Claims
- 1. A compound of the formula: ##STR22## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl;
- R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl;
- R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl)C.sub.1 -C.sub.6 alkyl;
- R.sup.4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, or morpholino group;
- R.sup.5 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, NR.sup.7 R.sup.8, or CONR.sup.7 R.sup.8 ;
- R.sup.7 and R.sup.8 are each independently H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkoxy)C.sub.2 -C.sub.4 alkyl or hydroxy C.sub.2 -C.sub.4 alkyl; and pharmaceutically acceptable salts thereof.
- 2. A compound as claimed in claim 1 wherein R.sup.1 is H, methyl or ethyl; R.sup.2 is C.sub.1 -C.sub.3 alkyl optionally substituted by OH or methoxy; R.sup.3 is C.sub.2 -C.sub.3 alkyl or allyl; R.sup.4 taken together with the nitrogen atom to which it is attached completes a piperidino group; R.sup.5 is H, NR.sup.7 R.sup.8 or CONR.sup.7 R.sup.8 ; and R.sup.7 and R.sup.8 are each independently H or methyl.
- 3. A pharmaceutical composition comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 2, together with a pharmaceutically acceptable diluent or carrier.
- 4. A method of treating, in a human being, angina, hypertension, heart failure or atherosclerosis which comprises administering to said human being an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 2, or a pharmaceutical composition as claimed in claim 3.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9013750.6 |
Jun 1990 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 07/882,988, filed on May 14, 1992, now U.S. Pat. No. 5,250,534, which is a continuation of Ser. No. 07/717,227, filed on Jun. 14, 1991, abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4052390 |
Broughton et al. |
Oct 1977 |
|
4167568 |
Knowles et al. |
Sep 1979 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
1095688 |
Aug 1988 |
AUX |
Divisions (1)
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Number |
Date |
Country |
Parent |
882988 |
May 1992 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
717227 |
Jun 1991 |
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