Claims
- 1. A compound of formula (I)
- 2. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable excipients, diluents or carriers.
- 3. A pharmaceutical composition according to claim 2 comprising one or more additional therapeutic agents.
- 4. A compound according to claim 1 for use as a medicament.
- 5. A pharmaceutical composition according to claim 2 or 3 for use as a medicament.
- 6. A compound according to claim 1 for use as a reverse transcriptase inhibitor or modulator.
- 7. A pharmaceutical composition according to claim 2 or 3 for use as a reverse transcriptase inhibitor or modulator.
- 8. A compound according to claim 1 for use in the treatment of an HIV or genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS).
- 9. A pharmaceutical composition according to claim 2 or 3 for use in the treatment of an HIV or genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS).
- 10. A method for inhibiting or modulating HIV reverse transcriptase in a subject in need thereof comprising administering to said subject an effective amount of a compound according to claim 1.
- 11. A method for inhibiting or modulating HIV reverse transcriptase in a subject in need thereof comprising administering to said subject an effective amount of a pharmaceutical composition according to claim 2 or 3.
- 12. A method for treating an HIV or genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS) comprising administering to a subject in need thereof an effective amount of a compound according to claim 1.
- 13. A method for treating an HIV or genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS) comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition according to claim 2 or 3.
- 14. A method of treating an HIV or a genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS), comprising administering an effective amount of a compound according to claim 1.
- 15. A method of treating an HIV or a genetically-related retroviral infection, or a resulting acquired immune deficiency syndrome (AIDS), comprising administering an effective amount of a pharmaceutical composition according to claim 2 or 3.
- 16. A process for preparing a compound according to claim 1, which comprises:
(A) reacting a compound of formula (II) 28with an amine of formula (IV) 29(B) reacting a compound of formula (III) 30with an amine of formula (IV) 31(C) preparing a compound of formula (I) in which R3 is halo, halogenating a compound of formula (XI) 32(D) interconventing a compound of formula (I) into another compound of formula (I); or (E) deprotecting a protected derivative of a compound of formula (I); and optionally converting a compound of formula (I) prepared by any one of processes (A) to (E) into a pharmaceutically acceptable salt, solvate or derivative thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0223232.0 |
Oct 2002 |
GB |
|
Parent Case Info
[0001] This application claims priority from United Kingdom application number 0223232.0, filed Oct. 7, 2002 and also claims the benefit of U.S. Provisional Application No. 60/432,859, filed Dec. 11, 2002, and incorporates each application by reference in its entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60432859 |
Dec 2002 |
US |