Claims
- 1. A therapeutic composition for topical treatment of ocular hypertension or glaucoma, containing a prostaglandin PGD in an amount sufficient to reduce intraocular pressure without causing substantial ocular irritation and an ophthalmologically compatible vehicle, in which the alpha chain of the prostaglandin comprises a chain of 6 to 10 carbon atoms, which is either
- (a) saturated or
- (b) unsaturated having one or more non-cumulated double bonds, or a triple bond,
- the alpha chain being
- (c) unsubstituted or
- (d) substituted with one or more substituents selected from the group of alkyl groups, alicyclic rings, aromatic rings or heteroaromatic rings,
- and in which the omega chain of the prostaglandin has the formula
- C.sub.13 --B--C.sub.14 --D.sub.15-24 --R.sub.2
- wherein
- C is a carbon atom (the number according to standard prostaglandin nomenclature being indicated by the subscript);
- B is a single bond, a double bond, or a triple bond;
- D represents a sub-chain of 1-10 carbon atoms and 1-2 heteroatoms selected from the group that consists of O, N, and S, with substituents on each sub-chain atom that are selected from the group consisting of a hydrogen atom, an alkyl group, an oxo group and a hydroxyl group, and
- R.sub.2 is an aromatic ring structure which is unsubstituted or has at least one substituent selected from the group consisting of
- C.sub.1 -C.sub.5 alkyl groups,
- C.sub.1 -C.sub.4 alkoxy groups,
- trifluoromethyl groups,
- C.sub.1 -C.sub.3 aliphatic acylamino groups,
- nitro groups,
- halogen atoms,
- a phenyl group.
- 2. A composition according to claim 1 in which, in the omega chain of the prostaglandin R.sub.2 is a phenyl group.
- 3. A composition according to claim 1 in which, in the omega chain of the prostaglandin, R.sub.2 is a phenyl group which is
- (1) unsubstituted or
- (2) has at least one substituent selected from the group consisting of
- C.sub.1 -C.sub.5 alkyl groups,
- C.sub.1 -C.sub.4 alkoxy groups,
- trifluoromethyl groups,
- C.sub.1 -C.sub.3 aliphatic acylamino groups,
- nitro groups,
- halogen atoms, or
- a phenyl group.
- 4. A composition according to claim 1 in which, in the omega chain of the prostaglandin,
- B is a single or double bond,
- D is a carbon chain with 2-5 carbon atoms, in which C.sub.15 is substituted with an oxo or hydroxyl substitutent, and C.sub.16 -C.sub.19 are unsubstituted or substituted with lower alkyl substituents, and
- R.sub.2 is a phenyl ring which is unsubstituted or substituted with one or more subsitutent selected from the group consisting of alkyl or alkoxy groups.
- 5. A composition according to claim 1 in which, in the omega chain of the prostaglandin,
- B is a single bond;
- D is a chain of 3 carbon atoms; and
- R.sub.2 is a phenyl group.
- 6. A composition according to claim 1 in which the prostaglandin is an isopropyl ester.
- 7. A composition according to claim 1 in which the prostaglandin is an ester of 13,14-dihydro-17-phenyl-18,19,20-trinor-PGD.
- 8. A composition according to claim 1 in which the prostaglandin is a 13,14-dihydro-17-phenyl-18,19,20-trinor-PGD.
- 9. A composition according to claim 1 in which the prostaglandin is a 13,14-dihydro-17-phenyl-18,19,20-trinor-PGD isopropyl ester.
- 10. A method of treating glaucoma or ocular hypertension by topical application of the therapeutic composition of claim 1.
- 11. A method of treating glaucoma or ocular hypertension by topical application of the therapeutic composition of claim 6.
- 12. A method of treating glaucoma or ocular hypertension by topical application of the therapeutic composition of claim 7.
- 13. A method of treating glaucoma or ocular hypertension by topical application of the therapeutic composition of claim 8.
- 14. A method of treating glaucoma or ocular hypertension by topical application of the therapeutic composition of claim 9.
- 15. A method of treating glaucoma or ocular hypertension by topical application of a therapeutic composition according to claim 2.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8803110 |
Sep 1988 |
SEX |
|
880385 |
Oct 1988 |
SEX |
|
Parent Case Info
This application is a division of application Ser. No. 07/986,943 filed on Dec. 8, 1992, now U.S. Pat. No. 5,422,368, issued Jun. 6, 1995, which is a continuation of Ser. No. 07/469,442 filed on Apr. 10, 1990, now abandoned.
US Referenced Citations (20)
Foreign Referenced Citations (1)
Number |
Date |
Country |
573018 |
Feb 1986 |
AUX |
Divisions (1)
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Number |
Date |
Country |
Parent |
986943 |
Dec 1992 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
469442 |
Apr 1990 |
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