Pyrazolesulfonamide derivative, and herbicide containing it

Abstract

Disclosed are a pyrazolesulfonamide derivative represented by Formula (I): ##STR1## wherein B, D, Q, E, W and G have the same meaning as defined in the specification,a process for its production and a herbicide containing it.

Description

BACKGROUND OF THE INVENTION

This invention relates to a novel pyrazolesulfonamide derivative compound, a process for preparing the compound and a herbicide containing the compounds as an active component.

In order to protect important crops such as rice plants, wheat, cotton, sugar beets, corn and soybean from damages by weeds to achieve an increased yield, it is indispensable to use a herbicide. In recent years in particular, a herbicide having selectivity (or discriminativity) is sought after as it can kill only weeds selectively without damages to crops even when a foliage treatment is applied simultaneously on crops and weeds in a cultivated land wherein useful crops and weeds are grown together. Also, from viewpoints of the prevention of environmental pollution, the transportation, and the economical cost reduction in application of chemicals, studies and researches have been made over many years on such compounds that may achieve a higher herbicidal activity with use of chemicals in a lower amount. Some of the compounds having such a property are presently used as the herbicide having selectivity. Still, however, there are further demands for new compounds having such a property.

SUMMARY OF THE INVENTION

The present inventors have made researches over many years to develop herbicides having the selectivity on important crops, and have examined herbicidal properties of a number of compounds to create compounds having a higher herbicidal effect and the selectivity. As a result, it was found that a pyrazolesulfonamide derivative represented by Formula (I) (hereinafter referred to as "the compound of this invention"): ##STR2## wherein Q represents a group of; ##STR3## wherein R.sup.1, R.sup.3, R.sup.9 and R.sup.10 each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a cyano group or a group of CO.sub.2 R.sup.13 ;

R.sup.2 and R.sub.4 each represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group; R.sup.5 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a group of S(O).sub.n R.sup.12 ; R.sup.6 represents a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a group of CO.sub.2 R.sup.13 ; R.sup.7 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a dialkylamino group; R.sup.8 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a nitro group; R.sup.11 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a halogenated C.sub.1 -C.sub.8 alkyl group; W.sup.1 represents an oxygen atom, a sulfur atom or a group of NR.sup.13 ; R.sup.12 represents a C.sub.1 -C.sub.8 alkyl group; R.sup.13 represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group; and n represents an integer of 0, 1 or 2; B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.14, a group of CH.sub.2 COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of CH.sub.2 CN, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of COR.sup.13, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C.sub.1 -C.sub.8 alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group); R.sup.14 represents a hydrogen atom, an unsubstituted C.sub.1 -C.sub.8 alkyl group (or a C.sub.1 -C.sub.8 alkyl group substituted with an unsubstituted C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkoxy group substituted with a group of OR.sup.13, a halogenated C.sub.1 -C.sub.8 alkoxy group, a cyano group, a phenoxy group, a C.sub.1 -C.sub.8 alkoxycarbonyl group, a group of NR.sup.12 R.sup.13, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkylcarbonyl group), an unsubstituted C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkenyl group substituted with a halogen atom, an unsubstituted C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkynyl group substituted with a halogen atom, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a benzyl group; R.sup.15 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a phenyl group; R.sup.16 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group; R.sup.17 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a phenyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyloxy group or a C.sub.1 -C.sub.8 alkynyloxy group; n represents an integer of 0, 1 or 2; R.sup.18 and R.sup.19 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylcarbonyl group or a C.sub.1 -C.sub.8 alkylsulfonyl group; R.sup.20 and R.sup.21 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkynyl group; E represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl or a C.sub.1 -C.sub.8 alkoxy group; W represents an oxygen atom, a sulfur atom or a group of NR.sup.16 ; G represents ##STR4## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxyalkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkoxy group, a group of NR.sup.22 R.sup.23, a group of OCH(R.sup.13)COOR.sup.13, a group of COOR.sup.13, a cyclopropyl group, a group of CH(OR.sup.24).sub.2, a C.sub.1 -C.sub.8 alkylthio group or a halogenated C.sub.1 -C.sub.8 alkylthio group; R.sup.22 and R.sup.23 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group; R.sup.24 represents a C.sub.1 -C.sub.8 alkyl group; X.sup.1 and Y.sup.1 each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group; X.sup.2 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkoxy group; Y.sup.2 represents a C.sub.1 -C.sub.8 alkyl group; X.sup.3 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group or a halogen atom; Y.sup.3 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a halogen atom, a monoalkylamino group or a dialkylamino group; Y.sup.4 represents a cyano group, a group of CO.sub.2 R.sup.13, a nitro group, a group of S(O).sub.n R.sup.12, a C.sub.1 -C.sub.8 alkyl group or a halogenated C.sub.1 -C.sub.8 alkyl group; Z represents a nitrogen atom or a group of C--R.sup.25 ; Z.sup.1 represents a nitrogen atom or a group of CH; R.sup.25 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a halogen atom, a C.sub.1 -C.sub.8 alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ; with the proviso that the group: ##STR5## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of --CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a group of --CH.sub.2 COOR.sup.13, a group of --COR.sup.13, a group of --SO.sub.2 R.sup.24, a group of --SO.sub.2 NR.sup.13 R.sup.24 or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group). has a strong herbicidal effect to various weeds while retaining high safety to the important crops in either case of the soil treatment or the foliage treatment, whereby this invention has been accomplished. Particularly, some of these compounds show extremely high selectivity to sugar beets. Conventionally, a number of compounds having sulfonylurea structure have been known. Any of these, however, show very strong activities to sugar beets. For example, sugar beets have extremely high sensibility to chlorsulfuron which is known as a herbicide for wheat, and accordingly the sugar beets which are cultured as second crops after wheat are known to be seriously suffered from damages by the agricultural chemicals even after two years, because of a trace amount of the active component remaining in the soil. Also, other sulfonylurea compounds than the chlorsulfuron are also considered to have very particularly strong effect on sugar beets, and, of the sulfonylurea type compounds, almost no compound which may have the selectivity to sugar beets have been hitherto unknown. Also, certain compounds of the compounds of this invention have the selectivity not only to beets but also to rice plants, wheat, cotton, corn, etc. The compound of this invention, on the other hand, shows a high herbicidal activity in an application of a very low amount of the active component as compared with the conventional herbicides, and accordingly it is useful also as a herbicide for orchards and uncultivated lands. As a prior technique, European Patent Publication No. 87,780 discloses a pyrazolesulfonylurea which has the structure similar to the compound of this invention. However, there has been nothing disclosing the compound wherein a fused heterocyclic ring is substituted on a pyrazole ring as the compound of this invention. Thus, the compound of this invention can be said to be a novel one.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The compound of this invention, represented by Formula (I) can be readily prepared by selecting any of reaction schemes 1 to 3 shown below. ##STR6## wherein W.sup.2 represents an oxygen atom or a sulfur atom, and B, D, Q, E and G have the same meanings as defined above.

Namely, the pyrazolesulfonyl(thio)isocyanate derivative (II) is dissolved in a sufficiently dried inert solvent such as dioxane and acetonitrile and thereto is added a pyrimidine, triazine or triazole derivative represented by Formula (III), with stirring. Thus, the reactants generally are reacted with each other rapidly to give the compound (I)' which is a part of the compound of this invention. In cases where it is difficult for the reaction to proceed, a trace or small amount of a suitable base, such as triethylamine, triethylenediamine, pyridine, a sodium alkoxide, sodium hydride and the like, may be added to the reaction system to allow the reaction to proceed readily. ##STR7## wherein R represents a C.sub.1 -C.sub.8 alkyl group or a phenyl group and B, D, Q, E, W.sup.2 and G have the same meanings as defined above.

Namely, the pyrazolesulfonamide derivative (V) is reacted with a chloroformic acid (thio)ester or a carbonic acid (thio)ester in such a solvent as acetone, methyl ethyl ketone and acetonitrile in the presence of a base such as potassium carbonate to give the compound (IV). Then, the resulting compound (IV) is heated with the compound (III) in such a solvent as toluene to give the compound (I)' which is a part of the compound of this invention. ##STR8## wherein B, D, Q, E, G and R.sup.16 have the same meanings as defined above.

Namely, the above sulfonylguanidine type compound which is a part of the compound of this invention can be synthesized in accordance with the process disclosed in Japanese Unexamined Patent Publication No. 167570/1984, No. 6654/1985 and No. 36467/1985.

The starting materials, the pyrazolesulfonyl (thio)isocyanate (II) and the pyrazolesulfonyl (thio)carbamate derivatives (IV) which is used in Reaction Schemes 1 and 2 may be synthesized by selecting appropriately the methods as will be described hereinafter to synthesize the pyrazolesulfonamide (V) and further it can be led to a final product with reference to the methods as described in Published European Patent Application No. 87,780 and Japanese Unexamined Patent Publication No. 13266/1980.

The pyrazolesulfonamide which is an intermediate compound to be used in the present invention is also a novel compound, which can be obtained by selecting appropriately one of the following Reaction schemes 4 to 8. ##STR9## p1 (a) NaNO.sub.2.HCl or NaNO.sub.2.HBr (b) SO.sub.2.Cu salt

(c) NH.sub.4 OH or ammonium carbonate (d) Cu salt (e) POCl.sub.3 or POBr.sub.3 (f) P.sub.2 S.sub.5 (g) NaSH (h) NaOH.NH.sub.4 OH.NaOCl (i) NaSCH.sub.2 Ph (j) Cl.sub.2 /CH.sub.3 COOH.H.sub.2 O or NaOCl/HCl BuLi or LiN(i-Pr).sub.2 subsequently, Cl.sub.2 or Br.sub.2 (l) Oxidizing agent (m) (1) ClSO.sub.3 H [2)SOCl.sub.2 or PCl.sub.5 ] (n) (1) BuLi or LiN(i-Pr).sub.2 (2) SO.sub.2 (3) N-chlorosuccinimide ClC(.dbd.S)NMe.sub.2 /base (p) heating (q) RHal/base wherein B, D, Q and E, have the same meanings as defined above; R represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group, of --CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a group of --CH.sub.2 COOR.sup.13, a group of --COR.sup.13, a group of --SO.sub.2 R.sup.24 or a group of --SO.sub.2 NR.sup.13 R.sup.24 ; and R.sup.13 and R.sup.24 have the same meanings as defined above.

The pyrazolesulfonamide (V) may usually be obtained by reacting a corresponding pyrazolesulfonyl chloride with an aqueous ammonia or ammonium carbonate. In order to introduce a sulfonyl group into a pyrazole, there may be adopted such a method as follows:

(1) The amino group is subjected to diazonium decomposition in the presence of sulfur dioxide to give a pyrazolesulfonyl chloride;

(2) A hydroxypyrazole is converted into an O-pyrazole thiocarbamate, which is then subjected to rearrangement reaction to introduce a sulfur atom in the pyrazole ring followed by oxidation to give a pyrazolesulfonyl chloride;

(3) A sulfur atom is introduced in the pyrazole ring by a nucleophilic substitution reaction with a halogen atom or the like and optionally the resulting compound is further oxidized to give a pyrazolesulfonyl chloride;

(4) A carbanion of a pyrazole is formed by using a base and the sulfur dioxide is reacted therewith followed by halogenation to give a pyrazolesulfonyl chloride;

(5) Chlorosulfonic acid or the like is directly used to give a pyrazolesulfonyl chloride;

(6) The pyrazole derivative, which has been obtained by any of the above-mentioned methods, is functionally modified by utilizing the properties of the pyrazole.

Namely, (1) according to Reaction scheme 4, an aminopyrazole is converted into a diazonium salt by using sodium nitrite or the like in hydrochloric acid, hydrobromic acid or the like and then sulfur dioxide is reacted with the resulting diazonium salt in the presence of a catalyst which is used usually for diazonium decomposition such as a copper salt or the like, to afford a corresponding pyrazolesulfonyl chloride. With the resulting compound was reacted an aqueous ammonia to give the desired pyrazolesulfonamide (V).

(2) According to Reaction scheme 8, starting from a hydroxypyrazole, an O-pyrazole thiocarbamate is obtained and then the resulting compound is rearranged under heating to give an S-pyrazole thiolcarbamate which is then oxidized with chlorine in such a solvent as acetic acid to afford a pyrazolesulfonyl chloride. As in Reaction scheme 4, action of an aqueous ammonia gives the desired pyrazolesulfonamide (V).

Be noted that these Reaction schemes 4 and 8 may be applied without any dependency upon the position(s) of the substituent(s).

(3) In the nucleophilic substitution reaction on the pyrazole, the 5 position on the pyrazole ring is usually reacted most easily, but there may be a case where the nucleophilic substitution reaction further occurs at the 3 position when an electron attracting group is substituted at the 4 position.

By using this property, according to Reaction scheme 5, a pyrazole halogenated at the 5 position is treated with sodium sulfide, sodium salt of benzylmercaptan or the like to introduce a sulfur atom into the 5 position followed by oxidation with chlorine in such a solvent as acetic acid to give a pyrazolesulfonyl chloride. As in Reaction scheme 4, a reaction with an aqueous ammonia gives the desired pyrazolesulfonamide (V). The desired pyrazolesulfonamide may also be obtained by converting the intermediate 5-mercaptopyrazole into a sulfenamide which is then oxidized. The starting material, the pyrazole halogenated at the 5 position, may be obtained by diazo-decomposition of an aminopyrazole; by the reaction of a hydroxypyrazole with phosphorus oxychloride or phosphorus oxybromide; or by formation of an anion at the 5 position by using such a strong base as butyl lithium, lithium diisopropylamide or the like, followed by halogenation.

(4) In cases where there is a substituent at the 1 position, the hydrogen atom at the 5 position on the pyrazole ring has a relatively strong acidity. According to Reaction scheme 7, an anion may be formed by using such a strong base as butyl lithium, lithium diisopropylamide or the like, and the resulting anion may further be treated by sulfur dioxide and subsequently with an N-halogenosuccinimide to form a pyrazolesulfonyl chloride which is then treated with an aqueous ammonia to give the pyrazolesulfonamide (V).

(5) As compared with the nucleophilic substitution reaction, the electrophilic substitution reaction on the pyrazole ring may usually occur more easily at the 4 position. According to Reaction scheme 6, use of chlorosulfonic acid may give directly a pyrazolesulfonyl chloride.

(6) According to Reaction scheme 9, when a pyrazolesulfonamide having no substituent on the 1 position is subjected to alkylation, acylation or sulfonylation, the 1 or 2 position may be alkylated, acylated or sulfonylated, respectively. According to this method, there may be obtained, depending upon the starting material used, a mixture of two kinds of compounds in which substituents on the 3 and 5 positions have been switched with each other. However, these compounds may be separated by recrystallization, column chromatography or the like and used as an intermediate compound for the compound of this invention.

Further, various kinds of pyrazolesulfonamide (V) may be obtained by newly introducing a substituent in the pyrazolesulfonamide or by modifying the introduced substituent, utilizing the properties of a pyrazole.

As to the synthesis of pyrazolesulfonamide in which a hetero ring is substituted on the pyrazole ring, specifications of Japanese Patent Application No. 78784/1985 and No. 236780/1985 can be referred to.

The pyrazoles used as starting materials in the above-mentioned reactions may be synthesized in many cases with reference to A. N. Kost & I. I. Groundberg, Advances in Heterocyclic Chemistry Vol. 6, 347 (1966); T. L. Yacobs, Heterocyclic Compounds, R. C. Elderfield, Vol. 5, 45, Wiley, New York (1957); K. Shofield, M. R. Grimmett and B. R. T. Keene, Heterocyclic Nitrogen Compounds, The Azoles, Cambridge University Press, London, New York, Melbourne (1976); and Kevin T. Potts, Comprehensive Heterocyclic Chemistry, Vol. 5, 167 (1984), Pergamon Press. In cases where Q is substituted at the 1 position of the pyrazole ring, QNHNH.sub.2 may be used in many cases for the synthesis in place of hydrazine, methlyhydrazine, phenylhydrazine and so on as described in the above-mentioned literatures.

A person skilled in the art would be able to obtain an intermediate for the compound of the present invention by investigating reaction conditions and the like taking into consideration the above descriptions and the prior art technologies as mentioned above.

Hereinafter, there will be described Synthesis examples of the present compounds and the intermediate compounds therefor as working examples or referential examples, which however should not be construed to limit the present invention.

REFERENCE EXAMPLE 1

Synthesis of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide

(1) Synthesis of ethyl 5-amino-1-(2-quinolyl)pyrazole-4-carboxylate:

17.1 g of ethyl ethoxymethylene cyanoacetate was dissolved in 200 ml of n-butyl alcohol and 16 g of 2-hydradinoquinoline was added thereto, followed by stirring at room temperature for 12 hours. The suspension obtained was refluxed for 2.5 hours and then cooled. Crystals precipitated were filtered, washed with n-hexane and dried to obtain 25.7 g of the title compound. m.p.: 146.degree. to 147.degree. C.

(2) Synthesis of ethyl 5-chloro-1-(2-quinolyl)pyrazole-4-carboxylate:

24.7 g of ethyl 5-amino-1-(2-quinolyl)pyrazole-4-carboxylate was suspended in 400 ml of conc. hydrochloric acid, and the suspension obtained was cooled to -5.degree. C., to which 7.9 g of sodium nitrite dissolved in 15 ml of water was added dropwise, and thereafter stirred for 30 minutes, followed by addition of 1.45 g of urea. The solution thus obtained was added dropwise at 5.degree. C. to a solution obtained by adding 14 g of sulfur dioxide and 1.5 g of cuprous chloride to 150 ml of 1,2-dichloroethane. After stirring at room temperature for 1 hour, 1000 ml of ice water was added thereto, followed by extraction with chloroform. Seperation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 23 g of the mixture of the title compound and ethyl 1-(2-quinolyl)pyrazole-4-carboxylate (about 3:2). The mixture obtained can be used in the next procedure without purification.

(3) Synthesis of ethyl 5-mercapto-1-(2-quinolyl)-pyrazole-4-carboxylate:

23 g of the mixture of ethyl 5-chloro-1-(2-quinolyl)pyrazole-4-carboxylate and ethyl 1-(2-quinolyl)-pyrazole-4-carboxylate (about 3:2) was dissolved in 100 ml of dimethylformamide, to which 15.3 g of 70% sodium hydrosulfide was added and then heated at 80.degree. to 85.degree. C. for 1.5 hours. After the reaction was completed, ice water was added, followed by the filtration of ethyl 1-(2-quinolyl)pyrazole-4-carboxylate which was insoluble, to make the aqueous layer acidic with use of conc. hydrochloric acid. The orange crystal precipitated was filtered, washed with water and dried to obtain 13.1 g of the title compound. m.p.: 113.degree. to 117.degree. C.

(4) Synthesis of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide:

13 g of ethyl 5-mercapto-1-(2-quinolyl)pyrazole-4-carboxylate was suspended in 100 ml of 80% acetic acid, into which chlorine was introduced at 5.degree. to 15.degree. C. until it became light yellow homogeneous solution. After the reaction was completed, 500 ml of ice water was added, and crystals precipitated were filtered and washed with water to obtain 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonylchloride. The sulfonylchloride obtained was dissolved in 50 ml of tetrahydrofuran, followed by addition of 8 ml of 28% aqueous ammonia and stirring at room temperature for 0.5 hour. After solvent was evaporated, crystals precipitated were washed with water and dried to obtain 7 g of the title compound. m.p.: 140.degree. to 141.degree. C.

REFERENCE EXAMPLE 2

Synthesis of 4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfoamide

Synthesis was carried out following the procedures in Reference Example 1. m.p.: 165.degree. to 170.degree. C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(1-isoquinolyl)pyrazole-4-carbonylate (it was obtained by heating 1-hydrazinoisoquinoline and ethyl ethoxymethylene cyanoacetate ester in n-butyl alcohol), m.p.: 126.degree. to 128.degree. C.

Ethyl 5-chloro-1-(1-isoquinolyl)pyrazole-4-carboxylate, m.p.: 89.degree. to 90.degree. C.

Ethyl 5-mercapto-1-(1-isoquinolyl)pyrazole-4-carboxylate, m.p.: 121.degree. to 122.degree. C.

EXAMPLE 1

Synthesis of N-[(4,6-dimethoxyprimidine-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide (Compound No. 11)

To a mixture of 6 g of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide and 3.6 g of anhydrous potassium carbonate dissolved in 40 ml of acetonitrile, was added 1.9 g of n-butylisocyanate at room temperature, followed by heating under reflux for 1.5 hours. After the reaction was completed, acetonitrile was evaporated under reduced pressure, and then the residue was poured into ice water to filter insolubles off, and then the filtrate was precipitated with hydrochloric acid. Crystals precipitated were filtered, washed with water and dried to obtain 7 g of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide. m.p: 140.degree. to 142.degree. C.

Subsequently, the above compound was added to 70 ml of dried toluene, into which 7.5 g of phosgene was introduced while heating under reflux, and thereafter the reaction mixture was further heated under reflux for 1.5 hours. After the reaction was completed, solvent was evaporated under reduced pressure to obtain 6 g of crude 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonylisocyanate. 1.0 g of this crude suflonylisocyanate was added to a solution containing 0.37 g of 2-amino-4,6-dimethoxyprimidine dissolved in 5 ml of dried acetonitrile, followed by stirring at room temperature. Crystals precipitated were filtered, washed and dried to obtain 1.2 g of the title compound. m.p: 179.degree. to 182.degree. C.

EXAMPLE 2

Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide (Compound No. 315)

Synthesis was carried out following the procedures in Example 1. m.p.: 213.degree. to 214.degree. C.

The intermediate of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide had a melting point of 131.degree. to 132.degree. C.

In the following, examples of specific compounds included in the compound of this invention are shown in Table 1 to Table 7 in addition to the compounds synthesized in the above Examples, which, however, should not be construed to limit this invention.

TABLE 1______________________________________ ##STR10##No. A B D X Y Z______________________________________1 Q.sub.1 H COOMe Me Me CH2 Q.sub.1 H COOMe Me OMe CH3 Q.sub.1 H COOMe OMe OMe CH4 Q.sub.1 H COOMe Me Me N5 Q.sub.1 H COOMe Me OMe N6 Q.sub.1 H COOMe OMe OMe N7 Q.sub.1 H COOMe Me OCHF.sub.2 CH8 Q.sub.1 H COOMe Cl OMe CH9 Q.sub.1 H COOEt Me Me CH10 Q.sub.1 H COOEt Me OMe CH11 Q.sub.1 H COOEt OMe OMe CH12 Q.sub.1 H COOEt Me Me N13 Q.sub.1 H COOEt Me OMe N14 Q.sub.1 H COOEt OMe OMe N15 Q.sub.1 H COOEt Me OCHF.sub.2 CH16 Q.sub.1 H COOEt Cl OMe CH17 Q.sub.1 H COOPrn Me OMe CH18 Q.sub.1 H COOPrn OMe OMe CH19 Q.sub.1 H COOPrn Me OMe N20 Q.sub.1 H COOPri Me OMe CH21 Q.sub.1 H COOPri OMe OMe CH22 Q.sub.1 H COOPri Me OMe N23 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH24 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH25 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe N26 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe CH27 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH28 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe N29 Q.sub.1 H COOCH.sub.2 CCH Me OMe CH30 Q.sub.1 H COOCH.sub.2 CCH OMe OMe CH31 Q.sub.1 H COOCH.sub.2 CCH Me OMe N32 Q.sub.1 Me COOMe Me Me CH33 Q.sub.1 Me COOMe Me OMe CH34 Q.sub.1 Me COOMe OMe OMe CH35 Q.sub.1 Me COOMe Me OMe N36 Q.sub.1 Me COOMe OMe OMe N37 Q.sub.1 Me COOEt Me Me CH38 Q.sub.1 Me COOEt Me OMe CH39 Q.sub.1 Me COOEt OMe OMe CH40 Q.sub.1 Me COOEt Me OMe N41 Q.sub.1 Me COOEt OMe OMe N42 Q.sub.1 Cl COOMe Me OMe CH43 Q.sub.1 Cl COOMe OMe OMe CH44 Q.sub.1 Cl COOMe Me OMe N45 Q.sub.1 Cl COOEt Me OMe CH46 Q.sub.1 Cl COOEt OMe OMe CH47 Q.sub.1 Cl COOEt Me OMe N48 Q.sub.1 OMe COOMe Me OMe CH49 Q.sub.1 OMe COOMe OMe OMe CH50 Q.sub.1 OMe COOMe Me OMe N51 Q.sub.1 OMe COOEt Me OMe CH52 Q.sub.1 OMe COOEt OMe OMe CH53 Q.sub.1 OMe COOEt Me OMe N54 Q.sub.1 H Cl Me OMe CH55 Q.sub.1 H Cl OMe OMe CH56 Q.sub.1 H Cl Me OMe N57 Q.sub.1 H NO.sub.2 Me OMe CH58 Q.sub.1 H NO.sub.2 OMe OMe CH59 Q.sub.1 H NO.sub.2 Me OMe N60 Q.sub.1 H So.sub.2 NMe.sub.2 Me OMe CH61 Q.sub.1 H So.sub.2 NMe.sub.2 OMe OMe CH62 Q.sub.1 H So.sub.2 NMe.sub.2 Me OMe N63 Q.sub.1 H CN Me OMe CH64 Q.sub.1 H CN OMe OMe CH65 Q.sub.1 H CN Me OMe N66 Q.sub.1 Me CN Me OMe CH67 Q.sub.1 Me CN OMe OMe CH68 Q.sub.1 Me CN Me OMe N69 Q.sub.1 H Me Me OMe CH70 Q.sub.1 H Me OMe OMe CH71 Q.sub.1 H Me Me OMe N72 Q.sub.1 H Et Me OMe CH73 Q.sub.1 H Et OMe OMe CH74 Q.sub.1 H Et Me OMe N75 Q.sub.1 H H Me OMe CH76 Q.sub.1 H H OMe OMe CH77 Q.sub.1 H H Me OMe N78 Q.sub.1 H COPh Me OMe CH79 Q.sub.1 H COPh OMe OMe CH80 Q.sub.1 H COPh Me OMe N81 Me Q.sub. 1 COOMe Me OMe CH82 Me Q.sub.1 COOMe OMe OMe CH83 Me Q.sub.1 COOMe Me OMe N84 H H Q.sub.1 Me OMe CH85 H H Q.sub.1 OMe OMe CH86 H H Q.sub.1 Me OMe N87 Me H Q.sub.1 Me Me CH88 Me H Q.sub.1 Me OMe CH89 Me H Q.sub.1 OMe OMe CH90 Me H Q.sub.1 Me OMe N91 Me H Q.sub.1 OMe OMe N92 Me Me Q.sub.1 Me OMe CH93 Me Me Q.sub.1 OMe OMe CH94 Me Me Q.sub.1 Me OMe N95 Q.sub.2 H COOMe Me Me CH96 Q.sub.2 H COOMe Me OMe CH97 Q.sub.2 H COOMe OMe OMe CH98 Q.sub.2 H COOMe Me OMe N99 Q.sub.2 H COOMe OMe OMe N100 Q.sub.2 H COOEt Me Me CH101 Q.sub.2 H COOEt Me OMe CH102 Q.sub.2 H COOEt OMe OMe CH103 Q.sub.2 H COOEt Me OMe N104 Q.sub.2 H COOEt OMe OMe N105 Q.sub.2 Me COOMe Me OMe CH106 Q.sub.2 Me COOMe OMe OMe CH107 Q.sub.2 Me COOMe Me OMe N108 Q.sub.2 Me COOEt Me OMe CH109 Q.sub.2 Me COOEt OMe OMe CH110 Q.sub.2 Me COOEt Me OMe N111 Q.sub.2 H CN Me OMe CH112 Q.sub.2 H CN OMe OMe CH113 Q.sub.2 H CN Me OMe N114 Q.sub.2 H H Me OMe CH115 Q.sub.2 H H OMe OMe CH116 Q.sub.2 H H Me OMe N117 Me H Q.sub.2 Me Me CH118 Me H Q.sub.2 Me OMe CH119 Me H Q.sub.2 OMe OMe CH120 Me H Q.sub.2 Me OMe N121 Me H Q.sub.2 OMe OMe N122 Q.sub.3 H COOMe Me Me CH123 Q.sub.3 H COOMe Me OMe CH124 Q.sub.3 H COOMe OMe OMe CH125 Q.sub.3 H COOMe Me OMe N126 Q.sub.3 H COOMe OMe OMe N127 Q.sub.3 H COOEt Me Me CH128 Q.sub.3 H COOEt Me OMe CH129 Q.sub.3 H COOEt OMe OMe CH130 Q.sub.3 H COOEt Me OMe N131 Q.sub.3 H COOEt OMe OMe N132 Q.sub.3 Me COOMe Me OMe CH133 Q.sub.3 Me COOMe OMe OMe CH134 Q.sub.3 Me COOMe Me OMe N135 Q.sub.3 Me COOEt Me OMe CH136 Q.sub.3 Me COOEt OMe OMe CH137 Q.sub.3 Me COOEt Me OMe N138 Q.sub.3 H CN Me OMe CH139 Q.sub.3 H CN OMe OMe CH140 Q.sub.3 H CN Me OMe N141 Q.sub.3 H H Me OMe CH142 Q.sub.3 H H OMe OMe CH143 Q.sub.3 H H Me OMe N144 Me H Q.sub.3 Me Me CH145 Me H Q.sub.3 Me OMe CH146 Me H Q.sub.3 OMe OMe CH147 Me H Q.sub.3 Me OMe N148 Me H Q.sub.3 OMe OMe N149 Q.sub.4 H COOMe Me Me CH150 Q.sub.4 H COOMe Me OMe CH151 Q.sub.4 H COOMe OMe OMe CH152 Q.sub.4 H COOMe Me OMe N153 Q.sub.4 H COOMe OMe OMe N154 Q.sub.4 H COOEt Me Me CH155 Q.sub.4 H COOEt Me OMe CH156 Q.sub.4 H COOEt OMe OMe CH157 Q.sub.4 H COOEt Me OMe N158 Q.sub.4 H COOEt OMe OMe N159 Q.sub.4 Me COOMe Me OMe CH160 Q.sub.4 Me COOMe OMe OMe CH161 Q.sub.4 Me COOMe Me OMe N162 Q.sub.4 Me COOEt Me OMe CH163 Q.sub.4 Me COOEt OMe OMe CH164 Q.sub.4 Me COOEt Me OMe N165 Q.sub.4 H CN Me OMe CH166 Q.sub.4 H CN OMe OMe CH167 Q.sub.4 H CN Me OMe N168 Q.sub.4 H H Me OMe CH169 Q.sub.4 H H OMe OMe CH170 Q.sub.4 H H Me OMe N171 Me H Q.sub.4 Me Me CH172 Me H Q.sub.4 Me OMe CH173 Me H Q.sub.4 OMe OMe CH174 Me H Q.sub.4 Me OMe N175 Me H Q.sub.4 OMe OMe N176 Q.sub.5 H COOMe Me Me CH177 Q.sub.5 H COOMe Me OMe CH178 Q.sub.5 H COOMe OMe OMe CH179 Q.sub.5 H COOMe Me OMe N180 Q.sub.5 H COOMe OMe OMe N181 Q.sub.5 H COOEt Me Me CH182 Q.sub.5 H COOEt Me OMe CH183 Q.sub.5 H COOEt OMe OMe CH184 Q.sub.5 H COOEt Me OMe N185 Q.sub.5 H COOEt OMe OMe N186 Q.sub.5 Me COOMe Me OMe CH187 Q.sub.5 Me COOMe OMe OMe CH188 Q.sub.5 Me COOMe Me OMe N189 Q.sub.5 Me COOEt Me OMe CH190 Q.sub.5 Me COOEt OMe OMe CH191 Q.sub.5 Me COOEt Me OMe N192 Q.sub.5 H CN Me OMe CH193 Q.sub.5 H CN OMe OMe CH194 Q.sub.5 H CN Me OMe N195 Q.sub.5 H H Me OMe CH196 Q.sub.5 H H OMe OMe CH197 Q.sub.5 H H Me OMe N198 Me H Q.sub.5 Me Me CH199 Me H Q.sub.5 Me OMe CH200 Me H Q.sub.5 OMe OMe CH201 Me H Q.sub.5 Me OMe N202 Me H Q.sub.5 OMe OMe N203 Q.sub.6 H COOMe Me Me CH204 Q.sub.6 H COOMe Me OMe CH205 Q.sub.6 H COOMe OMe OMe CH206 Q.sub.6 H COOMe Me OMe N207 Q.sub.6 H COOMe OMe OMe N208 Q.sub.6 H COOEt Me Me CH209 Q.sub.6 H COOEt Me OMe CH210 Q.sub.6 H COOEt OMe OMe CH211 Q.sub.6 H COOEt Me OMe N212 Q.sub.6 H COOEt OMe OMe N213 Q.sub.6 Me COOMe Me OMe CH214 Q.sub.6 Me COOMe OMe OMe CH215 Q.sub.6 Me COOMe Me OMe N216 Q.sub.6 Me COOEt Me OMe CH217 Q.sub.6 Me COOEt OMe OMe CH218 Q.sub.6 Me COOEt Me OMe N219 Q.sub.6 H CN Me OMe CH220 Q.sub.6 H CN OMe OMe CH221 Q.sub.6 H CN Me OMe N222 Q.sub.6 H H Me OMe CH223 Q.sub.6 H H OMe OMe CH224 Q.sub.6 H H Me OMe N225 Me H Q.sub.6 Me Me CH226 Me H Q.sub.6 Me OMe CH227 Me H Q.sub.6 OMe OMe CH228 Me H Q.sub.6 Me OMe N229 Me H Q.sub.6 OMe OMe N230 Q.sub.7 H COOMe Me OMe CH231 Q.sub.7 H COOMe OMe OMe CH232 Q.sub.7 H COOEt Me OMe CH233 Q.sub.7 H COOEt OMe OMe CH234 Q.sub.7 Me COOMe Me OMe CH235 Q.sub.7 Me COOMe OMe OMe CH236 Q.sub.7 Me COOEt Me OMe CH237 Q.sub.7 Me COOEt OMe OMe CH238 Q.sub.7 H H Me OMe CH239 Q.sub.7 H H OMe OMe CH240 Me H Q.sub.7 Me OMe CH241 Me H Q.sub.7 OMe OMe CH242 Q.sub.8 H COOMe Me OMe CH243 Q.sub.8 H COOMe OMe OMe CH244 Q.sub.8 H COOEt Me OMe CH245 Q.sub.8 H COOEt OMe OMe CH246 Q.sub.8 Me COOMe Me OMe CH247 Q.sub.8 Me COOMe OMe OMe CH248 Q.sub.8 Me COOEt Me OMe CH249 Q.sub.8 Me COOEt OMe OMe CH250 Q.sub.8 H H Me OMe CH251 Q.sub.8 H H OMe OMe CH252 Me H Q.sub.8 Me OMe CH253 Me H Q.sub.8 OMe OMe CH254 Q.sub.9 H COOMe Me OMe CH255 Q.sub.9 H COOMe OMe OMe CH256 Q.sub.9 H COOEt Me OMe CH257 Q.sub.9 H COOEt OMe OMe CH258 Q.sub.9 Me COOMe Me OMe CH259 Q.sub.9 Me COOMe OMe OMe CH260 Q.sub.9 Me COOEt Me OMe CH261 Q.sub.9 Me COOEt OMe OMe CH262 Q.sub.9 H H Me OMe CH263 Q.sub.9 H H OMe OMe CH264 Me H Q.sub.9 Me OMe CH265 Me H Q.sub.9 OMe OMe CH266 Q.sub.10 H COOMe Me OMe CH267 Q.sub.10 H COOMe OMe OMe CH268 Q.sub.10 H COOEt Me OMe CH269 Q.sub.10 H COOEt OMe OMe CH270 Q.sub.10 Me COOMe Me OMe CH271 Q.sub.10 Me COOMe OMe OMe CH272 Q.sub.10 Me COOEt Me OMe CH273 Q.sub.10 Me COOEt OMe OMe CH274 Q.sub.10 H H Me OMe CH275 Q.sub.10 H H OMe OMe CH276 Me H Q.sub.10 Me OMe CH277 Me H Q.sub.10 OMe OMe CH278 Q.sub.11 H COOMe Me Me CH279 Q.sub.11 H COOMe Me OMe CH280 Q.sub.11 H COOMe OMe OMe CH281 Q.sub.11 H COOMe Me OMe N282 Q.sub.11 H COOMe OMe OMe N283 Q.sub.11 H COOEt Me Me CH284 Q.sub.11 H COOEt Me OMe CH285 Q.sub.11 H COOEt OMe OMe CH286 Q.sub.11 H COOEt Me OMe N287 Q.sub.11 H COOEt OMe OMe N288 Q.sub.11 Me COOMe Me OMe CH289 Q.sub.11 Me COOMe OMe OMe CH290 Q.sub.11 Me COOMe Me OMe N291 Q.sub.11 Me COOEt Me OMe CH292 Q.sub.11 Me COOEt OMe OMe CH293 Q.sub.11 Me COOEt Me OMe N294 Q.sub.11 H CN Me OMe CH295 Q.sub.11 H CN OMe OMe CH296 Q.sub.11 H CN Me OMe N297 Q.sub.11 H H Me OMe CH298 Q.sub.11 H H OMe OMe CH299 Q.sub.11 H H Me OMe N300 Me H Q.sub.11 Me Me CH301 Me H Q.sub.11 Me OMe CH302 Me H Q.sub.11 OMe OMe CH303 Me H Q.sub.11 Me OMe N304 Me H Q.sub.11 OMe OMe N305 Q.sub.12 H COOMe Me Me CH306 Q.sub.12 H COOMe Me OMe CH307 Q.sub.12 H COOMe OMe OMe CH308 Q.sub.12 H COOMe Me Me N309 Q.sub.12 H COOMe Me OMe N310 Q.sub.12 H COOMe OMe OMe N311 Q.sub.12 H COOMe Me OCHF.sub.2 CH312 Q.sub.12 H COOMe Cl OMe CH313 Q.sub.12 H COOEt Me Me CH314 Q.sub.12 H COOEt Me OMe CH315 Q.sub.12 H COOEt OMe OMe CH316 Q.sub.12 H COOEt Me Me N317 Q.sub.12 H COOEt Me OMe N318 Q.sub.12 H COOEt OMe OMe N319 Q.sub.12 H COOEt Me OCHF.sub.2 CH320 Q.sub.12 H COOEt Cl OMe CH321 Q.sub.12 H COOPrn Me OMe CH322 Q.sub.12 H COOPrn OMe OMe CH323 Q.sub.12 H COOPrn Me OMe N324 Q.sub.12 H COOPri Me OMe CH325 Q.sub.12 H COOPri OMe OMe CH326 Q.sub.12 H COOPri Me OMe N327 Q.sub.12 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH328 Q.sub.12 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH329 Q.sub.12 H COOCH.sub.2 CH.sub.2 Cl Me OMe N330 Q.sub.12 H COOCH.sub.2 CHCH.sub.2 Me OMe CH331 Q.sub.12 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH332 Q.sub.12 H COOCH.sub.2 CHCH.sub.2 Me OMe N333 Q.sub.12 H COOCH.sub.2 CCH Me OMe CH334 Q.sub.12 H COOCH.sub.2 CCH OMe OMe CH335 Q.sub.12 H COOCH.sub.2 CCH Me OMe N336 Q.sub.12 Me COOMe Me Me CH337 Q.sub.12 Me COOMe Me OMe CH338 Q.sub.12 Me COOMe OMe OMe CH339 Q.sub.12 Me COOMe Me OMe N340 Q.sub.12 Me COOMe OMe OMe N341 Q.sub.12 Me COOEt Me Me CH342 Q.sub.12 Me COOEt Me OMe CH343 Q.sub.12 Me COOEt OMe OMe CH344 Q.sub.12 Me COOEt Me OMe N345 Q.sub.12 Me COOEt OMe OMe N346 Q.sub.12 Cl COOMe Me OMe CH347 Q.sub.12 Cl COOMe OMe OMe CH348 Q.sub.12 Cl COOMe Me OMe N349 Q.sub.12 Cl COOEt Me OMe CH350 Q.sub.12 Cl COOEt OMe OMe CH351 Q.sub.12 Cl COOEt Me OMe N352 Q.sub.12 OMe COOMe Me OMe CH353 Q.sub.12 OMe COOMe OMe OMe CH354 Q.sub.12 OMe COOMe Me OMe N355 Q.sub.12 OMe COOEt Me OMe CH356 Q.sub.12 OMe COOEt OMe OMe CH357 Q.sub.12 OMe COOEt Me OMe N358 Q.sub.12 H Cl Me OMe CH359 Q.sub.12 H Cl OMe OMe CH360 Q.sub.12 H Cl Me OMe N361 Q.sub.12 H NO.sub.2 Me OMe CH362 Q.sub.12 H NO.sub.2 OMe OMe CH363 Q.sub.12 H NO.sub.2 Me OMe N364 Q.sub.12 H SO.sub.2 NMe.sub.2 Me OMe CH365 Q.sub.12 H SO.sub.2 NMe.sub.2 OMe OMe CH366 Q.sub.12 H SO.sub.2 NMe.sub.2 Me OMe N367 Q.sub.12 H CN Me OMe CH368 Q.sub.12 H CN OMe OMe CH369 Q.sub.12 H CN Me OMe N370 Q.sub.12 Me CN Me OMe CH371 Q.sub.12 Me CN OMe OMe CH372 Q.sub.12 Me CN Me OMe N373 Q.sub.12 H Me Me OMe CH374 Q.sub.12 H Me OMe OMe CH375 Q.sub.12 H Me Me OMe N376 Q.sub.12 H Et Me OMe CH377 Q.sub.12 H Et OMe OMe CH378 Q.sub.12 H Et Me OMe N379 Q.sub.12 H H Me OMe CH380 Q.sub.12 H H OMe OMe CH381 Q.sub.12 H H Me OMe N382 Q.sub.12 H COPh Me OMe CH383 Q.sub.12 H COPh OMe OMe CH384 Q.sub.12 H COPh Me OMe N385 Me Q.sub.12 COOMe Me OMe CH386 Me Q.sub.12 COOMe OMe OMe CH387 Me Q.sub.12 COOMe Me OMe N388 H H Q.sub.12 Me OMe CH389 H H Q.sub.12 OMe OMe CH390 H H Q.sub.12 Me OMe N391 Me H Q.sub.12 Me Me CH392 Me H Q.sub.12 Me OMe CH393 Me H Q.sub.12 OMe OMe CH394 Me H Q.sub.12 Me OMe N395 Me H Q.sub.12 OMe OMe N396 Me Me Q.sub.12 Me OMe CH397 Me Me Q.sub.12 OMe OMe CH398 Me Me Q.sub.12 Me OMe N399 Q.sub.13 H COOMe Me Me CH400 Q.sub.13 H COOMe Me OMe CH401 Q.sub.13 H COOMe OMe OMe CH402 Q.sub.13 H COOMe Me OMe N403 Q.sub.13 H COOMe OMe OMe N404 Q.sub.13 H COOEt Me Me CH405 Q.sub.13 H COOEt Me OMe CH406 Q.sub.13 H COOEt OMe OMe CH407 Q.sub.13 H COOEt Me OMe N408 Q.sub.13 H COOEt OMe OMe N409 Q.sub.13 Me COOMe Me OMe CH410 Q.sub.13 Me COOMe OMe OMe CH411 Q.sub.13 Me COOMe Me OMe N412 Q.sub.13 Me COOEt Me OMe CH413 Q.sub.13 Me COOEt OMe OMe CH414 Q.sub.13 Me COOEt Me OMe N415 Q.sub.13 H CN Me OMe CH416 Q.sub.13 H CN OMe OMe CH417 Q.sub.13 H CN Me OMe N118 Q.sub.13 H H Me OMe CH419 Q.sub.13 H H OMe OMe CH420 Q.sub.13 H H Me OMe N421 Me H Q.sub.13 Me Me CH422 Me H Q.sub.13 Me OMe CH423 Me H Q.sub.13 OMe OMe CH424 Me H Q.sub.13 Me OMe N425 Me H Q.sub.13 OMe OMe N426 Q.sub.14 H COOMe Me Me CH427 Q.sub.14 H COOMe Me OMe CH428 Q.sub.14 H COOMe OMe OMe CH429 Q.sub.14 H COOMe Me OMe N430 Q.sub.14 H COOMe OMe OMe N431 Q.sub.14 H COOEt Me Me CH432 Q.sub.14 H COOEt Me OMe CH433 Q.sub.14 H COOEt OMe OMe CH434 Q.sub.14 H COOEt Me OMe N435 Q.sub.14 H COOEt OMe OMe N436 Q.sub.14 Me COOMe Me OMe CH437 Q.sub.14 Me COOMe OMe OMe CH438 Q.sub.14 Me COOMe Me OMe N439 Q.sub.14 Me COOEt Me OMe CH440 Q.sub.14 Me COOEt OMe OMe CH441 Q.sub.14 Me COOEt Me OMe N442 Q.sub.14 H CN Me OMe CH443 Q.sub.14 H CN OMe OMe CH444 Q.sub.14 H CN Me OMe N445 Q.sub.14 H H Me OMe CH446 Q.sub.14 H H OMe OMe CH447 Q.sub.14 H H Me OMe N448 Me H Q.sub.14 Me Me CH449 Me H Q.sub.14 Me OMe CH450 Me H Q.sub.14 OMe OMe CH451 Me H Q.sub.14 Me OMe N452 Me H Q.sub.14 OMe OMe N453 Q.sub.15 H COOMe Me OMe CH454 Q.sub.15 H COOMe OMe OMe CH455 Q.sub.15 H COOEt Me OMe CH456 Q.sub.15 H COOEt OMe OMe CH457 Q.sub.15 Me COOMe Me OMe CH458 Q.sub.15 Me COOMe OMe OMe CH459 Q.sub.15 Me COOEt Me OMe CH460 Q.sub.15 Me COOEt OMe OMe CH461 Q.sub.15 H H Me OMe CH462 Q.sub.15 H H OMe OMe CH463 Me H Q.sub.15 Me OMe CH464 Me H Q.sub.15 OMe OMe CH465 Q.sub.16 H COOMe Me OMe CH466 Q.sub.16 H COOMe OMe OMe CH467 Q.sub.16 H COOEt Me OMe CH468 Q.sub.16 H COOEt OMe OMe CH469 Q.sub.16 Me COOMe Me OMe CH470 Q.sub.16 Me COOMe OMe OMe CH471 Q.sub.16 Me COOEt Me OMe CH472 Q.sub.16 Me COOEt OMe OMe CH473 Q.sub.16 H H Me OMe CH474 Q.sub.16 H H OMe OMe CH475 Me H Q.sub.16 Me OMe CH476 Me H Q.sub.16 OMe OMe CH477 Q.sub.17 H COOMe Me OMe CH478 Q.sub.17 H COOMe OMe OMe CH479 Q.sub.17 H COOEt Me OMe CH480 Q.sub.17 H COOEt OMe OMe CH481 Q.sub.17 Me COOMe Me OMe CH482 Q.sub.17 Me COOMe OMe OMe CH483 Q.sub.17 Me COOEt Me OMe CH484 Q.sub.17 Me COOEt OMe OMe CH485 Q.sub.17 H H Me OMe CH486 Q.sub.17 H H OMe OMe CH487 Me H Q.sub.17 Me OMe CH488 Me H Q.sub.17 OMe OMe CH489 Q.sub.18 H COOMe Me OMe CH490 Q.sub.18 H COOMe OMe OMe CH491 Q.sub.18 H COOEt Me OMe CH492 Q.sub.18 H CCOOEt OMe OMe CH493 Q.sub.18 Me COOMe Me OMe CH494 Q.sub.18 Me COOMe OMe OMe CH495 Q.sub.18 Me COOEt Me OMe CH496 Q.sub.18 Me COOEt OMe OMe CH497 Q.sub.18 H H Me OMe CH498 Q.sub.18 H H OMe OMe CH499 Me H Q.sub.18 Me OMe CH500 Me H Q.sub.18 OMe OMe CH501 Q.sub.19 H COOMe Me Me CH502 Q.sub.19 H COOMe Me OMe CH503 Q.sub.19 H COOMe OMe OMe CH504 Q.sub.19 H COOMe Me OMe N505 Q.sub.19 H COOMe OMe OMe N506 Q.sub.19 H COOEt Me Me CH507 Q.sub.19 H COOEt Me OMe CH508 Q.sub.19 H COOEt OMe OMe CH509 Q.sub.19 H COOEt Me OMe N510 Q.sub.19 H COOEt OMe OMe N511 Q.sub.19 Me COOMe Me OMe CH512 Q.sub.19 Me COOMe OMe OMe CH513 Q.sub.19 Me COOMe Me OMe N514 Q.sub.19 Me COOEt Me OMe CH515 Q.sub.19 Me COOEt OMe OMe CH516 Q.sub.19 Me COOEt Me OMe N517 Q.sub.19 H CN Me OMe CH518 Q.sub.19 H CN OMe OMe CH519 Q.sub.19 H CN Me OMe N520 Q.sub.19 H H Me OMe CH521 Q.sub.19 H H OMe OMe CH522 Q.sub.19 H H Me OMe N523 Me H Q.sub.19 Me Me CH524 Me H Q.sub.19 Me OMe CH525 Me H Q.sub.19 OMe OMe CH526 Me H Q.sub.19 Me OMe N527 Me H Q.sub.19 OMe OMe N528 Q.sub.20 H COOMe Me OMe CH529 Q.sub.10 H COOMe OMe OMe CH530 Q.sub.10 H COOEt Me OMe CH531 Q.sub.10 H COOEt OMe OMe CH532 Q.sub.20 Me COOMe Me OMe CH533 Q.sub.20 Me COOMe OMe OMe CH534 Q.sub.20 Me COOEt Me OMe CH535 Q.sub.20 Me COOEt OMe OMe CH536 Q.sub.20 H H Me OMe CH537 Q.sub.20 H H OMe OMe CH538 Me H Q.sub.20 Me OMe CH539 Me H Q.sub.20 OMe OMe CH540 Q.sub.21 H COOMe Me OMe CH541 Q.sub.21 H COOMe OMe OMe CH542 Q.sub.21 H COOEt Me OMe CH543 Q.sub.21 H COOEt OMe OMe CH544 Q.sub.21 Me COOMe Me OMe CH545 Q.sub.21 Me COOMe OMe OMe CH546 Q.sub.21 Me COOEt Me OMe CH547 Q.sub.21 Me COOEt OMe OMe CH548 Q.sub.21 H H Me OMe CH549 Q.sub.21 H H OMe OMe CH550 Me H Q.sub.21 Me OMe CH551 Me H Q.sub.21 OMe OMe CH552 Q.sub.22 H COOMe Me Me CH553 Q.sub.22 H COOMe Me OMe CH554 Q.sub.22 H COOMe OMe OMe CH555 Q.sub.22 H COOMe Me Me N556 Q.sub.22 H COOMe Me OMe N557 Q.sub.22 H COOMe OMe OMe N558 Q.sub.22 H COOMe Me OCHF.sub.2 CH559 Q.sub.22 H COOMe Cl OMe CH560 Q.sub.22 H COOEt Me Me CH561 Q.sub.22 H COOEt Me OMe CH562 Q.sub.22 H COOEt OMe OMe CH563 Q.sub.22 H COOEt Me Me N564 Q.sub.22 H COOEt Me OMe N565 Q.sub.22 H COOEt OMe OMe N566 Q.sub.22 H COOEt Me OCHF.sub.2 CH567 Q.sub.22 H COOEt Cl OMe CH568 Q.sub.22 H COOPrn Me OMe CH569 Q.sub.22 H COOPrn OMe OMe CH570 Q.sub.22 H COOPrn Me OMe N571 Q.sub.22 H COOPri Me OMe CH572 Q.sub.22 H COOPr i OMe OMe CH573 Q.sub.22 H COOPri Me OMe N574 Q.sub.22 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH575 Q.sub.22 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH576 Q.sub.22 H COOCH.sub.2 CH.sub.2 Cl Me OMe N577 Q.sub.22 H COOCH.sub.2 CHCH.sub.2 Me OMe CH578 Q.sub.22 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH579 Q.sub.22 H COOCH.sub.2 CHCH.sub.2 Me OMe N580 Q.sub.22 H COOCH.sub.2 CCH Me OMe CH581 Q.sub.22 H COOCH.sub.2 CCH OMe OMe CH582 Q.sub.22 H COOCH.sub.2 CCH Me OMe N583 Q.sub.22 Me COOMe Me Me CH584 Q.sub.22 Me COOMe Me OMe CH585 Q.sub.22 Me COOMe OMe OMe CH586 Q.sub.22 Me COOMe Me OMe N587 Q.sub.22 Me COOMe OMe OMe N588 Q.sub.22 Me COOEt Me Me CH589 Q.sub.22 Me COOEt Me OMe CH590 Q.sub.22 Me COOEt OMe OMe CH591 Q.sub.22 Me COOEt Me OMe N592 Q.sub.22 Me COOEt OMe OMe N593 Q.sub.22 Cl COOMe Me OMe CH594 Q.sub.22 Cl COOMe OMe OMe CH595 Q.sub.22 Cl COOMe Me OMe N596 Q.sub.22 Cl COOEt Me OMe CH597 Q.sub.22 Cl COOEt OMe OMe CH598 Q.sub.22 Cl COOEt Me OMe N599 Q.sub.22 OMe COOMe Me OMe CH600 Q.sub.22 OMe COOMe OMe OMe CH601 Q.sub.22 OMe COOMe Me OMe N602 Q.sub.22 OMe COOEt Me OMe CH603 Q.sub.22 OMe COOEt OMe OMe CH604 Q.sub.22 OMe COOEt Me OMe N605 Q.sub.22 H Cl Me OMe CH606 Q.sub.22 H Cl OMe OMe CH607 Q.sub.22 H Cl Me OMe N608 Q.sub.22 H NO.sub.2 Me OMe CH609 Q.sub.22 H NO.sub.2 OMe OMe CH610 Q.sub.22 H NO.sub.2 Me OMe N611 Q.sub.22 H SO.sub.2 NMe.sub.2 Me OMe CH612 Q.sub.22 H SO.sub.2 NMe.sub.2 OMe OMe CH613 Q.sub.22 H SO.sub.2 NMe.sub.2 Me OMe N614 Q.sub.22 H CN Me OMe CH615 Q.sub.22 H CN OMe OMe CH616 Q.sub.22 H CN Me OMe N617 Q.sub.22 Me CN Me OMe CH618 Q.sub.22 Me CN OMe OMe CH619 Q.sub.22 Me CN Me OMe N620 Q.sub.22 H Me Me OMe CH621 Q.sub.22 H Me OMe OMe CH622 Q.sub.22 H Me Me OMe N623 Q.sub.22 H Et Me OMe CH624 Q.sub.22 H Et OMe OMe CH625 Q.sub.22 H Et Me OMe N626 Q.sub.22 H H Me OMe CH627 Q.sub.22 H H OMe OMe CH628 Q.sub.22 H H Me OMe N629 Q.sub.22 H COPh Me OMe CH630 Q.sub.22 H COPh OMe OMe CH631 Q.sub.22 H COPh Me OMe N632 Me Q.sub.22 COOMe Me OMe CH633 Me Q.sub.22 COOMe OMe OMe CH634 Me Q.sub.22 COOMe Me OMe N635 H H Q.sub.22 Me OMe CH636 H H Q.sub.22 OMe OMe CH637 H H Q.sub.22 Me OMe N638 Me H Q.sub.22 Me Me CH639 Me H Q.sub.22 Me OMe CH640 Me H Q.sub.22 OMe OMe CH641 Me H Q.sub.22 Me OMe N642 Me H Q.sub.22 OMe OMe N643 Me Me Q.sub.22 Me OMe CH644 Me Me Q.sub.22 OMe OMe CH645 Me Me Q.sub.22 Me OMe N646 Q.sub.23 H COOMe Me Me CH647 Q.sub.23 H COOMe Me OMe CH648 Q.sub.23 H COOMe OMe OMe CH649 Q.sub.23 H COOMe Me OMe N650 Q.sub.23 H COOMe OMe OMe N651 Q.sub.23 H COOEt Me Me CH652 Q.sub.23 H COOEt Me OMe CH653 Q.sub.23 H COOEt OMe OMe CH654 Q.sub.23 H COOEt Me OMe N655 Q.sub.23 H COOEt OMe OMe N656 Q.sub.23 Me COOMe Me OMe CH657 Q.sub.23 Me COOMe OMe OMe CH658 Q.sub.23 Me COOMe Me OMe N659 Q.sub.23 Me COOEt Me OMe CH660 Q.sub.23 Me COOEt OMe OMe CH661 Q.sub.23 Me COOEt Me OMe N662 Q.sub.23 H CN Me OMe CH663 Q.sub.23 H CN OMe OMe CH664 Q.sub.23 H CN Me OMe N665 Q.sub.23 H H Me OMe CH666 Q.sub.23 H H OMe OMe CH667 Q.sub.23 H H Me OMe N668 Me H Q.sub.23 Me Me CH669 Me H Q.sub.23 Me OMe CH670 Me H Q.sub.23 OMe OMe CH671 Me H Q.sub.23 Me OMe N672 Me H Q.sub.23 OMe OMe N673 Q.sub.24 H COOMe Me Me CH674 Q.sub.24 H COOMe Me OMe CH675 Q.sub.24 H COOMe OMe OMe CH676 Q.sub.24 H COOMe Me OMe N677 Q.sub.24 H COOMe OMe OMe N678 Q.sub.24 H COOEt Me Me CH679 Q.sub.24 H COOEt Me OMe CH680 Q.sub.24 H COOEt OMe OMe CH681 Q.sub.24 H COOEt Me OMe N682 Q.sub.24 H COOEt OMe OMe N683 Q.sub.24 Me COOMe Me OMe CH684 Q.sub.24 Me COOMe OMe OMe CH685 Q.sub.24 Me COOMe Me OMe N686 Q.sub.24 Me COOEt Me OMe CH687 Q.sub.24 Me COOEt OMe OMe CH688 Q.sub.24 Me COOEt Me OMe N689 Q.sub.24 H CN Me OMe CH690 Q.sub.24 H CN OMe OMe CH691 Q.sub.24 H CN Me OMe N692 Q.sub.24 H H Me OMe CH693 Q.sub.24 H H OMe OMe CH694 Q.sub.24 H H Me OMe N695 Me H Q.sub.24 Me Me CH696 Me H Q.sub.24 Me OMe CH697 Me H Q.sub.24 OMe OMe CH698 Me H Q.sub.24 Me OMe N699 Me H Q.sub.24 OMe OMe N700 Q.sub.25 H COOMe Me Me CH701 Q.sub.25 H COOMe Me OMe CH702 Q.sub.25 H COOMe OMe OMe CH703 Q.sub.25 H COOMe Me OMe N704 Q.sub.25 H COOMe OMe OMe N705 Q.sub.25 H COOEt Me Me CH706 Q.sub.25 H COOEt Me OMe CH707 Q.sub.25 H COOEt OMe OMe CH708 Q.sub.25 H COOEt Me OMe N709 Q.sub.25 H COOEt OMe OMe N710 Q.sub.25 Me COOMe Me OMe CH711 Q.sub.25 Me COOMe OMe OMe CH712 Q.sub.25 Me COOMe Me OMe N713 Q.sub.25 Me COOEt Me OMe CH714 Q.sub.25 Me COOEt OMe OMe CH715 Q.sub.25 Me COOEt Me OMe N716 Q.sub.25 H CN Me OMe CH717 Q.sub.25 H CN OMe OMe CH718 Q.sub.25 H CN Me OMe N719 Q.sub.25 H H Me OMe CH720 Q.sub.25 H H OMe OMe CH721 Q.sub.25 H H Me OMe N722 Me H Q.sub.25 Me Me CH723 Me H Q.sub.25 Me OMe CH724 Me H Q.sub.25 OMe OMe CH725 Me H Q.sub.25 Me OMe N726 Me H Q.sub.25 OMe OMe N727 Q.sub.26 H COOMe Me OMe CH728 Q.sub.26 H COOMe OMe OMe CH729 Q.sub.26 H COOEt Me OMe CH730 Q.sub.26 H COOEt OMe OMe CH731 Q.sub.26 Me COOMe Me OMe CH732 Q.sub.26 Me COOMe OMe OMe CH733 Q.sub.26 Me COOEt Me OMe CH734 Q.sub.26 Me COOEt OMe OMe CH735 Q.sub.26 H H Me OMe CH736 Q.sub.26 H H OMe OMe CH737 Me H Q.sub.26 Me OMe CH738 Me H Q.sub.26 OMe OMe CH739 Q.sub.27 H COOMe Me OMe CH740 Q.sub.27 H COOMe OMe OMe CH741 Q.sub.27 H COOEt Me OMe CH742 Q.sub.27 H COOEt OMe OMe CH743 Q.sub.27 Me COOMe Me OMe CH744 Q.sub.27 Me COOMe OMe OMe CH745 Q.sub.27 Me COOEt Me OMe CH746 Q.sub.27 Me COOEt OMe OMe CH747 Q.sub.27 H H Me OMe CH748 Q.sub.27 H H OMe OMe CH749 Me H Q.sub.27 Me OMe CH750 Me H Q.sub.27 OMe OMe CH751 Q.sub.28 H COOMe Me OMe CH752 Q.sub.28 H COOMe OMe OMe CH753 Q.sub.28 H COOEt Me OMe CH754 Q.sub.28 H COOEt OMe OMe CH755 Q.sub.28 Me COOMe Me OMe CH756 Q.sub.28 Me COOMe OMe OMe CH757 Q.sub.28 Me COOEt Me OMe CH758 Q.sub.28 Me COOEt OMe OMe CH759 Q.sub.28 H H Me OMe CH760 Q.sub.28 H H OMe OMe CH761 Me H Q.sub.28 Me OMe CH762 Me H Q.sub.28 OMe OMe CH763 Q.sub.29 H COOMe Me OMe CH764 Q.sub.29 H COOMe OMe OMe CH765 Q.sub.29 H COOEt Me OMe CH766 Q.sub.29 H COOEt OMe OMe CH767 Q.sub.29 Me COOMe Me OMe CH768 Q.sub.29 Me COOMe OMe OMe CH769 Q.sub.29 Me COOEt Me OMe CH770 Q.sub.29 Me COOEt OMe OMe CH771 Q.sub.29 H H Me OMe CH772 Q.sub.29 H H OMe OMe CH773 Me H Q.sub.29 Me OMe CH774 Me H Q.sub.29 OMe OMe CH775 Q.sub.30 H COOMe Me OMe CH776 Q.sub.30 H COOMe OMe OMe CH777 Q.sub.30 H COOEt Me OMe CH778 Q.sub.30 H COOEt OMe OMe CH779 Q.sub.30 Me COOMe Me OMe CH780 Q.sub.30 Me COOMe OMe OMe CH781 Q.sub.30 Me COOEt Me OMe CH782 Q.sub.30 Me COOEt OMe OMe CH783 Q.sub.30 H H Me OMe CH784 Q.sub.30 H H OMe OMe CH785 Me H Q.sub.30 Me OMe CH786 Me H Q.sub.30 OMe OMe CH787 Q.sub.31 H COOMe Me OMe CH788 Q.sub. 31 H COOMe OMe OMe CH789 Q.sub.31 H COOEt Me OMe CH790 Q.sub.31 H COOEt OMe OMe CH791 Q.sub.31 Me COOMe Me OMe CH792 Q.sub.31 Me COOMe OMe OMe CH793 Q.sub.31 Me COOEt Me OMe CH794 Q.sub.31 Me COOEt OMe OMe CH795 Q.sub.31 H H Me OMe CH796 Q.sub.31 H H OMe OMe CH797 Me H Q.sub.31 Me OMe CH798 Me H Q.sub.31 OMe OMe CH799 Q.sub.32 H COOMe Me Me CH800 Q.sub.32 H COOMe Me OMe CH801 Q.sub.32 H COOMe OMe OMe CH802 Q.sub.32 H COOMe Me OMe N803 Q.sub.32 H COOMe OMe OMe N804 Q.sub.32 H COOEt Me Me CH805 Q.sub.32 H COOEt Me OMe CH806 Q.sub.32 H COOEt OMe OMe CH807 Q.sub.32 H COOEt Me OMe N808 Q.sub.32 H COOEt OMe OMe N809 Q.sub.32 Me COOMe Me OMe CH810 Q.sub.32 Me COOMe OMe OMe CH811 Q.sub.32 Me COOMe Me OMe N812 Q.sub.32 Me COOEt Me OMe CH813 Q.sub.32 Me COOEt OMe OMe CH814 Q.sub.32 Me COOEt Me OMe N815 Q.sub.32 H CN Me OMe CH816 Q.sub.32 H CN OMe OMe CH817 Q.sub.32 H CN Me OMe N818 Q.sub.32 H H Me OMe CH819 Q.sub.32 H H OMe OMe CH820 Q.sub.32 H H Me OMe N821 Me H Q.sub.32 Me Me CH822 Me H Q.sub.32 Me OMe CH823 Me H Q.sub.32 OMe OMe CH824 Me H Q.sub.32 Me OMe N825 Me H Q.sub.32 OMe OMe N826 Q.sub.33 H COOMe Me OMe CH827 Q.sub.33 H COOMe OMe OMe CH828 Q.sub.33 H COOEt Me OMe CH829 Q.sub.33 H COOEt OMe OMe CH830 Q.sub.33 Me COOMe Me OMe CH831 Q.sub.33 Me COOMe OMe OMe CH832 Q.sub.33 Me COOEt Me OMe CH833 Q.sub.33 Me COOEt OMe OMe CH834 Q.sub.33 H H Me OMe CH835 Q.sub.33 H H OMe OMe CH836 Me H Q.sub.33 Me OMe CH837 Me H Q.sub.33 OMe OMe CH838 Q.sub.34 H COOMe Me OMe CH839 Q.sub.34 H COOMe OMe OMe CH840 Q.sub.34 H COOEt Me OMe CH841 Q.sub.34 H COOEt OMe OMe CH842 Q.sub.34 Me COOMe Me OMe CH843 Q.sub.34 Me COOMe OMe OMe CH844 Q.sub.34 Me COOEt Me OMe CH845 Q.sub.34 Me COOEt OMe OMe CH846 Q.sub.34 H H Me OMe CH847 Q.sub.34 H H OMe OMe CH848 Me H Q.sub.34 Me OMe CH849 Me H Q.sub.34 OMe OMe CH850 Q.sub.35 H COOMe Me OMe CH851 Q.sub.35 H COOMe OMe OMe CH852 Q.sub.35 H COOEt Me OMe CH853 Q.sub.35 H COOEt OMe OMe CH854 Q.sub.35 Me COOMe Me OMe CH855 Q.sub.35 Me COOMe OMe OMe CH856 Q.sub.35 Me COOEt Me OMe CH857 Q.sub.35 Me COOEt OMe OMe CH858 Q.sub.35 H H Me OMe CH859 Q.sub.35 H H OMe OMe CH860 Me H Q.sub.35 Me OMe CH861 Me H Q.sub.35 OMe OMe CH862 Q.sub.36 H COOMe Me OMe CH863 Q.sub.36 H COOMe OMe OMe CH864 Q.sub.36 H COOEt Me OMe CH865 Q.sub.36 H COOEt OMe OMe CH866 Q.sub.36 Me COOMe Me OMe CH867 Q.sub.36 Me COOMe OMe OMe CH868 Q.sub.36 Me COOEt Me OMe CH869 Q.sub.36 Me COOEt OMe OMe CH870 Q.sub.36 H H Me OMe CH871 Q.sub.36 H H OMe OMe CH872 Me H Q.sub.36 Me OMe CH873 Me H Q.sub.36 OMe OMe CH874 Q.sub.37 H COOMe Me OMe CH875 Q.sub.37 H COOMe OMe OMe CH876 Q.sub.37 H COOEt Me OMe CH877 Q.sub.37 H COOEt OMe OMe CH878 Q.sub.37 Me COOMe Me OMe CH879 Q.sub.37 Me COOMe OMe OMe CH880 Q.sub.37 Me COOEt Me OMe CH881 Q.sub.37 Me COOEt OMe OMe CH882 Q.sub.37 H H Me OMe CH883 Q.sub.37 H H OMe OMe CH884 Me H Q.sub.37 Me OMe CH885 Me H Q.sub.37 OMe OMe CH886 Q.sub.38 H COOMe Me OMe CH887 Q.sub.38 H COOMe OMe OMe CH888 Q.sub.38 H COOEt Me OMe CH889 Q.sub.38 H COOEt OMe OMe CH890 Q.sub.38 Me COOMe Me OMe CH891 Q.sub.38 Me COOMe OMe OMe CH892 Q.sub.38 Me COOEt Me OMe CH893 Q.sub.38 Me COOEt OMe OMe CH932 Me H Q.sub.41 Me OMe CH933 Me H Q.sub.41 OMe OMe CH934 Q.sub.42 H COOMe Me OMe CH935 Q.sub.42 H COOMe OMe OMe CH936 Q.sub.42 H COOEt Me OMe CH937 Q.sub.42 H COOEt OMe OMe CH938 Q.sub.42 Me COOMe Me OMe CH939 Q.sub.42 Me COOMe OMe OMe CH940 Q.sub.42 Me COOEt Me OMe CH941 Q.sub.42 Me COOEt OMe OMe CH942 Q.sub.42 H H Me OMe CH943 Q.sub.42 H H OMe OMe CH944 Me H Q.sub.42 Me OMe CH945 Me H Q.sub.42 OMe OMe CH946 Q.sub.43 H COOMe Me OMe CH947 Q.sub.43 H COOMe OMe OMe CH948 Q.sub.43 H COOEt Me OMe CH949 Q.sub.43 H COOEt OMe OMe CH950 Q.sub.43 Me COOMe Me OMe CH951 Q.sub.43 Me COOMe OMe OMe CH952 Q.sub.43 Me COOEt Me OMe CH953 Q.sub.43 Me COOEt OMe OMe CH954 Q.sub.43 H H Me OMe CH955 Q.sub.43 H H OMe OMe CH956 Me H Q.sub.43 Me OMe CH957 Me H Q.sub.43 OMe OMe CH958 Q.sub.44 H COOMe Me OMe CH959 Q.sub.44 H COOMe OMe OMe CH960 Q.sub.44 H COOEt Me OMe CH961 Q.sub.44 H COOEt OMe OMe CH962 Q.sub.44 Me COOMe Me OMe CH963 Q.sub.44 Me COOMe OMe OMe CH964 Q.sub.44 Me COOEt Me OMe CH965 Q.sub.44 Me COOEt OMe OMe CH966 Q.sub.44 H H Me OMe CH967 Q.sub.44 H H OMe OMe CH968 Me H Q.sub.44 Me OMe CH969 Me H Q.sub.44 OMe OMe CH970 Q.sub.45 H COOMe Me OMe CH971 Q.sub.45 H COOMe OMe OMe CH972 Q.sub.45 H COOEt Me OMe CH973 Q.sub.45 H COOEt OMe OMe CH974 Q.sub.45 Me COOMe Me OMe CH975 Q.sub.45 Me COOMe OMe OMe CH976 Q.sub.45 Me COOEt Me OMe CH977 Q.sub.45 Me COOEt OMe OMe CH978 Q.sub.45 H H Me OMe CH979 Q.sub.45 H H OMe OMe CH980 Me H Q.sub.45 Me OMe CH981 Me H Q.sub.45 OMe OMe CH982 Q.sub.46 H COOMe Me OMe CH983 Q.sub.46 H COOMe OMe OMe CH984 Q.sub.46 H COOEt Me OMe CH985 Q.sub.46 H COOEt OMe OMe CH986 Q.sub.46 Me COOMe Me OMe CH987 Q.sub.46 Me COOMe OMe OMe CH988 Q.sub.46 Me COOEt Me OMe CH989 Q.sub.46 Me COOEt OMe OMe CH990 Q.sub.46 H H Me OMe CH991 Q.sub.46 H H OMe OMe CH992 Me H Q.sub.46 Me OMe CH993 Me H Q.sub.46 OMe OMe CH994 Q.sub.47 H COOMe Me OMe CH995 Q.sub.47 H COOMe OMe OMe CH996 Q.sub.47 H COOEt Me OMe CH997 Q.sub.47 H COOEt OMe OMe CH998 Q.sub.47 Me COOMe Me OMe CH999 Q.sub.47 Me COOMe OMe OMe CH1000 Q.sub.47 Me COOEt Me OMe CH1001 Q.sub.47 Me COOEt OMe OMe CH1002 Q.sub.47 H H Me OMe CH1003 Q.sub.47 H H OMe OMe CH1004 Me H Q.sub.47 Me OMe CH1005 Me H Q.sub.47 OMe OMe CH2001 Q.sub.48 H COOMe Me Me CH2002 Q.sub.48 H COOMe Me OMe CH2003 Q.sub.48 H COOMe OMe OMe CH2004 Q.sub.48 H COOEt Me OMe CH2005 Q.sub.48 H COOEt OMe OMe CH2006 Q.sub.48 Me COOMe Me Me CH2007 Q.sub.48 Me COOMe Me OMe CH2008 Q.sub.48 Me COOMe OMe OMe CH2009 Q.sub.48 Me COOEt Me OMe CH2010 Q.sub.48 Me COOEt OMe OMe CH2011 Q.sub.48 H H Me OMe CH2012 Q.sub.48 H H OMe OMe CH2013 Me H Q.sub.48 Me OMe CH2014 Me H Q.sub.48 OMe OMe CH2015 Q.sub.49 H COOMe Me Me CH2016 Q.sub.49 H COOMe Me OMe CH2017 Q.sub.49 H COOMe OMe OMe CH2018 Q.sub.49 H COOEt Me OMe CH2019 Q.sub.49 H COOEt OMe OMe CH2020 Q.sub.49 Me COOMe Me Me CH2021 Q.sub.49 Me COOMe Me OMe CH2022 Q.sub.49 Me COOMe OMe OMe CH2023 Q.sub.49 Me COOEt Me OMe CH2024 Q.sub.49 Me COOEt OMe OMe CH2025 Q.sub.49 H H Me OMe CH2026 Q.sub.49 H H OMe OMe CH2027 Me H Q.sub.49 Me OMe CH2028 Me H Q.sub.49 OMe OMe CH2029 Q.sub.50 H COOMe Me Me CH2030 Q.sub.50 H COOMe Me OMe CH2031 Q.sub.50 H COOMe OMe OMe CH2032 Q.sub.50 H COOEt Me OMe CH2033 Q.sub.50 H COOEt OMe OMe CH2034 Q.sub.50 Me COOMe Me Me CH2035 Q.sub.50 Me COOMe Me OMe CH2036 Q.sub.50 Me COOMe OMe OMe CH2037 Q.sub.50 Me COOEt Me OMe CH2038 Q.sub.50 Me COOEt OMe OMe CH2039 Q.sub.50 H H Me OMe CH2040 Q.sub.50 H H OMe OMe CH2041 Me H Q.sub.50 Me OMe CH2042 Me H Q.sub.50 OMe OMe CH2043 Q.sub.51 H COOMe Me Me CH2044 Q.sub.51 H COOMe Me OMe CH2045 Q.sub.51 H COOMe OMe OMe CH2046 Q.sub.51 H COOEt Me OMe CH2047 Q.sub.51 H COOEt OMe OMe CH2048 Q.sub.51 Me COOMe Me Me CH2049 Q.sub.51 Me COOMe Me OMe CH2050 Q.sub.51 Me COOMe OMe OMe CH2051 Q.sub.51 Me COOEt Me OMe CH2052 Q.sub.51 Me COOEt OMe OMe CH2053 Q.sub.51 H H Me OMe CH2054 Q.sub.51 H H OMe OMe CH2055 Me H Q.sub.51 Me OMe CH2056 Me H Q.sub.51 OMe OMe CH2057 Q.sub.52 H COOMe Me Me CH2058 Q.sub.52 H COOMe Me OMe CH2059 Q.sub.52 H COOMe OMe OMe CH2060 Q.sub.52 H COOEt Me OMe CH2061 Q.sub.52 H COOEt OMe OMe CH2062 Q.sub.52 Me COOMe Me Me CH2063 Q.sub.52 Me COOMe Me OMe CH2064 Q.sub.52 Me COOMe OMe OMe CH2065 Q.sub.52 Me COOEt Me OMe CH2066 Q.sub.52 Me COOEt OMe OMe CH2067 Q.sub.52 H H Me OMe CH2068 Q.sub.52 H H OMe OMe CH2069 Me H Q.sub.52 Me OMe CH2070 Me H Q.sub.52 OMe OMe CH2071 Q.sub.53 H COOMe Me Me CH2072 Q.sub.53 H COOMe Me OMe CH2073 Q.sub.53 H COOMe OMe OMe CH2074 Q.sub.53 H COOMe Me OMe N2075 Q.sub.53 H COOMe OMe OMe N2076 Q.sub.53 H COOEt Me Me CH2077 Q.sub.53 H COOEt Me OMe CH2078 Q.sub.53 H COOEt OMe OMe CH2079 Q.sub.53 H COOEt Me OMe N2080 Q.sub.53 H COOEt OMe OMe N2081 Q.sub.53 Me COOMe Me Me CH2082 Q.sub.53 Me COOMe Me OMe CH2083 Q.sub.53 Me COOMe OMe OMe CH2084 Q.sub.53 Me COOMe Me OMe N2085 Q.sub.53 Me COOEt Me OMe CH2086 Q.sub.53 Me COOEt OMe OMe CH2087 Q.sub.53 Me COOEt Me OMe N2088 Q.sub.53 H CN Me OMe CH2089 Q.sub.53 H CN OMe OMe CH2090 Q.sub.53 H CN Me OMe N2091 Q.sub.53 H H Me OMe CH2092 Q.sub.53 H H OMe OMe CH2093 Q.sub.53 H H Me OMe N2094 Me H Q.sub.53 Me Me CH2095 Me H Q.sub.53 Me OMe CH2096 Me H Q.sub.53 OMe OMe CH2097 Me H Q.sub.53 Me OMe N2098 Me H Q.sub.53 OMe OMe N2099 Q.sub.54 H COOMe Me Me CH2100 Q.sub.54 H COOMe Me OMe CH2101 Q.sub.54 H COOMe OMe OMe CH2102 Q.sub.54 H COOEt Me OMe CH2103 Q.sub.54 H COOEt OMe OMe CH2104 Q.sub.54 Me COOMe Me Me CH2105 Q.sub.54 Me COOMe Me OMe CH2106 Q.sub.54 Me COOMe OMe OMe CH2107 Q.sub.54 Me COOEt Me OMe CH2108 Q.sub.54 Me COOEt OMe OMe CH2109 Q.sub.54 H H Me OMe CH2110 Q.sub.54 H H OMe OMe CH2111 Me H Q.sub.54 Me OMe CH2112 Me H Q.sub.54 OMe OMe CH2113 Q.sub.55 H COOMe Me Me CH2114 Q.sub.55 H COOMe Me OMe CH2115 Q.sub.55 H COOMe OMe OMe CH2116 Q.sub.55 H COOEt Me OMe CH2117 Q.sub.55 H COOEt OMe OMe CH2118 Q.sub.55 Me COOMe Me Me CH2119 Q.sub.55 Me COOMe Me OMe CH2120 Q.sub.55 Me COOMe OMe OMe CH2121 Q.sub.55 Me COOEt Me OMe CH2122 Q.sub.55 Me COOEt OMe OMe CH2123 Q.sub.55 H H Me OMe CH2124 Q.sub.55 H H OMe OMe CH2125 Me H Q.sub.55 Me OMe CH2126 Me H Q.sub.55 OMe OMe CH2127 Q.sub.56 H COOMe Me Me CH2128 Q.sub.56 H COOMe Me OMe CH2129 Q.sub.56 H COOMe OMe OMe CH2130 Q.sub.56 H COOEt Me OMe CH2131 Q.sub.56 H COOEt OMe OMe CH2132 Q.sub.56 Me COOMe Me Me CH2133 Q.sub.56 Me COOMe Me OMe CH2134 Q.sub.56 Me COOMe OMe OMe CH2135 Q.sub.56 Me COOEt Me OMe CH2136 Q.sub.56 Me COOEt OMe OMe CH2137 Q.sub.56 H H Me OMe CH2138 Q.sub.56 H H OMe OMe CH2139 Me H Q.sub.56 Me OMe CH2140 Me H Q.sub.56 OMe OMe CH2141 Q.sub.57 H COOMe Me Me CH2142 Q.sub.57 H COOMe Me OMe CH2143 Q.sub.57 H COOMe OMe OMe CH2144 Q.sub.57 H COOEt Me OMe CH2145 Q.sub.57 H COOEt OMe OMe CH2146 Q.sub.57 Me COOMe Me Me CH2147 Q.sub.57 Me COOMe Me OMe CH2148 Q.sub.57 Me COOMe OMe OMe CH2149 Q.sub.57 Me COOEt Me OMe CH2150 Q.sub.57 Me COOEt OMe OMe CH2151 Q.sub.57 H H Me OMe CH2152 Q.sub.57 H H OMe OMe CH2153 Me H Q.sub.57 Me OMe CH2154 Me H Q.sub.57 OMe OMe C2155 Q.sub.58 H COOMe Me Me CH2156 Q.sub.58 H COOMe Me OMe CH2157 Q.sub.58 H COOMe OMe OMe CH2158 Q.sub.58 H COOEt Me OMe CH2159 Q.sub.58 H COOEt OMe OMe CH2160 Q.sub.58 Me COOMe Me Me CH2161 Q.sub.58 Me COOMe Me OMe CH2162 Q.sub.58 Me COOMe OMe OMe CH2163 Q.sub.58 Me COOEt Me OMe CH2164 Q.sub.58 Me COOEt OMe OMe CH2165 Q.sub.58 H H Me OMe CH2166 Q.sub.58 H H OMe OMe CH2167 Me H Q.sub.58 Me OMe CH2168 Me H Q.sub.58 OMe OMe CH2169 Q.sub.59 H COOMe Me Me CH2170 Q.sub.59 H COOMe Me OMe CH2171 Q.sub.59 H COOMe OMe OMe CH2172 Q.sub.59 H COOEt Me OMe CH2173 Q.sub.59 H COOEt OMe OMe CH2174 Q.sub.59 Me COOMe Me Me CH2175 Q.sub.59 Me COOMe Me OMe CH2176 Q.sub.59 Me COOMe OMe OMe CH2177 Q.sub.59 Me COOEt Me OMe CH2178 Q.sub.59 Me COOEt OMe OMe CH2179 Q.sub.59 H H Me OMe CH2180 Q.sub.59 H H OMe OMe CH2181 Me H Q.sub.59 Me OMe CH2182 Me H Q.sub.59 OMe OMe CH2183 Q.sub.60 H COOMe Me Me CH2184 Q.sub.60 H COOMe Me OMe CH2185 Q.sub.60 H COOMe OMe OMe CH2186 Q.sub.60 H COOMe Me OMe N2187 Q.sub.60 H COOMe OMe OMe N2188 Q.sub.60 H COOEt Me Me CH2189 Q.sub.60 H COOEt Me OMe CH2190 Q.sub.60 H COOEt OMe OMe CH2191 Q.sub.60 H COOEt Me OMe N2192 Q.sub.60 H COOEt OMe OMe N2193 Q.sub.60 Me COOMe Me Me CH2194 Q.sub.60 Me COOMe Me OMe CH2195 Q.sub.60 Me COOMe OMe OMe CH2196 Q.sub.60 Me COOMe Me OMe N2197 Q.sub.60 Me COOEt Me OMe CH2198 Q.sub.60 Me COOEt OMe OMe CH2199 Q.sub.60 Me COOEt Me OMe N2200 Q.sub.60 H CN Me OMe CH2201 Q.sub.60 H CN OMe OMe CH2202 Q.sub.60 H CN Me OMe N2203 Q.sub.60 H H Me OMe CH2204 Q.sub.60 H H OMe OMe CH2205 Q.sub.60 H H Me OMe N2206 Me H Q.sub.60 Me Me CH2207 Me H Q.sub.60 Me OMe CH2208 Me H Q.sub.60 OMe OMe CH2209 Me H Q.sub.60 Me OMe N2210 Me H Q.sub.60 OMe OMe N2211 Q.sub.61 H COOMe Me Me CH2212 Q.sub.61 H COOMe Me OMe CH2213 Q.sub.61 H COOMe OMe OMe CH2214 Q.sub.61 H COOEt Me OMe CH2215 Q.sub.61 H COOEt OMe OMe CH2216 Q.sub.61 Me COOMe Me Me CH2217 Q.sub.61 Me COOMe Me OMe CH2218 Q.sub.61 Me COOMe OMe OMe CH2219 Q.sub.61 Me COOEt Me OMe CH2220 Q.sub.61 Me COOEt OMe OMe CH2221 Q.sub.61 H H Me OMe CH2222 Q.sub.61 H H OMe OMe CH2223 Me H Q.sub.61 Me OMe CH2234 Me H Q.sub.61 OMe OMe CH2225 Q.sub.62 H COOMe Me Me CH2226 Q.sub.62 H COOMe Me OMe CH2227 Q.sub.62 H COOMe OMe OMe CH2228 Q.sub.62 H COOEt Me OMe CH2229 Q.sub.62 H COOEt OMe OMe CH2230 Q.sub.62 Me COOMe Me Me CH2231 Q.sub.62 Me COOMe Me OMe CH2232 Q.sub.62 Me COOMe OMe OMe CH2233 Q.sub.62 Me COOEt Me OMe CH2234 Q.sub.62 Me COOEt OMe OMe CH2235 Q.sub.62 H H Me OMe CH2236 Q.sub.62 H H OMe OMe CH2237 Me H Q.sub.62 Me OMe CH2238 Me H Q.sub.62 OMe OMe CH2239 Q.sub.63 H COOMe Me Me CH2240 Q.sub.63 H COOMe Me OMe CH2241 Q.sub.63 H COOMe OMe OMe CH2242 Q.sub.63 H COOEt Me OMe CH2243 Q.sub.63 H COOEt OMe OMe CH2244 Q.sub.63 Me COOMe Me Me CH2245 Q.sub.63 Me COOMe Me OMe CH2246 Q.sub.63 Me COOMe OMe OMe CH2247 Q.sub.63 Me COOEt Me OMe CH2248 Q.sub.63 Me COOEt OMe OMe CH2249 Q.sub.63 H H Me OMe CH2250 Q.sub.63 H H OMe OMe CH2251 Me H Q.sub.63 Me OMe CH2252 Me H Q.sub.63 OMe OMe CH2253 Q.sub.64 H COOMe Me Me CH2254 Q.sub.64 H COOMe Me OMe CH2255 Q.sub.64 H COOMe OMe OMe CH2256 Q.sub.64 H COOEt Me OMe CH2257 Q.sub.64 H COOEt OMe OMe CH2258 Q.sub.64 Me COOMe Me Me CH2259 Q.sub.64 Me COOMe Me OMe CH2260 Q.sub.64 Me COOMe OMe OMe CH2261 Q.sub.64 Me COOEt Me OMe CH2262 Q.sub.64 Me COOEt OMe OMe CH2263 Q.sub.64 H H Me OMe CH2264 Q.sub.64 H H OMe OMe CH2265 Me H Q.sub.64 Me OMe CH2266 Me H Q.sub.64 OMe OMe CH2267 Q.sub.65 H COOMe Me Me CH2268 Q.sub.65 H COOMe Me OMe CH2269 Q.sub.65 H COOMe OMe OMe CH2270 Q.sub.65 H COOMe Me OMe N2271 Q.sub.65 H COOMe OMe OMe N2272 Q.sub.65 H COOEt Me Me CH2273 Q.sub.65 H COOEt Me OMe CH2274 Q.sub.65 H COOEt OMe OMe CH2275 Q.sub.65 H COOEt Me OMe N2276 Q.sub.65 H COOEt OMe OMe N2277 Q.sub.65 Me COOMe Me Me CH2278 Q.sub.65 Me COOMe Me OMe CH2279 Q.sub.65 Me COOMe OMe OMe CH2280 Q.sub.65 Me COOMe Me OMe N2281 Q.sub.65 Me COOEt Me OMe CH2282 Q.sub.65 Me COOEt OMe OMe CH2283 Q.sub. 65 Me COOEt Me OMe N2284 Q.sub.65 H CN Me OMe CH2285 Q.sub.65 H CN OMe OMe CH2286 Q.sub.65 H CN Me OMe N2287 Q.sub.65 H H Me OMe CH2288 Q.sub.65 H H OMe OMe CH2289 Q.sub.65 H H Me OMe N2290 Me H Q.sub.65 Me Me CH2291 Me H Q.sub.65 Me OMe CH2292 Me H Q.sub.65 OMe OMe CH2293 Me H Q.sub.65 Me OMe N2294 Me H Q.sub.65 OMe OMe N2295 Q.sub.66 H COOMe Me Me CH2296 Q.sub.66 H COOMe Me OMe CH2297 Q.sub.66 H COOMe OMe OMe CH2298 Q.sub.66 H COOEt Me OMe CH2299 Q.sub.66 H COOEt OMe OMe CH2300 Q.sub.66 Me COOMe Me Me CH2301 Q.sub.66 Me COOMe Me OMe CH2302 Q.sub.66 Me COOMe OMe OMe CH2303 Q.sub.66 Me COOEt Me OMe CH2304 Q.sub.66 Me COOEt OMe OMe CH2305 Q.sub.66 H H Me OMe CH2306 Q.sub.66 H H OMe OMe CH2307 Me H Q.sub.66 Me OMe CH2308 Me H Q.sub.66 OMe OMe CH2309 Q.sub.67 H COOMe Me Me CH2310 Q.sub.67 H COOMe Me OMe CH2311 Q.sub.67 H COOMe OMe OMe CH2312 Q.sub.67 H COOEt Me OMe CH2313 Q.sub.67 H COOEt OMe OMe CH2314 Q.sub.67 Me COOMe Me Me CH2315 Q.sub.67 Me COOMe Me OMe CH2316 Q.sub.67 Me COOMe OMe OMe CH2317 Q.sub.67 Me COOEt Me OMe CH2318 Q.sub.67 Me COOEt OMe OMe CH2319 Q.sub.67 H H Me OMe CH2320 Q.sub.67 H H OMe OMe CH2321 Me H Q.sub.67 Me OMe CH2322 Me H Q.sub.67 OMe OMe CH2323 Q.sub.68 H COOMe Me Me CH2324 Q.sub.68 H COOMe Me OMe CH2325 Q.sub.68 H COOMe OMe OMe CH2326 Q.sub.68 H COOMe Me OMe N2327 Q.sub.68 H COOMe OMe OMe N2328 Q.sub.68 H COOEt Me Me CH2329 Q.sub.68 H COOEt Me OMe CH2330 Q.sub.68 H COOEt OMe OMe CH2331 Q.sub.68 H COOEt Me OMe N2332 Q.sub.68 H COOEt OMe OMe N2333 Q.sub.68 Me COOMe Me Me CH2334 Q.sub.68 Me COOMe Me OMe CH2335 Q.sub.68 Me COOMe OMe OMe CH2336 Q.sub.68 Me COOMe Me OMe N2337 Q.sub.68 Me COOEt Me OMe CH2338 Q.sub.68 Me COOEt OMe OMe CH2339 Q.sub.68 Me COOEt Me OMe N2340 Q.sub.68 H CN Me OMe CH2341 Q.sub.68 H CN OMe OMe CH2342 Q.sub.68 H CN Me OMe N2343 Q.sub.68 H H Me OMe CH2344 Q.sub.68 H H OMe OMe CH2345 Q.sub.68 H H Me OMe N2346 Me H Q.sub.68 Me Me CH2347 Me H Q.sub.68 Me OMe CH2348 Me H Q.sub.68 OMe OMe CH2349 Me H Q.sub.68 Me OMe N2350 Me H Q.sub.68 OMe OMe N2351 Q.sub.69 H COOMe Me Me CH2352 Q.sub.69 H COOMe Me OMe CH2353 Q.sub.69 H COOMe OMe OMe CH2354 Q.sub.69 H COOEt Me OMe CH2355 Q.sub.69 H COOEt OMe OMe CH2356 Q.sub.69 Me COOMe Me Me CH2357 Q.sub.69 Me COOMe Me OMe CH2358 Q.sub.69 Me COOMe OMe OMe CH2359 Q.sub.69 Me COOEt Me OMe CH2360 Q.sub.69 Me COOEt OMe OMe CH2361 Q.sub.69 H H Me OMe CH2362 Q.sub.69 H H OMe OMe CH2363 Me H Q.sub.69 Me OMe CH2364 Me H Q.sub.69 OMe OMe CH2365 Q.sub.70 H COOMe Me Me CH2366 Q.sub.70 H COOMe Me OMe CH2367 Q.sub.70 H COOMe OMe OMe CH2368 Q.sub.70 H COOEt Me OMe CH2369 Q.sub.70 H COOEt OMe OMe CH2370 Q.sub.70 Me COOMe Me Me CH2371 Q.sub.70 Me COOMe Me OMe CH2372 Q.sub.70 Me COOMe OMe OMe CH2373 Q.sub.70 Me COOEt Me OMe CH2374 Q.sub.70 Me COOEt OMe OMe CH2375 Q.sub.70 H H Me OMe CH2376 Q.sub.70 H H OMe OMe CH2377 Me H Q.sub.70 Me OMe CH2378 Me H Q.sub.70 OMe OMe CH2379 Q.sub.71 H COOMe Me Me CH2380 Q.sub.71 H COOMe Me OMe CH2381 Q.sub.71 H COOMe OMe OMe CH2382 Q.sub.71 H COOMe Me OMe N2383 Q.sub.71 H COOMe OMe OMe N2384 Q.sub.71 H COOEt Me Me CH2385 Q.sub.71 H COOEt Me OMe CH2386 Q.sub.71 H COOEt OMe OMe CH2387 Q.sub.71 H COOEt Me OMe N2388 Q.sub.71 H COOEt OMe OMe N2389 Q.sub.71 Me COOMe Me Me CH2390 Q.sub.71 Me COOMe Me OMe CH2391 Q.sub.71 Me COOMe OMe OMe CH2392 Q.sub.71 Me COOMe Me OMe N2393 Q.sub.71 Me COOEt Me OMe CH2394 Q.sub.71 Me COOEt OMe OMe CH2395 Q.sub.71 Me COOEt Me OMe N2396 Q.sub.71 H CN Me OMe CH2397 Q.sub.71 H CN OMe OMe CH2398 Q.sub.71 H CN Me OMe N2399 Q.sub.71 H H Me OMe CH2400 Q.sub.71 H H OMe OMe CH2401 Q.sub.71 H H Me OMe N2402 Me H Q.sub.71 Me Me CH2403 Me H Q.sub.71 Me OMe CH2404 Me H Q.sub.71 OMe OMe CH2405 Me H Q.sub.71 Me OMe N2406 Me H Q.sub.71 OMe OMe N2407 Q.sub.72 H COOMe Me Me CH2408 Q.sub.72 H COOMe Me OMe CH2409 Q.sub.72 H COOMe OMe OMe CH2410 Q.sub.72 H COOEt Me OMe CH2411 Q.sub.72 H COOEt OMe OMe CH2412 Q.sub.72 Me COOMe Me Me CH2413 Q.sub.72 Me COOMe Me OMe CH2414 Q.sub.72 Me COOMe OMe OMe CH2415 Q.sub.72 Me COOEt Me OMe CH2416 Q.sub.72 Me COOEt OMe OMe CH2417 Q.sub.72 H H Me OMe CH2418 Q.sub.72 H H OMe OMe CH2419 Me H Q.sub.72 Me OMe CH2420 Me H Q.sub.72 OMe OMe CH2421 Q.sub.73 H COOMe Me Me CH2422 Q.sub.73 H COOMe Me OMe CH2423 Q.sub.73 H COOMe OMe OMe CH2424 Q.sub.73 H COOEt Me OMe CH2425 Q.sub.73 H COOEt OMe OMe CH2426 Q.sub.73 Me COOMe Me Me CH2427 Q.sub.73 Me COOMe Me OMe CH2428 Q.sub.73 Me COOMe OMe OMe CH2429 Q.sub.73 Me COOEt Me OMe CH2430 Q.sub.73 Me COOEt OMe OMe CH2431 Q.sub.73 H H Me OMe CH2432 Q.sub.73 H H OMe OMe CH2433 Me H Q.sub.73 Me OMe CH2434 Me H Q.sub.73 OMe OMe CH2435 Q.sub.74 H COOMe Me Me CH2436 Q.sub.74 H COOMe Me OMe CH2437 Q.sub.74 H COOMe OMe OMe CH2438 Q.sub.74 H COOEt Me OMe CH2439 Q.sub.74 H COOEt OMe OMe CH2440 Q.sub.74 Me COOMe Me Me CH2441 Q.sub.74 Me COOMe Me OMe CH2442 Q.sub.74 Me COOMe OMe OMe CH2443 Q.sub.74 Me COOEt Me OMe CH2444 Q.sub.74 Me COOEt OMe OMe CH2445 Q.sub.74 H H Me OMe CH2446 Q.sub.74 H H OMe OMe CH2447 Me H Q.sub.74 Me OMe CH2448 Me H Q.sub.74 OMe OMe CH2449 Q.sub.75 H COOMe Me Me CH2450 Q.sub.75 H COOMe Me OMe CH2451 Q.sub.75 H COOMe OMe OMe CH2452 Q.sub.75 H COOEt OMe OMe CH2453 Q.sub.75 H COOEt OMe OMe CH2454 Q.sub.75 Me COOMe Me Me CH2455 Q.sub.75 Me COOMe Me OMe CH2456 Q.sub.75 Me COOMe OMe OMe CH2457 Q.sub.75 Me COOEt Me OMe CH2458 Q.sub.75 Me COOEt OMe OMe CH2459 Q.sub.75 H H Me OMe CH2460 Q.sub.75 H H OMe OMe CH2461 Me H Q.sub.75 Me OMe CH2462 Me H Q.sub.75 OMe OMe CH2463 Q.sub.76 H COOMe Me Me CH2464 Q.sub.76 H COOMe Me OMe CH2465 Q.sub.76 H COOMe OMe OMe CH2466 Q.sub.76 H COOEt Me OMe CH2467 Q.sub.76 H COOEt OMe OMe CH2468 Q.sub.76 Me COOMe Me Me CH2469 Q.sub.76 Me COOMe Me OMe CH2470 Q.sub.76 Me COOMe OMe OMe CH2471 Q.sub.76 Me COOEt Me OMe CH2472 Q.sub.76 Me COOEt OMe OMe CH2473 Q.sub.76 H H Me OMe CH2474 Q.sub.76 H H OMe OMe CH2475 Me H Q.sub.76 Me OMe CH2476 Me H Q.sub.76 OMe OMe CH2477 Q.sub.77 H COOMe Me Me CH2478 Q.sub.77 H COOMe Me OMe CH2479 Q.sub.77 H COOMe OMe OMe CH2480 Q.sub.77 H COOEt OMe OMe CH2481 Q.sub.77 H COOEt OMe OMe CH2482 Q.sub.77 Me COOMe Me Me CH2483 Q.sub. 77 Me COOMe Me OMe CH2484 Q.sub.77 Me COOMe OMe OMe CH2485 Q.sub.77 Me COOEt Me OMe CH2486 Q.sub.77 Me COOEt OMe OMe CH2487 Q.sub.77 H H Me OMe CH2488 Q.sub.77 H H OMe OMe CH2489 Me H Q.sub.77 Me OMe CH2490 Me H Q.sub.77 OMe OMe CH2491 Q.sub.78 H COOMe Me Me CH2492 Q.sub.78 H COOMe Me OMe CH2493 Q.sub.78 H COOMe OMe OMe CH2494 Q.sub.78 H COOEt OMe OMe CH2495 Q.sub.78 H COOEt OMe OMe CH2496 Q.sub.78 Me COOMe Me Me CH2497 Q.sub.78 Me COOMe Me OMe CH2498 Q.sub.78 Me COOMe OMe OMe CH2499 Q.sub.78 Me COOEt Me OMe CH2500 Q.sub.78 Me COOEt OMe OMe CH2501 Q.sub.78 H H Me OMe CH2502 Q.sub.78 H H OMe OMe CH2503 Me H Q.sub.78 Me OMe CH2504 Me H Q.sub.78 OMe OMe CH2505 Q.sub.79 H COOMe Me Me CH2506 Q.sub.79 H COOMe Me OMe CH2507 Q.sub.79 H COOMe OMe OMe CH2508 Q.sub.79 H COOEt Me OMe CH2509 Q.sub.79 H COOEt OMe OMe CH2510 Q.sub.79 Me COOMe Me Me CH2511 Q.sub.79 Me COOMe Me OMe CH2512 Q.sub.79 Me COOMe OMe OMe CH2513 Q.sub.79 Me COOEt Me OMe CH2514 Q.sub.79 Me COOEt OMe OMe CH2515 Q.sub.79 H H Me OMe CH2516 Q.sub.79 H H OMe OMe CH2517 Me H Q.sub.79 Me OMe CH2518 Me H Q.sub.79 OMe OMe CH2519 Q.sub.80 H COOMe Me Me CH2520 Q.sub.80 H COOMe Me OMe CH2521 Q.sub.80 H COOMe OMe OMe CH2522 Q.sub.80 H COOEt Me OMe CH2523 Q.sub.80 H COOEt OMe OMe CH2524 Q.sub.80 Me COOMe Me Me CH2525 Q.sub.80 Me COOMe Me OMe CH2526 Q.sub.80 Me COOMe OMe OMe CH2527 Q.sub.80 Me COOEt Me OMe CH2528 Q.sub.80 Me COOEt OMe OMe CH2529 Q.sub.80 H H Me OMe CH2530 Q.sub.80 H H OMe OMe CH2531 Me H Q.sub.80 Me OMe CH2532 Me H Q.sub.80 OMe OMe CH2533 Q.sub.81 H COOMe Me Me CH2534 Q.sub.81 H COOMe Me OMe CH2535 Q.sub.81 H COOMe OMe OMe CH2536 Q.sub.81 H COOEt Me OMe CH2537 Q.sub.81 H COOEt OMe OMe CH2538 Q.sub.81 Me COOMe Me Me CH2539 Q.sub.81 Me COOMe Me OMe CH2540 Q.sub.81 Me COOMe OMe OMe CH2541 Q.sub.81 Me COOEt Me OMe CH2542 Q.sub.81 Me COOEt OMe OMe CH2543 Q.sub.81 H H Me OMe CH2544 Q.sub.81 H H OMe OMe CH2545 Me H Q.sub.81 Me OMe CH2546 Me H Q.sub.81 OMe OMe CH2547 Q.sub.82 H COOMe Me Me CH2548 Q.sub.82 H COOMe Me OMe CH2549 Q.sub.82 H COOMe OMe OMe CH2550 Q.sub.82 H COOEt Me OMe CH2551 Q.sub.82 H COOEt OMe OMe CH2552 Q.sub.82 Me COOMe Me Me CH2553 Q.sub.82 Me COOMe Me OMe CH2554 Q.sub.82 Me COOMe OMe OMe CH2555 Q.sub.82 Me COOEt Me OMe CH2556 Q.sub.82 Me COOEt OMe OMe CH2557 Q.sub.82 H H Me OMe CH2558 Q.sub.82 H H OMe OMe CH2559 Me H Q.sub.82 Me OMe CH2560 Me H Q.sub.82 OMe OMe CH2561 Q.sub.83 H COOMe Me Me CH2562 Q.sub.83 H COOMe Me OMe CH2563 Q.sub.83 H COOMe OMe OMe CH2564 Q.sub.83 H COOEt Me OMe CH2565 Q.sub.83 H COOEt OMe OMe CH2566 Q.sub.83 Me COOMe Me Me CH2567 Q.sub.83 Me COOMe Me OMe CH2568 Q.sub.83 Me COOMe OMe OMe CH2569 Q.sub.83 Me COOEt Me OMe CH2570 Q.sub.83 Me COOEt OMe OMe CH2571 Q.sub.83 H H Me OMe CH2572 Q.sub.83 H H OMe OMe CH2573 Me H Q.sub.83 Me OMe CH2574 Me H Q.sub.83 OMe OMe CH2575 Q.sub.84 H COOMe Me Me CH2576 Q.sub.84 H COOMe Me OMe CH2577 Q.sub.84 H COOMe OMe OMe CH2578 Q.sub.84 H COOEt Me OMe CH2579 Q.sub.84 H COOEt OMe OMe CH2580 Q.sub.84 Me COOMe Me Me CH2581 Q.sub.84 Me COOMe Me OMe CH2582 Q.sub.84 Me COOMe OMe OMe CH2583 Q.sub.84 Me COOEt Me OMe CH2584 Q.sub.84 Me COOEt OMe OMe CH2585 Q.sub.84 H H Me OMe CH2586 Q.sub.84 H H OMe OMe CH2587 Me H Q.sub.84 Me OMe CH2588 Me H Q.sub.84 OMe OMe CH2589 Q.sub.85 H COOMe Me Me CH2590 Q.sub.85 H COOMe Me OMe CH2591 Q.sub.85 H COOMe OMe OMe CH2592 Q.sub.85 H COOEt Me OMe CH2593 Q.sub.85 H COOEt OMe OMe CH2594 Q.sub.85 Me COOMe Me Me CH2595 Q.sub.85 Me COOMe Me OMe CH2596 Q.sub.85 Me COOMe OMe OMe CH2597 Q.sub.85 Me COOEt Me OMe CH2598 Q.sub.85 Me COOEt OMe OMe CH2599 Q.sub.85 H H Me OMe CH2600 Q.sub.85 H H OMe OMe CH2601 Me H Q.sub.85 Me OMe CH2602 Me H Q.sub.85 OMe OMe CH2603 Q.sub.86 H COOMe Me Me CH2604 Q.sub.86 H COOMe Me OMe CH2605 Q.sub.86 H COOMe OMe OMe CH2606 Q.sub.86 H COOEt Me OMe CH2607 Q.sub.86 H COOEt OMe OMe CH2608 Q.sub.86 Me COOMe Me Me CH2609 Q.sub.86 Me COOMe Me OMe CH2610 Q.sub.86 Me COOMe OMe OMe CH2611 Q.sub.86 Me COOEt Me OMe CH2612 Q.sub.86 Me COOEt OMe OMe CH2613 Q.sub.86 H H Me OMe CH2614 Q.sub.86 H H OMe OMe CH2615 Me H Q.sub.86 Me OMe CH2616 Me H Q.sub.86 OMe OMe CH2617 Q.sub.87 H COOMe Me Me CH2618 Q.sub.87 H COOMe Me OMe CH2619 Q.sub.87 H COOMe OMe OMe CH2620 Q.sub.87 H COOEt Me OMe CH2621 Q.sub.87 H COOEt OMe OMe CH2622 Q.sub.87 Me COOMe Me Me CH2623 Q.sub.87 Me COOMe Me OMe CH2624 Q.sub.87 Me COOMe OMe OMe CH2625 Q.sub.87 Me COOEt Me OMe CH2626 Q.sub. 87 Me COOEt OMe OMe CH2627 Q.sub.87 H H Me OMe CH2628 Q.sub.87 H H OMe OMe CH2629 Me H Q.sub.87 Me OMe CH2630 Me H Q.sub.87 OMe OMe CH2631 Q.sub.88 H COOMe Me Me CH2632 Q.sub.88 H COOMe Me OMe CH2633 Q.sub.88 H COOMe OMe OMe CH2634 Q.sub.88 H COOEt Me OMe CH2635 Q.sub.88 H COOEt OMe OMe CH2636 Q.sub.88 Me COOMe Me Me CH2637 Q.sub.88 Me COOMe Me OMe CH2638 Q.sub.88 Me COOMe OMe OMe CH2639 Q.sub.88 Me COOEt Me OMe CH2640 Q.sub.88 Me COOEt OMe OMe CH2641 Q.sub.88 H H Me OMe CH2642 Q.sub.88 H H OMe OMe CH2643 Me H Q.sub.88 Me OMe CH2644 Me H Q.sub.88 OMe OMe CH2645 Q.sub.89 H COOMe Me Me CH2646 Q.sub.89 H COOMe Me OMe CH2647 Q.sub.89 H COOMe OMe OMe CH2648 Q.sub.89 H COOEt Me OMe CH2649 Q.sub.89 H COOEt OMe OMe CH2650 Q.sub.89 Me COOMe Me Me CH2651 Q.sub.89 Me COOMe Me OMe CH2652 Q.sub.89 Me COOMe OMe OMe CH2653 Q.sub.89 Me COOEt Me OMe CH2654 Q.sub.89 Me COOEt OMe OMe CH2655 Q.sub.89 H H Me OMe CH2656 Q.sub.89 H H OMe OMe CH2657 Me H Q.sub.89 Me OMe CH2658 Me H Q.sub.89 OMe OMe CH2659 Q.sub.90 H COOMe Me Me CH2660 Q.sub.90 H COOMe Me OMe CH2661 Q.sub.90 H COOMe OMe OMe CH2662 Q.sub.90 H COOMe Me OMe N2663 Q.sub.90 H COOMe OMe OMe N2664 Q.sub.90 H COOEt Me Me CH2665 Q.sub.90 H COOEt Me OMe CH2666 Q.sub.90 H COOEt OMe OMe CH2667 Q.sub.90 H COOEt Me OMe N2668 Q.sub.90 H COOEt OMe OMe N2669 Q.sub.90 Me COOMe Me Me CH2670 Q.sub.90 Me COOMe Me OMe CH2671 Q.sub.90 Me COOMe OMe OMe CH2672 Q.sub.90 Me COOMe Me OMe N2673 Q.sub.90 Me COOEt Me OMe CH2674 Q.sub.90 Me COOEt OMe OMe CH2675 Q.sub.90 Me COOEt Me OMe N2676 Q.sub.90 H CN Me OMe CH2677 Q.sub.90 H CN OMe OMe CH2678 Q.sub.90 H CN Me OMe N2679 Q.sub.90 H H Me OMe CH2680 Q.sub.90 H H OMe OMe CH2681 Q.sub.90 H H Me OMe N2682 Me H Q.sub.90 Me Me CH2683 Me H Q.sub. 90 Me OMe CH2684 Me H Q.sub.90 OMe OMe CH2685 Me H Q.sub.90 Me OMe N2686 Me H Q.sub.90 OMe OMe N2687 Q.sub.91 H COOMe Me Me CH2688 Q.sub.91 H COOMe Me OMe CH2689 Q.sub.91 H COOMe OMe OMe CH2690 Q.sub.91 H COOEt Me OMe CH2691 Q.sub.91 H COOEt OMe OMe CH2692 Q.sub.91 Me COOMe Me Me CH2693 Q.sub.91 Me COOMe Me OMe CH2694 Q.sub.91 Me COOMe OMe OMe CH2695 Q.sub.91 Me COOEt Me OMe CH2696 Q.sub.91 Me COOEt OMe OMe CH2697 Q.sub.91 H H Me OMe CH2698 Q.sub.91 H H OMe OMe CH2699 Me H Q.sub.91 Me OMe CH2700 Me H Q.sub.91 OMe OMe CH2701 Q.sub.92 H COOMe Me Me CH2702 Q.sub.92 H COOMe Me OMe CH2703 Q.sub.92 H COOMe OMe OMe CH2704 Q.sub.92 H COOMe Me OMe N2705 Q.sub.92 H COOMe OMe OMe N2706 Q.sub.92 H COOEt Me Me CH2707 Q.sub.92 H COOEt Me OMe CH2708 Q.sub.92 H COOEt OMe OMe CH2709 Q.sub.92 H COOEt Me OMe N2710 Q.sub.92 H COOEt OMe OMe N2711 Q.sub.92 Me COOMe Me Me CH2712 Q.sub.92 Me COOMe Me OMe CH2713 Q.sub.92 Me COOMe OMe OMe CH2714 Q.sub.92 Me COOMe Me OMe N2715 Q.sub.92 Me COOEt Me OMe CH2716 Q.sub.92 Me COOEt OMe OMe CH2717 Q.sub.92 Me COOEt Me OMe N2718 Q.sub.92 H CN Me OMe CH2719 Q.sub.92 H CN OMe OMe CH2720 Q.sub.92 H CN Me OMe N2721 Q.sub.92 H H Me OMe CH2722 Q.sub.92 H H OMe OMe CH2723 Q.sub.92 H H Me OMe N2724 Me H Q.sub.92 Me Me CH2725 Me H Q.sub.92 Me OMe CH2726 Me H Q.sub.92 OMe OMe CH2727 Me H Q.sub.92 Me OMe N2728 Me H Q.sub.92 OMe OMe N2729 Q.sub.93 H COOMe Me Me CH2730 Q.sub.93 H COOMe Me OMe CH2731 Q.sub.93 H COOMe OMe OMe CH2732 Q.sub.93 H COOEt Me OMe CH2733 Q.sub.93 H COOEt OMe OMe CH2734 Q.sub.93 Me COOMe Me Me CH2735 Q.sub.93 Me COOMe Me OMe CH2736 Q.sub.93 Me COOMe OMe OMe CH2737 Q.sub.93 Me COOEt Me OMe CH2738 Q.sub.93 Me COOEt OMe OMe CH2739 Q.sub.93 H H Me OMe CH2740 Q.sub.93 H H OMe OMe CH2741 Me H Q.sub.93 Me OMe CH2742 Me H Q.sub.93 OMe OMe CH2743 Q.sub.94 H COOMe Me Me CH2744 Q.sub.94 H COOMe Me OMe CH2745 Q.sub.94 H COOMe OMe OMe CH2746 Q.sub.94 H COOEt Me OMe CH2747 Q.sub.94 H COOEt OMe OMe CH2748 Q.sub.94 Me COOMe Me Me CH2749 Q.sub.94 Me COOMe Me OMe CH2750 Q.sub.94 Me COOMe OMe OMe CH2751 Q.sub.94 Me COOEt Me OMe CH2752 Q.sub.94 Me COOEt OMe OMe CH2753 Q.sub.94 H H Me OMe CH2754 Q.sub.94 H H OMe OMe CH2755 Me H Q.sub.94 Me OMe CH2756 Me H Q.sub.94 OMe OMe CH2757 Q.sub.95 H COOMe Me Me CH2758 Q.sub.95 H COOMe Me OMe CH2759 Q.sub.95 H COOMe OMe OMe CH2760 Q.sub.95 H COOEt Me OMe CH2761 Q.sub.95 H COOEt OMe OMe CH2762 Q.sub.95 Me COOMe Me Me CH2763 Q.sub.95 Me COOMe Me OMe CH2764 Q.sub.95 Me COOMe OMe OMe CH2765 Q.sub.95 Me COOEt Me OMe CH2766 Q.sub.95 Me COOEt OMe OMe CH2767 Q.sub.95 H H Me OMe CH2768 Q.sub.95 H H OMe OMe CH2769 Me H Q.sub.95 Me OMe CH2770 Me H Q.sub.95 OMe OMe CH2771 Q.sub.96 H COOMe Me Me CH2772 Q.sub.96 H COOMe Me OMe CH2773 Q.sub.96 H COOMe OMe OMe CH2774 Q.sub.96 H COOEt Me OMe CH2775 Q.sub.96 H COOEt OMe OMe CH2776 Q.sub.96 Me COOMe Me Me CH2777 Q.sub.96 Me COOMe Me OMe CH2778 Q.sub.96 Me COOMe OMe OMe CH2779 Q.sub.96 Me COOEt Me OMe CH2780 Q.sub.96 Me COOEt OMe OMe CH2781 Q.sub.96 H H Me OMe CH2782 Q.sub.96 H H OMe OMe CH2783 Me H Q.sub.96 Me OMe CH2784 Me H Q.sub.96 OMe OMe CH2785 Q.sub.97 H COOMe Me Me CH2786 Q.sub.97 H COOMe Me OMe CH2787 Q.sub.97 H COOMe OMe OMe CH2788 Q.sub.97 H COOEt Me OMe CH2789 Q.sub.97 H COOEt OMe OMe CH2790 Q.sub.97 Me COOMe Me Me CH2791 Q.sub.97 Me COOMe Me OMe CH2792 Q.sub.97 Me COOMe OMe OMe CH2793 Q.sub.97 Me COOEt Me OMe CH2794 Q.sub.97 Me COOEt OMe OMe CH2795 Q.sub.97 H H Me OMe CH2796 Q.sub.97 H H OMe OMe CH2797 Me H Q.sub.97 Me OMe CH2798 Me H Q.sub.97 OMe OMe CH2799 Q.sub.98 H COOMe Me Me CH2800 Q.sub.98 H COOMe Me OMe CH2801 Q.sub.98 H COOMe OMe OMe CH2802 Q.sub.98 H COOMe Me OMe N2803 Q.sub.98 H COOMe OMe OMe N2804 Q.sub.98 H COOEt Me Me CH2805 Q.sub.98 H COOEt Me OMe CH2806 Q.sub.98 H COOEt OMe OMe CH2807 Q.sub.98 H COOEt Me OMe N2808 Q.sub.98 H COOEt OMe OMe N2809 Q.sub.98 Me COOMe Me OMe CH2810 Q.sub.98 Me COOMe OMe OMe CH2811 Q.sub.98 Me COOMe Me OMe N2812 Q.sub.98 Me COOEt Me OMe CH2813 Q.sub.98 Me COOEt OMe OMe CH2814 Q.sub.98 Me COOEt Me OMe N2815 Q.sub.98 H CN Me OMe CH2816 Q.sub.98 H CN OMe OMe CH2817 Q.sub.98 H CN Me OMe N2818 Q.sub.98 H H Me OMe CH2819 Q.sub.98 H H OMe OMe CH2820 Q.sub.98 H H Me OMe N2821 Me H Q.sub.98 Me Me CH2822 Me H Q.sub.98 Me OMe CH2823 Me H Q.sub.98 OMe OMe CH2824 Me H Q.sub.98 Me OMe N2825 Me H Q.sub.98 OMe OMe N2826 Q.sub.99 H COOMe Me Me CH2827 Q.sub.99 H COOMe Me OMe CH2828 Q.sub.99 H COOMe OMe OMe CH2829 Q.sub.99 H COOEt Me OMe CH2830 Q.sub.99 H COOEt OMe OMe CH2831 Q.sub.99 Me COOMe Me Me CH2832 Q.sub.99 Me COOMe Me OMe CH2833 Q.sub.99 Me COOMe OMe OMe CH2834 Q.sub.99 Me COOEt Me OMe CH2835 Q.sub.99 Me COOEt OMe OMe CH2836 Q.sub.99 H H Me OMe CH2837 Q.sub.99 H H OMe OMe CH2838 Me H Q.sub.99 Me OMe CH2839 Me H Q.sub.99 OMe OMe CH2840 Q.sub.100 H COOMe Me Me CH2841 Q.sub.100 H COOMe Me OMe CH2842 Q.sub.100 H COOMe OMe OMe CH2843 Q.sub.100 H COOMe Me OMe N2844 Q.sub.100 H COOMe OMe OMe N2845 Q.sub.100 H COOEt Me Me CH2846 Q.sub.100 H COOEt Me OMe CH2847 Q.sub.100 H COOEt OMe OMe CH2848 Q.sub.100 H COOEt Me OMe N2849 Q.sub.100 H COOEt OMe OMe N2850 Q.sub.100 Me COOMe Me OMe CH2851 Q.sub.100 Me COOMe OMe OMe CH2852 Q.sub.100 Me COOMe Me OMe N2853 Q.sub.100 Me COOEt Me OMe CH2854 Q.sub.100 Me COOEt OMe OMe CH2855 Q.sub.100 Me COOEt Me OMe N2856 Q.sub.100 H CN Me OMe CH2857 Q.sub.100 H CN OMe OMe CH2858 Q.sub.100 H CN Me OMe N2859 Q.sub.100 H H Me OMe CH2860 Q.sub.100 H H OMe OMe CH2861 Q.sub.100 H H Me OMe N2862 Me H Q.sub.100 Me Me CH2863 Me H Q.sub.100 Me OMe CH2864 Me H Q.sub.100 OMe OMe CH2865 Me H Q.sub.100 Me OMe N2866 Me H Q.sub.100 OMe OMe N2867 Q.sub.101 H COOMe Me Me CH2868 Q.sub.101 H COOMe Me OMe CH2869 Q.sub.101 H COOMe OMe OMe CH2870 Q.sub.101 H COOEt Me OMe CH2871 Q.sub.101 H COOEt OMe OMe CH2872 Q.sub.101 Me COOMe Me Me CH2873 Q.sub.101 Me COOMe Me OMe CH2874 Q.sub.101 Me COOMe OMe OMe CH2875 Q.sub.101 Me COOEt Me OMe CH2876 Q.sub.101 Me COOEt OMe OMe CH2877 Q.sub.101 H H Me OMe CH2878 Q.sub.101 H H OMe OMe CH2879 Me H Q.sub.101 Me OMe CH2880 Me H Q.sub.101 OMe OMe CH2881 Q.sub.102 H COOMe Me Me CH2882 Q.sub.102 H COOMe Me OMe CH2883 Q.sub.102 H COOMe OMe OMe CH2884 Q.sub.102 H COOEt Me OMe CH2885 Q.sub.102 H COOEt OMe OMe CH2886 Q.sub.102 Me COOMe Me Me CH2887 Q.sub.102 Me COOMe Me OMe CH2888 Q.sub.102 Me COOMe OMe OMe CH2889 Q.sub.102 Me COOEt Me OMe CH2890 Q.sub.102 Me COOEt OMe OMe CH2891 Q.sub.102 H H Me OMe CH2892 Q.sub.102 H H OMe OMe CH2893 Me H Q.sub.102 Me OMe CH2894 Me H Q.sub.102 OMe OMe CH2895 Q.sub.103 H COOMe Me Me CH2896 Q.sub.103 H COOMe Me OMe CH2897 Q.sub.103 H COOMe OMe OMe CH2898 Q.sub.103 H COOEt Me OMe CH2899 Q.sub.103 H COOEt OMe OMe CH2900 Q.sub.103 Me COOMe Me Me CH2901 Q.sub.103 Me COOMe Me OMe CH2902 Q.sub.103 Me COOMe OMe OMe CH2903 Q.sub.103 Me COOEt Me OMe CH2904 Q.sub.103 Me COOEt OMe OMe CH2905 Q.sub.103 H H Me OMe CH2906 Q.sub.103 H H OMe OMe CH2907 Me H Q.sub.103 Me OMe CH2908 Me H Q.sub.103 OMe OMe CH2909 Q.sub.104 H COOMe Me Me CH2910 Q.sub.104 H COOMe Me OMe CH2911 Q.sub.104 H COOMe OMe OMe CH2912 Q.sub.104 H COOEt Me OMe CH2913 Q.sub.104 H COOEt OMe OMe CH2914 Q.sub.104 Me COOMe Me Me CH2915 Q.sub.104 Me COOMe Me OMe CH2916 Q.sub.104 Me COOMe OMe OMe CH2917 Q.sub.104 Me COOEt Me OMe CH2918 Q.sub.104 Me COOEt OMe OMe CH2919 Q.sub.104 H H Me OMe CH2920 Q.sub.104 H H OMe OMe CH2921 Me H Q.sub.104 Me OMe CH2922 Me H Q.sub.104 OMe OMe CH2923 Q.sub.105 H COOMe Me Me CH2924 Q.sub.105 H COOMe Me OMe CH2925 Q.sub.105 H COOMe OMe OMe CH2926 Q.sub.105 H COOEt Me OMe CH2927 Q.sub.105 H COOEt OMe OMe CH2928 Q.sub.105 Me COOMe Me Me CH2929 Q.sub.105 Me COOMe Me OMe CH2930 Q.sub.105 Me COOMe OMe OMe CH2931 Q.sub.105 Me COOEt Me OMe CH2932 Q.sub.105 Me COOEt OMe OMe CH2933 Q.sub.105 H H Me OMe CH2934 Q.sub.105 H H OMe OMe CH2935 Me H Q.sub.105 Me OMe CH2936 Me H Q.sub.105 OMe OMe CH2937 Q.sub.106 H COOMe Me Me CH2938 Q.sub.106 H COOMe Me OMe CH2939 Q.sub.106 H COOMe OMe OMe CH2940 Q.sub.106 H COOEt Me OMe CH2941 Q.sub.106 H COOEt OMe OMe CH2942 Q.sub.106 Me COOMe Me Me CH2943 Q.sub.106 Me COOMe Me OMe CH2944 Q.sub.106 Me COOMe OMe OMe CH2945 Q.sub.106 Me COOEt Me OMe CH2946 Q.sub.106 Me COOEt OMe OMe CH2947 Q.sub.106 H H Me OMe CH2948 Q.sub.106 H H OMe OMe CH2949 Me H Q.sub.106 Me OMe CH2950 Me H Q.sub.106 OMe OMe CH2951 Q.sub.107 H COOMe Me Me CH2952 Q.sub.107 H COOMe Me OMe CH2953 Q.sub.107 H COOMe OMe OMe CH2954 Q.sub.107 H COOEt Me OMe CH2955 Q.sub.107 H COOEt OMe OMe CH2956 Q.sub.107 Me COOMe Me Me CH2957 Q.sub.107 Me COOMe Me OMe CH2958 Q.sub.107 Me COOMe OMe OMe CH2959 Q.sub.107 Me COOEt Me OMe CH2960 Q.sub.107 Me COOEt OMe OMe CH2961 Q.sub.107 H H Me OMe CH2962 Q.sub.107 H H OMe OMe CH2963 Me H Q.sub.107 Me OMe CH2964 Me H Q.sub.107 OMe OMe CH2965 Q.sub.108 H COOMe Me Me CH2966 Q.sub.108 H COOMe Me OMe CH2967 Q.sub.108 H COOMe OMe OMe CH2968 Q.sub.108 H COOEt Me OMe CH2969 Q.sub. 108 H COOEt OMe OMe CH2970 Q.sub.108 Me COOMe Me Me CH2971 Q.sub.108 Me COOMe Me OMe CH2972 Q.sub.108 Me COOMe OMe OMe CH2973 Q.sub.108 Me COOEt Me OMe CH2974 Q.sub.108 Me COOEt OMe OMe CH2975 Q.sub.108 H H Me OMe CH2976 Q.sub.108 H H OMe OMe CH2977 Me H Q.sub.108 Me OMe CH2978 Me H Q.sub.108 OMe OMe CH2979 Q.sub.109 H COOMe Me Me CH2980 Q.sub.109 H COOMe Me OMe CH2981 Q.sub.109 H COOMe OMe OMe CH2982 Q.sub.109 H COOEt Me OMe CH2983 Q.sub.109 H COOEt OMe OMe CH2984 Q.sub.109 Me COOMe Me Me CH2985 Q.sub.109 Me COOMe Me OMe CH2986 Q.sub.109 Me COOMe OMe OMe CH2987 Q.sub.109 Me COOEt Me OMe CH2988 Q.sub.109 Me COOEt OMe OMe CH2989 Q.sub.109 H H Me OMe CH2990 Q.sub.109 H H OMe OMe CH2991 Me H Q.sub.109 Me OMe CH2992 Me H Q.sub.109 OMe OMe CH2993 Q.sub.110 H COOMe Me Me CH2994 Q.sub.110 H COOMe Me OMe CH2995 Q.sub.110 H COOMe OMe OMe CH2996 Q.sub.110 H COOEt Me OMe CH2997 Q.sub.110 H COOEt OMe OMe CH2998 Q.sub.110 Me COOMe Me Me CH2999 Q.sub.110 Me COOMe Me OMe CH3000 Q.sub.110 Me COOMe OMe OMe CH3001 Q.sub.110 Me COOEt Me OMe CH3002 Q.sub.110 Me COOEt OMe OMe CH3003 Q.sub.110 H H Me OMe CH3004 Q.sub.110 H H OMe OMe CH3005 Me H Q.sub.110 Me OMe CH3006 Me H Q.sub.110 OMe OMe CH3007 Q.sub.111 H COOMe Me Me CH3008 Q.sub.111 H COOMe Me OMe CH3009 Q.sub.111 H COOMe OMe OMe CH3010 Q.sub.111 H COOEt Me OMe CH3011 Q.sub.111 H COOEt OMe OMe CH3012 Q.sub.111 Me COOMe Me Me CH3013 Q.sub.111 Me COOMe Me OMe CH3014 Q.sub.111 Me COOMe OMe OMe CH3015 Q.sub.111 Me COOEt Me OMe CH3016 Q.sub.111 Me COOEt OMe OMe CH3017 Q.sub.111 H H Me OMe CH3018 Q.sub.111 H H OMe OMe CH3019 Me H Q.sub.111 Me OMe CH3020 Me H Q.sub.111 OMe OMe CH3021 Q.sub.112 H COOMe Me Me CH3022 Q.sub.112 H COOMe Me OMe CH3023 Q.sub.112 H COOMe OMe OMe CH3024 Q.sub.112 H COOEt Me OMe CH3025 Q.sub.112 H COOEt OMe OMe CH3026 Q.sub.112 Me COOMe Me Me CH3027 Q.sub.112 Me COOMe Me OMe CH3028 Q.sub.112 Me COOMe OMe OMe CH3029 Q.sub.112 Me COOEt Me OMe CH3030 Q.sub.112 Me COOEt OMe OMe CH3031 Q.sub.112 H H Me OMe CH3032 Q.sub.112 H H OMe OMe CH3033 Me H Q.sub.112 Me OMe CH3034 Me H Q.sub.112 OMe OMe CH3035 Q.sub.113 H COOMe Me Me CH3036 Q.sub.113 H COOMe Me OMe CH3037 Q.sub.113 H COOMe OMe OMe CH3038 Q.sub.113 H COOEt Me OMe CH3039 Q.sub.113 H COOEt OMe OMe CH3040 Q.sub.113 Me COOMe Me Me CH3041 Q.sub.113 Me COOMe Me OMe CH3042 Q.sub.113 Me COOMe OMe OMe CH3043 Q.sub.113 Me COOEt Me OMe CH3044 Q.sub.113 Me COOEt OMe OMe CH3045 Q.sub.113 H H Me OMe CH3046 Q.sub.113 H H OMe OMe CH3047 Me H Q.sub.113 Me OMe CH3048 Me H Q.sub.113 OMe OMe CH3049 Q.sub.114 H COOMe Me Me CH3050 Q.sub.114 H COOMe Me OMe CH3051 Q.sub.114 H COOMe OMe OMe CH3052 Q.sub.114 H COOEt Me OMe CH3053 Q.sub.114 H COOEt OMe OMe CH3054 Q.sub.114 Me COOMe Me Me CH3055 Q.sub.114 Me COOMe Me OMe CH3056 Q.sub.114 Me COOMe OMe OMe CH3057 Q.sub.114 Me COOEt Me OMe CH3058 Q.sub.114 Me COOEt OMe OMe CH3059 Q.sub.114 H H Me OMe CH3060 Q.sub.114 H H OMe OMe CH3061 Me H Q.sub.114 Me OMe CH3062 Me H Q.sub.114 OMe OMe CH3063 Q.sub.115 H COOMe Me Me CH3064 Q.sub.115 H COOMe Me OMe CH3065 Q.sub.115 H COOMe OMe OMe CH3066 Q.sub.115 H COOEt Me OMe CH3067 Q.sub.115 H COOEt OMe OMe CH3068 Q.sub.115 Me COOMe Me Me CH3069 Q.sub.115 Me COOMe Me OMe CH3070 Q.sub.115 Me COOMe OMe OMe CH3071 Q.sub.115 Me COOEt Me OMe CH3072 Q.sub.115 Me COOEt OMe OMe CH3073 Q.sub.115 H H Me OMe CH3074 Q.sub.115 H H OMe OMe CH3075 Me H Q.sub.115 Me OMe CH3076 Me H Q.sub.115 OMe OMe CH3077 Q.sub.116 H COOMe Me Me CH3078 Q.sub.116 H COOMe Me OMe CH3079 Q.sub.116 H COOMe OMe OMe CH3080 Q.sub.116 H COOEt Me OMe CH3081 Q.sub.116 H COOEt OMe OMe CH3082 Q.sub.116 Me COOMe Me Me CH3083 Q.sub.116 Me COOMe Me OMe CH3084 Q.sub.116 Me COOMe OMe OMe CH3085 Q.sub.116 Me COOEt Me OMe CH3086 Q.sub.116 Me COOEt OMe OMe CH3087 Q.sub.116 H H Me OMe CH3088 Q.sub.116 H H OMe OMe CH3089 Me H Q.sub.116 Me OMe CH3090 Me H Q.sub.116 OMe OMe CH3091 Q.sub.117 H COOMe Me Me CH3092 Q.sub.117 H COOMe Me OMe CH3093 Q.sub.117 H COOMe OMe OMe CH3094 Q.sub.117 H COOEt Me OMe CH3095 Q.sub.117 H COOEt OMe OMe CH3096 Q.sub.117 Me COOMe Me Me CH3097 Q.sub.117 Me COOMe Me OMe CH3098 Q.sub.117 Me COOMe OMe OMe CH3099 Q.sub.117 Me COOEt Me OMe CH3100 Q.sub.117 Me COOEt OMe OMe CH3101 Q.sub.117 H H Me OMe CH3102 Q.sub.117 H H OMe OMe CH3103 Me H Q.sub.117 Me OMe CH3104 Me H Q.sub.117 OMe OMe CH3105 Q.sub.118 H COOMe Me Me CH3106 Q.sub.118 H COOMe Me OMe CH3107 Q.sub.118 H COOMe OMe OMe CH3108 Q.sub.118 H COOEt Me OMe CH3109 Q.sub.118 H COOEt OMe OMe CH3110 Q.sub.118 Me COOMe Me Me CH3111 Q.sub.118 Me COOMe Me OMe CH3112 Q.sub.118 Me COOMe OMe OMe CH3113 Q.sub.118 Me COOEt Me OMe CH3114 Q.sub.118 Me COOEt OMe OMe CH3115 Q.sub.118 H H Me OMe CH3116 Q.sub.118 H H OMe OMe CH3117 Me H Q.sub.118 Me OMe CH3118 Me H Q.sub.118 OMe OMe CH3119 Q.sub.119 H COOMe Me Me CH3120 Q.sub.119 H COOMe Me OMe CH3121 Q.sub.119 H COOMe OMe OMe CH3122 Q.sub.119 H COOEt Me OMe CH3123 Q.sub.119 H COOEt OMe OMe CH3124 Q.sub.119 Me COOMe Me Me CH3125 Q.sub.119 Me COOMe Me OMe CH3126 Q.sub.119 Me COOMe OMe OMe CH3127 Q.sub.119 Me COOEt Me OMe CH3128 Q.sub.119 Me COOEt OMe OMe CH3129 Q.sub.119 H H Me OMe CH3130 Q.sub.119 H H OMe OMe CH3131 Me H Q.sub.119 Me OMe CH3132 Me H Q.sub.119 OMe OMe CH3133 Q.sub.120 H COOMe Me Me CH3134 Q.sub.120 H COOMe Me OMe CH3135 Q.sub.120 H COOMe OMe OMe CH3136 Q.sub.120 H COOEt Me OMe CH3137 Q.sub.120 H COOEt OMe OMe CH3138 Q.sub.120 Me COOMe Me Me CH3139 Q.sub.120 Me COOMe Me OMe CH3140 Q.sub.120 Me COOMe OMe OMe CH3141 Q.sub.120 Me COOEt Me OMe CH3142 Q.sub.120 Me COOEt OMe OMe CH3143 Me H Q.sub.120 Me OMe CH3144 Me H Q.sub.120 OMe OMe CH3145 Me Me Q.sub.120 Me OMe CH3146 Me Me Q.sub.120 OMe OMe CH3147 Q.sub.121 H COOMe Me Me CH3148 Q.sub.121 H COOMe Me OMe CH3149 Q.sub.121 H COOMe OMe OMe CH3150 Q.sub.121 H COOEt Me OMe CH3151 Q.sub.121 H COOEt OMe OMe CH3152 Q.sub.121 Me COOMe Me Me CH3153 Q.sub.121 Me COOMe Me OMe CH3154 Q.sub.121 Me COOMe OMe OMe CH3155 Q.sub.121 Me COOEt Me OMe CH3156 Q.sub.121 Me COOEt OMe OMe CH3157 Me H Q.sub.121 Me OMe CH3158 Me H Q.sub.121 OMe OMe CH3159 Me Me Q.sub.121 Me OMe CH3160 Me Me Q.sub.121 OMe OMe CH3161 Q.sub.122 H COOMe Me Me CH3162 Q.sub.122 H COOMe Me OMe CH3163 Q.sub.122 H COOMe OMe OMe CH3164 Q.sub.122 H COOEt Me OMe CH3165 Q.sub.122 H COOEt OMe OMe CH3166 Q.sub.122 Me COOMe Me Me CH3167 Q.sub.122 Me COOMe Me OMe CH3168 Q.sub.122 Me COOMe OMe OMe CH3169 Q.sub.122 Me COOEt Me OMe CH3170 Q.sub.122 Me COOEt OMe OMe CH3171 Me H Q.sub.122 Me OMe CH3172 Me H Q.sub.122 OMe OMe CH3173 Me Me Q.sub.122 Me OMe CH3174 Me Me Q.sub.122 OMe OMe CH3175 Q.sub.123 H COOMe Me Me CH3176 Q.sub.123 H COOMe Me OMe CH3177 Q.sub.123 H COOMe OMe OMe CH3178 Q.sub.123 H COOEt Me OMe CH3179 Q.sub.123 H COOEt OMe OMe CH3180 Q.sub.123 Me COOMe Me Me CH3181 Q.sub.123 Me COOMe Me OMe CH3182 Q.sub.123 Me COOMe OMe OMe CH3183 Q.sub.123 Me COOEt Me OMe CH3184 Q.sub.123 Me COOEt OMe OMe CH3185 Me H Q.sub.123 Me OMe CH3186 Me H Q.sub.123 OMe OMe CH3187 Me Me Q.sub.123 Me OMe CH3188 Me Me Q.sub.123 OMe OMe CH3189 Q.sub.124 H COOMe Me Me CH3190 Q.sub.124 H COOMe Me OMe CH3191 Q.sub.124 H COOMe OMe OMe CH3192 Q.sub.124 H COOEt Me OMe CH3193 Q.sub.124 H COOEt OMe OMe CH3194 Q.sub.124 Me COOMe Me Me CH3195 Q.sub.124 Me COOMe Me OMe CH3196 Q.sub.124 Me COOMe OMe OMe CH3197 Q.sub.124 Me COOEt Me OMe CH3198 Q.sub.124 Me COOEt OMe OMe CH3199 Me H Q.sub.124 Me OMe CH3200 Me H Q.sub.124 OMe OMe CH3201 Me Me Q.sub.124 Me OMe CH3202 Me Me Q.sub.124 OMe OMe CH3203 Q.sub.125 H COOMe Me Me CH3204 Q.sub.125 H COOMe Me OMe CH3205 Q.sub.125 H COOMe OMe OMe CH3206 Q.sub.125 H COOEt Me OMe CH3207 Q.sub.125 H COOEt OMe OMe CH3208 Q.sub.125 Me COOMe Me Me CH3209 Q.sub.125 Me COOMe Me OMe CH3210 Q.sub.125 Me COOMe OMe OMe CH3211 Q.sub.125 Me COOEt Me OMe CH3212 Q.sub.125 Me COOEt OMe OMe CH3213 Me H Q.sub.125 Me OMe CH3214 Me H Q.sub.125 OMe OMe CH3215 Me Me Q.sub.125 Me OMe CH3216 Me Me Q.sub.125 OMe OMe CH3217 Q.sub.126 H COOMe Me Me CH3218 Q.sub.126 H COOMe Me OMe CH3219 Q.sub.126 H COOMe OMe OMe CH3220 Q.sub.126 H COOEt Me OMe CH3221 Q.sub.126 H COOEt OMe OMe CH3222 Q.sub.126 Me COOMe Me Me CH3223 Q.sub.126 Me COOMe Me OMe CH3224 Q.sub.126 Me COOMe OMe OMe CH3225 Q.sub.126 Me COOEt Me OMe CH3226 Q.sub.126 Me COOEt OMe OMe CH3227 Me H Q.sub.126 Me OMe CH3228 Me H Q.sub.126 OMe OMe CH3229 Me Me Q.sub.126 Me OMe CH3230 Me Me Q.sub.126 OMe OMe CH3231 Q.sub.127 H COOMe Me Me CH3232 Q.sub.127 H COOMe Me OMe CH3233 Q.sub.127 H COOMe OMe OMe CH3234 Q.sub.127 H COOEt Me OMe CH3235 Q.sub.127 H COOEt OMe OMe CH3236 Q.sub.127 Me COOMe Me Me CH3237 Q.sub.127 Me COOMe Me OMe CH3238 Q.sub.127 Me COOMe OMe OMe CH3239 Q.sub.127 Me COOEt Me OMe CH3240 Q.sub.127 Me COOEt OMe OMe CH3241 Me H Q.sub.127 Me OMe CH3242 Me H Q.sub.127 OMe OMe CH3243 Me Me Q.sub.127 Me OMe CH3244 Me Me Q.sub.127 OMe OMe CH3245 Q.sub.128 H COOMe Me Me CH3246 Q.sub.128 H COOMe Me OMe CH3247 Q.sub.127 H COOMe OMe OMe CH3248 Q.sub.128 H COOEt Me OMe CH3249 Q.sub.128 H COOEt OMe OMe CH3250 Q.sub.128 Me COOMe Me Me CH3251 Q.sub.128 Me COOMe Me OMe CH3252 Q.sub.128 Me COOMe OMe OMe CH3253 Q.sub.128 Me COOEt Me OMe CH3254 Q.sub.128 Me COOEt OMe OMe CH3255 Me H Q.sub.128 Me OMe CH3256 Me H Q.sub.128 OMe OMe CH3257 Me Me Q.sub.128 Me OMe CH3258 Me Me Q.sub.128 OMe OMe CH3259 Q.sub.129 H COOMe Me Me CH3260 Q.sub.129 H COOMe Me OMe CH3261 Q.sub.129 H COOMe OMe OMe CH3262 Q.sub.129 H COOEt Me OMe CH3263 Q.sub.129 H COOEt OMe OMe CH3264 Q.sub.129 Me COOMe Me Me CH3265 Q.sub.129 Me COOMe Me OMe CH3266 Q.sub.129 Me COOMe OMe OMe CH3267 Q.sub.129 Me COOEt Me OMe CH3268 Q.sub.129 Me COOEt OMe OMe CH3269 Me H Q.sub.129 Me OMe CH3270 Me H Q.sub.129 OMe OMe CH3271 Me Me Q.sub.129 Me OMe CH3272 Me Me Q.sub.129 OMe OMe CH3273 Q.sub.130 H COOMe Me Me CH3274 Q.sub.130 H COOMe Me OMe CH3275 Q.sub.130 H COOMe OMe OMe CH3276 Q.sub.130 H COOEt Me OMe CH3277 Q.sub.130 H COOEt OMe OMe CH3278 Q.sub.130 Me COOMe Me Me CH3279 Q.sub.130 Me COOMe Me OMe CH3280 Q.sub.130 Me COOMe OMe OMe CH3281 Q.sub.130 Me COOEt Me OMe CH3282 Q.sub.130 Me COOEt OMe OMe CH3283 Me H Q.sub.130 Me OMe CH3284 Me H Q.sub.130 OMe OMe CH3285 Me Me Q.sub.130 Me OMe CH3286 Me Me Q.sub.130 OMe OMe CH3287 Q.sub.131 H COOMe Me Me CH3288 Q.sub.131 H COOMe Me OMe CH3289 Q.sub.131 H COOMe OMe OMe CH3290 Q.sub.131 H COOEt Me OMe CH3291 Q.sub.131 H COOEt OMe OMe CH3292 Q.sub.131 Me COOMe Me Me CH3293 Q.sub.131 Me COOMe Me OMe CH3294 Q.sub.131 Me COOMe OMe OMe CH3295 Q.sub.131 Me COOEt Me OMe CH3296 Q.sub.131 Me COOEt OMe OMe CH3297 Me H Q.sub.131 Me OMe CH3298 Me H Q.sub.131 OMe OMe CH3299 Me Me Q.sub.131 Me OMe CH3300 Me Me Q.sub.131 OMe OMe CH3301 Q.sub.132 H COOMe Me Me CH3302 Q.sub.132 H COOMe Me OMe CH3303 Q.sub.132 H COOMe OMe OMe CH3304 Q.sub.132 H COOEt Me OMe CH3305 Q.sub.132 H COOEt OMe OMe CH3306 Q.sub.132 Me COOMe Me Me CH3307 Q.sub.132 Me COOMe Me OMe CH3308 Q.sub.132 Me COOMe OMe OMe CH3309 Q.sub.132 Me COOEt Me OMe CH3310 Q.sub.132 Me COOEt OMe OMe CH3311 Me H Q.sub.132 Me OMe CH3312 Me H Q.sub.132 OMe OMe CH3313 Me Me Q.sub.132 Me OMe CH3314 Me Me Q.sub.132 OMe OMe CH______________________________________ TABLE 2______________________________________ ##STR11##No. A B D X Y Z______________________________________1006 Q.sub.1 Me Cl Me Me CH1007 Q.sub.1 Me Cl Me OMe CH1008 Q.sub.1 Me Cl OMe OMe CH1009 Q.sub.1 Me Cl Me OMe N1010 Q.sub.1 Me Cl OMe OMe N1011 Q.sub.1 Me OMe Me OMe CH1012 Q.sub.1 Me OMe OMe OMe CH1013 Q.sub.1 Me OMe Me OMe N1014 Q.sub.1 CF.sub.3 Me Me OMe CH1015 Q.sub.1 CF.sub.3 Me OMe OMe CH1016 Q.sub.1 CF.sub.3 Me Me OMe N1017 Q.sub.1 Me COOMe Me Me CH1018 Q.sub.1 Me COOMe Me OMe CH1019 Q.sub.1 Me COOMe OMe OMe CH1020 Q.sub.1 Me COOMe Me OMe N1021 Q.sub.1 Me COOMe OMe OMe N1022 Q.sub.1 Me COOMe Me OCHF.sub.2 CH1023 Q.sub.1 Me COOMe Me ##STR12## CH1024 Q.sub.1 Me SO.sub.2 Me Me OMe CH1025 Q.sub.1 Me SO.sub.2 Me OMe OMe CH1026 Q.sub.1 Me SO.sub.2 Me Me OMe N1027 H Q.sub.1 Me Me OMe CH1028 H Q.sub.1 Me OMe OMe CH1029 H Q.sub.1 Me Me OMe N1030 Me Q.sub.1 Me Me OMe CH1031 Me Q.sub.1 Me OMe OMe CH1032 Me Q.sub.1 Me Me OMe N1033 Me Q.sub.1 Cl Me OMe CH1034 Me Q.sub.1 Cl OMe OMe CH1035 Me Q.sub.1 Cl Me OMe N1036 Me Q.sub.1 COOMe Me OMe CH1037 Me Q.sub.1 COOMe OMe OMe CH1038 Me Q.sub.1 COOMe Me OMe N1039 Me Q.sub.1 Ph Me OMe CH1040 Me Q.sub.1 Ph OMe OMe CH1041 Me Q.sub.1 Ph Me OMe N1042 Me Me Q.sub.1 Me OMe CH1043 Me Me Q.sub.1 OMe OMe CH1044 Me Me Q.sub.1 Me OMe N1045 Q.sub.2 Me COOMe Me Me CH1046 Q.sub.2 Me COOMe Me OMe CH1047 Q.sub.2 Me COOMe OMe OMe CH1048 Q.sub.2 Me COOMe Me OMe N1049 Q.sub.2 Me COOMe OMe OMe N1050 Me Q.sub.2 Me Me OMe CH1051 Me Q.sub.2 Me OMe OMe CH1052 Me Q.sub.2 Me Me OMe N1053 Me Me Q.sub.2 Me OMe CH1054 Me Me Q.sub.2 OMe OMe CH1055 Me Me Q.sub.2 Me OMe N1056 Q.sub.3 Me COOMe Me Me CH1057 Q.sub.3 Me COOMe Me OMe CH1058 Q.sub.3 Me COOMe OMe OMe CH1059 Q.sub.3 Me COOMe Me OMe N1060 Q.sub.3 Me COOMe OMe OMe N1061 Me Q.sub.3 Me Me OMe CH1062 Me Q.sub.3 Me OMe OMe CH1063 Me Q.sub.3 Me Me OMe N1064 Me Me Q.sub.3 Me OMe CH1065 Me Me Q.sub.3 OMe OMe CH1066 Me Me Q.sub.3 Me OMe N1067 Q.sub.4 Me COOMe Me Me CH1068 Q.sub.4 Me COOMe Me OMe CH1069 Q.sub.4 Me COOMe OMe OMe CH1070 Q.sub.4 Me COOMe Me OMe N1071 Q.sub.4 Me COOMe OMe OMe N1072 Me Q.sub.4 Me Me OMe CH1073 Me Q.sub.4 Me OMe OMe CH1074 Me Q.sub.4 Me Me OMe N1075 Me Me Q.sub.4 Me OMe CH1076 Me Me Q.sub.4 OMe OMe CH1077 Me Me Q.sub.4 Me OMe N1078 Q.sub.5 Me COOMe Me Me CH1079 Q.sub.5 Me COOMe Me OMe CH1080 Q.sub.5 Me COOMe OMe OMe CH1081 Q.sub.5 Me COOMe Me OMe N1082 Q.sub.5 Me COOMe OMe OMe N1083 Me Q.sub.5 Me Me OMe CH1084 Me Q.sub.5 Me OMe OMe CH1085 Me Q.sub.5 Me Me OMe N1086 Me Me Q.sub.5 Me OMe CH1087 Me Me Q.sub.5 OMe OMe CH1088 Me Me Q.sub.5 Me OMe N1089 Q.sub.6 Me COOMe Me Me CH1090 Q.sub.6 Me COOMe Me OMe CH1091 Q.sub.6 Me COOMe OMe OMe CH1092 Q.sub.6 Me COOMe Me OMe N1093 Q.sub.6 Me COOMe OMe OMe N1094 Me Q.sub.6 Me Me OMe CH1095 Me Q.sub.6 Me OMe OMe CH1096 Me Q.sub.6 Me Me OMe N1097 Me Me Q.sub.6 Me OMe CH1098 Me Me Q.sub.6 OMe OMe CH1099 Me Me Q.sub.6 Me OMe N1100 Q.sub.7 Me COOMe Me OMe CH1101 Q.sub.7 Me COOMe OMe OMe CH1102 Q.sub.7 Me COOMe Me OMe N1103 Me Me Q.sub.7 OMe OMe CH1104 Me Me Q.sub.7 Me OMe N1105 Q.sub. 8 Me COOMe Me OMe CH1106 Q.sub.8 Me COOMe OMe OMe CH1107 Q.sub.8 Me COOMe Me OMe N1108 Me Me Q.sub.8 OMe OMe CH1109 Me Me Q.sub.8 Me OMe N1110 Q.sub.9 Me COOMe Me OMe CH1111 Q.sub.9 Me COOMe OMe OMe CH1112 Q.sub.9 Me COOMe Me OMe N1113 Me Me Q.sub.9 OMe OMe CH1114 Me Me Q.sub.9 Me OMe N1115 Q.sub.10 Me COOMe Me OMe CH1116 Q.sub.10 Me COOMe OMe OMe CH1117 Q.sub.10 Me COOMe Me OMe N1118 Me Me Q.sub.10 OMe OMe CH1119 Me Me Q.sub.10 Me OMe N1120 Q.sub.11 Me COOMe Me Me CH1121 Q.sub.11 Me COOMe Me OMe CH1122 Q.sub.11 Me COOMe OMe OMe CH1123 Q.sub.11 Me COOMe Me OMe N1124 Q.sub.11 Me COOMe OMe OMe N1125 Me Q.sub.11 Me Me OMe CH1126 Me Q.sub.11 Me OMe OMe CH1127 Me Q.sub.11 Me Me OMe N1128 Me Me Q.sub.11 Me OMe CH1129 Me Me Q.sub.11 OMe OMe CH1130 Me Me Q.sub.11 Me OMe N1131 Q.sub.12 Me Cl Me Me CH1132 Q.sub.12 Me Cl Me OMe CH1133 Q.sub.12 Me Cl OMe OMe CH1134 Q.sub.12 Me Cl Me OMe N1135 Q.sub.12 Me Cl OMe OMe N1136 Q.sub.12 Me OMe Me OMe CH1137 Q.sub.12 Me OMe OMe OMe CH1138 Q.sub.12 Me OMe Me OMe N1139 Q.sub.12 CF.sub.3 Me Me OMe CH1140 Q.sub.12 CF.sub.3 Me OMe OMe CH1141 Q.sub.12 CF.sub.3 Me Me OMe N1142 Q.sub.12 Me COOMe Me Me CH1143 Q.sub.12 Me COOMe Me OMe CH1144 Q.sub.12 Me COOMe OMe OMe CH1145 Q.sub.12 Me COOMe Me OMe N1146 Q.sub.12 Me COOMe OMe OMe N1147 Q.sub.12 Me COOMe Me OCHF.sub.2 CH1148 Q.sub.12 Me COOMe Me ##STR13## CH1149 Q.sub.12 Me SO.sub.2 Me Me OMe CH1150 Q.sub.12 Me SO.sub.2 Me OMe OMe CH1151 Q.sub.12 Me SO.sub.2 Me Me OMe N1152 H Q.sub.12 Me Me OMe CH1153 H Q.sub.12 Me OMe OMe CH1154 H Q.sub.12 Me Me OMe N1155 Me Q.sub.12 Me Me OMe CH1156 Me Q.sub.12 Me OMe OMe CH1157 Me Q.sub.12 Me Me OMe N1158 Me Q.sub.12 Cl Me OMe CH1159 Me Q.sub.12 Cl OMe OMe CH1160 Me Q.sub.12 Cl Me OMe N1161 Me Q.sub.12 COOMe Me OMe CH1162 Me Q.sub.12 COOMe OMe OMe CH1163 Me Q.sub.12 COOMe Me OMe N1164 Me Q.sub.12 Ph Me OMe CH1165 Me Q.sub.12 Ph OMe OMe CH1166 Me Q.sub.12 Ph Me OMe N1167 Me Me Q.sub.12 Me OMe CH1168 Me Me Q.sub.12 OMe OMe CH1169 Me Me Q.sub.12 Me OMe N1170 Q.sub.13 Me COOMe Me Me CH1171 Q.sub.13 Me COOMe Me OMe CH1172 Q.sub.13 Me COOMe OMe OMe CH1173 Q.sub.13 Me COOMe Me OMe N1174 Q.sub.13 Me COOMe OMe OMe N1175 Me Q.sub.13 Me Me OMe CH1176 Me Q.sub.13 Me OMe OMe CH1177 Me Q.sub.13 Me Me OMe N1178 Me Me Q.sub.13 Me OMe CH1179 Me Me Q.sub.13 OMe OMe CH1180 Me Me Q.sub.13 Me OMe N1181 Q.sub.14 Me COOMe Me Me CH1182 Q.sub.14 Me COOMe Me OMe CH1183 Q.sub.14 Me COOMe OMe OMe CH1184 Q.sub.14 Me COOMe Me OMe N1185 Q.sub.14 Me COOMe OMe OMe N1186 Me Q.sub.14 Me Me OMe CH1187 Me Q.sub.14 Me OMe OMe CH1188 Me Q.sub.14 Me Me OMe N1189 Me Me Q.sub.14 Me OMe CH1190 Me Me Q.sub.14 OMe OMe CH1191 Me Me Q.sub.14 Me OMe N1192 Q.sub.15 Me COOMe Me OMe CH1193 Q.sub.15 Me COOMe OMe OMe CH1194 Q.sub.15 Me COOMe Me OMe N1195 Me Me Q.sub.15 OMe OMe CH1196 Me Me Q.sub.15 Me OMe N1197 Q.sub.17 Me COOMe Me OMe CH1198 Q.sub.16 Me COOMe OMe OMe CH1199 Q.sub.16 Me COOMe Me OMe N1200 Me Me Q.sub.16 OMe OMe CH1201 Me Me Q.sub.16 Me OMe N1202 Q.sub.17 Me COOMe Me OMe CH1203 Q.sub.17 Me COOMe OMe OMe CH1204 Q.sub.17 Me COOMe Me OMe N1205 Me Me Q.sub.17 OMe OMe CH1206 Me Me Q.sub.17 Me OMe N1207 Q.sub.18 Me COOMe Me OMe CH1208 Q.sub.18 Me COOMe OMe OMe CH1209 Q.sub.18 Me COOMe Me OMe N1210 Me Me Q.sub.18 OMe OMe CH1211 Me Me Q.sub.18 Me OMe N1212 Q.sub.19 Me COOMe Me Me CH1213 Q.sub.19 Me COOMe Me OMe CH1214 Q.sub.19 Me COOMe OMe OMe CH1215 Q.sub.19 Me COOMe Me OMe N1216 Q.sub.19 Me COOMe OMe OMe N1217 Me Q.sub.19 Me Me OMe CH1218 Me Q.sub.19 Me OMe OMe CH1219 Me Q.sub.19 Me Me OMe N1220 Me Me Q.sub.19 Me OMe CH1221 Me Me Q.sub.19 OMe OMe CH1222 Me Me Q.sub.19 Me OMe N1223 Q.sub.20 Me COOMe Me OMe CH1224 Q.sub.20 Me COOMe OMe OMe CH1225 Q.sub.20 Me COOMe Me OMe N1226 Me Me Q.sub.20 OMe OMe CH1227 Me Me Q.sub.20 Me OMe N1228 Q.sub.21 Me COOMe Me OMe CH1229 Q.sub.21 Me COOMe OMe OMe CH1230 Q.sub.21 Me COOMe Me OMe N1231 Me Me Q.sub.21 OMe OMe CH1232 Me Me Q.sub.21 Me OMe N1233 Q.sub.22 Me Cl Me Me CH1234 Q.sub.22 Me Cl Me OMe CH1235 Q.sub.22 Me Cl OMe OMe CH1236 Q.sub.22 Me Cl Me OMe N1237 Q.sub.22 Me Cl OMe OMe N1238 Q.sub.22 Me OMe Me OMe CH1239 Q.sub.22 Me OMe OMe OMe CH1240 Q.sub.22 Me OMe Me OMe N1241 Q.sub.22 CF.sub.3 Me Me OMe CH1242 Q.sub.22 CF.sub.3 Me OMe OMe CH1243 Q.sub.22 CF.sub.3 Me Me OMe N1244 Q.sub.22 Me COOMe Me Me CH1245 Q.sub. 22 Me COOMe Me OMe CH1246 Q.sub.22 Me COOMe OMe OMe CH1247 Q.sub.22 Me COOMe Me OMe N1248 Q.sub.22 Me COOMe OMe OMe N1249 Q.sub.22 Me COOMe Me OCHF.sub.2 CH1250 Q.sub.22 Me COOMe Me ##STR14## CH1251 Q.sub.22 Me SO.sub.2 Me Me OMe CH1252 Q.sub.22 Me SO.sub.2 Me OMe OMe CH1253 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Q.sub.24 Me COOMe Me OMe N1287 Q.sub.24 Me COOMe OMe OMe N1288 Me Q.sub.24 Me Me OMe CH1289 Me Q.sub.24 Me OMe OMe CH1290 Me Q.sub.24 Me Me OMe N1291 Me Me Q.sub.24 Me OMe CH1292 Me Me Q.sub.24 OMe OMe CH1293 Me Me Q.sub.24 Me OMe N1294 Q.sub.25 Me COOMe Me Me CH1295 Q.sub.25 Me COOMe Me OMe CH1296 Q.sub.25 Me COOMe OMe OMe CH1297 Q.sub.25 Me COOMe Me OMe N1298 Q.sub.25 Me COOMe OMe OMe N1299 Me Q.sub.25 Me Me OMe CH1300 Me Q.sub. 25 Me OMe OMe CH1301 Me Q.sub.25 Me Me OMe N1302 Me Me Q.sub.25 Me OMe CH1303 Me Me Q.sub.25 OMe OMe CH1304 Me Me Q.sub.25 Me OMe N1305 Q.sub.26 Me COOMe Me OMe CH1306 Q.sub.26 Me COOMe OMe OMe CH1307 Q.sub.26 Me COOMe Me OMe N1308 Me Me Q.sub.26 OMe OMe CH1309 Me Me Q.sub.26 Me OMe N1310 Q.sub.27 Me COOMe Me OMe CH1311 Q.sub.27 Me COOMe OMe OMe CH1312 Q.sub.27 Me COOMe Me OMe N1313 Me Me Q.sub.27 OMe OMe CH1314 Me Me Q.sub.27 Me OMe N1315 Q.sub.28 Me COOMe Me OMe CH1316 Q.sub.28 Me COOMe OMe OMe CH1317 Q.sub.28 Me COOMe Me OMe N1318 Me Me Q.sub.28 OMe OMe CH1319 Me Me Q.sub.28 Me OMe N1320 Q.sub.29 Me COOMe Me OMe CH1321 Q.sub.29 Me COOMe OMe OMe CH1322 Q.sub.29 Me COOMe Me OMe N1323 Me Me Q.sub.29 OMe OMe CH1324 Me Me Q.sub.29 Me OMe N1325 Q.sub.30 Me COOMe Me OMe CH1326 Q.sub.30 Me COOMe OMe OMe CH1327 Q.sub.30 Me COOMe Me OMe N1328 Me Me Q.sub.30 OMe OMe CH1329 Me Me Q.sub.30 Me OMe N1330 Q.sub.31 Me COOMe Me OMe CH1331 Q.sub.31 Me COOMe OMe OMe CH1332 Q.sub.31 Me COOMe Me OMe N1333 Me Me Q.sub.31 OMe OMe CH1334 Me Me Q.sub.31 Me OMe N1335 Q.sub.32 Me COOMe Me Me CH1336 Q.sub.32 Me COOMe Me OMe CH1337 Q.sub.32 Me COOMe OMe OMe CH1338 Q.sub.32 Me COOMe Me OMe N1339 Q.sub.32 Me COOMe OMe OMe N1340 Me Q.sub.32 Me Me OMe CH1341 Me Q.sub.32 Me OMe OMe CH1342 Me Q.sub.32 Me Me OMe N1343 Me Me Q.sub.32 Me OMe CH1344 Me Me Q.sub.32 OMe OMe CH1345 Me Me Q.sub.32 Me OMe N1346 Q.sub.33 Me COOMe Me OMe CH1347 Q.sub.33 Me COOMe OMe OMe CH1348 Q.sub.33 Me COOMe Me OMe N1349 Me Me Q.sub.33 OMe OMe CH1350 Me Me Q.sub.33 Me OMe N1351 Q.sub.34 Me COOMe Me OMe CH1352 Q.sub.34 Me COOMe OMe OMe CH1353 Q.sub.34 Me COOMe Me OMe N1354 Me Me Q.sub.34 OMe OMe CH1355 Me Me Q.sub.34 Me OMe N1356 Q.sub.35 Me COOMe Me OMe CH1357 Q.sub.35 Me COOMe OMe OMe CH1358 Q.sub.35 Me COOMe Me OMe N1359 Me Me Q.sub.35 OMe OMe CH1360 Me Me Q.sub.35 Me OMe N1361 Q.sub.36 Me COOMe Me OMe CH1362 Q.sub.36 Me COOMe OMe OMe CH1363 Q.sub.36 Me COOMe Me OMe N1364 Me Me Q.sub.36 OMe OMe CH1365 Me Me Q.sub.36 Me OMe N1366 Q.sub.37 Me COOMe Me OMe CH1367 Q.sub.37 Me COOMe OMe OMe CH1368 Q.sub.37 Me COOMe Me OMe N1369 Me Me Q.sub.37 OMe OMe CH1370 Me Me Q.sub.37 Me OMe N1371 Q.sub.38 Me COOMe Me OMe CH1372 Q.sub.38 Me COOMe OMe OMe CH1373 Q.sub.38 Me COOMe Me OMe N1374 Me Me Q.sub.38 OMe OMe CH1375 Me Me Q.sub.38 Me OMe N1376 Q.sub.39 Me COOMe Me OMe CH1377 Q.sub.39 Me COOMe OMe OMe CH1378 Q.sub.39 Me COOMe Me OMe N1379 Me Me Q.sub.39 OMe OMe CH1380 Me Me Q.sub.39 Me OMe N1381 Q.sub.40 Me COOMe Me OMe CH1382 Q.sub.40 Me COOMe OMe OMe CH1383 Q.sub.40 Me COOMe Me OMe N1384 Me Me Q.sub.40 OMe OMe CH1385 Me Me Q.sub.40 Me OMe N1386 Q.sub.41 Me COOMe Me OMe CH1387 Q.sub.41 Me COOMe OMe OMe CH1388 Q.sub.41 Me COOMe Me OMe N1389 Me Me Q.sub.41 OMe OMe CH1390 Me Me Q.sub.41 Me OMe N1391 Q.sub.42 Me COOMe Me OMe CH1392 Q.sub.42 Me COOMe OMe OMe CH1393 Q.sub.42 Me COOMe Me OMe N1394 Me Me Q.sub.42 OMe OMe CH1395 Me Me Q.sub.42 Me OMe N1396 Q.sub.43 Me COOMe Me OMe CH1397 Q.sub.43 Me COOMe OMe OMe CH1398 Q.sub.43 Me COOMe Me OMe N1399 Me Me Q.sub.43 OMe OMe CH1400 Me Me Q.sub.43 Me OMe N1401 Q.sub.44 Me COOMe Me OMe CH1402 Q.sub.44 Me COOMe OMe OMe CH1403 Q.sub.44 Me COOMe Me OMe N1404 Me Me Q.sub.44 OMe OMe CH1405 Me Me Q.sub.44 Me OMe N1406 Q.sub.45 Me COOMe Me OMe CH1407 Q.sub.45 Me COOMe OMe OMe CH1408 Q.sub.45 Me COOMe Me OMe N1409 Me Me Q.sub.45 OMe OMe CH1410 Me Me Q.sub.45 Me OMe N1411 Q.sub.46 Me COOMe Me OMe CH1412 Q.sub.46 Me COOMe OMe OMe CH1413 Q.sub.46 Me COOMe Me OMe N1414 Me Me Q.sub.46 OMe OMe CH1415 Me Me Q.sub.46 Me OMe N1416 Q.sub.47 Me COOMe Me OMe CH1417 Q.sub.47 Me COOMe OMe OMe CH1418 Q.sub.47 Me COOMe Me OMe N1419 Me Me Q.sub.47 OMe OMe CH1420 Me Me Q.sub.47 Me OMe N3315 Q.sub.48 Me COOMe OMe OMe CH3316 Me Q.sub.48 Me Me Me CH3317 Me Q.sub.48 Me Me OMe CH3318 Me Q.sub.48 Me OMe OMe CH3319 Me Me Q.sub.48 Me Me CH3320 Me Me Q.sub.48 Me OMe CH3321 Me Me Q.sub.48 OMe OMe CH3322 H Me Q.sub.48 OMe OMe CH3323 Q.sub.49 Me COOMe OMe OMe CH3324 Me Q.sub.49 Me Me Me CH3325 Me Q.sub.49 Me Me OMe CH3326 Me Q.sub.49 Me OMe OMe CH3327 Me Me Q.sub.49 Me Me CH3328 Me Me Q.sub.49 Me OMe CH3329 Me Me Q.sub.49 OMe OMe CH3330 H Me Q.sub.49 OMe OMe CH3331 Q.sub.50 Me COOMe OMe OMe CH3332 Me Q.sub.50 Me Me Me CH3333 Me Q.sub.50 Me Me OMe CH3334 Me Q.sub.50 Me OMe OMe CH3335 Me Me Q.sub.50 Me Me CH3336 Me Me Q.sub.50 Me OMe CH3337 Me Me Q.sub.50 OMe OMe CH3338 H Me Q.sub.50 OMe OMe CH3339 Q.sub.51 Me COOMe OMe OMe CH3340 Me Q.sub.51 Me Me Me CH3341 Me Q.sub.51 Me Me OMe CH3342 Me Q.sub.51 Me OMe OMe CH3343 Me Me Q.sub.51 Me Me CH3344 Me Me Q.sub.51 Me OMe CH3345 Me Me Q.sub.51 OMe OMe CH3346 H Me Q.sub.51 OMe OMe CH3347 Q.sub.52 Me COOMe OMe OMe CH3348 Me Q.sub.52 Me Me Me CH3349 Me Q.sub.52 Me Me OMe CH3350 Me Q.sub.52 Me OMe OMe CH3351 Me Me Q.sub.52 Me Me CH3352 Me Me Q.sub.52 Me OMe CH3353 Me Me Q.sub.52 OMe OMe CH3354 H Me Q.sub.52 OMe OMe CH3355 Q.sub.53 Me COOMe Me Me CH3356 Q.sub.53 Me COOMe Me OMe CH3357 Q.sub.53 Me COOMe OMe OMe CH3358 Q.sub.53 Me COOMe Me OMe N3359 Q.sub.53 Me COOMe OMe OMe N3360 Me Q.sub.53 Me Me OMe CH3361 Me Q.sub.53 Me OMe OMe CH3362 Me Q.sub.53 Me Me OMe N3363 Me Me Q.sub.53 Me OMe CH3364 Me Me Q.sub.53 OMe OMe CH3365 Me Me Q.sub.53 Me OMe N3366 H Me Q.sub.53 OMe OMe CH3367 Q.sub.54 Me COOMe OMe OMe CH3368 Me Q.sub.54 Me Me Me CH3369 Me Q.sub.54 Me Me OMe CH3370 Me Q.sub.54 Me OMe OMe CH3371 Me Me Q.sub.54 Me Me CH3372 Me Me Q.sub.54 Me OMe CH3373 Me Me Q.sub.54 OMe OMe CH3374 H Me Q.sub.54 OMe OMe CH3375 Q.sub.55 Me COOMe OMe OMe CH3376 Me Q.sub.55 Me Me Me CH3377 Me Q.sub.55 Me Me OMe CH3378 Me Q.sub.55 Me OMe OMe CH3379 Me Me Q.sub.55 Me Me CH3380 Me Me Q.sub.55 Me OMe CH3381 Me Me Q.sub.55 OMe OMe CH3382 H Me Q.sub.55 OMe OMe CH3383 Q.sub.56 Me COOMe OMe OMe CH3384 Me Q.sub.56 Me Me Me CH3385 Me Q.sub.56 Me Me OMe CH3386 Me Q.sub.56 Me OMe OMe CH3387 Me Me Q.sub.56 Me Me CH3388 Me Me Q.sub.56 Me OMe CH3389 Me Me Q.sub.56 OMe OMe CH3390 H Me Q.sub.56 OMe OMe CH3391 Q.sub.57 Me COOMe OMe OMe CH3392 Me Q.sub.57 Me Me Me CH3393 Me Q.sub.57 Me Me OMe CH3394 Me Q.sub.57 Me OMe OMe CH3395 Me Me Q.sub.57 Me Me CH3396 Me Me Q.sub.57 Me OMe CH3397 Me Me Q.sub.57 OMe OMe CH3398 H Me Q.sub.57 OMe OMe CH3399 Q.sub.58 Me COOMe OMe OMe CH3400 Me Q.sub.58 Me Me Me CH3401 Me Q.sub.58 Me Me OMe CH3402 Me Q.sub.58 Me OMe OMe CH3403 Me Me Q.sub.58 Me Me CH3404 Me Me Q.sub.58 Me OMe CH3405 Me Me Q.sub.58 OMe OMe CH3406 H Me Q.sub.58 OMe OMe CH3407 Q.sub.59 Me COOMe OMe OMe CH3408 Me Q.sub.59 Me Me Me CH3409 Me Q.sub.59 Me Me OMe CH3410 Me Q.sub.59 Me OMe OMe CH3411 Me Me Q.sub.59 Me Me CH3412 Me Me Q.sub.59 Me OMe CH3413 Me Me Q.sub.59 OMe OMe CH3414 H Me Q.sub.59 OMe OMe CH3415 Q.sub.60 Me COOMe Me Me CH3416 Q.sub.60 Me COOMe Me OMe CH3417 Q.sub.60 Me COOMe OMe OMe CH3418 Q.sub.60 Me COOMe Me OMe N3419 Q.sub.60 Me COOMe OMe OMe N3420 Me Q.sub.60 Me Me OMe CH3421 Me Q.sub.60 Me OMe OMe CH3422 Me Q.sub.60 Me Me OMe N3423 Me Me Q.sub.60 Me OMe CH3424 Me Me Q.sub.60 OMe OMe CH3425 Me Me Q.sub.60 Me OMe N3426 H Me Q.sub.60 OMe OMe CH3427 Q.sub.61 Me COOMe OMe OMe CH3428 Me Q.sub.61 Me Me Me CH3429 Me Q.sub.61 Me Me OMe CH3430 Me Q.sub.61 Me OMe OMe CH3431 Me Me Q.sub.61 Me Me CH3432 Me Me Q.sub.61 Me OMe CH3433 Me Me Q.sub.61 OMe OMe CH3434 H Me Q.sub.61 OMe OMe CH3435 Q.sub.62 Me COOMe OMe OMe CH3436 Me Q.sub.62 Me Me Me CH3437 Me Q.sub.62 Me Me OMe CH3438 Me Q.sub.62 Me OMe OMe CH3439 Me Me Q.sub.62 Me Me CH3440 Me Me Q.sub.62 Me OMe CH3441 Me Me Q.sub.62 OMe OMe CH3442 H Me Q.sub.62 OMe OMe CH3443 Q.sub.63 Me COOMe OMe OMe CH3444 Me Q.sub.63 Me Me Me CH3445 Me Q.sub.63 Me Me OMe CH3446 Me Q.sub.63 Me OMe OMe CH3447 Me Me Q.sub.63 Me Me CH3448 Me Me Q.sub.63 Me OMe CH3449 Me Me Q.sub.63 OMe OMe CH3450 H Me Q.sub.63 OMe OMe CH3451 Q.sub.64 Me COOMe OMe OMe CH3452 Me Q.sub.64 Me Me Me CH3453 Me Q.sub.64 Me Me OMe CH3454 Me Q.sub.64 Me OMe OMe CH3455 Me Me Q.sub.64 Me Me CH3456 Me Me Q.sub.64 Me OMe CH3457 Me Me Q.sub.64 OMe OMe CH3458 H Me Q.sub.64 OMe OMe CH3459 Q.sub.65 Me COOMe Me Me CH3460 Q.sub.65 Me COOMe Me OMe CH3461 Q.sub.65 Me COOMe OMe OMe CH3462 Q.sub.65 Me COOMe Me OMe N3463 Q.sub.65 Me COOMe OMe OMe N3464 Me Q.sub.65 Me Me OMe CH3465 Me Q.sub.65 Me OMe OMe CH3466 Me Q.sub.65 Me Me OMe N3467 Me Me Q.sub.65 Me OMe CH3468 Me Me Q.sub.65 OMe OMe CH3469 Me Me Q.sub.65 Me OMe N3470 H Me Q.sub.65 OMe OMe CH3471 Q.sub.66 Me COOMe OMe OMe CH3472 Me Q.sub.66 Me Me Me CH3473 Me Q.sub.66 Me Me OMe CH3474 Me Q.sub.66 Me OMe OMe CH3475 Me Me Q.sub.66 Me Me CH3476 Me Me Q.sub.66 Me OMe CH3477 Me Me Q.sub.66 OMe OMe CH3478 H Me Q.sub.66 OMe OMe CH3479 Q.sub.67 Me COOMe OMe OMe CH3480 Me Q.sub.67 Me Me Me CH3481 Me Q.sub.67 Me Me OMe CH3482 Me Q.sub.67 Me OMe OMe CH3483 Me Me Q.sub.67 Me Me CH3484 Me Me Q.sub.67 Me OMe CH3485 Me Me Q.sub.67 OMe OMe CH3486 H Me Q.sub.67 OMe OMe CH3487 Q.sub.68 Me COOMe Me Me CH3488 Q.sub.68 Me COOMe Me OMe CH3489 Q.sub.68 Me COOMe OMe OMe CH3490 Q.sub.68 Me COOMe Me OMe N3491 Q.sub.68 Me COOMe OMe OMe N3492 Me Q.sub.68 Me Me OMe CH3493 Me Q.sub.68 Me OMe OMe CH3494 Me Q.sub.68 Me Me OMe N3495 Me Me Q.sub.68 Me OMe CH3496 Me Me Q.sub.68 OMe OMe CH3497 Me Me Q.sub.68 Me OMe N3498 H Me Q.sub.68 OMe OMe CH3499 Q.sub.69 Me COOMe OMe OMe CH3500 Me Q.sub.69 Me Me Me CH3501 Me Q.sub.69 Me Me OMe CH3502 Me Q.sub.69 Me OMe OMe CH3503 Me Me Q.sub.69 Me Me CH3504 Me Me Q.sub.69 Me OMe CH3505 Me Me Q.sub.69 OMe OMe CH3506 H Me Q.sub.69 OMe OMe CH3507 Q.sub.70 Me COOMe OMe OMe CH3508 Me Q.sub.70 Me Me Me CH3509 Me Q.sub.70 Me Me OMe CH3510 Me Q.sub.70 Me OMe OMe CH3511 Me Me Q.sub.70 Me Me CH3512 Me Me Q.sub.70 Me OMe CH3513 Me Me Q.sub.70 OMe OMe CH3514 H Me Q.sub.70 OMe OMe CH3515 Q.sub.71 Me COOMe Me Me CH3516 Q.sub.71 Me COOMe Me OMe CH3517 Q.sub.71 Me COOMe OMe OMe CH3518 Q.sub.71 Me COOMe Me OMe N3519 Q.sub.71 Me COOMe OMe OMe N3520 Me Q.sub.71 Me Me OMe CH3519 Me Q.sub.71 Me OMe OMe CH3520 Me Q.sub.71 Me Me OMe N3521 Me Me Q.sub.71 Me OMe CH3522 Me Me Q.sub.71 OMe OMe CH3523 Me Me Q.sub.71 Me OMe N3524 H Me Q.sub.71 OMe OMe CH3525 Q.sub.72 Me COOMe OMe OMe CH3526 Me Q.sub.72 Me Me Me CH3527 Me Q.sub.72 Me Me OMe CH3528 Me Q.sub.72 Me OMe OMe CH3529 Me Me Q.sub.72 Me Me CH3530 Me Me Q.sub.72 Me OMe CH3531 Me Me Q.sub.72 OMe OMe CH3532 H Me Q.sub.72 OMe OMe CH3533 Q.sub.73 Me COOMe OMe OMe CH3534 Me Q.sub.73 Me Me Me CH3535 Me Q.sub.73 Me Me OMe CH3536 Me Q.sub.73 Me OMe OMe CH3537 Me Me Q.sub.73 Me Me CH3538 Me Me Q.sub.73 Me OMe CH3539 Me Me Q.sub.73 OMe OMe CH3540 H Me Q.sub.73 OMe OMe CH3541 Q.sub.74 Me COOMe OMe OMe CH3542 Me Q.sub.74 Me Me Me CH3543 Me Q.sub.74 Me Me OMe CH3544 Me Q.sub.74 Me OMe OMe CH3545 Me Me Q.sub.74 Me Me CH3546 Me Me Q.sub.74 Me OMe CH3547 Me Me Q.sub.74 OMe OMe CH3548 H Me Q.sub.74 OMe OMe CH3549 Q.sub.75 Me COOMe OMe OMe CH3550 Me Q.sub.75 Me Me Me CH3551 Me Q.sub.75 Me Me OMe CH3552 Me Q.sub.75 Me OMe OMe CH3553 Me Me Q.sub.75 Me Me CH3554 Me Me Q.sub.75 Me OMe CH3555 Me Me Q.sub.75 OMe OMe CH3556 H Me Q.sub.75 OMe OMe CH3557 Q.sub.76 Me COOMe OMe OMe CH3558 Me Q.sub.76 Me Me Me CH3559 Me Q.sub.76 Me Me OMe CH3560 Me Q.sub.76 Me OMe OMe CH3561 Me Me Q.sub.76 Me Me CH3562 Me Me Q.sub.76 Me OMe CH3563 Me Me Q.sub.76 OMe OMe CH3564 H Me Q.sub.76 OMe OMe CH3565 Q.sub.77 Me COOMe OMe OMe CH3566 Me Q.sub.77 Me Me Me CH3567 Me Q.sub.77 Me Me OMe CH3568 Me Q.sub.77 Me OMe OMe CH3569 Me Me Q.sub.77 Me Me CH3570 Me Me Q.sub.77 Me OMe CH3571 Me Me Q.sub.77 OMe OMe CH3572 H Me Q.sub.77 OMe OMe CH3573 Q.sub.78 Me COOMe OMe OMe CH3574 Me Q.sub.78 Me Me Me CH3575 Me Q.sub.78 Me Me OMe CH3576 Me Q.sub.78 Me OMe OMe CH3577 Me Me Q.sub.78 Me Me CH3578 Me Me Q.sub.78 Me OMe CH3579 Me Me Q.sub.78 OMe OMe CH3580 H Me Q.sub.78 OMe OMe CH3581 Q.sub.79 Me COOMe OMe OMe CH3582 Me Q.sub.79 Me Me Me CH3583 Me Q.sub.79 Me Me OMe CH3584 Me Q.sub.79 Me OMe OMe CH3585 Me Me Q.sub.79 Me Me CH3586 Me Me Q.sub.79 Me OMe CH3587 Me Me Q.sub.79 OMe OMe CH3588 H Me Q.sub.79 OMe OMe CH3589 Q.sub.80 Me COOMe OMe OMe CH3590 Me Q.sub.80 Me Me Me CH3591 Me Q.sub.80 Me Me OMe CH3592 Me Q.sub.80 Me OMe OMe CH3593 Me Me Q.sub.80 Me Me CH3594 Me Me Q.sub.80 Me OMe CH3595 Me Me Q.sub.80 OMe OMe CH3596 H Me Q.sub.80 OMe OMe CH3597 Q.sub.81 Me COOMe OMe OMe CH3598 Me Q.sub.81 Me Me Me CH3599 Me Q.sub.81 Me Me OMe CH3600 Me Q.sub.81 Me OMe OMe CH3601 Me Me Q.sub.81 Me Me CH3602 Me Me Q.sub.81 Me OMe CH3603 Me Me Q.sub.81 OMe OMe CH3604 H Me Q.sub.81 OMe OMe CH3605 Q.sub.79 Me COOMe OMe OMe CH3606 Me Q.sub.82 Me Me Me CH3607 Me Q.sub.82 Me Me OMe CH3608 Me Q.sub.82 Me OMe OMe CH3609 Me Me Q.sub.82 Me Me CH3610 Me Me Q.sub.82 Me OMe CH3611 Me Me Q.sub.82 OMe OMe CH3612 H Me Q.sub.82 OMe OMe CH3613 Q.sub.83 Me COOMe OMe OMe CH3614 Me Q.sub.83 Me Me Me CH3615 Me Q.sub.83 Me Me OMe CH3616 Me Q.sub.83 Me OMe OMe CH3617 Me Me Q.sub.83 Me Me CH3618 Me Me Q.sub.83 Me OMe CH3619 Me Me Q.sub.83 OMe OMe CH3620 H Me Q.sub.83 OMe OMe CH3619 Q.sub.84 Me COOMe OMe OMe CH3620 Me Q.sub.84 Me Me Me CH3621 Me Q.sub.84 Me Me OMe CH3622 Me Q.sub.84 Me OMe OMe CH3623 Me Me Q.sub.84 Me Me CH3624 Me Me Q.sub.84 Me OMe CH3625 Me Me Q.sub.84 OMe OMe CH3626 H Me Q.sub.84 OMe OMe CH3627 Q.sub.85 Me COOMe OMe OMe CH3628 Me Q.sub.85 Me Me Me CH3629 Me Q.sub.85 Me Me OMe CH3630 Me Q.sub.85 Me OMe OMe CH3631 Me Me Q.sub.85 Me Me CH3632 Me Me Q.sub.85 Me OMe CH3633 Me Me Q.sub.85 OMe OMe CH3634 H Me Q.sub.85 OMe OMe CH3635 Q.sub.86 Me COOMe OMe OMe CH3636 Me Q.sub.86 Me Me Me CH3637 Me Q.sub.86 Me Me OMe CH3638 Me Q.sub.86 Me OMe OMe CH3639 Me Me Q.sub.86 Me Me CH3640 Me Me Q.sub.86 Me OMe CH3641 Me Me Q.sub.86 OMe OMe CH3642 H Me Q.sub.86 OMe OMe CH3643 Q.sub.87 Me COOMe OMe OMe CH3644 Me Q.sub.87 Me Me Me CH3645 Me Q.sub.87 Me Me OMe CH3646 Me Q.sub.87 Me OMe OMe CH3647 Me Me Q.sub.87 Me Me CH3648 Me Me Q.sub.87 Me OMe CH3649 Me Me Q.sub.87 OMe OMe CH3650 H Me Q.sub.87 OMe OMe CH3651 Q.sub.88 Me COOMe OMe OMe CH3652 Me Q.sub.88 Me Me Me CH3653 Me Q.sub.88 Me Me OMe CH3654 Me Q.sub.88 Me OMe OMe CH3655 Me Me Q.sub.88 Me Me CH3656 Me Me Q.sub.88 Me OMe CH3657 Me Me Q.sub.88 OMe OMe CH3658 H Me Q.sub.88 OMe OMe CH3659 Q.sub.89 Me COOMe OMe OMe CH3660 Me Q.sub.89 Me Me Me CH3661 Me Q.sub.89 Me Me OMe CH3662 Me Q.sub.89 Me OMe OMe CH3663 Me Me Q.sub.89 Me Me CH3664 Me Me Q.sub.89 Me OMe CH3665 Me Me Q.sub.89 OMe OMe CH3666 H Me Q.sub.89 OMe OMe CH3667 Q.sub.90 Me COOMe Me Me CH3668 Q.sub.90 Me COOMe Me OMe CH3669 Q.sub.90 Me COOMe OMe OMe CH3670 Q.sub.90 Me COOMe Me OMe N3671 Q.sub.90 Me COOMe OMe OMe N3672 Me Q.sub.90 Me Me OMe CH3673 Me Q.sub.90 Me OMe OMe CH3674 Me Q.sub.90 Me Me OMe N3675 Me Me Q.sub.90 Me OMe CH3676 Me Me Q.sub.90 OMe OMe CH3677 Me Me Q.sub.90 Me OMe N3678 H Me Q.sub.90 OMe OMe CH3679 Q.sub.91 Me COOMe OMe OMe CH3680 Me Q.sub.91 Me Me Me CH3681 Me Q.sub.91 Me Me OMe CH3682 Me Q.sub.91 Me OMe OMe CH3683 Me Me Q.sub.91 Me Me CH3684 Me Me Q.sub.91 Me OMe CH3685 Me Me Q.sub.91 OMe OMe CH3686 H Me Q.sub.91 OMe OMe CH3687 Q.sub.92 Me COOMe Me Me CH3688 Q.sub.92 Me COOMe Me OMe CH3689 Q.sub.92 Me COOMe OMe OMe CH3690 Q.sub.92 Me COOMe Me OMe N3691 Q.sub.92 Me COOMe OMe OMe N3692 Me Q.sub.92 Me Me OMe CH3693 Me Q.sub.92 Me OMe OMe CH3694 Me Q.sub.92 Me Me OMe N3695 Me Me Q.sub.92 Me OMe CH3696 Me Me Q.sub.92 OMe OMe CH3697 Me Me Q.sub.92 Me OMe N3698 H Me Q.sub.92 OMe OMe CH3699 Q.sub.93 Me COOMe OMe OMe CH3700 Me Q.sub.93 Me Me Me CH3701 Me Q.sub.93 Me Me OMe CH3702 Me Q.sub.93 Me OMe OMe CH3703 Me Me Q.sub.93 Me Me CH3704 Me Me Q.sub. 93 Me OMe CH3705 Me Me Q.sub.93 OMe OMe CH3706 H Me Q.sub.93 OMe OMe CH3707 Q.sub.94 Me COOMe OMe OMe CH3708 Me Q.sub.94 Me Me Me CH3709 Me Q.sub.94 Me Me OMe CH3710 Me Q.sub.94 Me OMe OMe CH3711 Me Me Q.sub.94 Me Me CH3712 Me Me Q.sub.94 Me OMe CH3713 Me Me Q.sub.94 OMe OMe CH3714 H Me Q.sub.94 OMe OMe CH3715 Q.sub.95 Me COOMe OMe OMe CH3716 Me Q.sub.95 Me Me Me CH3717 Me Q.sub.95 Me Me OMe CH3718 Me Q.sub.95 Me OMe OMe CH3719 Me Me Q.sub.95 Me Me CH3720 Me Me Q.sub.95 Me OMe CH3721 Me Me Q.sub.95 OMe OMe CH3722 H Me Q.sub.95 OMe OMe CH3723 Q.sub.96 Me COOMe OMe OMe CH3724 Me Q.sub.96 Me Me Me CH3725 Me Q.sub.96 Me Me OMe CH3726 Me Q.sub.96 Me OMe OMe CH3727 Me Me Q.sub.96 Me Me CH3728 Me Me Q.sub.96 Me OMe CH3729 Me Me Q.sub.96 OMe OMe CH3730 H Me Q.sub.96 OMe OMe CH3731 Q.sub.97 Me COOMe OMe OMe CH3732 Me Q.sub.97 Me Me Me CH3733 Me Q.sub.97 Me Me OMe CH3734 Me Q.sub.97 Me OMe OMe CH3735 Me Me Q.sub.97 Me Me CH3736 Me Me Q.sub.97 Me OMe CH3737 Me Me Q.sub.97 OMe OMe CH3738 H Me Q.sub.97 OMe OMe CH3739 Q.sub.98 Me COOMe Me Me CH3740 Q.sub.98 Me COOMe Me OMe CH3741 Q.sub.98 Me COOMe OMe OMe CH3742 Q.sub.98 Me COOMe Me OMe N3743 Q.sub.98 Me COOMe OMe OMe N3744 Me Q.sub.98 Me Me OMe CH3745 Me Q.sub.98 Me OMe OMe CH3746 Me Q.sub.98 Me Me OMe N3747 Me Me Q.sub.98 Me OMe CH3748 Me Me Q.sub.98 OMe OMe CH3749 Me Me Q.sub.98 Me OMe N3750 H Me Q.sub.98 OMe OMe CH3751 Q.sub.99 Me COOMe OMe OMe CH3752 Me Q.sub.99 Me Me Me CH3753 Me Q.sub.99 Me Me OMe CH3754 Me Q.sub.99 Me OMe OMe CH3755 Me Me Q.sub.99 Me Me CH3756 Me Me Q.sub.99 Me OMe CH3757 Me Me Q.sub.99 OMe OMe CH3758 H Me Q.sub.99 OMe OMe CH3759 Q.sub.100 Me COOMe Me Me CH3760 Q.sub.100 Me COOMe Me OMe CH3761 Q.sub.100 Me COOMe OMe OMe CH3762 Q.sub.100 Me COOMe Me OMe N3763 Q.sub.100 Me COOMe OMe OMe N3764 Me Q.sub.100 Me Me OMe CH3765 Me Q.sub.100 Me OMe OMe CH3766 Me Q.sub.100 Me Me OMe N3767 Me Me Q.sub.100 Me OMe CH3768 Me Me Q.sub.100 OMe OMe CH3769 Me Me Q.sub.100 Me OMe N3770 H Me Q.sub.100 OMe OMe CH3771 Q.sub.101 Me COOMe OMe OMe CH3772 Me Q.sub.101 Me Me Me CH3773 Me Q.sub.101 Me Me OMe CH3774 Me Q.sub.101 Me OMe OMe CH3775 Me Me Q.sub.101 Me Me CH3776 Me Me Q.sub.101 Me OMe CH3777 Me Me Q.sub.101 OMe OMe CH3778 H Me Q.sub.101 OMe OMe CH3779 Q.sub.102 Me COOMe OMe OMe CH3780 Me Q.sub.102 Me Me Me CH3781 Me Q.sub.102 Me Me OMe CH3782 Me Q.sub.102 Me OMe OMe CH3783 Me Me Q.sub.102 Me Me CH3784 Me Me Q.sub.102 Me OMe CH3785 Me Me Q.sub.102 OMe OMe CH3786 H Me Q.sub.102 OMe OMe CH3787 Q.sub.103 Me COOMe OMe OMe CH3788 Me Q.sub.103 Me Me Me CH3789 Me Q.sub.103 Me Me OMe CH3790 Me Q.sub.103 Me OMe OMe CH3791 Me Me Q.sub.103 Me Me CH3792 Me Me Q.sub.103 Me OMe CH3793 Me Me Q.sub.103 OMe OMe CH3794 H Me Q.sub.103 OMe OMe CH3795 Q.sub.104 Me COOMe OMe OMe CH3796 Me Q.sub.104 Me Me Me CH3797 Me Q.sub.104 Me Me OMe CH3798 Me Q.sub.104 Me OMe OMe CH3799 Me Me Q.sub.104 Me Me CH3800 Me Me Q.sub.104 Me OMe CH3801 Me Me Q.sub.104 OMe OMe CH3802 H Me Q.sub.104 OMe OMe CH3803 Q.sub.105 Me COOMe OMe OMe CH3804 Me Q.sub.105 Me Me Me CH3805 Me Q.sub.105 Me Me OMe CH3806 Me Q.sub.105 Me OMe OMe CH3807 Me Me Q.sub.105 Me Me CH3808 Me Me Q.sub.105 Me OMe CH3809 Me Me Q.sub.105 OMe OMe CH3810 H Me Q.sub.105 OMe OMe CH3811 Q.sub.106 Me COOMe OMe OMe CH3812 Me Q.sub.106 Me Me Me CH3813 Me Q.sub.106 Me Me OMe CH3814 Me Q.sub.106 Me OMe OMe CH3815 Me Me Q.sub.106 Me Me CH3816 Me Me Q.sub.106 Me OMe CH3817 Me Me Q.sub.106 OMe OMe CH3818 H Me Q.sub.106 OMe OMe CH3819 Q.sub.107 Me COOMe OMe OMe CH3820 Me Q.sub.107 Me Me Me CH3819 Me Q.sub.107 Me Me OMe CH3820 Me Q.sub.107 Me OMe OMe CH3821 Me Me Q.sub.107 Me Me CH3822 Me Me Q.sub.107 Me OMe CH3823 Me Me Q.sub.107 OMe OMe CH3824 H Me Q.sub.107 OMe OMe CH3825 Q.sub.108 Me COOMe OMe OMe CH3826 Me Q.sub.108 Me Me Me CH3827 Me Q.sub.108 Me Me OMe CH3828 Me Q.sub.108 Me OMe OMe CH3829 Me Me Q.sub.108 Me Me CH3830 Me Me Q.sub.108 Me OMe CH3831 Me Me Q.sub.108 OMe OMe CH3832 H Me Q.sub.108 OMe OMe CH3833 Q.sub.109 Me COOMe OMe OMe CH3834 Me Q.sub.109 Me Me Me CH3835 Me Q.sub.109 Me Me OMe CH3836 Me Q.sub.109 Me OMe OMe CH3837 Me Me Q.sub.109 Me Me CH3838 Me Me Q.sub.109 Me OMe CH3839 Me Me Q.sub.109 OMe OMe CH3840 H Me Q.sub.109 OMe OMe CH3841 Q.sub.110 Me COOMe OMe OMe CH3842 Me Q.sub.110 Me Me Me CH3843 Me Q.sub.110 Me Me OMe CH3844 Me Q.sub.110 Me OMe OMe CH3845 Me Me Q.sub.110 Me Me CH3846 Me Me Q.sub.110 Me OMe CH3847 Me Me Q.sub.110 OMe OMe CH3848 H Me Q.sub.110 OMe OMe CH3849 Q.sub.111 Me COOMe OMe OMe CH3850 Me Q.sub.111 Me Me Me CH3851 Me Q.sub.111 Me Me OMe CH3852 Me Q.sub.111 Me OMe OMe CH3853 Me Me Q.sub.111 Me Me CH3854 Me Me Q.sub.111 Me OMe CH3855 Me Me Q.sub.111 OMe OMe CH3856 H Me Q.sub.111 OMe OMe CH3857 Q.sub.112 Me COOMe OMe OMe CH3858 Me Q.sub.112 Me Me Me CH3859 Me Q.sub.112 Me Me OMe CH3860 Me Q.sub.112 Me OMe OMe CH3861 Me Me Q.sub.112 Me Me CH3862 Me Me Q.sub.112 Me OMe CH3863 Me Me Q.sub.112 OMe OMe CH3864 H Me Q.sub.112 OMe OMe CH3865 Q.sub.113 Me COOMe OMe OMe CH3866 Me Q.sub.113 Me Me Me CH3867 Me Q.sub.113 Me Me OMe CH3868 Me Q.sub.113 Me OMe OMe CH3869 Me Me Q.sub.113 Me Me CH3870 Me Me Q.sub.113 Me OMe CH3871 Me Me Q.sub.113 OMe OMe CH3872 H Me Q.sub.113 OMe OMe CH3873 Q.sub.114 Me COOMe OMe OMe CH3874 Me Q.sub.114 Me Me Me CH3875 Me Q.sub.114 Me Me OMe CH3876 Me Q.sub.114 Me OMe OMe CH3877 Me Me Q.sub.114 Me Me CH3878 Me Me Q.sub.114 Me OMe CH3879 Me Me Q.sub.114 OMe OMe CH3880 H Me Q.sub.114 OMe OMe CH3881 Q.sub.115 Me COOMe OMe OMe CH3882 Me Q.sub.115 Me Me Me CH3883 Me Q.sub.115 Me Me OMe CH3884 Me Q.sub.115 Me OMe OMe CH3885 Me Me Q.sub.115 Me Me CH3886 Me Me Q.sub.115 Me OMe CH3887 Me Me Q.sub.115 OMe OMe CH3888 H Me Q.sub.115 OMe OMe CH3889 Q.sub.116 Me COOMe OMe OMe CH3890 Me Q.sub.116 Me Me Me CH3891 Me Q.sub.116 Me Me OMe CH3892 Me Q.sub.116 Me OMe OMe CH3893 Me Me Q.sub.116 Me Me CH3894 Me Me Q.sub.116 Me OMe CH3895 Me Me Q.sub.116 OMe OMe CH3896 H Me Q.sub.116 OMe OMe CH3897 Q.sub.117 Me COOMe OMe OMe CH3898 Me Q.sub.117 Me Me Me CH3899 Me Q.sub.117 Me Me OMe CH3900 Me Q.sub.117 Me OMe OMe CH3901 Me Me Q.sub.117 Me Me CH3902 Me Me Q.sub. 117 Me OMe CH3903 Me Me Q.sub.117 OMe OMe CH3904 H Me Q.sub.117 OMe OMe CH3905 Q.sub.118 Me COOMe OMe OMe CH3906 Me Q.sub.118 Me Me Me CH3907 Me Q.sub.118 Me Me OMe CH3908 Me Q.sub.118 Me OMe OMe CH3909 Me Me Q.sub.118 Me Me CH3910 Me Me Q.sub.118 Me OMe CH3911 Me Me Q.sub.118 OMe OMe CH3912 H Me Q.sub.118 OMe OMe CH3913 Q.sub.119 Me COOMe OMe OMe CH3914 Me Q.sub.119 Me Me Me CH3915 Me Q.sub.119 Me Me OMe CH3916 Me Q.sub.119 Me OMe OMe CH3917 Me Me Q.sub.119 Me Me CH3918 Me Me Q.sub.119 Me OMe CH3919 Me Me Q.sub.119 OMe OMe CH3920 H Me Q.sub.119 OMe OMe CH3919 Q.sub.120 Me COOMe OMe OMe CH3920 Me Q.sub.120 Me Me Me CH3921 Me Q.sub.120 Me Me OMe CH3922 Me Q.sub.120 Me OMe OMe CH3923 Me Me Q.sub.120 Me Me CH3924 Me Me Q.sub.120 Me OMe CH3925 Me Me Q.sub.120 OMe OMe CH3926 H Me Q.sub.120 OMe OMe CH3927 Q.sub.121 Me COOMe OMe OMe CH3928 Me Q.sub.121 Me Me Me CH3929 Me Q.sub.121 Me Me OMe CH3930 Me Q.sub.121 Me OMe OMe CH3931 Me Me Q.sub.121 Me Me CH3932 Me Me Q.sub.121 Me OMe CH3933 Me Me Q.sub.121 OMe OMe CH3934 H Me Q.sub.121 OMe OMe CH3935 Q.sub.122 Me COOMe OMe OMe CH3936 Me Q.sub.122 Me Me Me CH3937 Me Q.sub.122 Me Me OMe CH3938 Me Q.sub.122 Me OMe OMe CH3939 Me Me Q.sub.122 Me Me CH3940 Me Me Q.sub.122 Me OMe CH3941 Me Me Q.sub.122 OMe OMe CH3942 H Me Q.sub.122 OMe OMe CH3943 Q.sub.123 Me COOMe OMe OMe CH3944 Me Q.sub.123 Me Me Me CH3945 Me Q.sub.123 Me Me OMe CH3946 Me Q.sub.123 Me OMe OMe CH3947 Me Me Q.sub.123 Me Me CH3948 Me Me Q.sub.123 Me OMe CH3949 Me Me Q.sub.123 OMe OMe CH3950 H Me Q.sub.123 OMe OMe CH3951 Q.sub.124 Me COOMe OMe OMe CH3952 Me Q.sub.124 Me Me Me CH3953 Me Q.sub.124 Me Me OMe CH3954 Me Q.sub.124 Me OMe OMe CH3955 Me Me Q.sub.124 Me Me CH3956 Me Me Q.sub.124 Me OMe CH3957 Me Me Q.sub.124 OMe OMe CH3958 H Me Q.sub.124 OMe OMe CH3959 Q.sub.125 Me COOMe OMe OMe CH3960 Me Q.sub.125 Me Me Me CH3961 Me Q.sub.125 Me Me OMe CH3962 Me Q.sub.125 Me OMe OMe CH3963 Me Me Q.sub.125 Me Me CH3964 Me Me Q.sub.125 Me OMe CH3965 Me Me Q.sub.125 OMe OMe CH3966 H Me Q.sub.125 OMe OMe CH3967 Q.sub.126 Me COOMe OMe OMe CH3968 Me Q.sub.126 Me Me Me CH3969 Me Q.sub.126 Me Me OMe CH3970 Me Q.sub.126 Me OMe OMe CH3971 Me Me Q.sub.126 Me Me CH3972 Me Me Q.sub.126 Me OMe CH3973 Me Me Q.sub.126 OMe OMe CH3974 H Me Q.sub.126 OMe OMe CH3975 Q.sub.127 Me COOMe OMe OMe CH3976 Me Q.sub.127 Me Me Me CH3977 Me Q.sub.127 Me Me OMe CH3978 Me Q.sub.127 Me OMe OMe CH3979 Me Me Q.sub.127 Me Me CH3980 Me Me Q.sub.127 Me OMe CH3981 Me Me Q.sub.127 OMe OMe CH3982 H Me Q.sub.127 OMe OMe CH3983 Q.sub.128 Me COOMe OMe OMe CH3984 Me Q.sub.128 Me Me Me CH3985 Me Q.sub.128 Me Me OMe CH3986 Me Q.sub.128 Me OMe OMe CH3987 Me Me Q.sub.128 Me Me CH3988 Me Me Q.sub.128 Me OMe CH3989 Me Me Q.sub.128 OMe OMe CH3990 H Me Q.sub.128 OMe OMe CH3991 Q.sub.129 Me COOMe OMe OMe CH3992 Me Q.sub.129 Me Me Me CH3993 Me Q.sub.129 Me Me OMe CH3994 Me Q.sub.129 Me OMe OMe CH3995 Me Me Q.sub.129 Me Me CH3996 Me Me Q.sub.129 Me OMe CH3997 Me Me Q.sub.129 OMe OMe CH3998 H Me Q.sub.129 OMe OMe CH3999 Q.sub.130 Me COOMe OMe OMe CH4000 Me Q.sub.130 Me Me Me CH4001 Me Q.sub.130 Me Me OMe CH4002 Me Q.sub.130 Me OMe OMe CH4003 Me Me Q.sub.130 Me Me CH4004 Me Me Q.sub.130 Me OMe CH4005 Me Me Q.sub.130 OMe OMe CH4006 H Me Q.sub.130 OMe OMe CH4007 Q.sub.131 Me COOMe OMe OMe CH4008 Me Q.sub.131 Me Me Me CH4009 Me Q.sub.131 Me Me OMe CH4010 Me Q.sub.131 Me OMe OMe CH4011 Me Me Q.sub.131 Me Me CH4012 Me Me Q.sub.131 Me OMe CH4013 Me Me Q.sub.131 OMe OMe CH4014 H Me Q.sub.131 OMe OMe CH4015 Q.sub.132 Me COOMe OMe OMe CH4016 Me Q.sub.132 Me Me Me CH4017 Me Q.sub.132 Me Me OMe CH4018 Me Q.sub.132 Me OMe OMe CH4019 Me Me Q.sub.132 Me Me CH4020 Me Me Q.sub.132 Me OMe CH4021 Me Me Q.sub.132 OMe OMe CH4022 H Me Q.sub.132 OMe OMe CH______________________________________ TABLE 3______________________________________ ##STR15##No. A B D X Y Z______________________________________1421 Q.sub.1 H H Me OMe CH1422 Q.sub.1 H H OMe OMe CH1423 Q.sub.1 H H Me OMe N1424 Q.sub.1 Me H Me OMe CH1425 Q.sub.1 Me H OMe OMe CH1426 Q.sub.1 Me H Me OMe N1427 Q.sub.1 Cl H Me OMe CH1428 Q.sub.1 Cl H OMe OMe CH1429 Q.sub.1 Cl H Me OMe N1430 Q.sub.1 Br H Me OMe CH1431 Q.sub.1 Br H OMe OMe CH1432 Q.sub.1 Br H Me OMe N1433 Q.sub.1 COOMe H Me OMe CH1434 Q.sub.1 COOMe H OMe OMe CH1435 Q.sub.1 COOMe H Me OMe N1436 Q.sub.1 COOEt H Me OMe CH1437 Q.sub.1 COOEt H OMe OMe CH1438 Q.sub.1 COOEt H Me OMe N1439 Me Q.sub.1 H Me Me CH1440 Me Q.sub.1 H Me OMe CH1441 Me Q.sub.1 H OMe OMe CH1442 Me Q.sub.1 H Me OMe N1443 Me Q.sub.1 H OMe OMe N1444 COMe Q.sub.1 H Me OMe CH1445 COMe Q.sub.1 H OMe OMe CH1446 COMe Q.sub.1 H Me OMe N1447 Q.sub.2 H H Me OMe CH1448 Q.sub.2 H H OMe OMe CH1449 Q.sub.2 H H Me OMe N1450 Q.sub.2 Cl H Me OMe CH1451 Q.sub.2 Cl H OMe OMe CH1452 Q.sub.2 Cl H Me OMe N1453 Q.sub.2 COOMe H Me OMe CH1454 Q.sub.2 COOMe H OMe OMe CH1455 Q.sub.2 COOMe H Me OMe N1456 Me Q.sub.2 H Me OMe CH1457 Me Q.sub.2 H OMe OMe CH1458 Me Q.sub.2 H Me OMe N1459 Q.sub. 3 H H Me OMe CH1460 Q.sub.3 H H OMe OMe CH1461 Q.sub.3 H H Me OMe N1462 Q.sub.3 Cl H Me OMe CH1463 Q.sub.3 Cl H OMe OMe CH1464 Q.sub. 3 Cl H Me OMe N1465 Q.sub.3 COOMe H Me OMe CH1466 Q.sub.3 COOMe H OMe OMe CH1467 Q.sub.3 COOMe H Me OMe N1468 Me Q.sub.3 H Me OMe CH1469 Me Q.sub.3 H OMe OMe CH1470 Me Q.sub.3 H Me OMe N1471 Q.sub.4 H H Me OMe CH1471 Q.sub.4 H H OMe OMe CH1473 Q.sub.4 H H Me OMe N1474 Q.sub.4 Cl H Me OMe CH1475 Q.sub.4 Cl H OMe OMe CH1476 Q.sub.4 Cl H Me OMe N1477 Q.sub.4 COOMe H Me OMe CH1478 Q.sub.4 COOMe H OMe OMe CH1479 Q.sub.4 COOMe H Me OMe N1480 Me Q.sub.4 H Me OMe CH1481 Me Q.sub.4 H OMe OMe CH1482 Me Q.sub.4 H Me OMe N1483 Q.sub.5 H H Me OMe CH1484 Q.sub.5 H H OMe OMe CH1485 Q.sub.5 H H Me OMe N1486 Q.sub.5 Cl H Me OMe CH1487 Q.sub.5 Cl H OMe OMe CH1488 Q.sub.5 Cl H Me OMe N1489 Q.sub.5 COOMe H Me OMe CH1490 Q.sub.5 COOMe H OMe OMe CH1491 Q.sub.5 COOMe H Me OMe N1492 Me Q.sub.5 H Me OMe CH1493 Me Q.sub.5 H OMe OMe CH1494 Me Q.sub.5 H Me OMe N1495 Q.sub.6 H H Me OMe CH1496 Q.sub.6 H H OMe OMe CH1497 Q.sub.6 H H Me OMe N1498 Q.sub.6 Cl H Me OMe CH1499 Q.sub.6 Cl H OMe OMe CH1500 Q.sub.6 Cl H Me OMe N1501 Q.sub.6 COOMe H Me OMe CH1502 Q.sub.6 COOMe H OMe OMe CH1503 Q.sub.6 COOMe H Me OMe N1504 Me Q.sub.6 H Me OMe CH1505 Me Q.sub.6 H OMe OMe CH1506 Me Q.sub.6 H Me OMe N1507 Q.sub.7 Cl H Me OMe CH1508 Q.sub.7 Cl H OMe OMe CH1509 Q.sub.7 Cl H Me OMe N1510 Q.sub.7 COOMe H Me OMe CH1511 Q.sub.7 COOMe H OMe OMe CH1512 Q.sub.7 COOMe H Me OMe N1513 Me Q.sub.7 H Me OMe CH1514 Me Q.sub.7 H OMe OMe CH1515 Me Q.sub.7 H Me OMe N1516 Q.sub.8 Cl H Me OMe CH1517 Q.sub.8 Cl H OMe OMe CH1518 Q.sub.8 Cl H Me OMe N1519 Q.sub.8 COOMe H Me OMe CH1520 Q.sub.8 COOMe H OMe OMe CH1521 Q.sub.8 COOMe H Me OMe N1522 Me Q.sub.8 H Me OMe CH1523 Me Q.sub.8 H OMe OMe CH1524 Me Q.sub.8 H Me OMe N1525 Q.sub.9 Cl H Me OMe CH1526 Q.sub.9 Cl H OMe OMe CH1527 Q.sub.9 Cl H Me OMe N1528 Q.sub.9 COOMe H Me OMe CH1529 Q.sub.9 COOMe H OMe OMe CH1530 Q.sub.9 COOMe H Me OMe N1531 Me Q.sub.9 H Me OMe CH1532 Me Q.sub.9 H OMe OMe CH1533 Me Q.sub.9 H Me OMe N1534 Q.sub.10 Cl H Me OMe CH1535 Q.sub.10 Cl H OMe OMe CH1536 Q.sub.10 Cl H Me OMe N1537 Q.sub.10 COOMe H Me OMe CH1538 Q.sub.10 COOMe H OMe OMe CH1539 Q.sub.10 COOMe H Me OMe N1540 Me Q.sub.10 H Me OMe CH1541 Me Q.sub.10 H OMe OMe CH1542 Me Q.sub.10 H Me OMe N1543 Q.sub.11 H H Me OMe CH1544 Q.sub.11 H H OMe OMe CH1545 Q.sub.11 H H Me OMe N1546 Q.sub.11 Cl H Me OMe CH1547 Q.sub.11 Cl H OMe OMe CH1548 Q.sub.11 Cl H Me OMe N1549 Q.sub.11 COOMe H Me OMe CH1550 Q.sub.11 COOMe H OMe OMe CH1551 Q.sub.11 COOMe H Me OMe N1552 Me Q.sub.11 H Me OMe CH1553 Me Q.sub.11 H OMe OMe CH1554 Me Q.sub.11 H Me OMe N1555 Q.sub.12 H H Me OMe CH1556 Q.sub.12 H H OMe OMe CH1557 Q.sub.12 H H Me OMe N1558 Q.sub.12 Me H Me OMe CH1559 Q.sub.12 Me H OMe OMe CH1560 Q.sub.12 Me H Me OMe N1561 Q.sub.12 Cl H Me OMe CH1562 Q.sub.12 Cl H OMe OMe CH1563 Q.sub.12 Cl H Me OMe N1564 Q.sub.12 Br H Me OMe CH1565 Q.sub.12 Br H OMe OMe CH1566 Q.sub.12 Br H Me OMe N1567 Q.sub.12 COOMe H Me OMe CH1568 Q.sub.12 COOMe H OMe OMe CH1569 Q.sub.12 COOMe H Me OMe N1570 Q.sub.12 COOEt H Me OMe CH1571 Q.sub.12 COOEt H OMe OMe CH1572 Q.sub.12 COOEt H Me OMe N1573 Me Q.sub.12 H Me Me CH1574 Me Q.sub.12 H Me OMe CH1575 Me Q.sub.12 H OMe OMe CH1576 Me Q.sub.12 H Me OMe N1577 Me Q.sub.12 H OMe OMe N1578 COMe Q.sub.12 H Me OMe CH1579 COMe Q.sub.12 H OMe OMe CH1580 COMe Q.sub.12 H Me OMe N1581 Q.sub.13 H H Me OMe CH1582 Q.sub.13 H H OMe OMe CH1583 Q.sub.13 H H Me OMe N1584 Q.sub.13 Cl H Me OMe CH1585 Q.sub.13 Cl H OMe OMe CH1586 Q.sub.13 Cl H Me OMe N1587 Q.sub.13 COOMe H Me OMe CH1588 Q.sub.13 COOMe H OMe OMe CH1589 Q.sub.13 COOMe H Me OMe N1590 Me Q.sub.13 H Me OMe CH1591 Me Q.sub.13 H OMe OMe CH1592 Me Q.sub.13 H Me OMe N1593 Q.sub.14 H H Me OMe CH1594 Q.sub.14 H H OMe OMe CH1595 Q.sub.14 H H Me OMe N1596 Q.sub.14 Cl H Me OMe CH1597 Q.sub.14 Cl H OMe OMe CH1598 Q.sub.14 Cl H Me OMe N1599 Q.sub.14 COOMe H Me OMe CH1600 Q.sub.14 COOMe H OMe OMe CH1601 Q.sub.14 COOMe H Me OMe N1602 Me Q.sub.14 H Me OMe CH1603 Me Q.sub.14 H OMe OMe CH1604 Me Q.sub.14 H Me OMe N1605 Q.sub.15 Cl H Me OMe CH1606 Q.sub.15 Cl H OMe OMe CH1607 Q.sub.15 Cl H Me OMe N1608 Q.sub.15 COOMe H Me OMe CH1609 Q.sub.15 COOMe H OMe OMe CH1610 Q.sub.15 COOMe H Me OMe N1611 Me Q.sub.15 H Me OMe CH1612 Me Q.sub.15 H OMe OMe CH1613 Me Q.sub.15 H Me OMe N1614 Q.sub.16 Cl H Me OMe CH1615 Q.sub.16 Cl H OMe OMe CH1616 Q.sub.16 Cl H Me OMe N1617 Q.sub.16 COOMe H Me OMe CH1618 Q.sub.16 COOMe H OMe OMe CH1619 Q.sub.16 COOMe H Me OMe N1620 Me Q.sub.16 H Me OMe CH1621 Me Q.sub.16 H OMe OMe CH1622 Me Q.sub.16 H Me OMe N1623 Q.sub.17 Cl H Me OMe CH1624 Q.sub.17 Cl H OMe OMe CH1625 Q.sub.17 Cl H Me OMe N1626 Q.sub.17 COOMe H Me OMe CH1627 Q.sub.17 COOMe H OMe OMe CH1628 Q.sub.17 COOMe H Me OMe N1629 Me Q.sub.17 H Me OMe CH1630 Me Q.sub.17 H OMe OMe CH1631 Me Q.sub.17 H Me OMe N1632 Q.sub.18 Cl H Me OMe CH1633 Q.sub.18 Cl H OMe OMe CH1634 Q.sub.18 Cl H Me OMe N1635 Q.sub.18 COOMe H Me OMe CH1636 Q.sub.18 COOMe H OMe OMe CH1637 Q.sub.18 COOMe H Me OMe N1638 Me Q.sub.18 H Me OMe CH1639 Me Q.sub.18 H OMe OMe CH1640 Me Q.sub.18 H Me OMe N1641 Q.sub.19 H H Me OMe CH1642 Q.sub.19 H H OMe OMe CH1643 Q.sub.19 H H Me OMe N1644 Q.sub.19 Cl H Me OMe CH1645 Q.sub.19 Cl H OMe OMe CH1646 Q.sub.19 Cl H Me OMe N1647 Q.sub.19 COOMe H Me OMe CH1648 Q.sub.19 COOMe H OMe OMe CH1649 Q.sub.19 COOMe H Me OMe N1650 Me Q.sub.19 H Me OMe CH1651 Me Q.sub.19 H OMe OMe CH1652 Me Q.sub.19 H Me OMe N1653 Q.sub.20 Cl H Me OMe CH1654 Q.sub.20 Cl H OMe OMe CH1655 Q.sub.20 Cl H Me OMe N1656 Q.sub.20 COOMe H Me OMe CH1657 Q.sub.20 COOMe H OMe OMe CH1658 Q.sub.20 COOMe H Me OMe N1659 Me Q.sub.20 H Me OMe CH1660 Me Q.sub.20 H OMe OMe CH1661 Me Q.sub.20 H Me OMe N1662 Q.sub.21 Cl H Me OMe CH1663 Q.sub.21 Cl H OMe OMe CH1664 Q.sub. 21 Cl H Me OMe N1665 Q.sub.21 COOMe H Me OMe CH1666 Q.sub.21 COOMe H OMe OMe CH1667 Q.sub.21 COOMe H Me OMe N1668 Me Q.sub.21 H Me OMe CH1669 Me Q.sub.21 H OMe OMe CH1670 Me Q.sub.21 H Me OMe N1671 Q.sub.22 H H Me OMe CH1672 Q.sub.22 H H OMe OMe CH1673 Q.sub.22 H H Me OMe N1674 Q.sub.22 Me H Me OMe CH1675 Q.sub.22 Me H OMe OMe CH1676 Q.sub.22 Me H Me OMe N1677 Q.sub.22 Cl H Me OMe CH1678 Q.sub.22 Cl H OMe OMe CH1679 Q.sub.22 Cl H Me OMe N1680 Q.sub.22 Br H Me OMe CH1681 Q.sub.22 Br H OMe OMe CH1682 Q.sub.22 Br H Me OMe N1683 Q.sub.22 COOMe H Me OMe CH1684 Q.sub.22 COOMe H OMe OMe CH1685 Q.sub.22 COOMe H Me OMe N1686 Q.sub.22 COOEt H Me OMe CH1687 Q.sub.22 COOEt H OMe OMe CH1688 Q.sub.22 COOEt H Me OMe N1689 Me Q.sub.22 H Me Me CH1690 Me Q.sub.22 H Me OMe CH1691 Me Q.sub.22 H OMe OMe CH1692 Me Q.sub.22 H Me OMe N1693 Me Q.sub.22 H OMe OMe N1694 COMe Q.sub.22 H Me OMe CH1695 COMe Q.sub.22 H OMe OMe CH1696 COMe Q.sub.22 H Me OMe N1697 Q.sub.23 H H Me OMe CH1698 Q.sub.23 H H OMe OMe CH1699 Q.sub.23 H H Me OMe N1700 Q.sub.23 Cl H Me OMe CH1701 Q.sub.23 Cl H OMe OMe CH1702 Q.sub.23 Cl H Me OMe N1703 Q.sub.23 COOMe H Me OMe CH1704 Q.sub.23 COOMe H OMe OMe CH1705 Q.sub.23 COOMe H Me OMe N1706 Me Q.sub.23 H Me OMe CH1707 Me Q.sub.23 H OMe OMe CH1708 Me Q.sub.23 H Me OMe N1709 Q.sub.24 H H Me OMe CH1710 Q.sub.24 H H OMe OMe CH1711 Q.sub.24 H H Me OMe N1712 Q.sub.24 Cl H Me OMe CH1713 Q.sub.24 Cl H OMe OMe CH1714 Q.sub.24 Cl H Me OMe N1715 Q.sub.24 COOMe H Me OMe CH1716 Q.sub.24 COOMe H OMe OMe CH1717 Q.sub.24 COOMe H Me OMe N1718 Me Q.sub.24 H Me OMe CH1719 Me Q.sub.24 H OMe OMe CH1720 Me Q.sub.24 H Me OMe N1721 Q.sub.25 H H Me OMe CH1722 Q.sub.25 H H OMe OMe CH1723 Q.sub.25 H H Me OMe N1724 Q.sub.25 Cl H Me OMe CH1725 Q.sub.25 Cl H OMe OMe CH1726 Q.sub.25 Cl H Me OMe N1727 Q.sub.25 COOMe H Me OMe CH1728 Q.sub.25 COOMe H OMe OMe CH1729 Q.sub.25 COOMe H Me OMe N1730 Me Q.sub.25 H Me OMe CH1731 Me Q.sub.25 H OMe OMe CH1732 Me Q.sub.25 H Me OMe N1733 Q.sub.26 Cl H Me OMe CH1734 Q.sub.26 Cl H OMe OMe CH1735 Q.sub.26 Cl H Me OMe N1736 Q.sub.26 COOMe H Me OMe CH1737 Q.sub.26 COOMe H OMe OMe CH1738 Q.sub.26 COOMe H Me OMe N1739 Me Q.sub.26 H Me OMe CH1740 Me Q.sub.26 H OMe OMe CH1741 Me Q.sub.26 H Me OMe N1742 Q.sub.27 Cl H Me OMe CH1743 Q.sub.27 Cl H OMe OMe CH1744 Q.sub.27 Cl H Me OMe N1745 Q.sub.27 COOMe H Me OMe CH1746 Q.sub.27 COOMe H OMe OMe CH1747 Q.sub.27 COOMe H Me OMe N1748 Me Q.sub.47 H Me OMe CH1749 Me Q.sub.47 H OMe OMe CH1750 Me Q.sub.47 H Me OMe N1751 Q.sub.28 Cl H Me OMe CH1752 Q.sub.28 Cl H OMe OMe CH1753 Q.sub.28 Cl H Me OMe N1754 Q.sub.28 COOMe H Me OMe CH1755 Q.sub.28 COOMe H OMe OMe CH1756 Q.sub.28 COOMe H Me OMe N1757 Me Q.sub.28 H Me OMe CH1758 Me Q.sub.28 H OMe OMe CH1759 Me Q.sub.28 H Me OMe N1760 Q.sub.29 Cl H Me OMe CH1761 Q.sub.29 Cl H OMe OMe CH1762 Q.sub.29 Cl H Me OMe N1763 Q.sub.29 COOMe H Me OMe CH1764 Q.sub.29 COOMe H OMe OMe CH1765 Q.sub.29 COOMe H Me OMe N1766 Me Q.sub.29 H Me OMe CH1767 Me Q.sub.29 H OMe OMe CH1768 Me Q.sub.29 H Me OMe N1769 Q.sub.30 Cl H Me OMe CH1770 Q.sub.30 Cl H OMe OMe CH1771 Q.sub.30 Cl H Me OMe N1772 Q.sub.30 COOMe H Me OMe CH1773 Q.sub.30 COOMe H OMe OMe CH1774 Q.sub.30 COOMe H Me OMe N1775 Me Q.sub.30 H Me OMe CH1776 Me Q.sub.30 H OMe OMe CH1777 Me Q.sub.30 H Me OMe N1778 Q.sub.31 Cl H Me OMe CH1779 Q.sub.31 Cl H OMe OMe CH1780 Q.sub.31 Cl H Me OMe N1781 Q.sub.31 COOMe H Me OMe CH1782 Q.sub.31 COOMe H OMe OMe CH1783 Q.sub.31 COOMe H Me OMe N1784 Me Q.sub.31 H Me OMe CH1785 Me Q.sub.31 H OMe OMe CH1786 Me Q.sub.31 H Me OMe N1787 Q.sub.32 H H Me OMe CH1788 Q.sub.32 H H OMe OMe CH1789 Q.sub.32 H H Me OMe N1790 Q.sub.32 Cl H Me OMe CH1791 Q.sub.32 Cl H OMe OMe CH1792 Q.sub.32 Cl H Me OMe N1793 Q.sub.32 COOMe H Me OMe CH1794 Q.sub.32 COOMe H OMe OMe CH1795 Q.sub.32 COOMe H Me OMe N1796 Me Q.sub.32 H Me OMe CH1797 Me Q.sub.32 H OMe OMe CH1798 Me Q.sub.32 H Me OMe N1799 Q.sub.33 Cl H Me OMe CH1800 Q.sub.33 Cl H OMe OMe CH1801 Q.sub.33 Cl H Me OMe N1802 Q.sub.33 COOMe H Me OMe CH1803 Q.sub.33 COOMe H OMe OMe CH1804 Q.sub.33 COOMe H Me OMe N1805 Me Q.sub.33 H Me OMe CH1806 Me Q.sub.33 H OMe OMe CH1807 Me Q.sub.33 H Me OMe N1808 Q.sub.34 Cl H Me OMe CH1809 Q.sub.34 Cl H OMe OMe CH1810 Q.sub.34 Cl H Me OMe N1811 Q.sub.34 COOMe H Me OMe CH1812 Q.sub.34 COOMe H OMe OMe CH1813 Q.sub.34 COOMe H Me OMe N1814 Me Q.sub.34 H Me OMe CH1815 Me Q.sub.34 H OMe OMe CH1816 Me Q.sub.34 H Me OMe N1817 Q.sub.35 Cl H Me OMe CH1818 Q.sub.35 Cl H OMe OMe CH1819 Q.sub.35 Cl H Me OMe N1820 Q.sub.35 COOMe H Me OMe CH1821 Q.sub.35 COOMe H OMe OMe CH1822 Q.sub.35 COOMe H Me OMe N1823 Me Q.sub.35 H Me OMe CH1824 Me Q.sub.35 H OMe OMe CH1825 Me Q.sub.35 H Me OMe N1826 Q.sub.36 Cl H Me OMe CH1827 Q.sub.36 Cl H OMe OMe CH1828 Q.sub.36 Cl H Me OMe N1829 Q.sub.36 COOMe H Me OMe CH1830 Q.sub.36 COOMe H OMe OMe CH1831 Q.sub.36 COOMe H Me OMe N1832 Me Q.sub.36 H Me OMe CH1833 Me Q.sub.36 H OMe OMe CH1834 Me Q.sub.36 H Me OMe N1835 Q.sub.37 Cl H Me OMe CH1836 Q.sub.37 Cl H OMe OMe CH1837 Q.sub.37 Cl H Me OMe N1838 Q.sub.37 COOMe H Me OMe CH1839 Q.sub.37 COOMe H OMe OMe CH1840 Q.sub.37 COOMe H Me OMe N1841 Me Q.sub.37 H Me OMe CH1842 Me Q.sub.37 H OMe OMe CH1843 Me Q.sub.37 H Me OMe N1844 Q.sub.38 Cl H Me OMe CH1845 Q.sub.38 Cl H OMe OMe CH1846 Q.sub.38 Cl H Me OMe N1847 Q.sub.38 COOMe H Me OMe CH1848 Q.sub.38 COOMe H OMe OMe CH1849 Q.sub.38 COOMe H Me OMe N1850 Me Q.sub.38 H Me OMe CH1851 Me Q.sub.38 H OMe OMe CH1852 Me Q.sub.38 H Me OMe N1853 Q.sub.39 Cl H Me OMe CH1854 Q.sub.39 Cl H OMe OMe CH1855 Q.sub.39 Cl H Me OMe N1856 Q.sub.39 COOMe H Me OMe CH1857 Q.sub.39 COOMe H OMe OMe CH1858 Q.sub.39 COOMe H Me OMe N1859 Me Q.sub.39 H Me OMe CH1860 Me Q.sub.39 H OMe OMe CH1861 Me Q.sub.39 H Me OMe N1862 Q.sub.40 Cl H Me OMe CH1863 Q.sub.40 Cl H OMe OMe CH1864 Q.sub.40 Cl H Me OMe N1865 Q.sub.40 COOMe H Me OMe CH1866 Q.sub.40 COOMe H OMe OMe CH1867 Q.sub.40 COOMe H Me OMe N1868 Me Q.sub.40 H Me OMe CH1869 Me Q.sub.40 H OMe OMe CH1870 Me Q.sub.40 H Me OMe N1871 Q.sub.41 Cl H Me OMe CH1872 Q.sub.41 Cl H OMe OMe CH1873 Q.sub.41 Cl H Me OMe N1874 Q.sub.41 COOMe H Me OMe CH1875 Q.sub.41 COOMe H OMe OMe CH1876 Q.sub.41 COOMe H Me OMe N1877 Me Q.sub.41 H Me OMe CH1878 Me Q.sub.41 H OMe OMe CH1879 Me Q.sub.41 H Me OMe N1880 Q.sub.42 Cl H Me OMe CH1881 Q.sub.42 Cl H OMe OMe CH1882 Q.sub.42 Cl H Me OMe N1883 Q.sub.42 COOMe H Me OMe CH1884 Q.sub.42 COOMe H OMe OMe CH1885 Q.sub.42 COOMe H Me OMe N1886 Me Q.sub.42 H Me OMe CH1887 Me Q.sub.42 H OMe OMe CH1888 Me Q.sub.42 H Me OMe N1889 Q.sub.43 Cl H Me OMe CH1890 Q.sub.43 Cl H OMe OMe CH1891 Q.sub.43 Cl H Me OMe N1892 Q.sub.43 COOMe H Me OMe CH1893 Q.sub.43 COOMe H OMe OMe CH1894 Q.sub.43 COOMe H Me OMe N1895 Me Q.sub.43 H Me OMe CH1896 Me Q.sub.43 H OMe OMe CH1897 Me Q.sub.43 H Me OMe N1898 Q.sub.44 Cl H Me OMe CH1899 Q.sub.44 Cl H OMe OMe CH1900 Q.sub.44 Cl H Me OMe N1901 Q.sub.44 COOMe H Me OMe CH1902 Q.sub.44 COOMe H OMe OMe CH1903 Q.sub.44 COOMe H Me OMe N1904 Me Q.sub.44 H Me OMe CH1905 Me Q.sub.44 H OMe OMe CH1906 Me Q.sub.44 H Me OMe N1907 Q.sub.45 Cl H Me OMe CH1908 Q.sub.45 Cl H OMe OMe CH1909 Q.sub.45 Cl H Me OMe N1910 Q.sub.45 COOMe H Me OMe CH1911 Q.sub.45 COOMe H OMe OMe CH1912 Q.sub.45 COOMe H Me OMe N1913 Me Q.sub.45 H Me OMe CH1914 Me Q.sub.45 H OMe OMe CH1915 Me Q.sub.45 H Me OMe N1916 Q.sub.46 Cl H Me OMe CH1917 Q.sub.46 Cl H OMe OMe CH1918 Q.sub.46 Cl H Me OMe N1919 Q.sub.46 COOMe H Me OMe CH1920 Q.sub.46 COOMe H OMe OMe CH1921 Q.sub.46 COOMe H Me OMe N1922 Me Q.sub.46 H Me OMe CH1923 Me Q.sub.46 H OMe OMe CH1924 Me Q.sub.46 H Me OMe N1925 Q.sub.47 Cl H Me OMe CH1926 Q.sub.47 Cl H OMe OMe CH1927 Q.sub.47 Cl H Me OMe N1928 Q.sub.47 COOMe H Me OMe CH1929 Q.sub.47 COOMe H OMe OMe CH1930 Q.sub.47 COOMe H Me OMe N1931 Me Q.sub.47 H Me OMe CH1932 Me Q.sub.47 H OMe OMe CH1933 Me Q.sub.47 H Me OMe N4023 Q.sub.48 Br H Me OMe CH4024 Q.sub.48 Br H OMe OMe CH4025 Q.sub.48 Br H Me OMe N4026 Me Q.sub.48 H OMe OMe CH4027 Q.sub.49 Br H Me OMe CH4028 Q.sub.49 Br H OMe OMe CH4029 Q.sub.49 Br H Me OMe N4030 Me Q.sub.49 H OMe OMe CH4031 Q.sub.48 Br H Me OMe CH4032 Q.sub.48 Br H OMe OMe CH4033 Q.sub.48 Br H Me OMe N4034 Me Q.sub.48 H OMe OMe CH4035 Q.sub.50 Br H Me OMe CH4036 Q.sub.50 Br H OMe OMe CH4037 Q.sub.50 Br H Me OMe N4038 Me Q.sub.50 H OMe OMe CH4039 Q.sub.51 Br H Me OMe CH4040 Q.sub.51 Br H OMe OMe CH4041 Q.sub.51 Br H Me OMe N4042 Me Q.sub.51 H OMe OMe CH4043 Q.sub.52 Br H Me OMe CH4044 Q.sub.52 Br H OMe OMe CH4045 Q.sub.52 Br H Me OMe N4046 Me Q.sub.52 H OMe OMe CH4047 Q.sub.53 Br H Me OMe CH4048 Q.sub.53 Br H OMe OMe CH4049 Q.sub.53 Br H Me OMe N4050 Me Q.sub.53 H OMe OMe CH4051 Q.sub.54 Br H Me OMe CH4052 Q.sub. 54 Br H OMe OMe CH4053 Q.sub.54 Br H Me OMe N4054 Me Q.sub.54 H OMe OMe CH4055 Q.sub.55 Br H Me OMe CH4056 Q.sub.55 Br H OMe OMe CH4057 Q.sub.55 Br H Me OMe N4058 Me Q.sub.55 H OMe OMe CH4059 Q.sub.56 Br H Me OMe CH4060 Q.sub.56 Br H OMe OMe CH4061 Q.sub.56 Br H Me OMe N4062 Me Q.sub.56 H OMe OMe CH4063 Q.sub.57 Br H Me OMe CH4064 Q.sub.57 Br H OMe OMe CH4065 Q.sub.57 Br H Me OMe N4066 Me Q.sub.57 H OMe OMe CH4067 Q.sub.58 Br H Me OMe CH4068 Q.sub.58 Br H OMe OMe CH4069 Q.sub.58 Br H Me OMe N4070 Me Q.sub.58 H OMe OMe CH4071 Q.sub.59 Br H Me OMe CH4072 Q.sub.59 Br H OMe OMe CH4073 Q.sub.59 Br H Me OMe N4074 Me Q.sub.59 H OMe OMe CH4075 Q.sub.60 Br H Me OMe CH4076 Q.sub.60 Br H OMe OMe CH4077 Q.sub.60 Br H Me OMe N4078 Me Q.sub.60 H OMe OMe CH4079 Q.sub.61 Br H Me OMe CH4080 Q.sub.61 Br H OMe OMe CH4081 Q.sub.61 Br H Me OMe N4082 Me Q.sub.61 H OMe OMe CH4083 Q.sub.62 Br H Me OMe CH4084 Q.sub.62 Br H OMe OMe CH4085 Q.sub.62 Br H Me OMe N4086 Me Q.sub.62 H OMe OMe CH4087 Q.sub.63 Br H Me OMe CH4088 Q.sub.63 Br H OMe OMe CH4089 Q.sub.69 Br H Me OMe N4090 Me Q.sub.63 H OMe OMe CH4091 Q.sub.64 Br H Me OMe CH4092 Q.sub.64 Br H OMe OMe CH4093 Q.sub.64 Br H Me OMe N4094 Me Q.sub.64 H OMe OMe CH4095 Q.sub.65 Br H Me OMe CH4096 Q.sub.65 Br H OMe OMe CH4097 Q.sub.65 Br H Me OMe N4098 Me Q.sub.65 H OMe OMe CH4099 Q.sub.66 Br H Me OMe CH4100 Q.sub.66 Br H OMe OMe CH4101 Q.sub.66 Br H Me OMe N4102 Me Q.sub.66 H OMe OMe CH4103 Q.sub.67 Br H Me OMe CH4104 Q.sub.67 Br H OMe OMe CH4105 Q.sub.67 Br H Me OMe N4106 Me Q.sub.67 H OMe OMe CH4107 Q.sub.68 Br H Me OMe CH4108 Q.sub.68 Br H OMe OMe CH4109 Q.sub.68 Br H Me OMe N4110 Me Q.sub.68 H OMe OMe CH4111 Q.sub.69 Br H Me OMe CH4112 Q.sub.69 Br H OMe OMe CH4113 Q.sub.69 Br H Me OMe N4114 Me Q.sub.69 H OMe OMe CH4115 Q.sub.70 Br H Me OMe CH4116 Q.sub.70 Br H OMe OMe CH4117 Q.sub.70 Br H Me OMe N4118 Me Q.sub.70 H OMe OMe CH4119 Q.sub.71 Br H Me OMe CH4120 Q.sub.71 Br H OMe OMe CH4121 Q.sub.71 Br H Me OMe N4122 Me Q.sub.71 H OMe OMe CH4123 Q.sub.72 Br H Me OMe CH4124 Q.sub.72 Br H OMe OMe CH4125 Q.sub.72 Br H Me OMe N4126 Me Q.sub.72 H OMe OMe CH4127 Q.sub.73 Br H Me OMe CH4128 Q.sub.73 Br H OMe OMe CH4129 Q.sub.73 Br H Me OMe N4130 Me Q.sub.73 H OMe OMe CH4131 Q.sub.74 Br H Me OMe CH4132 Q.sub.74 Br H OMe OMe CH4133 Q.sub.74 Br H Me OMe N4134 Me Q.sub.74 H OMe OMe CH4135 Q.sub.75 Br H Me OMe CH4136 Q.sub.75 Br H OMe OMe CH4137 Q.sub.75 Br H Me OMe N4138 Me Q.sub.75 H OMe OMe CH4139 Q.sub.76 Br H Me OMe CH4140 Q.sub.76 Br H OMe OMe CH4141 Q.sub.76 Br H Me OMe N4142 Me Q.sub.76 H OMe OMe CH4143 Q.sub.77 Br H Me OMe CH4144 Q.sub.77 Br H OMe OMe CH4145 Q.sub.77 Br H Me OMe N4146 Me Q.sub.77 H OMe OMe CH4147 Q.sub.78 Br H Me OMe CH4148 Q.sub.78 Br H OMe OMe CH4149 Q.sub.78 Br H Me OMe N4150 Me Q.sub.78 H OMe OMe CH4151 Q.sub.79 Br H Me OMe CH4152 Q.sub.79 Br H OMe OMe CH4153 Q.sub. 79 Br H Me OMe N4154 Me Q.sub.79 H OMe OMe CH4155 Q.sub.80 Br H Me OMe CH4156 Q.sub.80 Br H OMe OMe CH4157 Q.sub.80 Br H Me OMe N4158 Me Q.sub.80 H OMe OMe CH4159 Q.sub.81 Br H Me OMe CH4160 Q.sub.81 Br H OMe OMe CH4161 Q.sub.81 Br H Me OMe N4162 Me Q.sub.81 H OMe OMe CH4163 Q.sub.82 Br H Me OMe CH4164 Q.sub.82 Br H OMe OMe CH4165 Q.sub.82 Br H Me OMe N4166 Me Q.sub.82 H OMe OMe CH4167 Q.sub.83 Br H Me OMe CH4168 Q.sub.83 Br H OMe OMe CH4169 Q.sub.83 Br H Me OMe N4170 Me Q.sub.83 H OMe OMe CH4171 Q.sub.83 Br H Me OMe CH4172 Q.sub.83 Br H OMe OMe CH4173 Q.sub.83 Br H Me OMe N4174 Me Q.sub.83 H OMe OMe CH4175 Q.sub.84 Br H Me OMe CH4176 Q.sub.84 Br H OMe OMe CH4177 Q.sub.84 Br H Me OMe N4178 Me Q.sub.84 H OMe OMe CH4179 Q.sub.85 Br H Me OMe CH4180 Q.sub.85 Br H OMe OMe CH4181 Q.sub.85 Br H Me OMe N4182 Me Q.sub.85 H OMe OMe CH4183 Q.sub.86 Br H Me OMe CH4184 Q.sub.86 Br H OMe OMe CH4185 Q.sub.86 Br H Me OMe N4186 Me Q.sub.86 H OMe OMe CH4187 Q.sub.87 Br H Me OMe CH4188 Q.sub.87 Br H OMe OMe CH4189 Q.sub.87 Br H Me OMe N4190 Me Q.sub.87 H OMe OMe CH4191 Q.sub.88 Br H Me OMe CH4192 Q.sub.88 Br H OMe OMe CH4193 Q.sub.88 Br H Me OMe N4194 Me Q.sub.88 H OMe OMe CH4195 Q.sub.89 Br H Me OMe CH4196 Q.sub.89 Br H OMe OMe CH4197 Q.sub.89 Br H Me OMe N4198 Me Q.sub.89 H OMe OMe CH4199 Q.sub.90 Br H Me OMe CH4200 Q.sub.90 Br H OMe OMe CH4201 Q.sub.90 Br H Me OMe N4202 Me Q.sub.90 H OMe OMe CH4203 Q.sub.91 Br H Me OMe CH4204 Q.sub.91 Br H OMe OMe CH4205 Q.sub.91 Br H Me OMe N4206 Me Q.sub.91 H OMe OMe CH4207 Q.sub.92 Br H Me OMe CH4208 Q.sub.92 Br H OMe OMe CH4209 Q.sub.92 Br H Me OMe N4210 Me Q.sub. 92 H OMe OMe CH4211 Q.sub.93 Br H Me OMe CH4212 Q.sub.93 Br H OMe OMe CH4213 Q.sub.93 Br H Me OMe N4214 Me Q.sub.93 H OMe OMe CH4215 Q.sub.94 Br H Me OMe CH4216 Q.sub.94 Br H OMe OMe CH4217 Q.sub.94 Br H Me OMe N4218 Me Q.sub.94 H OMe OMe CH4219 Q.sub.95 Br H Me OMe CH4220 Q.sub.95 Br H OMe OMe CH4221 Q.sub.95 Br H Me OMe N4222 Me Q.sub.95 H OMe OMe CH4223 Q.sub.96 Br H Me OMe CH4224 Q.sub.96 Br H OMe OMe CH4225 Q.sub.96 Br H Me OMe N4226 Me Q.sub.96 H OMe OMe CH4227 Q.sub.97 Br H Me OMe CH4228 Q.sub.97 Br H OMe OMe CH4229 Q.sub.97 Br H Me OMe N4230 Me Q.sub.97 H OMe OMe CH4231 Q.sub.98 Br H Me OMe CH4232 Q.sub.98 Br H OMe OMe CH4233 Q.sub.98 Br H Me OMe N4234 Me Q.sub.98 H OMe OMe CH4235 Q.sub.99 Br H Me OMe CH4236 Q.sub.99 Br H OMe OMe CH4237 Q.sub.99 Br H Me OMe N4238 Me Q.sub.99 H OMe OMe CH4239 Q.sub.100 Br H Me OMe CH4240 Q.sub.100 Br H OMe OMe CH4241 Q.sub.100 Br H Me OMe N4242 Me Q.sub.100 H OMe OMe CH4243 Q.sub.101 Br H Me OMe CH4244 Q.sub.101 Br H OMe OMe CH4245 Q.sub.101 Br H Me OMe N4246 Me Q.sub.101 H OMe OMe CH4247 Q.sub.102 Br H Me OMe CH4248 Q.sub.102 Br H OMe OMe CH4249 Q.sub.102 Br H Me OMe N4250 Me Q.sub.102 H OMe OMe CH4251 Q.sub.103 Br H Me OMe CH4252 Q.sub.103 Br H OMe OMe CH4253 Q.sub.103 Br H Me OMe N4254 Me Q.sub.103 H OMe OMe CH4255 Q.sub.104 Br H Me OMe CH4256 Q.sub.104 Br H OMe OMe CH4257 Q.sub.104 Br H Me OMe N4258 Me Q.sub.104 H OMe OMe CH4259 Q.sub.105 Br H Me OMe CH4260 Q.sub.105 Br H OMe OMe CH4261 Q.sub.105 Br H Me OMe N4262 Me Q.sub.105 H OMe OMe CH4263 Q.sub.106 Br H Me OMe CH4264 Q.sub.106 Br H OMe OMe CH4265 Q.sub.106 Br H Me OMe N4266 Me Q.sub.106 H OMe OMe CH4267 Q.sub.107 Br H Me OMe CH4268 Q.sub.107 Br H OMe OMe CH4269 Q.sub.107 Br H Me OMe N4270 Me Q.sub.107 H OMe OMe CH4271 Q.sub.108 Br H Me OMe CH4272 Q.sub.108 Br H OMe OMe CH4273 Q.sub.108 Br H Me OMe N4274 Me Q.sub.108 H OMe OMe CH4275 Q.sub.109 Br H Me OMe CH4276 Q.sub.109 Br H OMe OMe CH4277 Q.sub.109 Br H Me OMe N4278 Me Q.sub.108 H OMe OMe CH4279 Q.sub.110 Br H Me OMe CH4280 Q.sub.110 Br H OMe OMe CH4281 Q.sub.110 Br H Me OMe N4282 Me Q.sub.110 H OMe OMe CH4283 Q.sub.111 Br H Me OMe CH4284 Q.sub.111 Br H OMe OMe CH4285 Q.sub.111 Br H Me OMe N4286 Me Q.sub.111 H OMe OMe CH4287 Q.sub.112 Br H Me OMe CH4288 Q.sub.112 Br H OMe OMe CH4289 Q.sub.112 Br H Me OMe N4290 Me Q.sub.112 H OMe OMe CH4291 Q.sub.113 Br H Me OMe CH4292 Q.sub.113 Br H OMe OMe CH4293 Q.sub.113 Br H Me OMe N4294 Me Q.sub.113 H OMe OMe CH4295 Q.sub.114 Br H Me OMe CH4296 Q.sub.114 Br H OMe OMe CH4297 Q.sub.114 Br H Me OMe N4298 Me Q.sub.114 H OMe OMe CH4299 Q.sub.115 Br H Me OMe CH4300 Q.sub.115 Br H OMe OMe CH4301 Q.sub.115 Br H Me OMe N4302 Me Q.sub.115 H OMe OMe CH4303 Q.sub.116 Br H Me OMe CH4304 Q.sub.116 Br H OMe OMe CH4305 Q.sub.116 Br H Me OMe N4306 Me Q.sub.116 H OMe OMe CH4307 Q.sub.117 Br H Me OMe CH4308 Q.sub.117 Br H OMe OMe CH4309 Q.sub.117 Br H Me OMe N4310 Me Q.sub.117 H OMe OMe CH4311 Q.sub.118 Br H Me OMe CH4312 Q.sub.118 Br H OMe OMe CH4313 Q.sub.118 Br H Me OMe N4314 Me Q.sub.118 H OMe OMe CH4315 Q.sub.119 Br H Me OMe CH4316 Q.sub.119 Br H OMe OMe CH4317 Q.sub.119 Br H Me OMe N4318 Me Q.sub.119 H OMe OMe CH4319 Q.sub.120 Br H Me OMe CH4320 Q.sub.120 Br H OMe OMe CH4321 Q.sub.120 Br H Me OMe N4322 Me Q.sub.120 H OMe OMe CH4323 Q.sub.121 Br H Me OMe CH4324 Q.sub.121 Br H OMe OMe CH4325 Q.sub.121 Br H Me OMe N4326 Me Q.sub.121 H OMe OMe CH4327 Q.sub.122 Br H Me OMe CH4328 Q.sub.122 Br H OMe OMe CH4329 Q.sub.122 Br H Me OMe N4330 Me Q.sub.122 H OMe OMe CH4331 Q.sub.123 Br H Me OMe CH4332 Q.sub.123 Br H OMe OMe CH4333 Q.sub.123 Br H Me OMe N4334 Me Q.sub.123 H OMe OMe CH4335 Q.sub.124 Br H Me OMe CH4336 Q.sub.124 Br H OMe OMe CH4337 Q.sub.124 Br H Me OMe N4338 Me Q.sub.124 H OMe OMe CH4339 Q.sub.125 Br H Me OMe CH4340 Q.sub.125 Br H OMe OMe CH4341 Q.sub.125 Br H Me OMe N4342 Me Q.sub.125 H OMe OMe CH4343 Q.sub.126 Br H Me OMe CH4344 Q.sub.126 Br H OMe OMe CH4345 Q.sub.126 Br H Me OMe N4346 Me Q.sub.126 H OMe OMe CH4347 Q.sub.127 Br H Me OMe CH4348 Q.sub.127 Br H OMe OMe CH4349 Q.sub.127 Br H Me OMe N4350 Me Q.sub.127 H OMe OMe CH4351 Q.sub.128 Br H Me OMe CH4352 Q.sub.128 Br H OMe OMe CH4353 Q.sub. 128 Br H Me OMe N4354 Me Q.sub.128 H OMe OMe CH4355 Q.sub.129 Br H Me OMe CH4356 Q.sub.129 Br H OMe OMe CH4357 Q.sub.129 Br H Me OMe N4358 Me Q.sub.129 H OMe OMe CH4359 Q.sub.130 Br H Me OMe CH4360 Q.sub.130 Br H OMe OMe CH4361 Q.sub.130 Br H Me OMe N4362 Me Q.sub.130 H OMe OMe CH4363 Q.sub.131 Br H Me OMe CH4364 Q.sub.131 Br H OMe OMe CH4365 Q.sub.131 Br H Me OMe N4366 Me Q.sub.131 H OMe OMe CH4367 Q.sub.132 Br H Me OMe CH4368 Q.sub.132 Br H OMe OMe CH4369 Q.sub.132 Br H Me OMe N4370 Me Q.sub.132 H OMe OMe CH______________________________________ TABLE 4__________________________________________________________________________ ##STR16##No. A B D E W X Y Z__________________________________________________________________________1934 Q.sub.1 H COOMe H S Me OMe CH1935 Q.sub.1 H COOMe H S OMe OMe CH1936 Q.sub.1 H COOEt H S Me OMe CH1937 Q.sub.1 H COOEt H S OMe OMe CH1938 Q.sub.1 H COOMe Me O Me OMe CH1939 Q.sub.1 H COOMe Me O OMe OMe CH1940 Q.sub.1 H COOEt Me O OMe OMe CH1941 Q.sub.1 H COOMe OMe O Me OMe CH1942 Q.sub.1 H COOMe OMe O OMe OMe CH1943 Q.sub.1 H COOEt OMe O OMe OMe CH1944 Q.sub.1 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH1945 Q.sub.1 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH1946 Q.sub.1 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH1947 Q.sub.1 H COOMe CH.sub.2 CCH O Me OMe CH1948 Q.sub.1 H COOMe CH.sub.2 CCH O OMe OMe CH1949 Q.sub.1 H COOEt CH.sub.2 CCH O OMe OMe CH1950 Q.sub.12 H COOMe H S Me OMe CH1951 Q.sub.12 H COOMe H S OMe OMe CH1952 Q.sub.12 H COOEt H S Me OMe CH1953 Q.sub.12 H COOEt H S OMe OMe CH1954 Q.sub.12 H COOMe Me O Me OMe CH1955 Q.sub.12 H COOMe Me O OMe OMe CH1956 Q.sub.12 H COOEt Me O OMe OMe CH1957 Q.sub.12 H COOMe OMe O Me OMe CH1958 Q.sub.12 H COOMe OMe O OMe OMe CH1959 Q.sub.12 H COOEt OMe O OMe OMe CH1960 Q.sub.12 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH1961 Q.sub.12 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH1962 Q.sub.12 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH1963 Q.sub.12 H COOMe CH.sub.2 CCH O Me OMe CH1964 Q.sub.12 H COOMe CH.sub.2 CCH O OMe OMe CH1965 Q.sub.12 H COOEt CH.sub.2 CCH O OMe OMe CH1966 Q.sub.22 H COOMe H S Me OMe CH1967 Q.sub.22 H COOMe H S OMe OMe CH1968 Q.sub.22 H COOEt H S Me OMe CH1969 Q.sub.22 H COOEt H S OMe OMe CH1970 Q.sub.22 H COOMe Me O Me OMe CH1971 Q.sub.22 H COOMe Me O OMe OMe CH1972 Q.sub.22 H COOEt Me O OMe OMe CH1973 Q.sub.22 H COOMe OMe O Me OMe CH1974 Q.sub.22 H COOMe OMe O OMe OMe CH1975 Q.sub.22 H COOEt OMe O OMe OMe CH1976 Q.sub.22 H cOOMe CH.sub.2 CHCH.sub.2 O Me OMe CH1977 Q.sub.22 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH1978 Q.sub.22 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH1979 Q.sub.22 H COOMe CH.sub.2 CCH O Me OMe CH1980 Q.sub.22 H COOMe CH.sub.2 CCH O OMe OMe CH1981 Q.sub.22 H COOEt CH.sub.2 CCH O OMe OMe CH4371 Q.sub.1 H COOMe H NOMe Me OMe CH4372 Q.sub.1 H COOMe H NOMe OMe OMe CH4373 Q.sub.1 H COOEt H NOMe Me OMe CH4374 Q.sub.1 H COOEt H NOMe OMe OMe CH4375 Q.sub.1 H COOMe H NOEe Me OMe CH4376 Q.sub.1 H COOMe H NOEe OMe OMe CH4377 Q.sub.1 H COOEt H NOEe Me OMe CH4378 Q.sub. 1 H COOEt H NOEe OMe OMe CH4379 Q.sub.1 H COOMe H NMe Me OMe CH4380 Q.sub.1 H COOMe H NMe OMe OMe CH4381 Q.sub.1 H COOEt H NMe Me OMe CH4382 Q.sub.1 H COOEt H NMe OMe OMe CH4383 Q.sub.1 H COOMe H NH Me OMe CH4384 Q.sub.1 H COOMe H NH OMe OMe CH4385 Q.sub.1 H COOEt H NH Me OMe CH4386 Q.sub.1 H COOEt H NH OMe OMe CH4387 Q.sub.12 H COOMe H NOMe Me OMe CH4388 Q.sub.12 H COOMe H NOMe OMe OMe CH4389 Q.sub.12 H COOEt H NOMe Me OMe CH4390 Q.sub.12 H COOEt H NOMe OMe OMe CH4391 Q.sub.12 H COOMe H NOEe Me OMe CH4392 Q.sub.12 H COOMe H NOEe OMe OMe CH4393 Q.sub.12 H COOEt H NOEe Me OMe CH4394 Q.sub.12 H COOEt H NOEe OMe OMe CH4395 Q.sub.12 H COOMe H NMe Me OMe CH4396 Q.sub.12 H COOMe H NMe OMe OMe CH4397 Q.sub.12 H COOEt H NMe Me OMe CH4398 Q.sub.12 H COOEt H NMe OMe OMe CH4399 Q.sub.12 H COOMe H NH Me OMe CH4400 Q.sub.12 H COOMe H NH OMe OMe CH4401 Q.sub.12 H COOEt H NH Me OMe CH4402 Q.sub.12 H COOEt H NH OMe OMe CH4403 Q.sub.22 H COOMe H NOMe Me OMe CH4404 Q.sub.22 H COOMe H NOMe OMe OMe CH4405 Q.sub.22 H COOEt H NOMe Me OMe CH4406 Q.sub.22 H COOEt H NOMe OMe OMe CH4407 Q.sub.22 H COOMe H NOEe Me OMe CH4408 Q.sub.22 H COOMe H NOEe OMe OMe CH4409 Q.sub.22 H COOEt H NOEe Me OMe CH4410 Q.sub.22 H COOEt H NOEe OMe OMe CH4411 Q.sub.22 H COOMe H NMe Me OMe CH4412 Q.sub.22 H COOMe H NMe OMe OMe CH4413 Q.sub.22 H COOEt H NMe Me OMe CH4414 Q.sub.22 H COOEt H NMe OMe OMe CH4415 Q.sub.22 H COOMe H NH Me OMe CH4416 Q.sub.22 H COOMe H NH OMe OMe CH4417 Q.sub.22 H COOEt H NH Me OMe CH4418 Q.sub.22 H COOEt H NH OMe OMe CH__________________________________________________________________________ TABLE 5______________________________________ ##STR17##No. A B D X.sup.1 Y.sup.1 Z______________________________________1982 Q.sub.1 H COOMe Me Me CH1983 Q.sub.1 H COOMe Me OMe CH1984 Q.sub.1 H COOEt Me Me CH1985 Q.sub.1 H COOEt Me OMe CH1986 Q.sub.1 H COOEt Me Me N1987 Q.sub.12 H COOMe Me Me CH1988 Q.sub.12 H COOMe Me OMe CH1989 Q.sub.22 H COOMe Me Me CH1990 Q.sub.22 H COOMe Me OMe CH______________________________________ TABLE 6______________________________________ ##STR18##No. A B D X.sup.2 Y.sup.2______________________________________1991 Q.sub.1 H COOMe Me Me1992 Q.sub.1 H COOMe OMe Me1993 Q.sub.1 H COOMe SMe Me1994 Q.sub.1 H COOEt Me Me1995 Q.sub.1 H COOEt OMe Me1996 Q.sub.1 H COOEt SMe Me1997 Q.sub.12 H COOMe Me Me1998 Q.sub.12 H COOMe OMe Me1999 Q.sub.22 H COOMe Me Me2000 Q.sub.22 H COOMe OMe Me______________________________________ TABLE 7______________________________________ ##STR19##No. A B D Y.sup.4 X.sup.3 Y.sup.3 Z.sup.1______________________________________4419 Q.sub.1 H COOMe COOMe Me Me CH4420 Q.sub.1 H COOMe CN Me Me CH4421 Q.sub.1 H COOMe Me OMe OMe N4422 Q.sub.1 H COOEt COOMe Me Me CH4423 Q.sub.1 H COOEt CN Me Me CH4424 Q.sub.1 H COOEt Me OMe OMe N4425 Q.sub.1 Me COOMe COOMe Me Me CH4426 Q.sub.1 Me COOMe CN Me Me CH4427 Q.sub.1 Me COOMe Me OMe OMe N4428 Q.sub.1 Me COOEt COOMe Me Me CH4429 Q.sub.1 Me COOEt CN Me Me CH4430 Q.sub.1 Me COOEt Me OMe OMe N4431 Q.sub.12 H COOMe COOMe Me Me CH4432 Q.sub.12 H COOMe CN Me Me CH4433 Q.sub.12 H COOMe Me OMe OMe N4434 Q.sub.12 H COOEt COOMe Me Me CH4435 Q.sub.12 H COOEt CN Me Me CH4436 Q.sub.12 H COOEt Me OMe OMe N4437 Q.sub.12 Me COOMe COOMe Me Me CH4438 Q.sub.12 Me COOMe CN Me Me CH4439 Q.sub.12 Me COOMe Me OMe OMe N4440 Q.sub.12 Me COOEt COOMe Me Me CH4441 Q.sub.12 Me COOEt CN Me Me CH4442 Q.sub.12 Me COOEt Me OMe OMe N4443 Q.sub.22 H COOMe COOMe Me Me CH4444 Q.sub.22 H COOMe CN Me Me CH4445 Q.sub.22 H COOMe Me OMe OMe N4446 Q.sub.22 H COOEt COOMe Me Me CH4447 Q.sub.22 H COOEt CN Me Me CH4448 Q.sub.22 H COOEt Me OMe OMe N4449 Q.sub.22 Me COOMe COOMe Me Me CH4450 Q.sub.22 Me COOMe CN Me Me CH4451 Q.sub.22 Me COOMe Me OMe OMe N4452 Q.sub.22 Me COOET COOMe Me Me CH4453 Q.sub.22 Me COOEt CN Me Me CH4454 Q.sub.22 Me COOEt Me OMe OMe N______________________________________

Q.sub.1 to Q.sub.132 in Tables 1 to 7 each have the meanings shown below: ##STR20##

The compounds shown in Table 1 to Table 7 can be synthesized following the procedures in Examples 1 and 2 or the procedures described above. Properties of some of these compounds are shown in Table 8. In Table 8, the compound number correspond to the compound number in Table 1 to Table 7.

TABLE 8______________________________________Comp. No. m.p. (.degree.C.)______________________________________ 9 169-173 10 169-173 11 179-193313 215-216314 212-213315 213-214______________________________________

In application of the compounds of this invention as herbicides, they can be applied by mixing with suitable carriers such as solid carriers, including for example clay, talc, bentonite, diatomaceous earth and others, or liquid carriers, including for example water, alcohols (methanol, ethanol and the like), aromatic hydrocarbons (benzene, toluene, xylene and the like), chlorinated hydrocarbons, ethers, ketones, esters (ethyl acetate, etc.), acid amides (dimethylformamide, etc.) and others. They can be provided for practical use with addition of any desired additive selected from an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader and a stablizer and in any desired form such as a soluble concentrate, an emulsifiable concentrate, a wettable powder, a dust, a granule, etc.

In the following, there are shown examples of formulations of herbicides containing the compounds of this invention as active ingredients, but they are not limitative of this invention. In the exemplary formulations shown below, "parts" means "parts by weight".

EXEMPLARY FORMULATION 1

Wettable powder

Compound No. 9 of this invention: 50 parts Zeeklite PFP: 46 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039: 5 parts (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent): 2 parts (white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.)

All of the above components are mixed and pulverized homogeneously to prepare a wettable powder.

EXEMPLARY FORMULATION 2

Wettable powder

Compound No. 315 of this invention: 45 parts Zeeklite A: 48 parts (kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.) Solpol 5039: 5 parts (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) Carplex (anticaking agent): 4 parts (white carbon; trade name; produced by Shionogi Seiyaku Co., Ltd.)

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

EXEMPLARY FORMULATION 3

Emulsifiable concentrate

Compound No. 313 of this invention: 2 parts Xylene: 73 parts Dimethylformamide: 15 parts Solpol 2680: 10 parts (mixture of nonionic surfactant and anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.)

The above components are homogeneously mixed to prepare an emulsifiable concentrate.

In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

EXEMPLARY FORMULATION 4

Flowable

Compound No. 11 of this invention: 25 parts Agrisol S-710: 10 parts (nonionic surfactant; trade name; produced by Kao Co., Ltd.) Runox 1000 C: 0.5 part (anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.) 1% Rodopol water: 20 parts (thickener; trade name; produced by Rhone-Poulenc Co., Ltd.) Water: 44.5 parts

The above components are mixed homogeneously to provide a flowable agent.

EXEMPLARY FORMULATION 5

Granule

Compound No. 314 of this invention: 0.1 part Bentonite: 55.0 parts Talc: 44.9 parts

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

EXEMPLARY FORMULATION 6

Granule

Compound No. 315 of this invention: 0.5 part Bentonite: 55.0 parts Talc: 44.5 parts

All of the above components are mixed and pulverized homogenerously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

If desired, the compound of this invention may be applied as a mixture with other kinds of herbicides, various insecticides, sterilizers or adjuvants during preparation or spraying In particular, when applied in beet fields, useful ones include phenmedipham, desmedipham, lenacil, PAC., ethofumesate and so on.

As the other kinds of herbicides mentioned above, there may be included compounds as described in Farm Chemicals Handbook (1986).

The compounds of this invention can also be applied, in addition to the agricultural and horticultural fields such as farm fields, paddy fields, fruit gardens and the like, to the non-agricultural fields such as athletic grounds, vacant lands, belts along railroads and others in order to prevent and eliminate various weeds. The amounts of the herbicide to be applied, which may differ depending on the scenes to be applied, the time of application, the application method, the kinds of the objective grasses and the crops harvested, may generally range suitably from about 0.25 g to about 10 kg per hectare in terms of the active ingredient. When applied to beets in particular, it may range suitably from 0.25 to 1000 g/ha, preferably from 0.5 to 500 g/ha.

The following test examples are set forth for illustration of the utility of the compounds of this invention as herbicides.

TEST EXAMPLE 1

Herbicidal effect test by soil treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa spp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max) and (K) cotton (Gossypium spp) were sown mixedly. After covering soil to about 1.5 cm over the seeds, herbicides were sprayed evenly on the soil surface to predetermined proportions of the active ingredient.

In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria shown below.

The results are shown in Table 9.

Some of the compounds of this invention show the selectivity on certain crops.

Judgement criteria

5 . . . Growth control rates of more than 90% (almost completely withered) 4 . . . Growth control rates of 70 to 90% 3 . . . Growth control rates of 40 to 70% 2 . . . Growth control rates of 20 to 40% 1 . . . Growth control rates of 5 to 20% 0 . . . Growth control rates of less than 5% (substantially no effect)

The above growth control rates are determined by measuring the top fresh weights of the treated plants and those of the non-treated plants, and calculated from the following formula: ##EQU1##

TEST EXAMPLE 2

Herbicidal effect test by foliage treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the foliage portion at predetermined proportions of the active ingredient. In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface of the foliage portions of various weeds by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria as shown in Test example 1.

The results are shown in Table 10.

TEST EXAMPLE 3

Agricultural chemical damage test on sugar beet

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (L) sugar beet (Beta vulgaris), (M) groundsel (Senecio vulgaris), (N) common field-speedwell (Veronica persica), (O) wild mustard (Sinapis arvensis) and (P) cleavers (Galium aparine) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.

On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on sugar beet were examined. The results are shown in Table 11.

TABLE 9__________________________________________________________________________ Amount of active ingredientCompound appliedNo. kg/ha (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L)__________________________________________________________________________ 9 0.16 4 5 2 5 5 5 5 0 0 5 3 -- 0.32 5 5 5 5 5 5 5 1 1 5 5 -- 10 0.63 5 5 5 5 5 5 5 0 0 5 5 -- 11 0.16 5 5 2 5 5 5 5 5 0 5 5 -- 0.32 5 5 5 5 5 5 5 5 0 5 0 --313 0.32 5 5 5 5 5 5 5 5 5 5 0 --314 0.16 3 4 2 5 5 5 5 5 5 4 0 -- 0.32 5 5 5 5 5 5 5 5 5 5 0 --315 0.82 0 5 2 5 5 5 5 5 5 5 0 -- 0.16 0 5 5 5 5 5 5 5 5 5 0 --__________________________________________________________________________ (A) rice (oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa spp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris). TABLE 10__________________________________________________________________________ Amount of active ingredientCompound appliedNo. kg/ha (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L)__________________________________________________________________________ 9 0.04 4 4 2 5 5 5 5 0 0 5 5 5 0.08 5 5 4 5 5 5 5 1 1 5 5 5 10 0.63 5 5 2 5 5 5 5 4 1 5 1 5 11 0.08 4 5 2 5 5 5 5 4 0 5 0 0 0.16 5 5 5 5 5 5 5 5 0 5 0 0313 0.16 0 4 2 5 5 5 5 5 0 5 5 5 0.32 0 5 4 5 5 5 5 5 0 5 5 5314 0.08 0 4 2 5 5 5 5 5 0 5 5 4 0.16 0 5 5 5 5 5 5 5 0 5 5 5315 0.04 0 4 2 5 5 5 5 5 4 5 5 0 0.08 0 5 4 5 5 5 5 5 5 5 5 0__________________________________________________________________________ (A) rice (oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa spp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris). TABLE 11______________________________________ Amount of active ingredientCompound appliedNo. kg/ha M N O P L______________________________________ 11 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.16 5 5 5 5 0315 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.16 5 5 5 5 0______________________________________ (L) sugar beet (Beta vulgaris), (M) groundsel (Senecio vulgaris), (N) common fieldspeedwell (Veronica persica), (O) wild mustard (Sinapis arvensis) and (P) cleavers (Galium aparine).

Claims

1. A pyrazolesulfonamide derivative represented by Formula (I): ##STR21## wherein Q represents a group of; ##STR22## wherein R.sup.1, R.sup.3, R.sup.9 and R.sup.10 each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a cyano group or a group of CO.sub.2 R.sup.13 ;

R.sup.2 and R.sup.4 each represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.5 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkylgroup, a C.sub.1 -C.sub.8 alkoxy group or a group of S(O).sub.n R.sup.12 ;

R.sup.6 represents a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a group of CO.sub.2 R.sup.13 ;

R.sup.7 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a dialkylamino group;

R.sup.8 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a nitro group;

R.sup.11 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a halogenated C.sub.1 -C.sub.8 alkyl group;

W.sup.1 represents an oxygen atom, a sulfur atom or a group of NR.sup.13 ;

R.sup.12 represents a C.sub.1 -C.sub.8 alkyl group;

R.sup.13 represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group; and n represents an integer of 0, 1 or 2;

B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.14, a group of CH.sub.2 COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of CH.sub.2 CN, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of COR.sup.13, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C.sub.1 -C.sub.8 alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

R.sup.14 represents a hydrogen atom, an unsubstituted C.sub.1 -C.sub.8 alkyl group (or a C.sub.1 -C.sub.8 alkyl group substituted with an unsubstituted C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkoxy group substituted with a group of OR.sup.13, a halogenated C.sub.1 -C.sub.8 alkoxy group, a cyano group, a phenoxy group, a C.sub.1 -C.sub.8 alkoxycarbonyl group, a group of NR.sup.12 R.sup.13, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkylcarbonyl group), an unsubstituted C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkenyl group substituted with a halogen atom, an unsubstituted C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkynyl group substituted with a halogen atom, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a benzyl group;

R.sup.15 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a phenyl group;

R.sup.16 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.17 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a phenyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyloxy group or a C.sub.1 -C.sub.8 alkynyloxy group; n represents an integer of 0, 1 or 2;

R.sup.18 and R.sup.19 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylcarbonyl group or a C.sub.1 -C.sub.8 alkylsulfonyl group;

R.sup.20 and R.sup.21 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkynyl group;

E represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkoxy group;

W represents an oxygen atom, a sulfur atom or a group of NR.sup.16 ;

G represents ##STR23## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxyalkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkoxy group, a group of NR.sup.22 R.sup.23, a group of OCH(R.sup.13)COOR.sup.13, a group of COOR.sup.13, a cyclopropyl group, a group of CH(OR.sup.24).sub.2, a C.sub.1 -C.sub.8 alkylthio group or a halogenated C.sub.1 -C.sub.8 alkylthio group;

R.sup.22 and R.sup.23 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.24 represents a C.sub.1 -C.sub.8 alkyl group;

X.sup.1 and Y.sup.1 each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

Z represents a group of C--R.sup.25 ;

R.sup.25 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a halogen atom, a C.sub.1 -C.sub.8 alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ;

with the proviso that the group: ##STR24## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of --CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a group of --CH.sub.2 COOR.sup.13, a group of --COR.sup.13, a group of --SO.sub.2 R.sup.24, a group of --SO.sub.2 NR.sup.13 R.sup.24 or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group).

2. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR25##

3. The pyrazolesulfonamide derivative according to claim 2, werein

B represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a halogen atom;

D represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.14, a group of S(O).sub.n R.sup.17, a group of SO.sub.2 NR.sup.20 R.sup.21 or COR.sup.13 ;

W represents an oxygen atom;

E represents a hydrogen atom; and

G represents a group of ##STR26##

4. The pyrazolesulfonamide derivative according to claim 3, wherein

D represents a group of --COOR.sup.14 (wherein R.sup.14 is selected from the group of a C.sub.1 -C.sub.8 alkyl group which may be substituted with a C.sub.1 -C.sub.8 alkoxy group or a halogen atom, a C.sub.1 -C.sub.8 alkenyl group and a C.sub.1 -C.sub.8 alkynyl group);

X and Y each represent a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a halogen atom or a group of --OCHF.sub.2 ; and

Z represents a nitrogen atom or a group of --CH.

5. The pyrazolesulfonamide derivative according to claim 3, wherein

Q represents ##STR27##

6. The pyrazolesulfonamide derivative according to claim 3, wherein

Q represents ##STR28##

7. The pyrazolesulfonamide derivative according to claim 3, wherein

Q represents ##STR29##

8. The pyrazolesulfonamide derivative according to claim 3, wherein

Q represents ##STR30##

9. The pyrazolesulfonamide derivative according to claim 3, wherein

Q represents ##STR31##

10. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR32##

11. The pyrazolesulfonamide derivative according to claim 10, wherein

B represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, C.sub.1 -C.sub.8 alkoxyalkyl group or a phenyl group which may be substituted (The substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

D represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a halogen atom;

W represents an oxygen atom;

E represents a hydrogen atom; and

G represents a group of ##STR33##

12. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represents by the formula: ##STR34##

13. The pyrazolesulfonamide derivative according to claim 12, wherein

B represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkoxyalkyl group;

D represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group;

W represents an oxygen atom;

E represents a hydrogen atom; and

G represents a group of ##STR35##

14. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR36##

15. The pyrazolesulfonamide derivative according to claim 2, wherein

B represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group;

D represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a halogen atom;

W represents an oxygen atom;

E represents a hydrogen atom; and

G represents a group of ##STR37##

16. The pyrazolesulfonamide derivative according to claim 1, wherein

Q represents ##STR38## B represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a C.sub.1 -C.sub.8 alkoxyalkyl group or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

D represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxyl group, a halogen atom;

W represents an oxygen atom;

E represents a hydrogen atom;

G represents the group ##STR39## and Z represents CH.

17. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula; ##STR40##

18. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR41##

19. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR42##

20. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR43##

21. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide.

22. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-3-methyl-1-(2-quinolyl)pyrazole-5-sulfonamide.

23. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide.

24. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(2-quinolyl)pyrazole-5-sulfonamide.

25. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.

26. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-3-methyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.

27. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.

28. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.

29. A herbicidal composition comprising an agricultural carrier and as an active component one or more kinds of a pyrazolesulfonamide derivative represented by Formula (I): ##STR44## wherein Q represents a group of; ##STR45## wherein R.sup.1, R.sup.3, R.sup.9 and R.sup.10 each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a cyano group or a group of CO.sub.2 R.sup.13 ;

R.sup.2 and R.sup.4 each represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.5 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a group of S(O).sub.n R.sup.12 ;

R.sup.6 represents a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a group of CO.sub.2 R.sup.13 ;

R.sup.7 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group or a dialkylamino group;

R.sup.8 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a nitro group;

R.sup.11 represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a halogenated C.sub.1 -C.sub.8 alkyl group;

W.sup.1 represents an oxygen atom, a sulfur atom or a group of NR.sup.13 ;

R.sup.12 represents a C.sub.1 -C.sub.8 alkyl group;

R.sup.13 represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group; and n represents an integer of 0, 1 or 2;

B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.14, a group of CH.sub.2 COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of CH.sub.2 CN, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of COR.sup.13, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C.sub.1 -C.sub.8 alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

R.sup.14 represents a hydrogen atom, an unsubstituted C.sub.1 -C.sub.8 alkyl group (or a C.sub.1 -C.sub.8 alkyl group substituted with an unsubstituted C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkoxy group substituted with a group of OR.sup.13, a halogenated C.sub.1 -C.sub.8 alkoxy group, a cyano group, a phenoxy group, a C.sub.1 -C.sub.8 alkoxycarbonyl group, a group of NR.sup.12 R.sup.13, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkylcarbonyl group), an unsubstituted C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkenyl group substituted with a halogen atom, an unsubstituted C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkynyl group substituted with a halogen atom, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a benzyl group;

R.sup.15 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a phenyl group;

R.sup.16 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.17 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a phenyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyloxy group or a C.sub.1 -C.sub.8 alkynyloxy group;

n represents an integer of 0, 1 or 2;

R.sup.18 and R.sup.19 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylcarbonyl group or a C.sub.1 -C.sub.8 alkylsulfonyl group;

R.sup.20 and R.sup.21 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkynyl group;

E represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkoxy group;

W represents an oxygen atom, a sulfur atom or a group of NR.sup.16 ;

G represents ##STR46## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxyalkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkoxy group, a group of NR.sup.22 R.sup.23, a group of OCH(R.sup.13)COOR.sup.13, a group of COOR.sup.13, a cyclopropyl group, a group of CH(OR.sup.24).sub.2, a C.sub.1 -C.sub.8 alkylthio group or a halogenated C.sub.1 -C.sub.8 alkylthio group;

R.sup.22 and R.sup.23 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

R.sup.24 represents a C.sub.1 -C.sub.8 alkyl group;

X.sup.1 and Y.sup.1 each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;

Z represents a group of C--R.sup.25 ;

R.sup.25 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 halogenated alkyl group, a halogen atom, a C.sub.1 -C.sub.8 alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y.sup.1 ;

with the proviso that the group: ##STR47## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of --CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxy-C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio-C.sub.1 -C.sub.8 alkyl group, a group of --CH.sub.2 COOR.sup.13, a group of --COR.sup.13, a group of --SO.sub.2 R.sup.24, a group of --SO.sub.2 NR.sup.13 R.sup.24 or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

and an agriculturally acceptable salt thereof.

30. The herbicidal composition according to claim 29, wherein

Q represents ##STR48## B represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a C.sub.1 -C.sub.8 alkoxyalkyl group or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR.sup.13 or a C.sub.1 -C.sub.8 alkyl group);

D represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxyl group, a halogen atom

W represents an oxygen atom;

E represents a hydrogen atom;

G represents the group ##STR49## Z represents CH.

31. The herbicidal composition according to claim 24, wherein the derivative is represented by the formula; ##STR50##

32. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR51##

33. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR52##

34. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR53##