Claims
- 1. A prostaglandin D represented by formula (I):
- wherein
- (X) is ##STR23## R.sub.1 is hydrogen, a physiologically acceptable salt residue or a physiologically acceptable alkyl ester residue;
- R.sub.2 is hydrogen or methyl;
- R.sub.3 is hydroxyl, methyl or hydroxymethyl;
- R.sub.4 and R.sub.5, which may be the same or different, each represents hydrogen, methyl or halogen;
- when at least 1 of R.sub.4 and R.sub.5 is halogen, R.sub.6 is C.sub.1-9 alkyl which may be branched or contain a double bond or is a C.sub.1-9 alkyl containing a C.sub.1-2 alkoxy substituent; or
- when R.sub.4 and R.sub.5 are independently hydrogen or methyl, R.sub.6 is C.sub.6-9 alkyl which may be branched or contain a double bond or a C.sub.1-9 alkyl containing a C.sub.1-2 alkoxy substituent;
- and wherein carbons at the 2-3 positions may have double bond.
- 2. A prostaglandin D of claim 1, in which R.sub.6 is a C.sub.4 -C.sub.9 alkyl group.
- 3. A prostaglandin D of claim 1, in which R.sub.6 is a C.sub.2 -C.sub.6 alkyl group having a methoxy or ethoxy substituent.
- 4. A prostaglandin D of claim 1, in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group.
- 5. A prostaglandin D of claim 1, in which R.sub.4 and/or R.sub.5 is methyl or fluorine atom.
- 6. A prostaglandin D of claim 1, in which the R.sub.1 ester residue is selected from the group consisting of a C.sub.1-4 alkyl group, an alkylsilicon group and a tetrahydroxypyran group.
- 7. A prostaglandin D of claim 1, in which at least one of R.sub.4 and R.sub.5 is a halogen atom.
- 8. A prostaglandin D of claim 7, in which the halogen atom is a fluorine atom.
- 9. A prostaglandin D of claim 8, in which both R.sub.4 and R.sub.5 are fluorine atoms.
- 10. A prostaglandin D of claim 8, in which one of R.sub.4 and R.sub.5 is a fluorine atom and the other is a hydrogen atom.
- 11. A prostaglandin D of claim 1, in which at least one of R.sub.4 and R.sub.5 is a methyl group.
- 12. A prostaglandin D of claim 11, in which both R.sub.4 and R.sub.5 are a methyl.
- 13. A prostaglandin D of claim 11, in which one of R.sub.4 and R.sub.5 is a methyl group and the other is a hydrogen atom.
- 14. A prostaglandin D of claim 1, in which R.sub.6 is --(CH.sub.2).sub.4 --C.sub.1-5 alkyl.
- 15. A prostaglandin D of claim 1, in which R.sub.6 is a C.sub.6 alkyl group.
- 16. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 1 as an active ingredient, and a pharmaceutically acceptable carrier.
- 17. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 2 as an active ingredient, and a pharmaceutically acceptable carrier.
- 18. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 3 as an active ingredient, and a pharmaceutically acceptable carrier.
- 19. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 4 as an active ingredient, and a pharmaceutically acceptable carrier.
- 20. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 5 as an active ingredient, and a pharmaceutically acceptable carrier.
- 21. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 6 as an active ingredient, and a pharmaceutically acceptable carrier.
- 22. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 7 as an active ingredient, and a pharmaceutically acceptable carrier.
- 23. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 8 as an active ingredient, and a pharmaceutically acceptable carrier.
- 24. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 9 as an active ingredient, and a pharmaceutically acceptable carrier.
- 25. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 10 as an active ingredient, and a pharmaceutically acceptable carrier.
- 26. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 11 as an active ingredient, and a pharmaceutically acceptable carrier.
- 27. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 12 as an active ingredient, and a pharmaceutically acceptable carrier.
- 28. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 13 as an active ingredient, and a pharmaceutically acceptable carrier.
- 29. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 14 as an active ingredient, and a pharmaceutically acceptable carrier.
- 30. A tranquilizer or soporific containing an amount effective as a tranquilizer or soporific of a prostaglandin D of claim 15 as an active ingredient, and a pharmaceutically acceptable carrier.
- 31. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 1.
- 32. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 2.
- 33. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 3.
- 34. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 4.
- 35. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 5.
- 36. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 6.
- 37. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 7.
- 38. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 8.
- 39. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 9.
- 40. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 10.
- 41. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 11.
- 42. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 12.
- 43. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 13.
- 44. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 14.
- 45. A process for treating a patient in need of a tranquilizer which comprises administering to said patient a tranquilizing effective amount of a compound of claim 15.
- 46. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 1.
- 47. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 2.
- 48. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 3.
- 49. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 4.
- 50. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 5.
- 51. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 6.
- 52. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 7.
- 53. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 8.
- 54. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 9.
- 55. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 10.
- 56. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 11.
- 57. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 12.
- 58. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 13.
- 59. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 14.
- 60. A process for treating a patient in need of a soporific which comprises administering to said patient a soporific effective amount of a compound of claim 15.
Priority Claims (1)
| Number |
Date |
Country |
Kind |
| 62-18821 |
Jun 1987 |
JPX |
|
Parent Case Info
This application is a divisional application of Ser. No. 07/403,774 filed Sept. 6, 1989, U.S. Pat. No. 5,073,569, in turn a continuation-in-part application of Ser. No. 07/149,272 filed Jan. 28, 1988, the latter abandoned.
US Referenced Citations (1)
| Number |
Name |
Date |
Kind |
|
5001153 |
Ueno |
Mar 1991 |
|
Foreign Referenced Citations (1)
| Number |
Date |
Country |
| 2272641 |
Dec 1975 |
FRX |
Non-Patent Literature Citations (3)
| Entry |
| Chemical Abstracts, vol 86, No. 11 Mar. 14, 1977, p. 69, Abstract No. 65891m, Columbus, Ohio. |
| Chemical Abstracts, vol. 102, No. 19, May 13, 1985, p. 125, Abstract No. 161123g, Columbus, Ohio. |
| Biochemical and Biophysical Research Communications vol. 109, No. 2, 1982, pp. 576-582. |
Divisions (1)
|
Number |
Date |
Country |
| Parent |
403774 |
Sep 1989 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
| Parent |
149272 |
Jan 1988 |
|
Patent Grant
5137915
