Claims
- 1. A compound of the formula ##STR12## wherein R.sup.1 is hydrogen or a group of formula ##STR13## n is the number 0 or 1; R.sup.2 and R.sup.5 are phenyl, m-halophenyl or m-trifluoromethylphenyl;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen, --CH.sub.2 COOH, --CH.sub.2 COO--C.sub.1-4 -alkyl, --(CH.sub.2).sub.2 O--C.sub.1-4 -alkyl or --(CH.sub.2).sub.2 O(Ch.sub.2).sub.1-4 --C.sub.6 H.sub.5 ;
- or a physiologically compatible salt thereof.
- 2. A compound according to claim 1 wherein R.sup.1 is hydrogen.
- 3. A compound according to claim 1, wherein R.sup.1 is the group (a); and n is the number 0 or 1.
- 4. A compound according to claim 1, wherein R.sup.1 is hydrogen and R.sup.4 is hydrogen, 2-ethoxyethyl or 2-phenyethoxyethyl.
- 5. A compound according to claim 4, wherein R.sup.2 is m-chlorophenyl.
- 6. A compound according to claim 4, wherein R.sup.2 is phenyl and R.sup.4 is 2-ethoxyethyl or ethoxy-carbonylmethyl.
- 7. A compound according to claim 6, selected from the group consisting of;
- (R or S)-(GL).beta.-[[[p-(2-ethoxyethoxy)phenethyl]amino]methyl]-phenethyl alcohol,
- ethyl [p-[2-[[.beta.-(hydroxymethyl[phenethyl]amino]ethyl]-phenoxy]acetate, and
- .beta.[[[(R)-p-(2-ethoxyethoxy)-.alpha.-methylphenethyl]amino[methyl]phenethyl alcohol.
- 8. A compound according to claim 1 wherein R.sup.3 is methyl and a C-atom of the compound attached to the methyl group of R.sup.3 has a R-configuration.
- 9. A compound according to claim 1, wherein R.sup.1 is the group of the formula (a): n is the number 1; R.sup.2 is phenyl or m-halophenyl; R.sup.3 is hydrogen, R.sup.4 is 2-ethoxy-ethyl; and R.sup.5 is phenyl or m-halophenyl.
- 10. A compound according to claim 9 wherein R.sup.5 is m-chlorophenyl.
- 11. A compound according to claim 9 wherein n is the number 0; and R.sup.5 is phenyl.
- 12. A compound according to claim 11 wherein a C-atom of the compound of formula I attached to the R.sup.5 has a R configuration.
- 13. A compound according to claim 9, wherein R.sup.2 is m-chlorophenyl.
- 14. A compound according to claim 9, wherein R.sup.1 is .beta.-hydroxyphenethyl and R.sup.2 is m-chlorophenyl.
- 15. A compound according to claim 14 wherein R.sup.1 is (R)-.beta.-hydroxylphenethyl.
- 16. A compound according to claim 1, (RS)-m-Chloro-.beta.-[p-(2-ethoxyethoxy)phenethyl] [[[(R)-.beta.-hydroxyphenethyl]-amino]methyl]phenethyl alcohol.
- 17. A composition for treating obesity or diabetes mellitus comprising:
- a) a compound of the formula ##STR14## wherein R.sup.1 is hydrogen or a group of formula ##STR15## n is the number 0 or 1; R.sup.2 and R.sup.5 are phenyl, m-halophenyl or m-trifluoromethylphenyl;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen, --CH.sub.2 COOH, --CH.sub.2 COO--C.sub.1-4 -alkyl, --(CH.sub.2).sub.2 O--C.sub.1-4 -alkyl or --(CH.sub.2).sub.2 O(CH.sub.2).sub.1-4 --C.sub.6 H.sub.5 ;
- or a physiologically compatible salt thereof, in an amount which is effective in treating obesity or diabetic mellitus, and
- b) a pharmaceutically acceptable carrier.
- 18. A composition according to claim 17 wherein the carrier is suitable for oral administration of the composition.
- 19. A method for treating obesity, or diabetes mellitus in a patient in need of such treatment comprising:
- administering a compound of the formula ##STR16## wherein R.sup.1 is hydrogen or a group of formula ##STR17## n is the number 0 or 1; R.sup.2 and R.sup.5 are phenyl, m-halophenyl, m-trifluoromethylphenyl;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen, --CH.sub.2 COOH, --CH.sub.2 COO--C.sub.1-4 -alkyl, --(CH.sub.2).sub.2 O--C.sub.1-4 -alkyl or --(CH.sub.2).sub.2 O(CH.sub.2).sub.1-4 --C.sub.6 H.sub.5 ;
- or a physiological compatible salt thereof, in an amount effective for treating obesity or diabetes mellitus.
- 20. A composition for fattening animals comprising:
- a) an effective amount to fatten animals of a compound of the formula ##STR18## wherein R.sup.1 is hydrogen or a group of formula ##STR19## n is the number 0 or 1; R.sup.2 and R.sup.5 are phenyl, m-halophenyl or m-trifluoromethylphenyl;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen, --CH.sub.2 COOH, --CH.sub.2 COO--C.sub.1-4 -alkyl, --(CH.sub.2).sub.2 O--C.sub.1-4 -alkyl or --(CH.sub.2).sub.2 O(CH.sub.2).sub.1-4 --C.sub.6 H.sub.5 ;
- or a physiologically compatible salt thereof, and
- b) a compatible carrier material.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2245/88 |
Jun 1989 |
CHX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/363,242, filed 6/8/89 now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (2)
Number |
Date |
Country |
7208391 |
Dec 1972 |
NLX |
8400956 |
Mar 1984 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Jen et al., Adrenergic Agents, J. Med. Chem., vol. 20, No. 5, 693-698 (1977). |
Kienzle, F., CA, vol. 112, 234956z, 1990. |
Continuations (1)
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Number |
Date |
Country |
Parent |
363242 |
Jun 1989 |
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