TREA

Purine compounds

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Information

  • Patent Application
  • 20070203159
  • Publication Number
    20070203159
  • Date Filed
    February 28, 2006
    19 years ago
  • Date Published
    August 30, 2007
    17 years ago
Information
Abstract
The invention provides an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl) purine and purine analog compounds.
Description
Claims
  • 1. An antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl) purine, 8-aza-purine or 7-deaza-purine compound or a physiologically tolerable salt thereof.
  • 2. A compound as claimed in claim 1 being a purine or 7-deaza-purine or a salt thereof.
  • 3. A compound as claimed in claim 1 having a 4-methoxy-benzyl group at the 9-position.
  • 4. A compound as claimed in claim 1 having a 2-furyl group at the 6-position.
  • 5. A compound as claimed in claim 1 having a substituent at the 2-position containing 1 to 4 non-hydrogen atoms.
  • 6. A pharmaceutical composition comprising an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl)-purine, 8-aza-purine or 7-deaza-purine or a physiologically tolerable salt thereof together with a physiologically tolerable carrier or excipient.
  • 7. The use of an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl)-purine, 8-aza-purine or 7-deaza-purine or a physiologically tolerable salt thereof for the manufacture of a medicament for use in combatting mycobacterial infection, in particular tuberculosis.
  • 8. A method of treatment of a human or non-human animal (e.g. a mammal) subject to combat mycobacterial infection, said method comprising administering to said subject an effective amount of an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl)-purine, 8-aza-purine or 7-deaza-purine or a physiologically tolerable salt thereof.
  • 9. A method as claimed in claim 8 wherein said infection is tuberculosis.
  • 10. A compound as claimed in claim 2 having a 4-methoxy-benzyl group at the 9-position.
  • 11. A compound as claimed in claim 2 having a 2-furyl group at the 6-position.
  • 12. A compound as claimed in claim 3 having a 2-furyl group at the 6-position.
  • 13. A compound as claimed in claim 2 having a substituent at the 2-position containing 1 to 4 non-hydrogen atoms.
  • 14. A compound as claimed in claim 3 having a substituent at the 2-position containing 1 to 4 non-hydrogen atoms.
  • 15. A compound as claimed in claim 4 having a substituent at the 2-position containing 1 to 4 non-hydrogen atoms.