Claims
- 1. A substituted purine of formula ##STR12## wherein X is sulphur or oxygen; R.sup.1 is halogen, hydrogen, thio,alkylthio, alkoxy or azide; R.sup.2 is hydrogen, halogen, amino or azide; R.sup.3 is nitrogen, straight or branched chain or cyclic alkyl, hydroxyalkyl, benzyloxyalkyl or phenyl; R.sup.4 is hydrogen, hydroxy, or lower alkyl; R.sup.5 is hydrogen, hydroxy, amino, alkyl, hydroxyalkyl, benzoyloxy, benzoyloxymethyl, benzyloxy, sulphamoyloxy, phosphate, carboxypropionyloxy, or acetoxy; and R.sup.6 is hydrogen alkyl, hydroxyalkyl or a pharmaceutically acceptable salt thereof.
- 2. A substituted purine of formula (I) according to claim 1 wherein X is an oxygen atom.
- 3. A method of treating a susceptible viral infection in a mammal which comprises administering an effective non-toxic amount of the compound or a pharmaceutically acceptable salt of claim 1.
- 4. The method of claim 3 in which X is oxygen.
- 5. The method of claim 4 in which R.sup.1 is chlorine, R.sup.2 is amino, R.sup.5 is benzoyloxy and R.sup.3, R.sup.4 and R.sup.6 are hydrogen.
- 6. The method of claim 3 in which the viral infection is a herpes virus infection.
- 7. The method of claim 5 in which the viral infection is a herpes virus infection.
- 8. A pharmaceutical composition comprising an effective anti-viral amount of the compound or salt of claim 1 and a pharmaceutically acceptable carrier therefore.
- 9. The composition of claim 8 in which X is oxygen.
- 10. The composition of claim 8 in which the amount is an effective anti-herpes amount.
- 11. The composition of claim 8 in a form for oral or topical administration.
- 12. A compound of formula (I) ##STR13## wherein R.sup.1 is chlorine, R.sup.2 is amino, R.sup.5 is benzoyloxy and R.sup.3, R.sup.4 and R.sup.6 are each hydrogen or a pharmaceutically acceptable salt thereof, wherein X is oxygen.
- 13. A method of treating a susceptible viral infection in a mammal which comprises administering an effective non-toxic amount of the compound or salt of claim 12.
- 14. A pharmaceutical composition comprising an effective anti-viral amount of the compound or salt of claim 12 and a pharmaceutically acceptable carrier therefor.
- 15. The compound of the formula I ##STR14## wherein X is sulphur or oxygen; R.sup.1 is hydrogen, halogen, hydroxy, alkoxy, azide, thio, or alkylthio; R.sup.2 is hydrogen, halogen, alkylthio, amino or azide, provided R.sup.2 is not amino when R.sup.1 is hydroxy; R.sup.3 is hydrogen, straight or branched chain or cyclic alkyl, hydroxyalkyl, benzyloxyalkyl or phenyl, R.sup.4 is hydrogen, hydroxy or alkyl; R.sup.5 is hydrogen hydroxy, amino, alkyl, hydroxyalkyl, benzyloxy, benzoyloxy, benzoyloxymethyl, sulphamoyloxy, phosphate, or straight or branched chain or cyclic acyloxy having from 1 to 8 carbon atoms; R.sup.6 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
- 16. The compound or salt of claim 15 wherein R.sup.5 is straight or branched chain or cyclic acyloxy having from 1 to 8 carbon atoms.
Priority Claims (1)
Number |
Date |
Country |
Kind |
38278/74 |
Sep 1974 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 718,105, filed Aug. 27, 1976, now abandoned, which is a continuation in part of U.S. applications Ser. No. 662,900, filed Mar. 1, 1976, now U.S. Pat. No. 4,199,574, and Ser. No. 608,263, filed Aug. 27, 1975, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4146715 |
Schaeffer |
Mar 1979 |
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4199574 |
Schaeffer |
Apr 1980 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
718105 |
Aug 1976 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
662900 |
Mar 1976 |
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