TREA

Pyrazinones and triazinones and their derivatives thereof

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Information

  • Patent Grant
  • 6159980
  • Patent Number
    6,159,980
  • Date Filed
    Monday, September 15, 1997
    26 years ago
  • Date Issued
    Tuesday, December 12, 2000
    23 years ago
Information
Abstract
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
Description

FIELD OF THE INVENTION
This invention relates to novel compounds and pharmaceutical compositions, and to methods of using same in the treatment of psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
BACKGROUND OF THE INVENTION
Corticotropin releasing factor (herein referred to as CRF), a 41 amino acid peptide, is the primary physiological regulator of proopiomelanocortin(POMC)-derived peptide secretion from the anterior pituitary gland [J. Rivier et al., Proc. Nat. Acad. Sci. (USA) 80:4851 (1983); W. Vale et al., Science 213:1394 (1981)]. In addition to its endocrine role at the pituitary gland, immunohistochemical localization of CRF has demonstrated that the hormone has a broad extrahypothalamic distribution in the central nervous system and produces a wide spectrum of autonomic, electrophysiological and behavioral effects consistent with a neurotransmitter or neuromodulator role in brain [W. Vale et al., Rec. Prog. Horm. Res. 39:245 (1983); G. F. Koob, Persp. Behav. Med. 2:39 (1985); E. B. De Souza et al., J. Neurosci. 5:3189 (1985)]. There is also evidence that CRF plays a significant role in integrating the response of the immune system to physiological, psychological, and immunological stressors [J. E. Blalock, Physiological Reviews 69:1 (1989); J. E. Morley, Life Sci. 41:527 (1987)].
Clinical data provide evidence that CRF has a role in psychiatric disorders and neurological diseases including depression, anxiety-related disorders and eating disorders. A role for CRF has also been postulated in the etiology and pathophysiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis as they relate to the dysfunction of CRF neurons in the central nervous system [for review see E. B. De Souza, Hosp. Practice 23:59 (1988)].
In affective disorder, or major depression, the concentration of CRF is significantly increased in the cerebral spinal fluid (CSF) of drug-free individuals [C. B. Nemeroff et al., Science 226:1342 (1984); C. M. Banki et al., Am. J. Psychiatry 144:873 (1987); R. D. France et al., Biol. Psychiatry 28:86 (1988); M. Arato et al., Biol Psychiatry 25:355 (1989)]. Furthermore, the density of CRF receptors is significantly decreased in the frontal cortex of suicide victims, consistent with a hypersecretion of CRF [C. B. Nemeroff et al., Arch. Gen. Psychiatry 45:577 (1988)]. In addition, there is a blunted adrenocorticotropin (ACTH) response to CRF (i.v. administered) observed in depressed patients [P. W. Gold et al., Am J. Psychiatry 141:619 (1984); F. Holsboer et al., Psychoneuroendocrinology 9:147 (1984); P. W. Gold et al., New Eng. J. Med. 314:1129 (1986)]. Preclinical studies in rats and non-human primates provide additional support for the hypothesis that hypersecretion of CRF may be involved in the symptoms seen in human depression [R. M. Sapolsky, Arch. Gen. Psychiatry 46:1047 (1989)]. There is preliminary evidence that tricyclic antidepressants can alter CRF levels and thus modulate the numbers of CRF receptors in brain [Grigoriadis et al., Neuropsychopharmacology 2:53 (1989)].
There has also been a role postulated for CRF in the etiology of anxiety-related disorders. CRF produces anxiogenic effects in animals and interactions between benzodiazepine/non-benzodiazepine anxiolytics and CRF have been demonstrated in a variety of behavioral anxiety models [D. R. Britton et al., Life Sci. 31:363 (1982); C. W. Berridge and A. J. Dunn Regul. Peptides 16:83 (1986)]. Preliminary studies using the putative CRF receptor antagonist a-helical ovine CRF (9-41) in a variety of behavioral paradigms demonstrate that the antagonist produces "anxiolytic-like" effects that are qualitatively similar to the benzodiazepines [C. W. Berridge and A. J. Dunn Horm. Behav. 21:393 (1987), Brain Research Reviews 15:71 (1990)]. Neurochemical, endocrine and receptor binding studies have all demonstrated interactions between CRF and benzodiazepine anxiolytics providing further evidence for the involvement of CRF in these disorders. Chlordiazepoxide attenuates the "anxiogenic" effects of CRF in both the conflict test [K. T. Britton et al., Psychopharmacology 86:170 (1985); K. T. Britton et al., Psychopharmacology 94:306 (1988)] and in the acoustic startle test [N. R. Swerdlow et al., Psychopharmacology 88:147 (1986)] in rats. The benzodiazepine receptor antagonist (Ro15-1788), which was without behavioral activity alone in the operant conflict test, reversed the effects of CRF in a dose-dependent manner while the benzodiazepine inverse agonist (FG7142) enhanced the actions of CRF [K. T. Britton et al., Psychopharmacology 94:306 (1988)].
The mechanisms and sites of action through which the standard anxiolytics and antidepressants produce their therapeutic effects remain to be elucidated. It has been hypothesized however, that they are involved in the suppression of the CRF hypersecretion that is observed in these disorders. Of particular interest is that preliminary studies examining the effects of a CRF receptor antagonist (a-helical CRF.sub.9-41) in a variety of behavioral paradigms have demonstrated that the CRF antagonist produces "anxiolytic-like" effects qualitatively similar to the benzodiazepines [for review see G. F. Koob and K. T. Britton, In: Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide, E. B. De Souza and C. B. Nemeroff eds., CRC Press p221 (1990)].
DuPont Merck PCT application WO95/10506 describes corticotropin releasing factor antagonist compounds and their use to treat psychiatric disorders and neurological diseases.
European patent application 0 576 350 A1 by Elf Sanofi describes corticotropin releasing factor antagonist compounds useful in the treatment of CNS and stress disorders.
Pfizer patent applications WO 94/13676, WO 94/13677, WO 94/13661, WO 95/33750, WO 95/34563, WO 95/33727 describe corticotropin releasing factor antagonist compounds useful in the treatment of CNS and stress disorders.
All of the aforementioned references are hereby incorporated by reference.
The compounds and the methods of the present invention provide for the production of compounds capable of inhibiting the action of CRF at its receptor protein in the brain. These compounds would be useful in the treatment of a variety of neurodegenerative, neuropsychiatric and stress-related disorders such as affective disorders, anxiety, depression, post-traumatic stress disorders, supranuclear palsy, seizure disorders, stroke, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal disease, anorexia nervosa or other eating disorders, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorders and fertility problems. It is further asserted that this invention may provide compounds and pharmaceutical compositions suitable for use in such a method.
SUMMARY OF THE INVENTION
This invention is a class of novel compounds which are CRF receptor antagonists and which can be represented by Formula (I): ##STR2## or a pharmaceutically acceptable salt form thereof, wherein Z is CR.sup.2 or N;
when Z is CR.sup.2 :
Y is NR.sup.4, O or S(O).sub.n ;
Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, indolinyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, benzothiazolyl, indazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 4 R.sup.5 groups; wherein Ar is attached to Y through an unsaturated carbon;
R.sup.1 is H, halo, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.9 R.sup.10, --NR.sup.9 COR.sup.10, --NR.sup.9 CO.sub.2 R.sup.10, --OR.sup.11, --SH or --S(O).sub.n R.sup.12 ;
R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.2 R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl,
with the proviso that when R.sup.3 is aryl, Ar is not imidazolyl;
R.sup.4 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl, wherein C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl is optionally substituted with C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, heterocyclyl, --NO.sub.2, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --SH, and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
aryl is phenyl, biphenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.15, --SH, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --OC(O)R.sup.14, --NO.sub.2, --NR.sup.8 COR.sup.15, --N(COR.sup.15).sub.2, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, --NR.sup.15 R.sup.16 and --CONR.sup.15 R.sup.16 ;
heterocyclyl is 5- to 10-membered heterocyclic ring which may be saturated, partially unsaturated or aromatic, and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S, wherein the heterocyclic ring is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.15, --SH, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --OC(O)R.sup.14, --NR.sup.8 COR.sup.15, --N(COR.sup.15).sub.2, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, --NR.sup.15 R.sup.16, and --CONR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2;
and wherein, when Z is N:
Y is NR.sup.4, O or S(O).sub.n ;
Ar, R.sup.1, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, aryl, heterocyclyl, heterocyclyl and n are as defined above, but
R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --S(O).sub.2 R.sup.13, --CO.sub.2 R.sup.7, --COR.sup.7 or --CONR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl,
with the proviso that when R.sup.3 is aryl, Ar is not imidazolyl.
[3] Preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is CR.sup.2 ;
Y is NR.sup.4 or O;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.4 haloalkyl, --CN, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7 or --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, halo, C.sub.1 -C.sub.4 haloalkyl;
R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.2 R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.l3, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.8 cycloalkylalkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13,
wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.8 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[4] More preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is CR.sup.2 ;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.3 haloalkyl, --CN, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --OR.sup.7 or --S(O).sub.n R.sup.13 wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.4 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 ;
R.sup.2 is H;
R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl, wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[5] Even more preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is CR.sup.2 ;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 2 to 4 R.sup.5 groups;
R.sup.1 is H, Cl, Br, methyl, ethyl, cyclopropyl, or --CN,
R.sup.2 is H;
R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl, wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, --CF.sub.3, halo, --CN, --OR.sup.7, and aryl;
R.sup.4 is H, methyl, ethyl, i-propyl, n-propyl, n-butyl, i-butyl, s-butyl, n-butyl, or allyl;
R.sup.5 is independently selected at each occurrence from methyl, ethyl, i-propyl, n-propyl, aryl, --CF.sub.3, halo, --CN, --N(CH.sub.3).sub.2, --C(.dbd.O)CH.sub.3, --OCH.sub.3, --OCH.sub.2 CH.sub.3, --OCF.sub.3, and --S(O).sub.2 CH.sub.3 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[6] Specifically preferred compounds of this invention are compounds of Formula (I), pharmaceutically acceptable salts and pro-drug forms thereof, which are:
3-[(2,4-Dibromophenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[(2,4-Dibromophenyl)ethylamino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[[2-Bromo-4-(1-methylethyl)phenyl]ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)ethylamino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
(+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Chloro-4,6-dimethoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
(+/-)-3-[(4,6-Dimethyl-2-iodophenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
(+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Acetyl-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(4,6-Dimethyl-2-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
(+/-)-3-[(4,6-Dimethyl-2-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Chloro-2-iodo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-phenyl-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dibromophenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
(+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,4-Dichloro-6-methylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,4-Dibromo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
3-[(2,4,6-Trimethylphenyl)amino]-5-Chloro-1-[1-(2-methoxyethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2 (1H)-pyrazinone;
(+/-)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-Chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
(+/-)3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-Chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone;
(+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone;
(+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-[1-(ethoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-Chloro-1-(2-ethoxy-1-methylethyl)-2(1H)-pyrazinone; and
(+/-)3-[(4-Bromo-2,6-difluorophenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dimethyl-6-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)-amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Chloro-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,6-Dimethyl-4-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
(+/-)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(4,6-Dimethyl-2-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
(+/-)3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
(+/-)3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-Chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; and
3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-(1-ethylpropyl)-2(1H)-pyrazinone.
[7] A second embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is CR.sup.2 ;
Y is NR.sup.4 or O;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, halo, C.sub.1 -C.sub.4 haloalkyl;
R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl and --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, heterocyclyl, --NO.sub.2, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl (C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
aryl is phenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[8] More preferred compounds of the second embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is CR.sup.2 ;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7 or --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.2 is H;
R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl and --NR.sup.6 R.sup.7.sub.1,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.l3, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[10] A third embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is N;
Y is NR.sup.4 or O;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, aryl, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7 or --S(O).sub.n R.sup.13,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --S(O).sub.2 R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7 or --CONR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.l3, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.8 cycloalkylalkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13,
wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.8 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 14 C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[11] More preferred compounds of the third embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is N;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 haloalkyl, cyclopropyl, --CN, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --OR.sup.7 or --S(O).sub.n R.sup.13,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.4 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 ;
R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl,
wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[12] Even more preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is N;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 2 to 4 R.sup.5 groups;
R.sup.1 is H, methyl, ethyl, cyclopropyl, --CF.sub.3, or --N(CH.sub.3).sub.2 ;
R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl, wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, --CF.sub.3, halo, --CN, --OR.sup.7, and aryl;
R.sup.4 is H, methyl, ethyl, i-propyl, n-propyl, n-butyl, i-butyl, s-butyl, n-butyl, or allyl;
R.sup.5 is independently selected at each occurrence from methyl, ethyl, i-propyl, n-propyl, aryl, --CF.sub.3, halo, --CN, --N(CH.sub.3).sub.2, --C(.dbd.O)CH.sub.3, --OCH.sub.3, --OCH.sub.2 CH.sub.3, --OCF.sub.3, and --S(O).sub.2 CH.sub.3 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[13] A fourth embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is N;
Y is NR.sup.4 or O;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.3 is C.sub.1 -C.sub.4 alkyl, --CN, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7 or --CONR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N (COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, heterocyclyl, --NO.sub.2, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
aryl is phenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
[14] More preferred compounds of the fourth embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein:
Z is N;
Y is NR.sup.4 ;
Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
R.sup.1 is H, halo, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7 or --NR.sup.6 R.sup.7,
wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
R.sup.3 is C.sub.1 -C.sub.4 alkyl, --CN, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --COR.sup.7 or --CO.sub.2 R.sup.7,
wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
n is independently at each occurrence 0, 1 or 2.
A fifth embodiment of this invention is the method of treating affective disorders, anxiety, depression, post-traumatic stress disorders, supranuclear palsy, seizure disorders, stroke, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal disease, anorexia nervosa or other eating disorders, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of Formula I.
A sixth embodiment of this invention are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of Formula I.
This invention also includes intermediate compounds useful in preparation of the CRF antagonist compounds and processes for making those intermediates, as described in the following description and claims.
The CRF antagonist compounds provided by this invention (and especially labelled compounds of this invention) are also useful as standards and reagents in determining the ability of a potential pharmaceutical to bind to the CRF receptor.
DETAILED DESCRIPTION OF INVENTION
Many compounds of this invention have one or more asymmetric centers or planes. Unless otherwise indicated, all chiral (enantiomeric and diastereomeric) and racemic forms are included in the present invention. Many geometric isomers of olefins, C.dbd.N double bonds, and the like can also be present in the compounds, and all such stable isomers are contemplated in the present invention. The compounds may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. All chiral, (enantiomeric and diastereomeric) and racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomer form is specifically indicated.
The term "alkyl" includes both branched and straight-chain alkyl having the specified number of carbon atoms. For example, the term "C.sub.1 -C.sub.10 alkyl" denotes alkyl having 1 to 10 carbon atoms; thus, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl, wherein, for example, butyl can be --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3, --CH.sub.2 CH(CH.sub.3).sub.2, --CH(CH.sub.3)CH.sub.2 CH.sub.3 or --CH(CH.sub.3).sub.3.
The term "alkenyl" includes hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon--Carbon bonds which may occur in any stable point along the chain. For example, the term "C.sub.2 -C.sub.10 alkenyl" denotes alkenyl having 2 to 10 carbon atoms; thus, ethenyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl and decenyl, such as allyl, propargyl, 1-buten-4-yl, 2-buten-4-yl and the like, wherein, for example, butenyl can be, but is not limited to, --CH.dbd.CH.sub.2 CH.sub.2 CH.sub.3, --CH.sub.2 CH.dbd.CHCH.sub.3, --CH.sub.2 CH.sub.2 CH.dbd.CH.sub.2, --CH.dbd.C(CH.sub.3).sub.2 or --CH.dbd.CHCH.dbd.CH.sub.2.
The term "alkynyl" includes hydrocarbon chains of either a straight or branched configuration and one or more triple carbon--carbon bonds which may occur in any stable point along the chain. The term "C.sub.2 -C.sub.10 alkynyl" denotes alkynyl having 2 to 10 carbon atoms; thus, ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonynyl and decynyl.
The term "haloalkyl" is intended to include both branched and straight-chain alkyl having the specified number of carbon atoms, substituted independently with 1 or more halogen, such as, but not limited to, --CH.sub.2 F, --CHF.sub.2, --CF.sub.3, --CF.sub.2 Br, --CH.sub.2 CF.sub.3, --CF.sub.2 CF.sub.3, --CH(CF.sub.3).sub.2 and the like.
The term "alkoxy" represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge.
The term "cycloalkyl" is intended to include saturated ring groups having the specified number of carbon atoms, including mono-, bi- or poly--Cyclic ring systems, such as cyclopropyl (c-Pr), cyclobutyl (c-Bu), cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, [3.3.0]bicyclooctyl, [2.2.2]bicyclooctyl and so forth.
As used herein, the term "heterocyclyl" or "heterocyclic" is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic ring which may be saturated, partially unsaturated, or aromatic, and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. Examples of such heterocycles include, but are not limited to, pyridyl (pyridinyl), pyrimidinyl, furanyl (furyl), thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, isoxazolinyl, isoxazolyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl, azocinyl, triazinyl, 6H-1,2,5-thiadiazinyl, 2H,6H-1,5,2-dithiazinyl, thianthrenyl, pyranyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathiinyl, 2H-pyrrolyl, pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolinyl, isoxazolyl, oxazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolizinyl, isoindolyl, 3H-indolyl, indolyl, 1H-indazolyl, purinyl, 4H-quinolizinyl, isoquinolinyl, quinolinyl, phthalazinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, cinnolinyl, pteridinyl, 4aH-carbazole, carbazole, .beta.-carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl, phenazinyl, phenarsazinyl, phenothiazinyl, furazanyl, phenoxazinyl, isochromanyl, chromanyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidinyl, piperazinyl, indolinyl, isoindolinyl, quinuclidinyl, morpholinyl, oxazolidinyl, benzothienyl, 2,3-dihydrobenzofuranyl or 2,3-dihydrobenzothienyl.
The term "halo" or "halogen" includes fluoro, chloro, bromo and iodo.
The term "substituted", as used herein, means that one or more hydrogen on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency is not exceeded, and that the substitution results in a stable compound. When a substituent is keto (i.e., .dbd.O), then 2 hydrogens on the atom are replaced.
Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. By "stable compound" or "stable structure" is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent.
The term "pharmaceutically acceptable salts" includes acid or base salts of the compounds of formula (I). Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like.
Pharmaceutically acceptable salts of the compounds of the invention can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418, the disclosure of which is hereby incorporated by reference.
"Prodrugs" are considered to be any covalently bonded carriers which release the active parent drug of formula (I) in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of formula (I) are prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compounds. Prodrugs include compounds wherein hydroxy, amine, or sulfhydryl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxyl, amino, or sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of formula (I); and the like.
The term "therapeutically effective amount" of a compound of this invention means an amount effective to antagonize abnormal level of CRF or treat the symptoms of affective disorder, anxiety or depression in a host.
Synthesis
The pyrazinones and triazinones of this invention can be prepared by one of the general schemes outlined below (Scheme 1-6).
Compounds of the Formula (I) wherein Z.dbd.CH, Y.dbd.NR.sup.4, R.sup.1 =halogen and R.sup.2 =H can be prepared as shown in Scheme 1. Compounds wherein R.sup.2 is a substituent other than H as defined in the broad scope of the invention can also be prepared as shown in Scheme 1 by using the corresponding R.sup.2 COH substituted aldehydes or ClCHR.sup.2 CN substituted haloacetonitriles. ##STR3##
Reaction of a cyanide salt with formaldehyde and the appropriate substituted amine afforded the corresponding aminoacetonitrile which was purified as the hydrochloride salt of Formula (III). Alternatively the same compounds of Formula (III) can be synthesized by reaction of the amine H.sub.2 NR.sup.3 with a haloacetonitrile, such as chloroacetonitrile, in the presence of a base such as a tertiary amine or an inorganic base such as K.sub.2 CO.sub.3 in an organic solvent and isolated as a salt of an inorganic acid by treatment with that acid. Amine salt of Formula (III) was treated with an oxalyl halide, R.sup.1 COCOR.sup.1, such as oxalyl chloride or bromide to afford the dihalo compound Formula (IV), as described in Vekemans, J.; Pollers-Wieers, C.; Hoornaert, G. J. Heterocyclic Chem. 20, 919, (1982). Compound Formula (IV) can be coupled with an aryl amine H.sub.2 NAr thermally, in the presence of a strong base such as NaH, KN(SiMe.sub.3).sub.2, LiN(SiMe.sub.3).sub.2 or NaN(SiMe.sub.3).sub.2 in an aprotic organic solvent, or under acid catalysis to give compounds of Formula (V). Compounds of Formula (V) can be alkylated with an alkyl halide R.sup.4 X to afford compounds of Formula (I).
Compounds where R.sup.1 =alkyl or substituted alkyl can be prepared according to Scheme 2. ##STR4## Reaction of the intermediate of Formula (IV) in Scheme 1, wherein R.sup.1 =X=halogen in Scheme 2, with an alkyl or aryl thiol, HSR", in the presence of base such as NaH affords the adduct of Formula (VII), which may then be treated with a trialkylaluminum as described in Hirota, K.; Kitade, Y.; Kanbe, Y.; Maki, Y.; J. Org. Chem. 57, 5268, (1992), in the presence of a palladium catalyst, such as Pd(PPh.sub.3).sub.2 Cl.sub.2, to give compounds of Formula (VIII). Condensation of compounds of Formula (VIII) with an aryl amine H.sub.2 NAr under thermal, base, or acid catalyzed conditions gives compounds of Formula (IX). Alternatively (VIII) may be oxidized to the corresponding sulfones with an oxidant such as KMnO.sub.4 and then condensed with the arylamines of formula H.sub.2 NAr to give (IX). The use of appropriately substituted aluminum alkyls, or simple transformations of those substituted alkyls can give access to compounds of Formula (I), where R.sup.1 is a substituted alkyl; see Ratovelomanana, V.; Linstrumelle, G.; Tet. Letters 52, 6001 (1984) and references cited therein.
Compounds of the Formula (I) wherein Z.dbd.CH, Y.dbd.O or S(O).sub.n and R.sup.1 =halogen can be prepared as shown in Scheme 3. ##STR5##
Reaction of the dihalo intermediate (IV) from Scheme 1 with a phenoxide or thiophenoxide, formed by treatment of the corresponding phenol or thiophenol with an appropriate base, such as NaH in an aprotic solvent, gives the adduct of Formula (X) or (XI). Adduct (XI) may be further oxidized to the sulfoxide or sulfone of Formula (XII), by treatment with the appropriate oxidant, such as a peroxide, NaIO4 or KMnO4.
Compounds of Formula (I) where R.sup.1 =OR, SR and S(O).sub.n R and Z.dbd.CH can be introduced on compounds of Formula (V) by copper or copper salt-catalyzed coupling of the corresponding anions RO.sup.- and RS.sup.- with the pyrazinone bromide. Keegstra, M. A.; Peters, T. H. A.; Brandsma, L.; Tetrahedron, 48, 3633 (1992) describes the addition of phenoxide anions by this method; alternatively, the same conditions can be used for the addition of thiophenoxide anions. Alternatively the same compounds can be synthesized by Scheme 4. ##STR6##
In Scheme 4, reaction of an aminoacetonitrile salt (III), described in Scheme 1, with an oxalyl halide ester (XIII) gives the corresponding amide (XIV), which in turn can be converted to the corresponding imidate salt (XV). This can be cyclized under treatment with a base, such as K.sub.2 CO.sub.3 or Et.sub.3 N to the pyrazinedione of Formula (XVI). This can be converted to the corresponding halide (XIX), using a halogenating agent such as POX.sub.3, oxalyl halide or SOX.sub.2. Alternatively, (XVI) can be converted to the corresponding mesylate, tosylate or triflate, by treatment with the corresponding mesyl, tosyl, or triflic anhydride. Subsequently, (XIX) can be coupled with an aniline to the corresponding adduct of Formula (XX), under the conditions described in Scheme 1, or (XIX) can be coupled with a phenoxide or thiophenoxide as described in Scheme 3 to yield compounds of Formula (I) wherein Y.dbd.O or S(O).sub.n.
Compounds of Formula (I) wherein R.sup.1 =substituted N and Z.dbd.CH can be introduced on compounds of Formula (XV) by reaction with an amine to form the corresponding amidate (XVII) according to Scheme 5. Subsequently, (XVII) can be cyclized, halogenated, and substituted with the appropriate aniline, phenoxide or thiophenoxide as described in Scheme 4 above.
Compounds of Formula I wherein Z.dbd.CH and R.sup.1 .dbd.COR.sup.7 or CO.sub.2 R.sup.7 can be synthesized from compounds of Formula (VII) by coupling with the appropriate vinyl aluminum or boron reagent in the presence of a palladium catalyst, such as Pd(PPh.sub.3).sub.2 Cl.sub.2, and further transformations of the vinyl group, using methods known to one skilled in the art. ##STR7##
The compounds of Formula (I) where Z.dbd.CH and R.sup.1 or R.sup.3 is a functional group not compatible with the procedures of Schemes 1-5 may be prepared from precursors where the interfering functionality of R.sup.1 or R.sup.3 is protected using methods known to one skilled in the art (see T. W. Green and P. G. M. Wuts, Protecting Groups in Organic Synthesis, Wiley, New York, 1991); or from precursors bearing R.sup.1 or R.sup.3 groups amenable to later conversion into the desired functionality using standard methods (see J. March, Advanced Organic Chemistry, Wiley, New York, 1992).
Triazinones of Formula (I) wherein Z.dbd.N and Y.dbd.NR.sup.4, O or S(O).sub.n can be prepared by the synthetic route shown in Scheme 6.
Condensation of a substituted hydrazine with acetamidines or imidates provides amidrazones of Formula (XXX) (Khrustalev, V. A., Zelenin, K. N. Zhurnal Organicheskoi Khimii, Vol. 15, No. 11, 1979, 2280). Cyclization of (XXX) with oxalyl derivatives such as oxalyl chloride provides diones of Formula (XXXI). Treatment of (XXXI) with chlorodehydrating agents such as thionyl chloride, oxalyl chloride or phosphorous oxychloride provides chlorotriazinones of Formula (XXXII), which may be treated with phenols, thiophenols, anilines and their heterocyclic analogs under basic, acidic or thermal conditions to provide compounds of Formula (I) where Z.dbd.N and Y.dbd.O, S or NH, respectively. In the preceding instance where Y.dbd.NH, alkylation of the nitrogen atom with e.g. alkyl iodides provides the related compounds of Formula (I) where Z.dbd.N and Y.dbd.NR.sup.4. In the preceding instance where Y.dbd.S, oxidation with e.g. mCPBA provides the compounds of Formula (I) where Z.dbd.N and Y.dbd.S(O) and S(O).sub.2. The compounds of Formula (I) where Z.dbd.N and R.sup.1 or R.sup.3 is a functional group not compatible with the procedures of Scheme 4 may be prepared from precursors such as amidrazones of Formula (XXX) or substituted hydrazines where the ##STR8## interfering functionality of R.sup.1 or R.sup.3 is protected using methods known to one skilled in the art (see T. W. Green and P. G. M. Wuts, Protecting Groups in Organic Synthesis, Wiley, New York, 1991); or from precursors bearing R.sup.1 or R.sup.3 groups amenable to later conversion into the desired functionality using standard methods (see J. March, Advanced Organic Chemistry, Wiley, New York, 1992).
Triazinones of Formula (I) wherein Z.dbd.N and Y.dbd.NR.sup.4, O or S(O).sub.n can also be prepared by the synthetic route shown in Scheme 7 ##STR9##
Reaction of ethyl oxalyl chloride with acylated hydrazines of Formula (XXXIV) provides the ethyl oxalyl acylhydrazine derviatives of Formula (XXXV). Compounds of Formula (XXXIV) may be arrived at via condensation of an appropriate ketone or aldehyde with an acylated hydrazide to give acylated hydrazones which may then be reduced under catalytic hydrogenation conditions or by other reducing agents to give the compounds of Formula (XXXIV). The abovementioned acylated hydrazones may also be produced by acylation of a hydrazone made from hydrazine and an appropriate ketone or aldehyde using methods known to one skilled in the art of organic synthesis. Alternatively, compounds of Formula (XXXIV) may also be produced by acylation of an appropriate hydrazine using methods known to one skilled in the art of organic synthesis.
The ethyl esters of compound (XXXV) may then be converted to the primary amide derivatives of Formula (XXXVI) by treatment with an ammonia source such as ammonium hydroxide. Cyclization of (XXXVI) to produce the diones of Formula (XXXI) may be achieved by treatment with, for example, iodotrimethylsilane (TMSI) or POCl.sub.3, or by heating in the presence of a Lewis acid such as ZnCl.sub.2. The oxo group in the 5 position of the 1,2,4-triazin-5,6-diones of Formula (XXXI) may then be converted to a leaving group using reagents such as trifluoromethanesulfonic anhydride under basic conditions to yield compounds of Formula (XXXVII) which may then be treated with phenols, thiophenols, anilines and their heterocyclic analogs under basic conditions to provide compounds of Formula (I)
Additional 1,2,4-triazinone syntheses are disclosed in the literature (A. R. Katritzky and C. W. Rees, Comprehensive Heterocyclic Chemistry, Pergamon Press, New York, Vol. 3, 1984, p. 385) and can be prepared by one skilled in the art.
Intermediates, for example ArYH, H.sub.2 NAr, HOAr or HSAr, in the synthesis of compounds of Formula (I) in Schemes 1-6 may be prepared using standard methods known to one skilled in the art (see, D. Barton and W. D. Ollis, Comprehensive Organic Chemistry, Pergamon Press, New York, Vol. 1-6, 1979; A. R. Katritzky and C. W. Rees, Comprehensive Heterocyclic Chemistry, Pergamon Press, New York, Vol. 1-8, 1984; B. Trost and I. Fleming, Comprehensive Organic Synthesis, Pergamon Press, New York, Vol. 1-9, 1991; and DuPont Merck PCT application WO95/10506).
All of the aforementioned references are hereby incorporated by reference.





EXAMPLE 1
3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
Part A
Hydrogen chloride (12M, aq., 3.8 mL), methanol (33 mL), water (30 mL), potassium cyanide (3 g), 1-ethylpropylamine (4 g), and formaldehyde (37% w/v, 3.7 mL) were stirred 18 hours at room temperature. Water (200 mL) was added, and the mixture was extracted with 2.times.200 mL methylene chloride, which was dried over MgSO4 and concentrated to a light oil (5.57 g). The oil was dissolved in ether and 1N HCl was added. The precipitate was collected on paper and dried to give N-(1-ethylpropyl)-aminoacetonitrile hydrochloride as an off-white solid (6.70 g).
Part B: The product from part A (2 g), chloroform (20 mL), and oxalyl chloride (4.68 g) were heated at reflux for 12 hours. The reaction was concentrated to remove excess oxalyl chloride and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dichloro-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (2.09 g).
Part C
The product from part B (0.68 g) and 2-bromo-4-isopropylaniline (1.24 g) were heated at 140.degree. C. for 5 hours. After cooling, methylene chloride (20 mL)was added, filtered, and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:9) as eluent to afford the title compound. 639 mg. mp 118.5-119.5.degree. C. Elemental analysis: calcd. for C.sub.18 H.sub.23 N.sub.3 OBrCl: C, 52.38; H, 5.626; N, 10.18; Br, 19.36; Cl, 8.599. Found: C, 52.62; H, 5.43; N, 10.13; Br, 19.53; Cl, 8.97.
EXAMPLE 2
3-[[2-Bromo-4-(1-methylethyl)phenyl]ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
The product from Example 1 (198 mg), N,N-dimethyl-formamide (5 mL), and sodium hydride (60% in oil, 96 mg) were stirred at room temperature 20 minutes. Iodoethane (112 mg) was added and the reaction was stirred overnight at room temperature and quenched with water (10 mL) and saturated sodium chloride (aq., 10 mL). The mixture was extracted with methylene chloride which was dried and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:19) as eluent to afford the title compound (125 mg). CI-HRMS calcd. for C.sub.20 H.sub.28 N.sub.3 OClBr (M+H).sup.+ : 440.110427. Found: 440.107480.
EXAMPLE 3
3-[(2,4-Dibromophenyl)amino]-5-Chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
2,4-Dibromoaniline (500 mg), toluene (8 mL), and sodium hydride (60% in oil, 398 mg) were stirred for 10 minutes at room temperature and then 3,5-dichloro-1-(1-ethylpropyl)-2(1H)-pyrazinone (468 mg, Example 1, part B) was added. The reaction was heated at reflux 3 hours, cooled, and quenched with water (50 mL). The mixture was extracted with ethyl acetate (100 mL), which was washed with brine, then dried and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:19) affording 400 mg of material, which was crystallized from ether/hexane to give the title compound (240 mg). Elemental analysis: calcd. for C.sub.15 H.sub.16 N.sub.3 OClBr.sub.2 : C, 40.07; H, 3.597; N, 9.356; Cl, 7.895; Br, 35.55. Found: C, 40.41; H, 3.49; N, 9.34; Cl, 8.27; Br, 35.71.
EXAMPLE 4
3-[(2,4-Dibromophenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 2. Elemental analysis calcd. for C.sub.17 H.sub.20 N.sub.3 OClBr.sub.2 : C,42.75; H,4.22; N, 8.807. Found: C, 42.82; H, 4.14; N, 8.67.
EXAMPLE 5
3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 OCl: C, 64.76; H, 7.256; N, 12.59. Found: C, 64.69; H, 7.03; N, 12.55.
EXAMPLE 6
3-[(2,4,6-Trimethylphenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 2. Elemental analysis calcd. for C.sub.20 H.sub.28 N.sub.3 OCl: C, 66.37; H, 7.808; N, 11.61. Found: C, 66.50; H, 7.69; N, 11.51.
EXAMPLE 7
(+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 O.sub.2 Cl: C, 61.80; H, 6.91; N, 12.01; Cl, 10.13. Found: C, 61.69; H, 7.00; N, 11.93; Cl, 9.87.
EXAMPLE 8
3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.3 BrCl: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.06; H, 4.61; N, 9.56.
EXAMPLE 9
3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone
Part A
3-[(2-Iodo-4,6-dimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone was prepared in a manner similar to Example 3.
Part B
The product from part A (460 mg), N,N-dimethylformamide (8 mL), cuprous cyanide (97 mg), and sodium cyanide were heated at 120.degree. C. for 18 hours and then at 130.degree. C. for 3 hours. After cooling, ethyl acetate (100 mL) was added to the reaction which was then washed with water (50 mL) and brine (50 mL), dried, and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent. The product was then crystallized from methylene chloride/hexane to afford the title compound (235 mg). Elemental analysis calcd. for C.sub.18 H.sub.21 N.sub.4 OCl: C, 62.69; H, 6.148; N, 16.25; Cl, 10.28. Found: C, 62.29; H, 6.27; N, 15.99; Cl, 10.20.
EXAMPLE 10
(+/-)-3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.4 BrCl: C, 45.71; H, 4.748; N, 9.416. Found: C, 45.86; H, 4.43; N, 9.26.
EXAMPLE 12
(+/-)-3-[(2-Iodo-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
Part A
Chloroacetonitrile (3.2 mL), 2-amino-1-methoxybutane (10.32 g), and deuterochloroform (50 mL) were stirred and heated at reflux for 48 h. Methylene chloride (100 mL) and sodium hydroxide (aq., 1N, 100 mL) were added to the reaction, the layers separated, and the organic layer concentrated to an oil (3.4 g). The oil was dissolved in ether (100 mL) and HCl/ether (1N, 100 mL) was added. The precipitate was collected on paper affording N-[(1-methoxymethyl)propyl]aminoacetonitrile hydrochloride (6.86 g).
Part B
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.2 ClI: C, 44.22; H, 4.58; N, 9.10. Found: C, 44.26; H, 4.60; N, 9.83.
EXAMPLE 15
(+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
To (+/-)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone (300 mg) and 4-bromo-2,6-dimethylaniline (238 mg) in THF (anhydrous, 9.4 mL) at 0.degree. C. was added sodium bis(trimethylsilyl)amide (1.0 M/THF, 2.6 mL). The mixture was stirred at 0.degree. C. for 10 minutes. Ethyl acetate (100 mL) was added and washed with water (25 mL) and brine (25 mL). The organic layer was dried over MgSO.sub.4 and concentrated and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent. The product was then crystallized from ethyl acetate/hexane to afford the title compound (419 mg). Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.2 BrCl: C, 49.23; H, 5.10; N, 10.13. Found: C, 49.33; H, 5.05; N, 10.09.
EXAMPLE 16
(+/-)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
To the product of Example 15 (250 mg), bis(triphenylphosphine)palladium(II) chloride (11 mg), and tetrakis(triphenylphosphine)palladium(0) (17 mg) in a dry flask under nitrogen was added toluene (1.5 mL) and 1-ethoxyvinyl tributyl tin (260 mg). The reaction was heated at reflux 18 hours, and then concentrated in vacuo. The residue was taken up in ether (15 mL) and saturated aqueous potassium fluoride (15 mL), and filtered. The layers were separated, and the ether layer was stirred with 1N HCl (aq., 15 mL). The layers were separated and the ether layer was dried over MgSO.sub.4 and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (3:7) as eluent to afford the title compound (90 mg). Elemental analysis calcd. for C.sub.19 H.sub.24 N.sub.3 O.sub.3 Cl: C, 60.39; H, 6.40; N, 11.12. Found: C, 60.51; H, 6.31; N, 11.00.
EXAMPLE 16a
(+/-)-3-[(4-Acetyl-2-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 16. Elemental analysis calcd. for C.sub.19 H.sub.24 N.sub.3 O.sub.4 Cl: C, 57.94; H, 6.14; N, 10.67. Found: C, 57.70; H, 5.98; N, 10.41.
EXAMPLE 20
(+/-)-3-[(4-Chloro-2-iodo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C.sub.16 H.sub.18 N.sub.3 O.sub.2 Cl.sub.2 I: C, 39.86; H, 3.76; N, 8.725. Found: C, 40.00; H, 3.69; N, 8.64.
EXAMPLE 21
3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
Part A
To serinol (9.90 g) in DMF (200 mL) was added triethyl amine (14.6 mL) and then chlorotriphenylmethane (24.3 g). The reaction mixture was stirred at room temperature for 18 hours. Toluene (800 mL) was added and washed with water (500 mL and 250 mL) and brine (250 mL), and then dried over K.sub.2 CO.sub.3 and concentrated to dryness. The product was crytallized from benzene/hexane (1:1) to afford product (14.57 g).
Part B
The product from part A (14.57 g), sodium hydroxide (17.5 g), and iodomethane (8.8 mL) were stirred overnight in DMSO (220 mL) at room temperature. Water (500 mL) was added and extracted with ethyl acetate (3.times.250 mL). The extracts were washed with water (2.times.250 mL) and brine (200 mL), dried over K.sub.2 CO.sub.3, and concentrated to give product (14.46 g).
Part C
The product from part B (14.46 g) and hydrogen chloride (1M/Et.sub.2 O, 84 mL) were stirred in methanol (300 mL) at room temperature for 6 hours. The solution was washed with hexane (3.times.300 mL), concentrated, and co-evaporated with ethanol affording 2-amino-1,3-methoxypropane (5.69 g).
Part D
The title compound was prepared in a manner similar the product of Example 3. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 O.sub.3 Cl: C, 59.09; H, 6.61; N, 11.49. Found: C, 20 59.27; H, 6.53; N, 11.47.
EXAMPLE 30a
(+/-)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C18H24N3O2Cl: C, 61.80; H, 6.91; N, 12.01. Found: C, 61.70; H, 6.94; N, 11.56.
EXAMPLE 36
3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.19 H.sub.26 N.sub.3 O.sub.3 Cl: C, 60.07; H, 6.908; N, 11.06. Found: C, 60.22; H, 7.16; N, 10.92.
EXAMPLE 36a
3-[(4-Bromo-2-methoxy-6-methylphenyl)amino]-5-chloro-l-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.18 H.sub.23 N.sub.3 O.sub.4 ClBr: C, 46.92; H, 5.03; N, 9.129. Found: C, 47.29; H, 5.03; N, 8.98.
EXAMPLE 45a
3-[(2-Bromo-6-flouro-4-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.16 H.sub.18 N.sub.3 O.sub.3 FClBr: C, 44.21; H, 4.17; N, 9.67. Found: C, 44.35; H, 4.25; N, 9.41.
EXAMPLE 46a
3-[(2-Chloro-4-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.20 N.sub.3 O.sub.4 C.sub.12: C, 50.89; H, 5.02; N, 10.47. Found: C, 50.72; H, 5.33; N, 10.37.
EXAMPLE 49
3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.18 H.sub.23 N.sub.3 O.sub.3 ClBr: C, 48.61; H, 5.21; N, 9.457. Found: C, 48.59; H, 5.32; N, 9.45.
EXAMPLE 53
3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.3 ClBr: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.52; H, 4.99; N, 9.72.
EXAMPLE 54
3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.3 Cl.sub.2 : C, 52.86; H, 5.489; N, 10.88. Found: C, 52.89; H, 5.44; N, 10.72.
EXAMPLE 77
(+/-)-3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 O.sub.2 ClS: C, 56.62; H, 6.33; N, 11.00; S, 8.405. Found: C, 56.66; H, 6.19; N, 10.89; S, 8.45.
EXAMPLE 79
(+/-)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.2 Cl.sub.2 : C, 55.14; H, 5.726; N, 11.35. Found: C, 55.27; H, 5.70; N, 11.25.
EXAMPLE 80
(+/-)-3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.3 BrCl: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.91; H, 4.95; N, 9.74.
EXAMPLE 81
3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 O.sub.3 ClS: C, 54.33; H, 6.08; N, 10.56; S, 8.06. Found: C, 54.48; H, 6.01; N, 10.46; S, 7.86.
EXAMPLE 83
3-[(4-Bromo-2-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C.sub.17 H.sub.21 N.sub.3 O.sub.4 ClBr: C, 45.71; H, 4.748; N, 9.416. Found: C, 45.80; H, 4.70; N, 9.39.
EXAMPLE 84
3-[(2,4,6-Trimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone
Part A
N-(1-ethylpropyl)aminoacetonitrile hydrochloride (1.41 g) and oxalyl bromide (2.0 M/CH.sub.2 Cl.sub.2, 13 mL) were heated at reflux for 18 hours. The reaction was concentrated to remove excess oxalyl bromide and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dibromo-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (1.19 g).
Part B
The product from part A (133 mg) and sodium thiomethoxide (29 mg) were combined in THF (1.5 mL) and stirred at 25.degree. C. 4 hours. More sodium thiomethoxide (29 mg) was added and the reaction was stirred for 2 hours more at room temperature. Water (20 mL) was added and extracted with CH.sub.2 Cl.sub.2 (2.times.20 mL). The organic layers were combined, dried over MgSO.sub.4, and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexanes (1:4) as eluent to afford 5-bromo-1-(l-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone (78 mg).
Part C
The product from part B (200 mg) and Pd(PPh.sub.3).sub.2 Cl.sub.2 (40 mg) were combined in dry THF (6 mL) under inert atmosphere (N.sub.2). To that a 2M solution AlMe.sub.3 in hexanes (0.5 mL) was added and the reaction was heated at reflux for one hour. The excess AlMe.sub.3 was quenched with water at 0.degree. C. and the mixture was partitioned between ethyl acetate (50 mL) and water (30 mL). The water was separated and extracted with ethyl acetate (50 mL), and the combined EtOAc extracts were washed with brine, dried (MgSO.sub.4) and stripped in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexanes as eluent (1:9) to give 1-(1-ethylpropyl)-5-methyl-3-thiomethyl-2(1H)-pyrazinone (100 mg).
Part D
The product from part B (50 mg) and 2,4,6-trimethylaniline (40 mg) were combined in dry THF (2 mL) under inert atmosphere (N.sub.2), and cooled to 0.degree. C. To that a 1M solution NaN(SiMe.sub.3).sub.2 in THF (0.5 mL) was added dropwise and the reaction was stirred at 0.degree. C. for 20 min. Then an additional NaN(SiMe.sub.3).sub.2 in THF (0.3 mL) was added and the reaction was stirred at 0.degree. C. for 30 min and at 25.degree. C. for one hour. Then it was quenched with water (30 mL) and extracted with ethyl acetate (80 mL). The ethyl acetate was washed with brine, dried (MgSO.sub.4) and stripped in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexanes as eluent (1:9) to give 3-[(2,4,6-trimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone (40 mg). mp. 109.degree. C.
EXAMPLE 84a
3-[(2-Chloro-4,6-dimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 OCl: C, 64.76; H, 7.256; N, 12.59. Found: C, 65.12; H, 7.28; N, 12.33.
EXAMPLE 84b
3-[(2-Chloro-4-methoxy-6-methylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C.sub.18 H.sub.24 N.sub.3 O.sub.2 Cl: C, 61.80; H, 6.91; N, 12.01. Found: C, 61.72; H, 6.96; N, 11.83.
EXAMPLE 84c
3-[(2,4,6-Trimethylphenyl)amino]-1-(1-ethylpropyl)-5-ethyl-2(1H)-pyrazinone
Part A
5-bromo-1-(1-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone was prepared in a manner similar to Example 84, parts A and B.
Part B
To the product of part A (2.14 g) and bis(triphenylphosphine)palladium(II) chloride (258 mg) in anhydrous THF (60 mL) under inert atmosphere was added triethyl aluminum (1 M/THF, 14.7 mL). The reaction was heated at reflux 3 hours and then cooled and quenched with water. Ethyl Acetate (200 mL) was added and washed with water and saturated aqueous sodium chloride. The ethyl acetate was dried over MgSO.sub.4 and concentrated in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexane (3:17) as eluent to afford 5-ethyl-1-(1-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone (809 mg).
Part C
The title compound was prepared in a manner similar to the product of Example 84 using the procuct from part B. Elemental analysis calcd. for C.sub.20 H.sub.29 N.sub.3 O: C, 73.36; H, 8.936; N, 12.83. Found: C, 73.01; H, 8.55; N, 12.69.
EXAMPLE 84d
3-[(2-Chloro-4,6-dimethylphenyl)amino]-1-(1-ethylpropyl)-5-ethyl-2(1H)-pyrazinone
The title compound was prepared in a manner similar to the product of Example 84c. Elemental analysis calcd. for C.sub.19 H.sub.26 N.sub.3 OCl: C, 65.60; H, 7.53; N, 12.08. Found: C, 65.53; H, 7.33; N, 11.92.
EXAMPLE 85
3-[(2,4,6-Trimethylphenyl)amino]-5-bromo-1-(1-ethylpropyl)-2(1H)-pyrazinone
Part A
N-(1-ethylpropyl)-aminoacetonitrile hydrochloride (1.41 g) and oxalyl bromide (2.0 M, CH.sub.2 Cl2, 13 mL) were heated at reflux for 18 hours. The reaction was concentrated to remove excess oxalyl bromide and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dibromo-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (1.19 g).
Part B
Using the product of part A, the title compound was prepared in a manner similar to the product of Example 3. MS m/z 378, (m+H).sup.+, 100%.
EXAMPLE 204
5-[(2,4,6-Trimethylphenyl)amino]-3-methyl-1-(1-ethylpropyl)-1,2,4-triazine-6(1H)-one
Part A
3-Pentanone (18.56 g, 0.215 mol), acetic hydrazide (14.8 g, 0.2 mol), and 200 mL of absolute ethanol were placed in a 500 mL flask. The reaction mixture was reluxed for 18 hr and then evaporated to dryness to afford the desired hydrazone of suitable purity.
The hydrazone was then dissolved in 200 mL of glacial acetic acid containing 1.0 g of PtO.sub.2 and hydrogenated at 50 psi hydrogen pressure for 14 hr. The mixture was decanted from the catalyst and evaporated to dryness to afford 23.9 g of a colorless oil (83% yield for the two steps).
Part B
The 1-acetyl-2-(1-ethylpropyl)hydrazine product from Part A (23.9 g, 0.166 mol) was dissolved in CH.sub.2 Cl.sub.2 (200 mL) and to the stirring solution was added triethylamine (27.9 mL, 0.2 mol) and ethyl oxalyl chloride (19 mL, 0.17 mol). After stirring at room temperature for 3 hr, the reaction mixture was poured into water and the organic layer was separated, dried (Na.sub.2 SO.sub.4), filtered and evaporated in vacuo. To the resultant oil was added ammonium hydroxide (250 mL), THF (100 mL), and ethanol (50 mL). The flask containing the mixture was sealed with a rubber septum and stirred for 18 hr at room temperature. The mixture was then concentrated in vacuo until the reduced volume of solvent remaining was approximately 100 mL, and a white precipitate had formed. The flask was then placed in the refrigerator for 1 hr. The precipitate was collected by vacuum filtration and washed with small volumes of cold water. 26.3 g of a white solid was collected (73% yield). .sup.1 H NMR (300 MHz, CDCl.sub.3): .delta.7.78 (s, 1H); 6.74 (br s, 1H); 5.6 (br s, 1H); 4.25 (m, 1H); 2.04 (s, 1H); 1.5 (m, 4H); 0.95 (t, 6H, J=7.3 Hz).
Part C
The 1-oxamyl-1-(3-pentyl)-2-acetylhydrazine product from Part B (2 g, 9.3 mmol) was suspended in chloroform (50 mL) and 2 mL of iodotrimethylsilane was added dropwise. The mixture was allowed to stir at room temperature for 12 hr. The reaction mixture was then partitioned between CH.sub.2 Cl.sub.2 and 1N NaOH. The aqueous layer was separated and made acidic by addition of conc. HCl and then extracted with CH.sub.2 Cl.sub.2. This organic layer was dried (Na.sub.2 SO.sub.4), filtered and evaporated in vacuo to yield 1.2 g of an off-white solid of suitable purity (65% yield). .sup.1 H NMR (300 MHz, CDCl.sub.3): .delta.7.85 (br s, 1H); 4.61 (m, 1H); 2.35 (s, 3H); 1.73 (m, 4H); 0.83 (t, 6H, J=7.3 Hz).
Part D
To a solution of the triazine dione product from above (198 mg, 1 mmol) in CH.sub.2 Cl.sub.2 (5 mL) was added trifluoromethanesulfonic anhydride (0.19 mL, 1.1 mmol) and 2,4,6-collidine (0.15 mL, 1.1 mmol). The resulting reaction mixture was stirred at room temperature for 30 min., then 2,4,6-trimethylaniline (162 mg, 1.2 mmol) in 5 mL of THF was added followed by addition of 2,4,6-collidine (0.15 mL, 1.1 mmol). The resulting reaction mixture was stirred at room temperature for 1 hr, at which time TLC showed complete reaction. The reaction mixture was partitioned between water and CH.sub.2 Cl.sub.2. The organic layer was dried (Na.sub.2 SO.sub.4), filtered and evaporated in vacuo. The residue was purified by column chromatography on silica gel using EtOAc/hexane (1:9) to afford 260 mg of the title compound (83% yield). mp=133-135.degree. C. .sup.1 H NMR (300 MHz, CDCl.sub.3): .delta.7.89 (br s, 1H); 6.94 (s, 2H); 4.72 (m, 1H); 2.31 (s, 3H); 2.19 (s, 9H); 1.9-1.7 (m, 4H); 0.85 (t, 6H, J=7.32 Hz). Mass Spec. (NH.sub.3 --CI): Calc. (M+H)+=315, Obs. (M+H)+=315.
EXAMPLE 703
(+/-)-5-Chloro-1-[1-(methoxymethyl)propyl]-3-(2,4,6-trimethylphenoxy)-2(1H)-pyrazinone
Part A
(+/-)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone was prepared in a manner similar to Example 12, part A, and Example 1, part B.
Part B
2,4,6-Trimethylphenol (59 mg) and potassium t-butoxide (48 mg) were added to pyridine (2 mL) at 0.degree. C. The mixture was warmed to ambient temperature and (+/-)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(lH)-pyrazinone (98 mg) and copper (I) iodide (19 mg) were added. The reaction mixture was stirred at ambient temperature for three hours and then heated at reflux for three hours and then cooled to 0.degree. C. Ethyl acetate (50 mL) and saturated ammonium chloride (50 mL) were added and the mixture was stirred overnight at ambient temperature. The layers were separated, and the organic layer was washed with 1M ammonium hydroxide (2.times.50 mL), 1N sodium hydroxide (2.times.50 mL), 1N hydrochloric acid (2.times.50 mL), and saturated sodium chloride (50 mL). The ethyl acetate was dried over MgSO.sub.4 and concentrated in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford the title compound (66 mg). mp=116.degree. C. Elemental analysis calcd. for C.sub.18 H.sub.23 N.sub.2 O.sub.3 Cl: C, 61.62; H, 6.618; N, 7.98. Found: C, 61.45; H, 6.44; N, 7.77.
Various analogs synthesized using Schemes 1, 2 and 3 are listed in Table 1.
TABLE 1__________________________________________________________________________ ##STR10##ExNo R.sup.1 R.sup.3 Y Ar mp/.degree. C.__________________________________________________________________________1 Cl Et.sub.2 CH NH 2-Br-4-iPr-phenyl 118.52 Cl Et.sub.2 CH NEt 2-Br-4-iPr-phenyl MS = 4403 Cl Et.sub.2 CH NH 2,4-Br.sub.2 -phenyl 155.54 Cl Et.sub.2 CH NEt 2,4-Br.sub.2 -phenyl 88.15 Cl Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl 180.86 Cl Et.sub.2 CH NEt 2,4,6-Me.sub.3 -phenyl 93.87 Cl MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl 153.88 Cl Et.sub.2 CH NH 2-Br-4,6-(MeO).sub.2 -phenyl 181.39 Cl Et.sub.2 CH NH 2-CN-4,6-Me.sub.2 -phenyl 174.010 Cl MeOCH.sub.2 (Et)CH NH 2-Br-4,6-(MeO).sub.2 -phenyl 175.811 Cl MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-(MeO).sub.2 -phenyl12 Cl MeOCH.sub.2 (Et)CH NH 2-I-4,6-Me.sub.2 -phenyl 109.413 Cl MeOCH.sub.2 (Et)CH NH 2-CN-4,6-Me.sub.2 -phenyl14 Cl MeOCH.sub.2 (Et)CH NH 2-Br-4,6-Me.sub.2 -phenyl15 Cl MeOCH.sub.2 (Et)CH NH 4-Br-2,6-Me.sub.2 -phenyl 152.816 Cl MeOCH.sub.2 (Et)CH NH 4-MeCO-2,6-Me.sub.2 -phenyl 127.116a Cl MeOCH.sub.2 (Et)CH NH 4-MeCO-2-OMe-6-Me-phenyl 179.817 Cl MeOCH.sub.2 (Et)CH NH 2-MeCO-4,6-Me.sub.2 -phenyl18 Cl MeOCH.sub.2 (Et)CH NH 4,6-Me.sub.2 -2-SMe-phenyl19 Cl MeOCH.sub.2 (Et)CH NH 4,6-Me.sub.2 -2-SO.sub.2 Me-phenyl20 Cl MeOCH.sub.2 (Et)CH NH 4-Cl-2-I-6-Me-phenyl 121.821 Cl (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl 127.222 Cl phenyl NH 2,4,6-Me.sub.3 -phenyl23 CN MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl24 CONH.sub.2 MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl25 COOH MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl26 CHO MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl27 CH.sub.2 OH MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl28 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Br.sub.2 -phenyl29 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-4-iPr-phenyl30 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl30a CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl 117.931 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl32 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl33 Cl (MeOCH.sub.2).sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl34 Cl (MeOCH.sub.2).sub.2 CH NH 2,4-Br.sub.2 -6-Me-phenyl35 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4,6-Me.sub.3 -phenyl36 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4,6-Me.sub.3 -phenyl 120.036a Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-Br-2-OMe-6-Me-phenyl 130.937 Cl (MeOC.sub.2 H.sub.4).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl38 Cl MeOCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-MeO-phenyl39 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeO-phenyl40 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeO-phenyl41 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-Br-2,6-Me.sub.2 -phenyl42 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2-Cl-4,6-Me.sub.2 -phenyl43 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl44 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl45 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4-Br-2,6-Me.sub.2 -phenyl45a CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Br-6-F-4-Me-phenyl 138.946 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl46a CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Cl-4-OMe-6-Me-phenyl 128.347 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl48 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeO-phenyl49 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-Br-2,6-Me.sub.2 -phenyl 138.650 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2-Cl-4,6-Me.sub.2 -phenyl51 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl52 Cl (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl53 Cl (MeOCH.sub.2).sub.2 CH NH 4-Br-2,6-Me.sub.2 -phenyl 152.154 Cl (MeOCH.sub.2).sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl 132.855 Cl (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl56 Cl MeOCH.sub.2 (Me)CH NH 2,4-Me.sub.2 -6-MeO-phenyl57 Cl MeOCH.sub.2 (Me)CH NH 4-Br-2,6-Me.sub.2 -phenyl58 Cl EtOCH.sub.2 (Et)CH NH 4-Br-2,6-Me.sub.2 -phenyl59 Cl EtOCH.sub.2 (Me)CH NH 4-Br-2,6-Me.sub.2 -phenyl60 Cl MeOCH.sub.2 (Et)CH NH 4-Br-2,6-F.sub.2 -phenyl61 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2-Br-4,6-Me.sub.2 -phenyl62 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-SMe-phenyl63 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-SO.sub.2 Me-phenyl64 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-NMe.sub.2 -2,6-Me.sub.2 -phenyl65 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Cl.sub.2 -6-Me-phenyl66 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-Cl-2,6-Me.sub.2 -phenyl67 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,6-Me.sub.2 -4-SMe-phenyl68 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,6-Me.sub.2 -4-OMe-phenyl69 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2, 6-Me.sub.2 -4-SO.sub.2 Me-phenyl70 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 4-MeC(O)-2,6-Me.sub.2 -phenyl71 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4-Br-2,6-Me.sub.2 -phenyl72 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4-MeC(O)-2,6-Me.sub.2 -phenyl73 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -4-SMe-phenyl74 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl75 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4-NMe.sub.2 -2,6-Me.sub.2 -phenyl76 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-NMe.sub.2 -4,6-Me.sub.2 -phenyl77 Cl MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -4-SMe-phenyl 104.978 Cl MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl79 Cl MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl 116.780 Cl MeOCH.sub.2 (Et)CH NH 4-Br-6-OMe-2-Me-phenyl 147.881 Cl (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -4-SMe-phenyl 158.982 Cl (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl83 Cl (MeOCH.sub.2).sub.2 CH NH 4-Br-6-OMe-2-Me-phenyl 175.584 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl 10984a CH.sub.3 Et.sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl 133.884b CH.sub.3 Et.sub.2 CH NH 2-Cl-4-OMe-6-Me-phenyl 121.984c CH.sub.2 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl 79.384d CH.sub.2 CH.sub.3 Et.sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl 95.685 Br Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl MS = 37886 Br Et.sub.2 CH NH 2-Br-4-iPr-phenyl87 Br Et.sub.2 CH NEt 2-Br-4-iPr-phenyl88 Br Et.sub.2 CH NH 2,4-Br.sub.2 -phenyl89 Br Et.sub.2 CH NEt 2,4-Br.sub.2 -phenyl90 Br Et.sub.2 CH NEt 2,4,6-Me.sub.3 -phenyl91 Br Et.sub.2 CH NEt 2,4,6-Me.sub.3 -phenyl92 Br MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl93 Br Et.sub.2 CH NH 2-Br-4,6-(MeO).sub.2 -phenyl94 Br Et.sub.2 CH NH 2-CN-4,6-Me.sub.2 -phenyl95 Br MeOCH.sub.2 (Et)CH NH 2-Br-4,6-(MeO).sub.2 -phenyl96 Br MeOCH.sub.2 (Et)CH NH 2-I-4,6-Me.sub.2 -phenyl97 Br MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -4-Br-phenyl98 Br MeOCH.sub.2 (Et)CH NH 2-I-4-Cl-6-Me-phenyl99 Br (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl100 Br MeOCH.sub.2 (Et)CH NH 2,6-Me2-4-SMe-phenyl101 Br MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl102 Br MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl103 Br MeOCH.sub.2 (Et)CH NH 2-Me-4-Br-6-OMe-phenyl104 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -pyrid-3-yl105 CH.sub.3 Et.sub.2 CH NH 4,6-Me.sub.2 -pyrid-3-yl106 CH.sub.3 Et.sub.2 CH NH 2-Br-6-Me-pyrid-3-yl107 CH.sub.3 Et.sub.2 CH NH 2-Br-6-OMe-pyrid-3-yl108 CH.sub.3 Et.sub.2 CH NH 2,6-Me.sub.2 -pyrid-3-yl109 CH.sub.3 Et.sub.2 CH NH 2-Cl-6-Me-pyrid-3-yl110 CH.sub.3 Et.sub.2 CH NH 2-Cl-6-OMe-pyrid-3-yl111 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -pyrid-3-yl112 CH.sub.3 MeOCH.sub.2 (Et)CH NH 4,6-Me.sub.2 -pyrid-3-yl113 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-6-Me-pyrid-3-yl114 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Br-6-OMe-pyrid-3-yl115 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -pyrid-3-yl116 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Cl-6-Me-pyrid-3-yl117 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Cl-6-OMe-pyrid-3-yl118 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-6-OMe-pyrid-3-yl119 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -pyrid-3-yl120 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-6-Me-pyrid-3-yl121 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-6-OMe-pyrid-3-yl120 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -pyrid-3-yl123 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4,6-Me.sub.2 -pyrid-3-yl124 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Br-6-Me-pyrid-3-yl125 Cl Et.sub.2 CH NH 2-Br-6-OMe-pyrid-3-yl124 Cl Et.sub.2 CH NH 2,6-Me.sub.2 -pyrid-3-yl127 Cl Et.sub.2 CH NH 2-Cl-6-Me-pyrid-3-yl128 Cl Et.sub.2 CH NH 2-Cl-6-OMe-pyrid-3-yl129 Cl MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -pyrid-3-yl130 Cl MeOCH.sub.2 (Et)CH NH 4,6-Me.sub.2 -pyrid-3-yl131 Cl MeOCH.sub.2 (Et)CH NH 2-Br-6-Me-pyrid-3-yl132 Cl Et.sub.2 CH NH 2,4,6-Me.sub.3 -pyrid-3-yl133 Cl Et.sub.2 CH NH 4,6-Me.sub.2 -pyrid-3-yl134 Cl Et.sub.2 CH NH 2-Br-6-Me-pyrid-3-yl135 Cl MeOCH.sub.2 (Et)CH NH 2-Br-6-OMe-pyrid-3-yl136 Cl MeOCH.sub.2 (Et)CH NH 2,6-Me.sub.2 -pyrid-3-yl137 Cl MeOCH.sub.2 (Et)CH NH 2-Cl-6-Me-pyrid-3-yl138 Cl MeOCH.sub.2 (Et)CH NH 2-Cl-6-OMe-pyrid-3-yl139 Cl (MeOCH.sub.2).sub.2 CH NH 2-Br-6-OMe-pyrid-3-yl140 Cl (MeOCH.sub.2).sub.2 CH NH 2,6-Me.sub.2 -pyrid-3-yl141 Cl (MeOCH.sub.2).sub.2 CH NH 2-Cl-6-Me-pyrid-3-yl142 Cl (MeOCH.sub.2).sub.2 CH NH 2-Cl-6-OMe-pyrid-3-yl143 Cl (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -pyrid-3-yl144 Cl (MeOCH.sub.2).sub.2 CH NH 4,6-Me.sub.2 -pyrid-3-yl145 Cl (MeOCH.sub.2).sub.2 CH NH 2-Br-6-Me-pyrid-3-yl146 Et.sub.2 CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl147 Et.sub.2 CH CH.sub.3 NH 2,6-Me.sub.2 -4-Br-phenyl148 Et.sub.2 CH CH.sub.3 NH 2-Br-4-iPr-phenyl149 MeOCH.sub.2 (Et)CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl150 MeOCH.sub.2 (Et)CH CH.sub.3 NH 2,6-Me.sub.2 -4-Br-phenyl151 MeOCH.sub.2 (Et)CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl152 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl153 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 2,6-Me.sub.2 -4-Br-phenyl154 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl155 Et.sub.2 CH CH.sub.3 NH 2-Br-4,6-(MeO).sub.2 -phenyl156 Et.sub.2 CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl400 CH.sub.3 Me(Et)CH NH 2,4,6-Me.sub.3 -phenyl401 CH.sub.3 Me(Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl402 CH.sub.3 Me(Et)CH NH 2,4-Cl.sub.2 -6-Me-phenyl403 CH.sub.3 Me(Et)CH NH 2,4,6-Cl.sub.3 -phenyl404 CH.sub.3 Me(Et)CH NH 2-Me-4-MeO-phenyl405 CH.sub.3 Me(Et)CH NH 2-Cl-4-MeO-phenyl406 CH.sub.3 Me(Et)CH NH 2,4,6-Me.sub.3 -5-F-phenyl407 CH.sub.3 Me(Et)CH NH 2,5-Me.sub.2 -4-MeO-phenyl408 CH.sub.3 Me(Et)CH NH 2,4-Me.sub.2 -6-MeO-phenyl409 CH.sub.3 Me(Et)CH NH 2,6-Cl.sub.2 -4-Me-phenyl410 CH.sub.3 Me(Et)CH NH 2,4-Cl.sub.2 -phenyl411 CH.sub.3 Me(Et)CH NH 2-Cl-4-Me-phenyl412 CH.sub.3 Me(Et)CH NH 2-Me-4-Cl-phenyl413 CH.sub.3 Me(Et)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl414 CH.sub.3 Me(Et)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl415 CH.sub.3 Me(Et)CH NH 2-Cl-4-MeO-6-Me-phenyl416 CH.sub.3 Me(Et)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl417 CH.sub.3 Me(Et)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl418 CH.sub.3 Me(Et)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl419 CH.sub.3 Me(n-Pr)CH NH 2,4,6-Me.sub.3 -phenyl420 CH.sub.3 Me(n-Pr)CH NH 2-Cl-4,6-Me.sub.2 -phenyl421 CH.sub.3 Me(n-Pr)CH NH 2,4-Cl.sub.2 -6-Me-phenyl422 CH.sub.3 Me(n-Pr)CH NH 2,4,6-Cl.sub.3 -phenyl423 CH.sub.3 Me(n-Pr)CH NH 2-Me-4-MeO-phenyl424 CH.sub.3 Me(n-Pr)CH NH 2-Cl-4-MeO-phenyl425 CH.sub.3 Me(n-Pr)CH NH 2,4,6-Me.sub.3 -5-F-phenyl426 CH.sub.3 Me(n-Pr)CH NH 2,5-Me.sub.2 -4-MeO-phenyl427 CH.sub.3 Me(n-Pr)CH NH 2,4-Me.sub.2 -6-MeO-phenyl428 CH.sub.3 Me(n-Pr)CH NH 2,6-Cl.sub.2 -4-Me-phenyl429 CH.sub.3 Me(n-Pr)CH NH 2,4-Cl.sub.2 -phenyl430 CH.sub.3 Me(n-Pr)CH NH 2-Cl-4-Me-phenyl431 CH.sub.3 Me(n-Pr)CH NH 2-Me-4-Cl-phenyl432 CH.sub.3 Me(n-Pr)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl433 CH.sub.3 Me(n-Pr)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl434 CH.sub.3 Me(n-Pr)CH NH 2-Cl-4-MeO-6-Me-phenyl435 CH.sub.3 Me(n-Pr)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl436 CH.sub.3 Me(n-Pr)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl437 CH.sub.3 Me(n-Pr)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl438 CH.sub.3 Et.sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl439 CH.sub.3 Et.sub.2 CH NH 2,4,6-Cl.sub.3 -phenyl440 CH.sub.3 Et.sub.2 CH NH 2-Me-4-MeO-phenyl441 CH.sub.3 Et.sub.2 CH NH 2-Cl-4-MeO-phenyl442 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -5-F-phenyl443 CH.sub.3 Et.sub.2 CH NH 2,5-Me.sub.2 -4-MeO-phenyl444 CH.sub.3 Et.sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl445 CH.sub.3 Et.sub.2 CH NH 2,6-Cl.sub.2 -4-Me-phenyl446 CH.sub.3 Et.sub.2 CH NH 2,4-Cl.sub.2 -phenyl447 CH.sub.3 Et.sub.2 CH NH 2-Cl-4-Me-phenyl448 CH.sub.3 Et.sub.2 CH NH 2-Me-4-Cl-phenyl449 CH.sub.3 Et.sub.2 CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl450 CH.sub.3 Et.sub.2 CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl451 CH.sub.3 Et.sub.2 CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl452 CH.sub.3 Et.sub.2 CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl453 CH.sub.3 Et.sub.2 CH NH 6-Me-2,3-dihydro-benzofuran-5-yl454 CH.sub.3 (c-Pr).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl455 CH.sub.3 (c-Pr).sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl456 CH.sub.3 (c-Pr).sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl457 CH.sub.3 (c-Pr).sub.2 CH NH 2,4,6-Cl.sub.3 -phenyl458 CH.sub.3 (c-Pr).sub.2 CH NH 2-Me-4-MeO-phenyl459 CH.sub.3 (c-Pr).sub.2 CH NH 2-Cl-4-MeO-phenyl460 CH.sub.3 (c-Pr).sub.2 CH NH 2,4,6-Me.sub.3 -5-F-phenyl461 CH.sub.3 (c-Pr).sub.2 CH NH 2,5-Me.sub.2 -4-MeO-phenyl462 CH.sub.3 (c-Pr).sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl463 CH.sub.3 (c-Pr).sub.2 CH NH 2,6-Cl.sub.2 -4-Me-phenyl464 CH.sub.3 (c-Pr).sub.2 CH NH 2,4-Cl.sub.2 -phenyl465 CH.sub.3 (c-Pr).sub.2 CH NH 2-Cl-4-Me-phenyl466 CH.sub.3 (c-Pr).sub.2 CH NH 2-Me-4-Cl-phenyl467 CH.sub.3 (c-Pr).sub.2 CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl468 CH.sub.3 (c-Pr).sub.2 CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl469 CH.sub.3 (c-Pr).sub.2 CH NH 2-Cl-4-MeO-6-Me-phenyl470 CH.sub.3 (c-Pr).sub.2 CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl471 CH.sub.3 (c-Pr).sub.2 CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl472 CH.sub.3 (c-Pr).sub.2 CH NH 6-Me-2,3-dihydro-benzofuran-5-yl473 CH.sub.3 c-Pr(Me)CH NH 2,4,6-Me.sub.3 -phenyl474 CH.sub.3 c-Pr(Me)CH NH 2-Cl-4,6-Me.sub.2 -phenyl475 CH.sub.3 c-Pr(Me)CH NH 2,4-Cl.sub.2 -6-Me-phenyl476 CH.sub.3 c-Pr(Me)CH NH 2,4,6-Cl.sub.3 -phenyl477 CH.sub.3 c-Pr(Me)CH NH 2-Me-4-MeO-phenyl478 CH.sub.3 c-Pr(Me)CH NH 2-Cl-4-MeO-phenyl479 CH.sub.3 c-Pr(Me)CH NH 2,4,6-Me.sub.3 -5-F-phenyl480 CH.sub.3 c-Pr(Me)CH NH 2,5-Me.sub.2 -4-MeO-phenyl481 CH.sub.3 c-Pr(Me)CH NH 2,4-Me.sub.2 -6-MeO-phenyl482 CH.sub.3 c-Pr(Me)CH NH 2,6-Cl.sub.2 -4-Me-phenyl483 CH.sub.3 c-Pr(Me)CH NH 2,4-Cl.sub.2 -phenyl484 CH.sub.3 c-Pr(Me)CH NH 2-Cl-4-Me-phenyl485 CH.sub.3 c-Pr(Me)CH NH 2-Me-4-Cl-phenyl486 CH.sub.3 c-Pr(Me)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl487 CH.sub.3 c-Pr(Me)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl488 CH.sub.3 c-Pr(Me)CH NH 2-Cl-4-MeO-6-Me-phenyl489 CH.sub.3 c-Pr(Me)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl490 CH.sub.3 c-Pr(Me)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl491 CH.sub.3 c-Pr(Me)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl492 CH.sub.3 c-Pr(Et)CH NH 2,4,6-Me.sub.3 -phenyl493 CH.sub.3 c-Pr(Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl494 CH.sub.3 c-Pr(Et)CH NH 2,4-Cl.sub.2 -6-Me-phenyl495 CH.sub.3 c-Pr(Et)CH NH 2,4,6-Cl.sub.3 -phenyl496 CH.sub.3 c-Pr(Et)CH NH 2-Me-4-MeO-phenyl497 CH.sub.3 c-Pr(Et)CH NH 2-Cl-4-MeO-phenyl498 CH.sub.3 c-Pr(Et)CH NH 2,4,6-Me.sub.3 -5-F-phenyl499 CH.sub.3 c-Pr(Et)CH NH 2,5-Me.sub.2 -4-MeO-phenyl500 CH.sub.3 c-Pr(Et)CH NH 2,4-Me.sub.2 -6-MeO-phenyl501 CH.sub.3 c-Pr(Et)CH NH 2,6-Cl.sub.2 -4-Me-phenyl502 CH.sub.3 c-Pr(Et)CH NH 2,4-Cl.sub.2 -phenyl503 CH.sub.3 c-Pr(Et)CH NH 2-Cl-4-Me-phenyl504 CH.sub.3 c-Pr(Et)CH NH 2-Me-4-Cl-phenyl505 CH.sub.3 c-Pr(Et)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl506 CH.sub.3 c-Pr(Et)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl507 CH.sub.3 c-Pr(Et)CH NH 2-Cl-4-MeO-6-Me-phenyl508 CH.sub.3 c-Pr(Et)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl509 CH.sub.3 c-Pr(Et)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl510 CH.sub.3 c-Pr(Et)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl511 CH.sub.3 c-Pr(n-Pr)CH NH 2,4,6-Me.sub.3 -phenyl512 CH.sub.3 c-Pr(n-Pr)CH NH 2-Cl-4,6-Me.sub.2 -phenyl513 CH.sub.3 c-Pr(n-Pr)CH NH 2,4-Cl.sub.2 -6-Me-phenyl514 CH.sub.3 c-Pr(n-Pr)CH NH 2,4,6-Cl.sub.3 -phenyl515 CH.sub.3 c-Pr(n-Pr)CH NH 2-Me-4-MeO-phenyl516 CH.sub.3 c-Pr(n-Pr)CH NH 2-Cl-4-MeO-phenyl517 CH.sub.3 c-Pr(n-Pr)CH NH 2,4,6-Me.sub.3 -5-F-phenyl518 CH.sub.3 c-Pr(n-Pr)CH NH 2,5-Me.sub.2 -4-MeO-phenyl519 CH.sub.3 c-Pr(n-Pr)CH NH 2,4-Me.sub.2 -6-MeO-phenyl520 CH.sub.3 c-Pr(n-Pr)CH NH 2,6-Cl.sub.2 -4-Me-phenyl521 CH.sub.3 c-Pr(n-Pr)CH NH 2,4-Cl.sub.2 -phenyl522 CH.sub.3 c-Pr(n-Pr)CH NH 2-Cl-4-Me-phenyl523 CH.sub.3 c-Pr(n-Pr)CH NH 2-Me-4-Cl-phenyl524 CH.sub.3 c-Pr(n-Pr)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl525 CH.sub.3 c-Pr(n-Pr)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl526 CH.sub.3 c-Pr(n-Pr)CH NH 2-Cl-4-MeO-6-Me-phenyl527 CH.sub.3 c-Pr(n-Pr)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl528 CH.sub.3 c-Pr(n-Pr)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl529 CH.sub.3 c-Pr(n-Pr)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl530 CH.sub.3 c-Pr(n-Bu)CH NH 2,4,6-Me.sub.3 -phenyl531 CH.sub.3 c-Pr(n-Bu)CH NH 2-Cl-4,6-Me.sub.2 -phenyl532 CH.sub.3 c-Pr(n-Bu)CH NH 2,4-Cl.sub.2 -6-Me-phenyl533 CH.sub.3 c-Pr(n-Bu)CH NH 2,4,6-Cl.sub.3 -phenyl534 CH.sub.3 c-Pr(n-Bu)CH NH 2-Me-4-MeO-phenyl535 CH.sub.3 c-Pr(n-Bu)CH NH 2-Cl-4-MeO-phenyl536 CH.sub.3 c-Pr(n-Bu)CH NH 2,4,6-Me.sub.3 -5-F-phenyl537 CH.sub.3 c-Pr(n-Bu)CH NH 2,5-Me.sub.2 -4-MeO-phenyl538 CH.sub.3 c-Pr(n-Bu)CH NH 2,4-Me.sub.2 -6-MeO-phenyl539 CH.sub.3 c-Pr(n-Bu)CH NH 2,6-Cl.sub.2 -4-Me-phenyl540 CH.sub.3 c-Pr(n-Bu)CH NH 2,4-Cl.sub.2 -phenyl541 CH.sub.3 c-Pr(n-Bu)CH NH 2-Cl-4-Me-phenyl542 CH.sub.3 c-Pr(n-Bu)CH NH 2-Me-4-Cl-phenyl543 CH.sub.3 c-Pr(n-Bu)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl544 CH.sub.3 c-Pr(n-Bu)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl545 CH.sub.3 c-Pr(n-Bu)CH NH 2-Cl-4-MeO-6-Me-phenyl546 CH.sub.3 c-Pr(n-Bu)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl547 CH.sub.3 c-Pr(n-Bu)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl548 CH.sub.3 c-Pr(n-Bu)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl549 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl550 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl551 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4-Cl.sub.2 -6-Me-phenyl552 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4,6-Cl.sub.3 -phenyl553 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Me-4-MeO-phenyl554 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Cl-4-MeO-phenyl555 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -5-F-phenyl556 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,5-Me.sub.2 -4-MeO-phenyl557 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-MeO-phenyl558 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,6-Cl.sub.2 -4-Me-phenyl559 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2,4-Cl.sub.2 -phenyl560 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Cl-4-Me-phenyl561 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Me-4-Cl-phenyl562 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl563 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl564 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Cl-4-MeO-6-Me-phenyl565 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl566 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl567 CH.sub.3 c-PrCH.sub.2 (Et)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl__________________________________________________________________________
Compounds that can be synthesized using synthetic Scheme 6 or Scheme 7 are listed in Table 2
TABLE 2__________________________________________________________________________ ##STR11##Ex.No. R.sup.1 R.sup.3 Y Ar mp__________________________________________________________________________200 CH.sub.3 Et.sub.2 CH NH 2,4-Br.sub.2 -phenyl201 CH.sub.3 Et.sub.2 CH NH 2-Br-4-iPr-phenyl202 CH.sub.3 Et.sub.2 CH NEt 2,4-Br.sub.2 -phenyl203 CH.sub.3 Et.sub.2 CH NEt 2-Br-4-iPr-phenyl204 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl 133205 CH.sub.3 Et.sub.2 CH NEt 2,4,6-Me.sub.3 -phenyl206 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -phenyl207 CH.sub.3 Et.sub.2 CH NH 2-Br-4,6-(MeO).sub.2 -phenyl208 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-4,6-(MeO).sub.2 -phenyl209 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-(MeO).sub.2 -phenyl210 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-I-phenyl211 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-CN-4,6-Me.sub.2 -phenyl212 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-4,6-Me.sub.2 -phenyl213 CH.sub.3 MeOCH.sub.2 (Et)CH NH 4-Br-2,6-Me.sub.2 -phenyl214 CH.sub.3 MeOCH.sub.2 (Et)CH NH 4-MeC(O)-2,6-Me.sub.2 -phenyl215 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-MeC(O)-4,6-Me.sub.2 -phenyl216 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-SMe-phenyl217 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-SO.sub.2 Me-phenyl218 CH.sub.3 MeOCH.sub.2 (Et)CH NH 4-Cl-2-I-6-Me-phenyl219 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl220 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -phenyl221 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl222 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Br.sub.2 -6-Me-phenyl223 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4,6-Me.sub.3 -phenyl224 CH.sub.3 (MeOC.sub.2 H.sub.4).sub.2 CH NH 2,4,6-Me.sub.3 -phenyl225 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Me.sub.2 -6-MeO-phenyl226 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeO-phenyl227 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2-Br-4,6-Me.sub.2 -phenyl228 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2-Cl-4,6-Me.sub.2 -phenyl229 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl230 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl231 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 4-Br-2,6-Me.sub.2 -phenyl232 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl233 CH.sub.3 (MeOCH.sub.2).sub.2 CH NH 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl234 CH.sub.3 MeOCH.sub.2 (Me)CH NH 2,4-Me.sub.2 -6-MeO-phenyl235 CH.sub.3 MeOCH.sub.2 (Me)CH NH 2-Br-4,6-Me.sub.2 -phenyl236 CH.sub.3 EtOCH.sub.2 (Et)CH NH 2-Br-4,6-Me.sub.2 -phenyl237 CH.sub.3 EtOCH.sub.2 (Me)CH NH 2-Br-4,6-Me.sub.2 -phenyl238 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Br-4,6-F.sub.2 -phenyl239 Et.sub.2 CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl240 Et.sub.2 CH CH.sub.3 NH 4-Br-2,6-Me.sub.2 -phenyl241 Et.sub.2 CH CH.sub.3 NH 2-Br-4-iPr-phenyl242 MeOCH.sub.2 (Et)CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl243 MeOCH.sub.2 (Et)CH CH.sub.3 NH 4-Br-2,6-Me.sub.2 -phenyl244 MeOCH.sub.2 (Et)CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl245 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 2,4,6-Me.sub.3 -phenyl246 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 4-Br-2,6-Me.sub.2 -phenyl247 (MeOCH.sub.2).sub.2 CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl248 Et.sub.2 CH CH.sub.3 NH 2-Br-4,6-(MeO).sub.2 -phenyl249 Et.sub.2 CH CH.sub.3 NH 2-Cl-4,6-Me.sub.2 -phenyl250 CH.sub.3 Et.sub.2 CH NH 2-Cl-4,6-Me.sub.2 -phenyl251 CH.sub.3 Et.sub.2 CH NH 2,4-Cl.sub.2 -6-Me-phenyl252 CH.sub.3 Et.sub.2 CH NH 2,4,6-Cl.sub.3 -phenyl253 CH.sub.3 Et.sub.2 CH NH 2-Me-4-MeO-phenyl254 CH.sub.3 Et.sub.2 CH NH 2-Cl-4-MeO-phenyl255 CH.sub.3 Et.sub.2 CH NH 2,4,6-Me.sub.3 -5-F-phenyl256 CH.sub.3 Et.sub.2 CH NH 2,5-Me.sub.2 -4-MeO-phenyl257 CH.sub.3 Et.sub.2 CH NH 2,4-Me.sub.2 -6-MeO-phenyl258 CH.sub.3 Et.sub.2 CH NH 2,6-Cl.sub.2 -4-Me-phenyl259 CH.sub.3 Et.sub.2 CH NH 2,4-Cl.sub.2 -phenyl260 CH.sub.3 Et.sub.2 CH NH 2-Cl-4-Me-phenyl261 CH.sub.3 Et.sub.2 CH NH 2-Me-4-Cl-phenyl262 CH.sub.3 Et.sub.2 CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl263 CH.sub.3 Et.sub.2 CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl264 CH.sub.3 Et.sub.2 CH NH 2-Cl-4-MeO-6-Me-phenyl265 CH.sub.3 Et.sub.2 CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl266 CH.sub.3 Et.sub.2 CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl267 CH.sub.3 Et.sub.2 CH NH 6-Me-2,3-dihydro-benzofuran-5-yl268 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -phenyl269 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Cl.sub.2 -6-Me-phenyl270 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4,6-Cl.sub.3 -phenyl271 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Me-4-MeO-phenyl272 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4-MeO-phenyl273 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4,6-Me.sub.3 -5-F-phenyl274 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,5-Me.sub.2 -4-MeO-phenyl275 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,6-Cl.sub.2 -4-Me-phenyl276 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2,4-Cl.sub.2 -phenyl277 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4-Me-phenyl278 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Me-4-Cl-phenyl279 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-NMe.sub.2 -6-Me-pyrid-5-yl280 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-NMe.sub.2 -4-Me-pyrid-5-yl281 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4-MeO-6-Me-phenyl282 CH.sub.3 MeOCH.sub.2 (Et)CH NH 2-Cl-4,6-Me.sub.2 -5-F-phenyl283 CH.sub.3 MeOCH.sub.2 (Et)CH NH 6-Cl-2,3-dihydro-benzofuran-5-yl284 CH.sub.3 MeOCH.sub.2 (Et)CH NH 6-Me-2,3-dihydro-benzofuran-5-yl__________________________________________________________________________
Compounds wherein Y=Oxygen that can be synthesized using synthetic Scheme 3 are listed in Table 3
TABLE 3__________________________________________________________________________ ##STR12##ExNo R.sup.1 R.sup.3 Y Ar mp/.degree. C.__________________________________________________________________________700 Cl Et.sub.2 CH O 2-Br-4-iPr-phenyl701 Cl Et.sub.2 CH O 2,4-Br.sub.2 -phenyl702 Cl Et.sub.2 CH O 2,4,6-Me.sub.3 -phenyl703 Cl MeOCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -phenyl 116704 Cl Et.sub.2 CH O 2-Br-4,6-(MeO).sub.2 -phenyl705 Cl Et.sub.2 CH O 2-CN-4,6-Me.sub.2 -phenyl706 Cl MeOCH.sub.2 (Et)CH O 2-Br-4,6-(MeO).sub.2 -phenyl707 Cl MeOCH.sub.2 (Et)CH O 2-Cl-4,6-(MeO).sub.2 -phenyl708 Cl MeOCH.sub.2 (Et)CH O 2-I-4,6-Me.sub.2 -phenyl709 Cl MeOCH.sub.2 (Et)CH O 2-CN-4,6-Me.sub.2 -phenyl710 Cl MeOCH.sub.2 (Et)CH O 2-Br-4,6-Me.sub.2 -phenyl711 Cl MeOCH.sub.2 (Et)CH O 4-Br-2,6-Me.sub.2 -phenyl712 Cl MeOCH.sub.2 (Et)CH O 4-MeCO-2,6-Me.sub.2 -phenyl713 Cl MeOCH.sub.2 (Et)CH O 4-MeCO-2-OMe-6-Me-phenyl714 Cl MeOCH.sub.2 (Et)CH O 2-MeCO-4,6-Me.sub.2 -phenyl715 Cl MeOCH.sub.2 (Et)CH O 4,6-Me.sub.2 -2-SMe-phenyl716 Cl MeOCH.sub.2 (Et)CH O 4,6-Me.sub.2 -2-SO.sub.2 Me-phenyl717 Cl MeOCH.sub.2 (Et)CH O 4-Cl-2-I-6-Me-phenyl718 Cl (MeOCH.sub.2).sub.2 CH O 2,4,6-Me.sub.3 -phenyl719 Cl phenyl O 2,4,6-Me.sub.3 -phenyl720 CH.sub.3 MeOCH.sub.2 (Et)CH O 2,4-Br.sub.2 -phenyl721 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Br-4-iPr-phenyl722 CH.sub.3 MeOCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -phenyl723 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Cl-4,6-Me.sub.2 -phenyl724 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,4,6-Me.sub.3 -phenyl725 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,4-Cl.sub.2 -6-Me-phenyl726 Cl (MeOCH.sub.2).sub.2 CH O 2,4-Cl.sub.2 -6-Me-phenyl727 Cl (MeOCH.sub.2).sub.2 CH O 2,4-Br.sub.2 -6-Me-phenyl728 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4,6-Me.sub.3 -phenyl729 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4,6-Me.sub.3 -phenyl730 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 4-Br-2-OMe-6-Me-phenyl731 Cl (MeOC.sub.2 H.sub.4).sub.2 CH O 2,4,6-Me.sub.3 -phenyl732 Cl MeOCH.sub.2 (Et)CH O 2,4-Me.sub.2 -6-MeO-phenyl733 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-MeO-phenyl734 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-MeO-phenyl735 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH 0 4-Br-2,6-Me.sub.2 -phenyl736 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2-Cl-4,6-Me.sub.2 -phenyl737 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl738 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,4-Me.sub.2 -6-MeO-phenyl739 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 4-Br-2,6-Me.sub.2 -phenyl740 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Br-6-F-4-Me-phenyl741 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Cl-4,6-Me.sub.2 -phenyl742 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Cl-4-OMe-6-Me-phenyl743 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl744 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-MeO-phenyl745 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 4-Br-2,6-Me.sub.2 -phenyl746 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2-Cl-4,6-Me.sub.2 -phenyl747 Cl MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl748 Cl (MeOCH.sub.2).sub.2 CH O 2,4-Me.sub.2 -6-MeO-phenyl749 Cl (MeOCH.sub.2).sub.2 CH O 4-Br-2,6-Me.sub.2 -phenyl750 Cl (MeOCH.sub.2).sub.2 CH O 2-Cl-4,6-Me.sub.2 -phenyl751 Cl (MeOCH.sub.2).sub.2 CH O 2,4-Me.sub.2 -6-MeOCH.sub.2 -phenyl752 Cl MeOCH.sub.2 (Me)CH O 2,4-Me.sub.2 -6-MeO-phenyl753 Cl MeOCH.sub.2 (Me)CH O 4-Br-2,6-Me.sub.2 -phenyl754 Cl EtOCH.sub.2 (Et)CH O 4-Br-2,6-Me.sub.2 -phenyl755 Cl EtOCH.sub.2 (Me)CH O 4-Br-2,6-Me.sub.2 -phenyl756 Cl MeOCH.sub.2 (Et)CH O 4-Br-2,6-F.sub.2 -phenyl757 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2-Br-4,6-Me.sub.2 -phenyl758 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-SMe-phenyl759 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Me.sub.2 -6-SO.sub.2 Me-phenyl760 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 4-NMe.sub.2 -2,6-Me.sub.2 -phenyl761 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,4-Cl.sub.2 -6-Me-phenyl762 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 4-Cl-2,6-Me.sub.2 -phenyl763 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,6-Me.sub.2 -4-SMe-phenyl764 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,6-Me.sub.2 -4-OMe-phenyl765 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl766 CH.sub.3 MeOC.sub.2 H.sub.4 (MeOCH.sub.2)CH O 4-MeC(O)-2,6-Me.sub.2 -phenyl767 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 4-Br-2,6-Me.sub.2 -phenyl768 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 4-MeC(O)-2,6-Me.sub.2 -phenyl769 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -4-SMe-phenyl770 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl771 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 4-NMe.sub.2 -2,6-Me.sub.2 -phenyl772 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-NMe.sub.2 -4,6-Me.sub.2 -phenyl773 Cl MeOCH.sub.2 (Et)CH O 2,6-Me.sub.2 -4-SMe-phenyl774 Cl MeOCH.sub.2 (Et)CH O 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl775 Cl MeOCH.sub.2 (Et)CH O 2-Cl-4,6-Me.sub.2 -phenyl776 Cl MeOCH.sub.2 (Et)CH O 4-Br-6-OMe-2-Me-phenyl777 Cl (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -4-SMe-phenyl778 Cl (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -4-SO.sub.2 Me-phenyl779 Cl (MeOCH.sub.2).sub.2 CH O 4-Br-6-OMe-2-Me-phenyl780 CH.sub.3 Et.sub.2 CH O 2,4,6-Me.sub.3 -phenyl781 CH.sub.3 Et.sub.2 CH O 2-Cl-4,6-Me.sub.2 -phenyl782 CH.sub.3 Et.sub.2 CH O 2-Cl-4-OMe-6-Me-phenyl783 CH.sub.3 Et.sub.2 CH O 2,4,6-Me.sub.3 -pyrid-3-yl784 CH.sub.3 Et.sub.2 CH O 4,6-Me.sub.2 -pyrid-3-yl785 CH.sub.3 Et.sub.2 CH O 2-Br-6-Me-pyrid-3-yl786 CH.sub.3 Et.sub.2 CH O 2-Br-6-OMe-pyrid-3-yl787 CH.sub.3 Et.sub.2 CH O 2,6-Me.sub.2 -pyrid-3-yl788 CH.sub.3 Et.sub.2 CH O 2-Cl-6-Me-pyrid-3-yl789 CH.sub.3 Et.sub.2 CH O 2-Cl-6-OMe-pyrid-3-yl790 CH.sub.3 MeOCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -pyrid-3-yl791 CH.sub.3 MeOCH.sub.2 (Et)CH O 4,6-Me.sub.2 -pyrid-3-yl792 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Br-6-Me-pyrid-3-yl793 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Br-6-OMe-pyrid-3-yl794 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -pyrid-3-yl795 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Cl-6-Me-pyrid-3-yl796 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Cl-6-OMe-pyrid-3-yl797 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Br-6-OMe-pyrid-3-yl798 CH.sub.3 MeOCH.sub.2 (Et)CH O 2,6-Me.sub.2 -pyrid-3-yl799 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Cl-6-Me-pyrid-3-yl800 CH.sub.3 MeOCH.sub.2 (Et)CH O 2-Cl-6-OMe-pyrid-3-yl801 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2,4,6-Me.sub.3 -pyrid-3-yl802 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 4,6-Me.sub.2 -pyrid-3-yl803 CH.sub.3 (MeOCH.sub.2).sub.2 CH O 2-Br-6-Me-pyrid-3-yl804 Cl Et.sub.2 CH O 2-Br-6-OMe-pyrid-3-yl805 Cl Et.sub.2 CH O 2,6-Me.sub.2 -pyrid-3-yl806 Cl Et.sub.2 CH O 2-Cl-6-Me-pyrid-3-yl807 Cl Et.sub.2 CH O 2-Cl-6-OMe-pyrid-3-yl808 Cl MeOCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -pyrid-3-yl809 Cl MeOCH.sub.2 (Et)CH O 4,6-Me.sub.2 -pyrid-3-yl810 Cl MeOCH.sub.2 (Et)CH O 2-Br-6-Me-pyrid-3-yl811 Cl Et.sub.2 CH O 2,4,6-Me.sub.3 -pyrid-3-yl812 Cl Et.sub.2 CH O 4,6-Me.sub.2 -pyrid-3-yl813 Cl Et.sub.2 CH O 2-Br-6-Me-pyrid-3-yl814 Cl MeOCH.sub.2 (Et)CH O 2-Br-6-OMe-pyrid-3-yl815 Cl MeOCH.sub.2 (Et)CH O 2,6-Me.sub.2 -pyrid-3-yl816 Cl MeOCH.sub.2 (Et)CH O 2-Cl-6-Me-pyrid-3-yl817 Cl MeOCH.sub.2 (Et)CH O 2-Cl-6-OMe-pyrid-3-yl818 Cl (MeOCH.sub.2).sub.2 CH O 2-Br-6-OMe-pyrid-3-yl819 Cl (MeOCH.sub.2).sub.2 CH O 2,6-Me.sub.2 -pyrid-3-yl820 Cl (MeOCH.sub.2).sub.2 CH O 2-Cl-6-Me-pyrid-3-yl821 Cl (MeOCH.sub.2).sub.2 CH O 2-Cl-6-OMe-pyrid-3-yl822 Cl (MeOCH.sub.2).sub.2 CH O 2,4,6-Me.sub.3 -pyrid-3-yl823 Cl (MeOCH.sub.2).sub.2 CH O 4,6-Me.sub.2 -pyrid-3-yl824 Cl (MeOCH.sub.2).sub.2 CH O 2-Br-6-Me-pyrid-3-yl825 CH.sub.3 Me(Et)CH O 2,4,6-Me.sub.3 -phenyl826 CH.sub.3 Me(Et)CH O 2-Cl-4,6-Me.sub.2 -phenyl827 CH.sub.3 Me(Et)CH O 2,4-Cl.sub.2 -6-Me-phenyl828 CH.sub.3 Me(Et)CH O 2,4,6-Cl.sub.3 -phenyl829 CH.sub.3 Me(Et)CH O 2-Me-4-MeO-phenyl830 CH.sub.3 Me(Et)CH O 2-Cl-4-MeO-phenyl831 CH.sub.3 Me(Et)CH O 2,4,6-Me.sub.3 -5-F-phenyl832 CH.sub.3 Me(Et)CH O 2,5-Me.sub.2 -4-MeO-phenyl833 CH.sub.3 Me(Et)CH O 2,4-Me.sub.2 -6-MeO-phenyl834 CH.sub.3 Me(Et)CH O 2,6-Cl.sub.2 -4-Me-phenyl835 CH.sub.3 Me(Et)CH O 2,4-Cl.sub.2 -phenyl836 CH.sub.3 Me(Et)CH O 2-Cl-4-Me-phenyl837 CH.sub.3 Me(Et)CH O 2-Me-4-Cl-phenyl838 CH.sub.3 Me(Et)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl839 CH.sub.3 Me(Et)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl840 CH.sub.3 Me(Et)CH O 2-Cl-4-MeO-6-Me-phenyl841 CH.sub.3 Me(Et)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl842 CH.sub.3 Me(Et)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl843 CH.sub.3 Me(Et)CH O 6-Me-2,3-dihydro-benzofuran-5-yl844 CH.sub.3 Me(n-Pr)CH O 2,4,6-Me.sub.3 -phenyl845 CH.sub.3 Me(n-Pr)CH O 2-Cl-4,6-Me.sub.2 -phenyl846 CH.sub.3 Me(n-Pr)CH O 2,4-Cl.sub.2 -6-Me-phenyl847 CH.sub.3 Me(n-Pr)CH O 2,4,6-Cl.sub.3 -phenyl848 CH.sub.3 Me(n-Pr)CH O 2-Me-4-MeO-phenyl849 CH.sub.3 Me(n-Pr)CH O 2-Cl-4-MeO-phenyl850 CH.sub.3 Me(n-Pr)CH O 2,4,6-Me.sub.3 -5-F-phenyl851 CH.sub.3 Me(n-Pr)CH O 2,5-Me.sub.2 -4-MeO-phenyl852 CH.sub.3 Me(n-Pr)CH O 2,4-Me.sub.2 -6-MeO-phenyl853 CH.sub.3 Me(n-Pr)CH O 2,6-Cl.sub.2 -4-Me-phenyl854 CH.sub.3 Me(n-Pr)CH O 2,4-Cl.sub.2 -phenyl855 CH.sub.3 Me(n-Pr)CH O 2-Cl-4-Me-phenyl856 CH.sub.3 Me(n-Pr)CH O 2-Me-4-Cl-phenyl857 CH.sub.3 Me(n-Pr)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl858 CH.sub.3 Me(n-Pr)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl859 CH.sub.3 Me(n-Pr)CH O 2-Cl-4-MeO-6-Me-phenyl860 CH.sub.3 Me(n-Pr)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl861 CH.sub.3 Me(n-Pr)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl862 CH.sub.3 Me(n-Pr)CH O 6-Me-2,3-dihydro-benzofuran-5-yl863 CH.sub.3 c-Pr.sub.2 CH O 2,4,6-Me.sub.3 -phenyl864 CH.sub.3 c-Pr.sub.2 CH O 2-Cl-4,6-Me.sub.2 -phenyl865 CH.sub.3 c-Pr.sub.2 CH O 2,4-Cl.sub.2 -6-Me-phenyl866 CH.sub.3 c-Pr.sub.2 CH O 2,4,6-Cl.sub.3 -phenyl867 CH.sub.3 c-Pr.sub.2 CH O 2-Me-4-MeO-phenyl868 CH.sub.3 c-Pr.sub.2 CH O 2-Cl-4-MeO-phenyl869 CH.sub.3 c-Pr.sub.2 CH O 2,4,6-Me.sub.3 -5-F-phenyl870 CH.sub.3 c-Pr.sub.2 CH O 2,5-Me.sub.2 -4-MeO-phenyl871 CH.sub.3 c-Pr.sub.2 CH O 2,4-Me.sub.2 -6-MeO-phenyl872 CH.sub.3 c-Pr.sub.2 CH O 2,6-Cl.sub.2 -4-Me-phenyl873 CH.sub.3 c-Pr.sub.2 CH O 2,4-Cl.sub.2 -phenyl874 CH.sub.3 c-Pr.sub.2 CH O 2-Cl-4-Me-phenyl875 CH.sub.3 c-Pr.sub.2 CH O 2-Me-4-Cl-phenyl876 CH.sub.3 c-Pr.sub.2 CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl877 CH.sub.3 c-Pr.sub.2 CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl878 CH.sub.3 c-Pr.sub.2 CH O 2-Cl-4-MeO-6-Me-phenyl879 CH.sub.3 c-Pr.sub.2 CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl880 CH.sub.3 c-Pr.sub.2 CH O 6-Cl-2,3-dihydro-benzofuran-5-yl881 CH.sub.3 c-Pr.sub.2 CH O 6-Me-2,3-dihydro-benzofuran-5-yl882 CH.sub.3 c-Pr(Me)CH O 2,4,6-Me.sub.3 -phenyl883 CH.sub.3 c-Pr(Me)CH O 2-Cl-4,6-Me.sub.2 -phenyl884 CH.sub.3 c-Pr(Me)CH O 2,4-Cl.sub.2 -6-Me-phenyl885 CH.sub.3 c-Pr(Me)CH O 2,4,6-Cl.sub.3 -phenyl886 CH.sub.3 c-Pr(Me)CH O 2-Me-4-MeO-phenyl887 CH.sub.3 c-Pr(Me)CH O 2-Cl-4-MeO-phenyl888 CH.sub.3 c-Pr(Me)CH O 2,4,6-Me.sub.3 -5-F-phenyl889 CH.sub.3 c-Pr(Me)CH O 2,5-Me.sub.2 -4-MeO-phenyl890 CH.sub.3 c-Pr(Me)CH O 2,4-Me.sub.2 -6-MeO-phenyl891 CH.sub.3 c-Pr(Me)CH O 2,6-Cl.sub.2 -4-Me-phenyl892 CH.sub.3 c-Pr(Me)CH O 2,4-Cl.sub.2 -phenyl893 CH.sub.3 c-Pr(Me)CH O 2-Cl-4-Me-phenyl894 CH.sub.3 c-Pr(Me)CH O 2-Me-4-Cl-phenyl895 CH.sub.3 c-Pr(Me)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl896 CH.sub.3 c-Pr(Me)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl897 CH.sub.3 c-Pr(Me)CH O 2-Cl-4-MeO-6-Me-phenyl898 CH.sub.3 c-Pr(Me)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl899 CH.sub.3 c-Pr(Me)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl900 CH.sub.3 c-Pr(Me)CH O 6-Me-2,3-dihydro-benzofuran-5-yl901 CH.sub.3 c-Pr(Et)CH O 2,4,6-Me.sub.3 -phenyl902 CH.sub.3 c-Pr(Et)CH O 2-Cl-4,6-Me.sub.2 -phenyl903 CH.sub.3 c-Pr(Et)CH O 2,4-Cl.sub.2 -6-Me-phenyl904 CH.sub.3 c-Pr(Et)CH O 2,4,6-Cl.sub.3 -phenyl905 CH.sub.3 c-Pr(Et)CH O 2-Me-4-MeO-phenyl906 CH.sub.3 c-Pr(Et)CH O 2-Cl-4-MeO-phenyl907 CH.sub.3 c-Pr(Et)CH O 2,4,6-Me.sub.3 -5-F-phenyl908 CH.sub.3 c-Pr(Et)CH O 2,5-Me.sub.2 -4-MeO-phenyl909 CH.sub.3 c-Pr(Et)CH O 2,4-Me.sub.2 -6-MeO-phenyl910 CH.sub.3 c-Pr(Et)CH O 2,6-Cl.sub.2 -4-Me-phenyl911 CH.sub.3 c-Pr(Et)CH O 2,4-Cl.sub.2 -phenyl912 CH.sub.3 c-Pr(Et)CH O 2-Cl-4-Me-phenyl913 CH.sub.3 c-Pr(Et)CH O 2-Me-4-Cl-phenyl914 CH.sub.3 c-Pr(Et)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl915 CH.sub.3 c-Pr(Et)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl916 CH.sub.3 c-Pr(Et)CH O 2-Cl-4-MeO-6-Me-phenyl917 CH.sub.3 c-Pr(Et)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl918 CH.sub.3 c-Pr(Et)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl919 CH.sub.3 c-Pr(Et)CH O 6-Me-2,3-dihydro-benzofuran-5-yl920 CH.sub.3 c-Pr(n-Pr)CH O 2,4,6-Me.sub.3 -phenyl921 CH.sub.3 c-Pr(n-Pr)CH O 2-Cl-4,6-Me.sub.2 -phenyl922 CH.sub.3 c-Pr(n-Pr)CH O 2,4-Cl.sub.2 -6-Me-phenyl923 CH.sub.3 c-Pr(n-Pr)CH O 2,4,6-Cl.sub.3 -phenyl924 CH.sub.3 c-Pr(n-Pr)CH O 2-Me-4-MeO-phenyl925 CH.sub.3 c-Pr(n-Pr)CH O 2-Cl-4-MeO-phenyl926 CH.sub.3 c-Pr(n-Pr)CH O 2,4,6-Me.sub.3 -5-F-phenyl927 CH.sub.3 c-Pr(n-Pr)CH O 2,5-Me.sub.2 -4-MeO-phenyl928 CH.sub.3 c-Pr(n-Pr)CH O 2,4-Me.sub.2 -6-MeO-phenyl929 CH.sub.3 c-Pr(n-Pr)CH O 2,6-Cl.sub.2 -4-Me-phenyl930 CH.sub.3 c-Pr(n-Pr)CH O 2,4-Cl.sub.2 -phenyl931 CH.sub.3 c-Pr(n-Pr)CH O 2-Cl-4-Me-phenyl932 CH.sub.3 c-Pr(n-Pr)CH O 2-Me-4-Cl-phenyl933 CH.sub.3 c-Pr(n-Pr)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl934 CH.sub.3 c-Pr(n-Pr)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl935 CH.sub.3 c-Pr(n-Pr)CH O 2-Cl-4-MeO-6-Me-phenyl936 CH.sub.3 c-Pr(n-Pr)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl937 CH.sub.3 c-Pr(n-Pr)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl938 CH.sub.3 c-Pr(n-Pr)CH O 6-Me-2,3-dihydro-benzofuran-5-yl939 CH.sub.3 c-Pr(n-Bu)CH O 2,4,6-Me.sub.3 -phenyl940 CH.sub.3 c-Pr(n-Bu)CH O 2-Cl-4,6-Me.sub.2 -phenyl941 CH.sub.3 c-Pr(n-Bu)CH O 2,4-Cl.sub.2 -6-Me-phenyl942 CH.sub.3 c-Pr(n-Bu)CH O 2,4,6-Cl.sub.3 -phenyl943 CH.sub.3 c-Pr(n-Bu)CH O 2-Me-4-MeO-phenyl944 CH.sub.3 c-Pr(n-Bu)CH O 2-Cl-4-MeO-phenyl945 CH.sub.3 c-Pr(n-Bu)CH O 2,4,6-Me.sub.3 -5-F-phenyl946 CH.sub.3 c-Pr(n-Bu)CH O 2,5-Me.sub.2 -4-MeO-phenyl947 CH.sub.3 c-Pr(n-Bu)CH O 2,4-Me.sub.2 -6-MeO-phenyl948 CH.sub.3 c-Pr(n-Bu)CH O 2,6-Cl.sub.2 -4-Me-phenyl949 CH.sub.3 c-Pr(n-Bu)CH O 2,4-Cl.sub.2 -phenyl950 CH.sub.3 c-Pr(n-Bu)CH O 2-Cl-4-Me-phenyl951 CH.sub.3 c-Pr(n-Bu)CH O 2-Me-4-Cl-phenyl952 CH.sub.3 c-Pr(n-Bu)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl953 CH.sub.3 c-Pr(n-Bu)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl954 CH.sub.3 c-Pr(n-Bu)CH O 2-Cl-4-MeO-6-Me-phenyl955 CH.sub.3 c-Pr(n-Bu)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl956 CH.sub.3 c-Pr(n-Bu)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl957 CH.sub.3 c-Pr(n-Bu)CH O 6-Me-2,3-dihydro-benzofuran-5-yl958 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -phenyl959 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Cl-4,6-Me.sub.2 -phenyl960 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4-Cl.sub.2 -6-Me-phenyl961 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4,6-Cl.sub.3 -phenyl962 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Me-4-MeO-phenyl963 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Cl-4-MeO-phenyl964 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4,6-Me.sub.3 -5-F-phenyl965 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,5-Me.sub.2 -4-MeO-phenyl966 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4-Me.sub.2 -6-MeO-phenyl967 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,6-Cl.sub.2 -4-Me-phenyl968 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2,4-Cl.sub.2 -phenyl969 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Cl-4-Me-phenyl970 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Me-4-Cl-phenyl971 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl972 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl973 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Cl-4-MeO-6-Me-phenyl974 CH.sub.3 c-PrCH.sub.2 (Et)CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl975 CH.sub.3 c-PrCH.sub.2 (Et)CH O 6-Cl-2,3-dihydro-benzofuran-5-yl976 CH.sub.3 c-PrCH.sub.2 (Et)CH O 6-Me-2,3-dihydro-benzofuran-5-yl977 CH.sub.3 Et.sub.2 CH O 2,4-Cl.sub.2 -6-Me-phenyl978 CH.sub.3 Et.sub.2 CH O 2,4,6-Cl.sub.3 -phenyl979 CH.sub.3 Et.sub.2 CH O 2-Me-4-MeO-phenyl980 CH.sub.3 Et.sub.2 CH O 2-Cl-4-MeO-phenyl981 CH.sub.3 Et.sub.2 CH O 2,4,6-Me.sub.3 -5-F-phenyl982 CH.sub.3 Et.sub.2 CH O 2,5-Me.sub.2 -4-MeO-phenyl983 CH.sub.3 Et.sub.2 CH O 2,4-Me.sub.2 -6-MeO-phenyl984 CH.sub.3 Et.sub.2 CH O 2,6-Cl.sub.2 -4-Me-phenyl985 CH.sub.3 Et.sub.2 CH O 2,4-Cl.sub.2 -phenyl986 CH.sub.3 Et.sub.2 CH O 2-Cl-4-Me-phenyl987 CH.sub.3 Et.sub.2 CH O 2-Me-4-Cl-phenyl988 CH.sub.3 Et.sub.2 CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl989 CH.sub.3 Et.sub.2 CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl990 CH.sub.3 Et.sub.2 CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl991 CH.sub.3 Et.sub.2 CH O 6-Cl-2,3-dihydro-benzofuran-5-yl992 CH.sub.3 Et.sub.2 CH O 6-Me-2,3-dihydro-benzofuran-5-yl__________________________________________________________________________
Additional compounds, wherein Y=oxygen that can be synthesized using synthetic Scheme 6 or Scheme 7 are listed Table 4
TABLE 4______________________________________ ##STR13##Ex.No. R.sup.1 R.sup.3 Y Ar mp______________________________________1000 CH.sub.3 Et.sub.2 CH O 2,4,6-Me.sub.3 -phenyl1001 CH.sub.3 Et.sub.2 CH O 2-Cl-4,6-Me.sub.2 -phenyl1002 CH.sub.3 Et.sub.2 CH O 2,4-Cl.sub.2 -6-Me-phenyl1003 CH.sub.3 Et.sub.2 CH O 2,4,6-Cl.sub.3 -phenyl1004 CH.sub.3 Et.sub.2 CH O 2-Me-4-MeO-phenyl1005 CH.sub.3 Et.sub.2 CH O 2-Cl-4-MeO-phenyl1006 CH.sub.3 Et.sub.2 CH O 2,4,6-Me.sub.3 -5-F-phenyl1007 CH.sub.3 Et.sub.2 CH O 2,5-Me.sub.2 -4-MeO-phenyl1008 CH.sub.3 Et.sub.2 CH O 2,4-Me.sub.2 -6-MeO-phenyl1009 CH.sub.3 Et.sub.2 CH O 2,6-Cl.sub.2 -4-Me-phenyl1010 CH.sub.3 Et.sub.2 CH O 2,4-Cl.sub.2 -phenyl1011 CH.sub.3 Et.sub.2 CH O 2-Cl-4-Me-phenyl1012 CH.sub.3 Et.sub.2 CH O 2-Me-4-Cl-phenyl1013 CH.sub.3 Et.sub.2 CH O 2-NMe.sub.2 -6-Me-pyrid-5-yl1014 CH.sub.3 Et.sub.2 CH O 2-NMe.sub.2 -4-Me-pyrid-5-yl1015 CH.sub.3 Et.sub.2 CH O 2-Cl-4-MeO-6-Me-phenyl1016 CH.sub.3 Et.sub.2 CH O 2-Cl-4,6-Me.sub.2 -5-F-phenyl1017 CH.sub.3 Et.sub.2 CH O 6-Cl-2,3-dihydro-benzofuran-5-yl1018 CH.sub.3 Et.sub.2 CH O 6-Me-2,3-dihydro-benzofuran-5-yl______________________________________
Utility
CRF-R1 Receptor Binding Assay for the Evaluation of Biological Activity
The following is a description of the isolation of cell membranes containing cloned human CRF-R1 receptors for use in the standard binding assay as well as a description of the assay itself.
Messenger RNA was isolated from human hippocampus. The mRNA was reverse transcribed using oligo (dt) 12-18 and the coding region was amplified by PCR from start to stop codons The resulting PCR fragment was cloned into the EcoRV site of PGEMV, from whence the insert was reclaimed using XhoI+XbaI and cloned into the XhoI+XbaI sites of vector pm3ar (which contains a CMV promoter, the SV40 `t` splice and early poly A signals, an Epstein-Barr viral origin of replication, and a hygromycin selectable marker). The resulting expression vector, called phchCRFR was transfected in 293EBNA cells and cells retaining the episome were selected in the presence of 400 mM hygromycin. Cells surviving 4 weeks of selection in hygromycin were pooled, adapted to growth in suspension and used to generate membranes for the binding assay described below. Individual aliquots containing approximately 1.times.10.sup.8 of the suspended cells were then centrifuged to form a pellet and frozen.
For the binding assay a frozen pellet described above containing 293EBNA cells transfected with hCRFR1 receptors is homogenized in 10 ml of ice cold tissue buffer (50 mM HEPES buffer pH 7.0, containing 10 mM MgCl.sub.2, 2 mM EGTA, 1 mg/l aprotinin, 1 mg/ml leupeptin and 1 mg/ml pepstatin). The homogenate is centrifuged at 40,000.times.g for 12 min and the resulting pellet rehomogenized in 10 ml of tissue buffer. After another centrifugation at 40,000.times.g for 12 min, the pellet is resuspended to a protein concentration of 360 mg/ml to be used in the assay.
Binding assays are performed in 96 well plates; each well having a 300 ml capacity. To each well is added 50 ml of test drug dilutions (final concentration of drugs range from 10.sup.-10 -10.sup.-5 M), 100 ml of .sup.125 I-ovine-CRF (.sup.125 I-o-CRF) (final concentration 150 pM) and 150 ml of the cell homogenate described above. Plates are then allowed to incubate at room temperature for 2 hours before filtering the incubate over GF/F filters (presoaked with 0.3% polyethyleneimine) using an appropriate cell harvester. Filters are rinsed 2 times with ice cold assay buffer before removing individual filters and assessing them for radioactivity on a gamma counter.
Curves of the inhibition of .sup.125 I-o-CRF binding to cell membranes at various dilutions of test drug are analyzed by the iterative curve fitting program LIGAND [P. J. Munson and D. Rodbard, Anal. Biochem. 107:220 (1980)], which provides Ki values for inhibition which are then used to assess biological activity.
A compound is considered to be active if it has a K.sub.i value of less than about 10000 nM for the inhibition of CRF. Compounds with a K.sub.i less than 100 nM for the inhibition of CRF are desirable. A number of compounds of the invention have been made and tested in the above assay and shown to have K.sub.i values less than 100 nM thus confirming the utility of the invention.
Inhibition of CRF-Stimulated Adenylate Cyclase Activity
Inhibition of CRF--Stimulated adenylate cyclase activity was performed as described by G. Battaglia et al. Synapse 1:572 (1987). Briefly, assays were carried out at 37.degree. C. for 10 min in 200 ml of buffer containing 100 mM Tris-HCl (pH 7.4 at 37.degree. C.), 10 mM MgCl.sub.2, 0.4 mM EGTA, 0.1% BSA, 1 mM isobutylmethylxanthine (IBMX), 250 units/ml phosphocreatine kinase, 5 mM creatine phosphate, 100 mM guanosine 5'-triphosphate, 100 nM OCRF, antagonist peptides (concentration range 10.sup.-9 to .sub.10.sup.-6 m) and 0.8 mg original wet weight tissue (approximately 40-60 mg protein). Reactions were initiated by the addition of 1 mM ATP/[.sup.32 P]ATP (approximately 2-4 mCi/tube) and terminated by the addition of 100 ml of 50 mM Tris-HCL, 45 mM ATP and 2% sodium dodecyl sulfate. In order to monitor the recovery of cAMP, 1 .mu.l of [.sup.3 H]cAMP (approximately 40,000 dpm) was added to each tube prior to separation. The separation of [.sup.32 P]cAMP from [.sup.32 P]ATP was performed by sequential elution over Dowex and alumina columns. Recovery was consistently greater than 80%.
A compound of this invention was tested in this assay and found to be active; IC.sub.50 <10000 nM.
In vivo Biological Assay
The in vivo activity of the compounds of the present invention can be assessed using any one of the biological assays available and accepted within the art. Illustrative of these tests include the Acoustic Startle Assay, the Stair Climbing Test, and the Chronic Administration Assay. These and other models useful for the testing of compounds of the present invention have been outlined in C. W. Berridge and A. J. Dunn Brain Research Reviews 15:71 (1990)
Compounds may be tested in any species of rodent or small mammal. Disclosure of the assays herein is not intended to limit the enablement of the invention.
Compounds of this invention have utility in the treatment of inbalances associated with abnormal levels of corticotropin releasing factor in patients suffering from depression, affective disorders, and/or anxiety.
Compounds of this invention can be administered to treat these abnormalities by means that produce contact of the active agent with the agent's site of action in the body of a mammal. The compounds can be administered by any conventional means available for use in conjunction with pharmaceuticals either as individual therapeutic agent or in combination of therapeutic agents. They can be administered alone, but will generally be administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice.
The dosage administered will vary depending on the use and known factors such as pharmacodynamic character of the particular agent, and its mode and route of administration; the recipient's age, weight, and health; nature and extent of symptoms; kind of concurrent treatment; frequency of treatment; and desired effect. For use in the treatment of said diseases or conditions, the compounds of this invention can be orally administered daily at a dosage of the active ingredient of 0.002 to 200 mg/kg of body weight. Ordinarily, a dose of 0.01 to 10 mg/kg in divided doses one to four times a day, or in sustained release formulation will be effective in obtaining the desired pharmacological effect.
Dosage forms (compositions) suitable for administration contain from about 1 mg to about 100 mg of active ingredient per unit. In these pharmaceutical compositions, the active ingredient will ordinarily be present in an amount of about 0.5 to 95% by weight based on the total weight of the composition.
The active ingredient can be administered orally is solid dosage forms, such as capsules, tablets and powders; or in liquid forms such as elixirs, syrups, and/or suspensions. The compounds of this invention can also be administered parenterally in sterile liquid dose formulations.
Gelatin capsules can be used to contain the active ingredient and a suitable carrier such as but not limited to lactose, starch, magnesium stearate, steric acid, or cellulose derivatives. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of time. Compressed tablets can be sugar-coated or film-coated to mask any unpleasant taste, or used to protect the active ingredients from the atmosphere, or to allow selective disintegration of the tablet in the gastrointestinal tract.
Liquid dose forms for oral administration can contain coloring or flavoring agents to increase patient acceptance.
In general, water, pharmaceutically acceptable oils, saline, aqueous dextrose (glucose), and related sugar solutions and glycols, such as propylene glycol or polyethylene glycol, are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, butter substances. Antioxidizing agents, such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or in combination, are suitable stabilizing agents. Also used are citric acid and its salts, and EDTA. In addition, parenteral solutions can contain preservatives such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol.
Suitable pharmaceutical carriers are described in "Remington's Pharmaceutical Sciences", A. Osol, a standard reference in the field.
Useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows:
Capsules
A large number of units capsules are prepared by filling standard two-piece hard gelatin capsules each with 100 mg of powdered active ingredient, 150 mg lactose, 50 mg cellulose, and 6 mg magnesium stearate.
Soft Gelatin Capsules
A mixture of active ingredient in a digestible oil such as soybean, cottonseed oil, or olive oil is prepared and injected by means of a positive displacement was pumped into gelatin to form soft gelatin capsules containing 100 mg of the active ingredient. The capsules were washed and dried.
Tablets
A large number of tablets are prepared by conventional procedures so that the dosage unit was 100 mg active ingredient, 0.2 mg of colloidal silicon dioxide, 5 mg of magnesium stearate, 275 mg of microcrystalline cellulose, 11 mg of starch, and 98.8 mg lactose. Appropriate coatings may be applied to increase palatability or delayed adsorption.
The compounds of this invention may also be used as reagents or standards in the biochemical study of neurological function, dysfunction, and disease.
Claims
  • 1. A compound of Formula I: ##STR14## or a pharmaceutically acceptable salt form thereof, wherein: Z is CR.sup.2 ;
  • Y is NR.sup.4, O, S(O).sub.n ;
  • Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, indolinyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, benzothiazolyl, indazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 4 R.sup.5 groups; wherein Ar is attached to Y through an unsaturated carbon;
  • R.sup.1 is H, halo, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
  • R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.9 R.sup.10, --NR.sup.9 COR.sup.10, --NR.sup.9 CO.sub.2 R.sup.10, --OR.sup.11, --SH or --S(O).sub.n R.sup.12 ;
  • R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.2 R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl, with the proviso that when R.sup.3 is aryl, Ar is not imidazolyl;
  • R.sup.4 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl, wherein C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl is optionally substituted with C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
  • R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, heterocyclyl, --NO.sub.2, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --SH, and --S(O).sub.n R.sup.13,
  • wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub..sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
  • R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;
  • wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
  • R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
  • R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
  • R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
  • aryl is phenyl, biphenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.15, --SH, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --OC(O)R.sup.14, --NO.sub.2, --NR.sup.8 COR.sup.15, --N(COR.sup.l5).sub.2, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, --NR.sup.15 R.sup.16 and --CONR.sup.15 R.sup.16 ;
  • heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.15, --SH, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --OC(O)R.sup.14, --NO.sub.2, --NR.sup.8 COR.sup.15, --N(COR.sup.15).sub.2, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, --NR.sup.15 R.sup.16 and --CONR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 2. A compound of claim 1 wherein:
  • Z is CR.sup.2 ;
  • Y is NR.sup.4 or O;
  • Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
  • R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.4 haloalkyl, --CN, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7 or --S(O).sub.n R.sup.13,
  • wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
  • R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, halo, C.sub.1 -C.sub.4 haloalkyl;
  • R.sup.3 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.2 R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7,
  • wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, aryl and heterocyclyl;
  • R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
  • R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.8 cycloalkylalkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON (OR.sup.9) R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13,
  • wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.8 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
  • R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl(C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine;
  • wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
  • R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
  • R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
  • R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
  • aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
  • heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, and --NR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 3. A compound of claim 2 wherein:
  • Z is CR.sup.2 ;
  • Y is NR.sup.4 ;
  • Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
  • R.sup.1 is H, halo, C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.3 haloalkyl, --CN, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --OR.sup.7 or --S(O).sub.n R.sup.13 wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.4 cycloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 ;
  • R.sup.2 is H;
  • R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl, wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and aryl;
  • R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
  • R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
  • R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
  • wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
  • R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
  • R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
  • aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, S(O).sub.n R.sup.14, --COR.sup.15 --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 4. A compound of claim 3 wherein:
  • Z is CR.sup.2 ;
  • Y is NR.sup.4 ;
  • Ar is phenyl or pyridyl, each substituted with 2 to 4 R.sup.5 groups;
  • R.sup.1 is H, Cl, Br, methyl, ethyl, cyclopropyl, or --CN,
  • R.sup.2 is H;
  • R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl or aryl, wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, --CF.sub.3, halo, --CN, --OR.sup.7, and aryl;
  • R.sup.4 is H, methyl, ethyl, i-propyl, n-propyl, n-butyl, i-butyl, s-butyl, n-butyl, or allyl;
  • R.sup.5 is independently selected at each occurrence from methyl, ethyl, i-propyl, n-propyl, aryl, --CF.sub.3, halo, --CN, --N(CH.sub.3)2, --C(.dbd.O)CH.sub.3, --OCH.sub.3, --OCH.sub.2 CH.sub.3, --OCF.sub.3, and --S(O).sub.2 CH.sub.3 ;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
  • aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sub.5, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 5. A compound of claim 4 selected from:
  • 3-[(2,4-Dibromophenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[(2,4-Dibromophenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[[2-Bromo-4-(1-methylethyl)phenyl]ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • 3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone;
  • 3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • (+/-)-3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • (+/-)-3-[(2-chloro-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • (+/-)-3-[(4,6-Dimethyl-2-iodophenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • [(2-cyano-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • (+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2 (1H)-pyrazinone;
  • (+/-)-3-[(2-Acetyl-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4,6-Dimethyl-2-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4,6-Dimethyl-2-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-chloro-2-iodo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-phenyl-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dibromophenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,4-Dichloro-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,4-Dibromo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(2-methoxyethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2-chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • 3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2-chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2-chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • 3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2-chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • (+/-)3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone;
  • (+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone;
  • (+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(ethoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-(2-ethoxy-1-methylethyl)-2(1H)-pyrazinone; and
  • (+/-)3-[(4-Bromo-2,6-difluorophenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H) pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dimethyl-6-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)-amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-chloro-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,6-Dimethyl-4-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • (+/-)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone;
  • 3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(4,6-Dimethyl-2-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • (+/-)3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)3-[(2-chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • (+/-)3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone;
  • 3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone;
  • 3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; and
  • 3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-(1-ethylpropyl)-2(1H)-pyrazinone.
  • 6.
  • 6. A compound of claim 1 wherein:
  • Z is CR.sup.2 ;
  • Y is NR.sup.4 or O;
  • Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
  • R.sup.1 is H, halo, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, or --NR.sup.6 R.sup.7,
  • wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or C.sub.3 -C.sub.8 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7.sub.1 --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
  • R.sup.2 is H, C.sub.1 -C.sub.4 alkyl, halo, C.sub.1 -C.sub.4 haloalkyl;
  • R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl and --NR.sup.6 R.sup.7,
  • wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.l3, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
  • R.sup.4 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, wherein C.sub.1 -C.sub.6 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, --OR.sup.7, --S(O).sub.n R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
  • R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, heterocyclyl, --NO.sub.2, halo, --CN, C.sub.1 -C.sub.4 haloalkyl, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7 and --S(O).sub.n R.sup.13, wherein C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --OR.sup.7, --COR.sup.7, --CO.sub.2 R.sup.7, --CONR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.8 COR.sup.7, --NR.sup.8 CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
  • R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl, heterocyclyl (C.sub.1 -C.sub.4 alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or --NR.sup.6 R.sup.7 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
  • wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
  • R.sup.8 is independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
  • R.sup.9 and R.sup.10 are independently at each occurrence selected from H, C.sub.1 -C.sub.4 alkyl and C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.11 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or C.sub.3 -C.sub.6 cycloalkyl;
  • R.sup.12 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or --NR.sup.6 R.sup.7 ;
  • R.sup.13 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.6 R.sup.7, aryl, aryl(C.sub.1 -C.sub.4 alkyl)-, heterocyclyl or heterocyclyl(C.sub.1 -C.sub.4 alkyl)-;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl and C.sub.4 -C.sub.12 cycloalkylalkyl; or --NR.sup.15 R.sup.16 taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine;
  • aryl is phenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15 and --NR.sup.15 R.sup.16 ;
  • heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --CO.sub.2 R.sup.15, --NO.sub.2, --NR.sup.8 COR.sup.15, --NR.sup.8 CONR.sup.15 R.sup.16, --NR.sup.8 CO.sub.2 R.sup.15, and --NR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 7. A compound of claim 6 wherein:
  • Z is CR.sup.2 ;
  • Y is NR.sup.4 ;
  • Ar is phenyl or pyridyl, each substituted with 0 to 4 R.sup.5 groups;
  • R.sup.1 is H, halo, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, aryl, heterocyclyl, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CONR.sup.6 R.sup.7, --CO.sub.2 R.sup.7 or --NR.sup.6 R.sup.7,
  • wherein C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, halo, C.sub.1 -C.sub.4 haloalkyl, --CN, --OR.sup.7, --SH, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --OC(O)R.sup.13, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7, --CONR.sup.6 R.sup.7, aryl and heterocyclyl;
  • R.sup.2 is H;
  • R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl and --NR.sup.6 R.sup.7,
  • wherein C.sub.1 -C.sub.4 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --OR.sup.7, --S(O).sub.n R.sup.13, --COR.sup.7, --CO.sub.2 R.sup.7, --NR.sup.8 COR.sup.7, --N(COR.sup.7).sub.2, --NR.sup.8 CONR.sup.6 R.sup.7, --NR.sup.8 CO.sub.2 R.sup.7 --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7 ;
  • R.sup.4 is H, allyl, or C.sub.1 -C.sub.4 alkyl, wherein C.sub.1 -C.sub.4 alkyl is optionally substituted with C.sub.1 -C.sub.4 alkyl, --OR.sup.7, --S(O).sub.2 R.sup.12, --CO.sub.2 R.sup.7, --NR.sup.6 R.sup.7 or --NR.sup.9 COR.sup.10 ;
  • R.sup.5 is independently selected at each occurrence from C.sub.1 -C.sub.6 alkyl, aryl, heterocyclyl, C.sub.1 -C.sub.4 haloalkyl, halo, --CN, --NO.sub.2, --NR.sup.6 R.sup.7, --COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, --CON(OR.sup.9)R.sup.7, --CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.l3, wherein C.sub.1 -C.sub.6 alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, --NO.sub.2, halo, --CN, --NR.sup.6 R.sup.7, COR.sup.7, --OR.sup.7, --CONR.sup.6 R.sup.7, CO.sub.2 R.sup.7 and --S(O).sub.n R.sup.13 ;
  • R.sup.6 and R.sup.7 are independently selected at each occurrence from H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl and C.sub.2 -C.sub.8 alkoxyalkyl;
  • wherein C.sub.1 -C.sub.4 alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from --OH or C.sub.1 -C.sub.4 alkoxy groups;
  • R.sup.8, R.sup.9 and R.sup.10 are independently at each occurrence H or C.sub.1 -C.sub.4 alkyl;
  • R.sup.12 and R.sup.13 are independently at each occurrence C.sub.1 -C.sub.4 alkyl or --NR.sup.6 R.sup.7 ;
  • R.sup.14 is C.sub.1 -C.sub.4 alkyl or --NR.sup.15 R.sup.16 ;
  • R.sup.15 and R.sup.16 are independently at each occurrence H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.8 alkoxyalkyl;
  • aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C.sub.1 -C.sub.4 alkyl, halo, --CN, --OR.sup.15, --S(O).sub.n R.sup.14, --COR.sup.15, --CO.sub.2 R.sup.15, --NO.sub.2 and --NR.sup.15 R.sup.16 ; and
  • n is independently at each occurrence 0, 1 or 2.
  • 8. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 1.
  • 9. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 2.
  • 10. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 3.
  • 11. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 4.
  • 12. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 5.
  • 13. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 6.
  • 14. A method for treating anxiety in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 7.
  • 15. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 1.
  • 16. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 2.
  • 17. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 3.
  • 18. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 4.
  • 19. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 5.
  • 20. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 6.
  • 21. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having a composition of claim 7.
  • 22. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 1.
  • 23. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 2.
  • 24. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 3.
  • 25. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 4.
  • 26. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 5.
  • 27. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 6.
  • 28. A method for treating depression in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound having a composition of claim 7.
Parent Case Info

This application claims the benefit of U.S. Provisional Application No. 60/026,373, filed Sep. 16, 1996.

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