Claims
- 1. A pyrazolidine derivative or a salt thereof expressed by the following formula 1: ##STR9## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO--; B represents a group expressed by --O-- or --NH--; n is an integer of 1 or 2; R represents an alkenyl group; and R.sub.1, and R.sub.2 represent a lower alkyl or benzyl group.
- 2. A pyrazolidine derivative or a salt thereof according to claim 1, wherein R is a branched alkenyl group.
- 3. A pyrazolidine derivative or a salt thereof according to claim 2, wherein R is a group expressed by R.sub.3 --C(CH.sub.3).dbd.CH--CH--.sub.2 -- in which R.sub.3 represents methyl, prenyl, or geranyl group.
- 4. A pyrazolidine derivative or a salt thereof according to claim 1, wherein each of R.sub.1 and R.sub.2 is ethyl group.
- 5. A pyrazolidine derivative or a salt thereof according to claim 1, wherein A is --CO-- group and B is --NH-- group.
- 6. A pyrazoldine derivative or a salt thereof according to claim 1, expressed by the following formula 2: ##STR10## wherein wherein R is a group expressed by R.sub.3 --C(CH.sub.3).dbd.CH--CH.sub.2 -- in which R.sub.3 represents an alkenyl group.
- 7. A pyrazolidine derivative or a salt thereof according to claim 6, wherein R.sub.3 is prenyl group.
- 8. A pyrazolidine derivative or a salt thereof according to claim 1, expressed by the following formula 3: ##STR11## wherein R.sub.3 represents methyl, prenyl, or geranyl group and R.sub.1 and R.sub.2 represent a lower alkyl or benzyl group.
- 9. A pyrazolidine derivative or a salt thereof according to claim 8, wherein each of R.sub.1 and R.sub.2 is ethyl group.
- 10. A pyrazolidine derivative or a salt thereof according to claim 8 or wherein R.sub.3 is prenyl group.
- 11. A pyrazolidine derivative or a salt thereof according to claim 1, expressed by the following formula 4: ##STR12## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO-- and B represents a group expressed by --O-- or --NH--.
- 12. A radical scavenger comprising, as an effective ingredient, a pyrazolidine derivative or a pharmacologically acceptable salt thereof according to claim 1, together with a pharmaceutically acceptable carrier and/or adjuvant.
- 13. A brain infarction depressant comprising, as an effective ingredient, a pyrazolidine derivative or a pharmacologically acceptable salt thereof according to claim 1, together with a pharmaceutically acceptable carrier and/or adjuvant.
- 14. A brain edema depressant comprising, as an effective ingredient, a pyrazolidine derivative or a pharmacologically acceptable salt thereof according to claim 1, together with a pharmaceutically acceptable carrier and/or adjuvant.
- 15. A method for inhibiting a brain infarction in man or mammals, which compises administration to it of an effective amount of a pyrazolidine derivative or a pharmacologically acceptable salt thereof according to claim 1.
- 16. A method for inhibiting a brain edema in man or mammals, which compises administration to it of an effective amount of a pyrazolidine derivative or a pharmacologically acceptable salt thereof according to claim 1.
- 17. A pyrazolidine derivative or a salt thereof according to claim 1, wherein R is neryl group.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7-101711 |
Apr 1995 |
JPX |
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RELATED APPLICATIONS
This application is a continuation of application Ser. No. 08/617,707, filed Apr. 1, 1996 now abandoned.
This application claims the priority of Japanese Patent Application No.7-101711 filed on Apr. 3, 1995, which is incorporated herein by reference.
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Continuations (1)
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Number |
Date |
Country |
Parent |
617707 |
Apr 1996 |
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