Claims
- 1. A compound of formula (I)
- 2. The compound of claim 1 wherein
X is —CRx; Y is —CRy—; Z is —CRz—; one of Rx, Ry, Rz, and R1 is aryl and the others are hydrogen; and R2 is heterocycle, wherein the heterocycle is other than imidazolyl.
- 3. The compound of claim 2 wherein the aryl is 4-hydroxy-3-methoxyphenyl and the heterocycle is selected from the group consisting of pyrrolopyridinyl, and unsubstituted pyrrolyl.
- 4. The compound of claim 3 selected from the group consisting of
(3Z)-5-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; and (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-1,3-dihydro-2H-indol-2-one.
- 5. The compound of claim 2 wherein the aryl is 4-hydroxy-3-methoxyphenyl and the heterocycle is selected from the group consisting of indolyl and pyridinyl.
- 6. The compound of claim 5 selected from the group consisting of
(3E)-6-(4-hydroxy-3-methoxyphenyl)-3-(pyridin-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-[(7-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-indol-2-one; and (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-indol-3-ylmethylene)-1,3-dihydro-2H-indol-2-one.
- 7. The compound of claim 2 wherein the aryl is 4-hydroxy-3-methoxyphenyl and the heterocycle is substituted pyrrolyl.
- 8. The compound of claim 7 selected from the group consisting of
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-6-(4-hydroxy-3-methoxyphenyl)-1,3-dihydro-2H-indol-2-one; methyl 3-(5-{(Z)-[6-(4-hydroxy-3-methoxyphenyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoate; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-[(3-isopropyl-5-methyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[4-(2-hydroxyethyl)-3,5-dimethyl-1H-pyrrol-2-yl]methylene}-6-(4-hydroxy-3-methoxyphenyl)-1,3-dihydro-2H-indol-2-one; and (3Z)-3-({4-[(dimethylamino)methyl]-3-isopropyl-5-methyl-1H-pyrrol-2-yl}methylene)-6-(4-hydroxy-3-methoxyphenyl)-1,3-dihydro-2H-indol-2-one.
- 9. The compound of claim 2 wherein the aryl is 4-hydroxy-2-methoxyphenyl and the heterocycle is pyrrolyl.
- 10. The compound of claim 9 which is
(3Z)-6-(4-hydroxy-2-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one.
- 11. The compound of claim 2 wherein the aryl is 4-hydroxy-2-methylphenyl and the heterocycle is pyrrolyl.
- 12. The compound of claim 11 which is
(3E)-6-(4-hydroxy-2-methylphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one.
Parent Case Info
[0001] This application claims priority to the U.S. Provisional Application Ser. No. 60/341,410, filed Dec. 13, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
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60341410 |
Dec 2001 |
US |