the treatments and replicates of the test as classification variables. The means were compared using the Fisher test for p<0.05. The statistical program used was InfoStat (2016).
Results:
Balcarce
Portulaca oleracea
Conclusions:
Portulaca oleracea
Amaranthus hibridus
Conclusions:
Margarita
Amaranthus hibridus
Conclusions:
From conclusions of the previous tests, the inventors of the present invention unexpectedly found that when micro-emulsion of promethrin was used at low concentration, it had a reduction in the application dose compared to using promethrin 50 EC in the treatment of weeds of the sunflower.
This result is not expected since the active ingredient used in both cases is the same and the person skilled in the art would suppose that both types of formulation would be applied at the same dose.
In addition to the above-described main advantage of showing a reduction in the application dose, and thanks to the combination of the other components of the micro-emulsion formulations that the researchers used for this embodiment, the present micro-emulsion formulation of promethrin offered protection against physicochemical losses (evaporation, rolling, etc.); improvement of the absorption rate; significant reduction of the environmental impact variables; drastic reduction of solvent evaporation; allowing the active ingredients to be kept in the liquid phase; allowing hydrophobic actives to solubilize in water; a large increase in the Surface/Volume ratio and controlled release of active ingredients.
Combination of Promethrin Compositions in Micro-Emulsion Form with Glyphosate and 2-4 D Compositions
The micro-emulsion compositions of promethrin developed in the present description were combined with commercial compositions of glyphosate potassium salt 54% w/v and 2.4 D 30% w/v ME at different volume ratios in binary and ternary compositions, measuring stability in hours by means of the Emulsion Test, in all cases it was found that the mixture unexpectedly showed comparable stability within 12 to 20 hours after preparation, which is a more than acceptable time to mix the products in formulation tanks to the corresponding dilution to apply to the crops.
For example, for a 40 L broth having three components it would be 32.3 L of water+3.5 L of Promethrin 18.5% ME+2.5 L Glyphosate 54% SL+1.3 L 2.4 D 30% ME. For an 80 L broth having three components it would be 72, L of water+3.5 L of Promethrin 18.5% ME+2.5 L Glyphosate 54% SL+1.3 L 2.4 D 30% ME.
The results obtained are shown in the following Table:
| Number | Date | Country | Kind |
|---|---|---|---|
| P20200101331 | May 2020 | AR | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/IB2020/057235 | 7/30/2020 | WO |
