PROTEASE INHIBITORS AND LPS INDUCED FEVER

Information

• Research Project
• 6078399

• ApplicationId

  6078399

• Core Project Number

  R03TW000992

• Full Project Number

  5R03TW000992-02

• Serial Number

  992

• FOA Number

  PA-95-11

• Sub Project Id

• Project Start Date

  9/30/1998 - 26 years ago

• Project End Date

  9/29/2000 - 24 years ago

• Program Officer Name

  MICHELS, KATHLEEN M

• Budget Start Date

  9/30/1999 - 25 years ago

• Budget End Date

  9/29/2000 - 24 years ago

• Fiscal Year

  1999

• Support Year

  2

• Suffix

• Award Notice Date

  9/21/1999 - 25 years ago

Organizations

• LOVELACE RESPIRATORY RESEARCH INSTITUTE

Studies in this proposal focus on the mechanism by which the acute-phase proteins a1-antitrypsin (AAT) and a2-macroglobulin (AMG) act as positive modulators of fever. Because these proteins are protease inhibitors, the investigators hypothesize that they act by increasing the concentrations of pyrogenic cytokines in the circulatory system and the hypothalamus. The proposed studies are to test two potential models. The specific aims are to: 1. Test the hypothesis that AAT acts as an endogenous pyrogen during LPS-induced fever; 2. Test the hypothesis that AMG acts as an endogenous pyrogen during LPS-induced fever; 3. Test the hypothesis that circulating AAT and AMG modulate fever via the regulation of cytokine clearance.

IC Name

• Activity

  R03

• Administering IC

  TW

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  989

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ICP

• Study Section Name

  International and Cooperative Projects Study Section

• Organization Name

  LOVELACE RESPIRATORY RESEARCH INSTITUTE

• Organization Department

• Organization DUNS

• Organization City

  ALBUQUERQUE

• Organization State

  NM

• Organization Country

  UNITED STATES

• Organization Zip Code

  87108

• Organization District

  UNITED STATES