Claims
- 1. A method of forming a compound having the general formula I
- 2. The method of claim 1 wherein said reaction with compound (III) occurs in the presence of an acid.
- 3. The method of claim 2 wherein said acid is selected from the group consisting of tosic acid or p-toluenesulfonic acid.
- 4. The method of claim 1 wherein said reducing agent is a borane anion.
- 5. The method of claim 1 wherein said ester is triethylorthoformate.
- 6. The method of claim 1, wherein said halogenating agent is a chlorinating agent.
- 7. The method of claim 1 wherein said compound of formula I is 3-(3-Cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H-purine.
- 8. A method of forming a compound having the general formula I
- 9. The method of claim 8 wherein said reaction with compound (III) occurs in the presence of an acid.
- 10. The method of claim 9 wherein said acid is selected from the group consisting of tosic acid or p-toluenesulfonic acid.
- 11. The method of claim 8 wherein said ester is ethyl ester.
- 12. The method of claim 8 wherein said cyclization agent is ethyl 3-ethoxyacrylate.
- 13. The method of claim 8, wherein said halogenating agent is a chlorinating agent.
- 14. The method of claim 8 wherein said compound of formula I is 3-(3-Cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H-purine.
- 15. A method of forming a compound having the general formula I
- 16. The method of claim 15 wherein X1 and X2 of compound (II) are bromide.
- 17. The method of claim 15 wherein said cyclization agent is ethyl 3-ethoxyacrylate.
- 18. The method of claim 15, wherein said halogenating agent is a chlorinating agent.
- 19. The method of claim 15 wherein said ester of compound (IV) is ethyl ester.
- 20. The method of claim 15 wherein said compound of formula I is 3-(3-Cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H-purine.
- 21. A method of forming a compound having the general formula I
- 22. The method of claim 21 wherein X1 and X2 of compound (II) are bromide.
- 23. The method of claim 21 wherein said cyclization agent is triethylorthoformate when Y1 is CH.
- 24. The method of claim 21, wherein said halogenating agent is a chlorinating agent.
- 25. The method of claim 15 wherein said compound of formula I is 3-(3-Cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H-purine.
- 26. A compound having the general formula (I):
- 27. The compound of claim 26 wherein R4 is cyclopentyl.
- 28. The compound of claim 27 wherein R3 is methyl.
- 29. The compound of claim 28 where Z is CH2.
- 30. A pharmaceutical composition of a compound of claim 26.
- 31. A method of effecting selective PDE IV inhibition in mammals requiring the same, which comprises administering an effective amount of a compound of claim 26.
- 32. A method of treating a mammal suffering from a disease state selected from consisting of asthma, allergies, inflammation, dementia, atopic diseases, rhinitis, states associated with abnormally high physiological levels of cytokine, administering an effective amount of a compound of claim 26.
Parent Case Info
[0001] This application is a continuation-in-part of provisional application Serial No. 60/069,371, filed Dec. 12, 1997.
Continuations (1)
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Continuation in Parts (14)
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