Claims
- 1. A pressurized aerosol composition comprising:a liquefied hydrofluorocarbon propellant of general formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1; from 0.01 to 15% w/w of a particulate medicament dispersed in said liquefied hydrofluorocarbon propellant; and from 0.01 to 10% w/w of a fluorinated surfactant which is soluble in said liquefied hydrofluorocarbon propellant; wherein the pressurized aerosol composition comprises no solvent, other than the liquefied hydrofluorocarbon propellant.
- 2. A composition according to claim 1, wherein said liquefied hydrofluorocarbon propellant is selected from the group consisting of CF3CFH2, CF3CHFCF3 and mixtures thereof and the fluorinated surfactant is non-ionic.
- 3. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains at least one (CF2) group.
- 4. A composition according 2, wherein the non-ionic fluorinated surfactant contains one or more ether or carboxylic ester linkages.
- 5. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains at least one (CH2) group.
- 6. A composition according to claim 2, wherein the medicament is selected from the group consisting of sodium cromoglycate, nedocromil sodium, beclomethasone dipropionate, fluticasone, tipredane, ipratropium bromide, atropine or a bronchodilator selected from salbutamol, reproterol, terbutaline, formoterol, pirbuterol, isoprenaline, salmeterol, fenoterol and a salt of any one thereof.
- 7. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains from 2 to 60 (CF2) groups.
- 8. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains from 2 to 60 ether or carboxylic ester linkages.
- 9. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains both ether and carboxylic ester linkages.
- 10. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains 2 to 60 (CH2) groups.
- 11. A composition according to claim 2, wherein the non-ionic fluorinated surfactant contains from 2 to 30 (OCH2CH2) groups.
- 12. A composition according to claim 2, wherein the non-ionic fluorinated surfactant is a polyfluoroalkyloxyethylene of the general formula CmF2m+1CH2(OC2H4)nOH in which m is an integer from 7 to 18 and n is an integer from 2 to 6.
- 13. A composition according to claim 2, wherein the non-ionic fluorinated surfactant is selected from the group consisting of (CF3)2CFO(CF2)zCONH(CH2)3N(O)CH3)2 in which z is an integer from 2 to 20, CF3CFOCF2CF2CH2CH2(OCH2CH2)zOH in which z is an integer from 2 to 20, CF3CF2CF2O(CF(CF3)CF2CF2O)nCF2CF2CF3 in which n is an integer from 10 to 60, and fluoroaliphatic polymeric esters having a fluorinated portion based on and a portion including an ethylene/propylene oxide block copolymer.
- 14. A composition according to claim 2, wherein the liquefied hydrofluorocarbon propellant contains CF3CHFCF3.
- 15. A pressurized aerosol composition comprising:a liquefied hydrofluorocarbon propellant of general formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1; from 0.05 to 15% w/w of a particulate medicament dispersed in said liquefied hydrofluorocarbon propellant; and from 0.1 to 10% w/w of a fluorinated surfactant which is soluble in said liquefied hydrofluorocarbon propellant; wherein the pressurized aerosol composition comprises no solvent.
Priority Claims (4)
Number |
Date |
Country |
Kind |
9002351 |
Feb 1990 |
GB |
|
9023655 |
Oct 1990 |
GB |
|
9026476 |
Dec 1990 |
GB |
|
PCT/GB91/00133 |
Jan 1991 |
WO |
|
Parent Case Info
This is a Rule 62 Continuation of application Ser. No. 08/355,106, filed Dec. 13, 1994, now abandoned, which is a Rule 62 Continuation of application Ser. No. 07/916,107, filed Jul. 22, 1992, now abandoned.
US Referenced Citations (17)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0372777 |
Jun 1990 |
EP |
PCTGB9000015 |
Jul 1990 |
WO |
9200062 |
Jan 1992 |
WO |
Continuations (2)
|
Number |
Date |
Country |
Parent |
08/355106 |
Dec 1994 |
US |
Child |
08/766580 |
|
US |
Parent |
07/916107 |
Jul 1992 |
US |
Child |
08/355106 |
|
US |