Pyridine-3-carboxamide derivatives

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel compounds which belong to 1,4-dihydro-4-oxo-3-pyridinecarboxamides. The compounds of this invention show growth inhibitory activities on plants and also antiinflammatory activity.
2. Description of the Prior Arts
Some compounds belonging to 1,4-dihydro-4-oxo-3-pyridinecarboxamides are found in literatures.
In Bull. Acad. Pol. Sci., Ser. Sci. Chim. 23(11), 901 (1975), Zankowska-Jasinska. W. et al., reported on N-(4-chlorophenyl)-1,4-dihydro-4-oxo-1,2,6-triphenyl-3-pyridinecarboxamide and 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-N,2,6-triphenyl-3-pyridinecarboxamide. In Zesz. Nauk. Uniw. Jagiellon., Pr. Chim, 21., 141 (1976), Zankowska-Jasinska. W. et al., reported on 1,4-dihydro-4-oxo-N,2,6-triphenyl-3-pyridinecarboxamide, 1,4-dihydro-4-oxo-N,1,2,6-tetraphenyl-3-pyridinecarboxaminde, 1,4-dihydro-2,6-dimethyl-4-oxo-N,1-diphenyl-3-pyridinecarboxamide.
In Yakugakuzassi, 101, 40 (1981), Kato et al. reported on four compounds, namely N-(4-clorophenyl)-1,4-dihydro-2,6-dimethyl-4-oxo-3-pyridinecarboxamide, 1,4-dihydro-2,6-dimethyl-4-oxo-N-phenyl-1-(phenylmethyl)-3-pyridinecarboxamide, 1,4-dihydro-N-(4-methoxyphenyl)-2,6-dimethyl-4-oxo-1-(phenylmethyl)-3-pyridinecarboxamide and N-(4-chlorophenyl)-1,4-dihydro-2,6-dimethyl-4-oxo-1-(phenylmethyl)-3-pyridinecarboxamide, as one of the studies on reactivity of ketene derivatives but they did not refer to utility thereof. Canadian Patent No. 1,115,278 [and also J. B. Pierce et al, J. Med. Chem. 25, 131 (1982)], there are disclosed 4-pyridone compounds possessing antiinflammatory activity, i.e., 1,4-dihydro-2,6-dimethyl-4-oxo-N,1-diphenyl-3-pyridinecarboxamide, N,1-dibutyl-1,4-dihydro-2,6-dimethyl-4-oxo-3-pyridinecarboxamide, N,1-didodecyl-1,4-dihydro-2,6-dimethyl-4-oxo-3-pyridinecarboxamide, N-(4-chlorophenyl)-1-ethyl-1,4-dihydro-2,6-dimethyl-4-oxo-3-pyridinecarboxamide, etc.
Cephalosporins which contain a partial structure of 1,4-dihydro-4-oxo-3-pyridinecarboxamide are known as medicine in Japanese Patent Unexamined Publication Nos. Sho 54(1979)-24892, Sho 51(1976)-43783 and Sho 51(1976)-48686.
On the other hand, 1,4-dihydro-4-oxo-3-pyridine-carboxylic acid derivatives as compounds which show plant growth regulating activity, especially chemical hybridizing activity, are known in Japanese Patent Unexamined Publication Nos. Sho 52(1977)-144,676 (see also U.S. Pat. No. 4,051,142) and Sho 57(1982)-114,573 (see also E.P. 40,082). However, plant growth inhibitory agents whose active ingredients are 1,4-dihydro-4-oxo-3-pyridinecarboxamide as in the formula (I) shown below are not known.
SUMMARY OF THE INVENTION
This invention provides compounds of the formula (I) and salts thereof. ##STR2## or a salt thereof wherein R is hydrogen atom, phenyl group which may be substituted freely or a group of --(CH.sub.2).sub.n --R.sub.1 wherein n is an integer from 1 to 3 and R.sub.1 is hydrogen atom, hydroxy group, lower alkoxy group, mercapto group, lower alkylthio group, amino group, di-lower alkylamino group, C.sub.3-11 alkyl group, lower alkenyl group, lower alkynyl group, cycloalkyl group, 5- or 6-membered heterocyclic group, or phenyl group which may be substituted by one or two substituents of halogen, lower alkyl or lower alkoxy; R.sub.2 and R.sub.7 are different, hydrogen atom, C.sub.1-11 alkyl group, lower alkenyl group, lower alkynyl group, cycloalkyl group, lower alkoxyalkyl group, lower alkylthioalkyl group, phenyl group which may be substituted freely, aralkyl group whose nucleus may be substituted by one or two substituents of halogen, lower alkyl or lower alkoxy or haloalkyl group or 5-or 6-membered heterocyclic group;
R.sub.3, R.sub.4 and R.sub.5 are, the same of different, hydrogen atom, halogen atom, cyano group, nitro group, amino group, lower alkyl group, lower haloalkyl group, hydroxy group, lower alkoxy group, aryloxy group, carboxy group or lower alkoxycarbonyl group;
R.sub.6 is hydrogen atom, halogen atom, lower alkyl group, phenyl group which may be substituted freely or aralkyl group which may be substituted freely; or R.sub.6 and R.sub.7 may be combined to form a group of --(CH.sub.2).sub.m --(m is 3 or 4).
This invention also provides plant growth inhibitors which contain at least one kind of compounds of the formula (I) and salts thereof as active ingredient.
DESCRIPTION OF PREFERRED EMBODIMENTS
The term of "lower" used for lower alkyl, lower alkoxy or like group in this invention means a group containing 1-5 carbon atoms. Specifically, there may be mentioned as lower alkyl group methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl or isopentyl; as lower alkoxy group methoxy, ethoxy, propoxy, isopropoxy or butoxy; as lower alkoxycarbonyl group methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl or butoxycarbonyl; or as lower alkylthio group methylthio, ethylthio, propylthio, isopropylthio, butylthio or pentylthio. As lower alkenyl or lower alkynyl group may be mentioned vinyl, allyl, isopropenyl 2-butenyl, 1,3-butadienyl, 2-pentenyl, 1,4-pentadienyl, 1,6-heptadienyl, 1-hexenyl, ethynyl or 2-propynyl.
Examples of cycloalkyl group include cyclopropyl, cyclopentyl and cyclohexyl.
Examples of haloalkyl group include trifluoromethyl, chloromethyl and the like.
Examples of lower alkoxyalkyl group include methoxymethyl, ethoxymethyl, propoxymethyl, butoxymethyl and the like.
Examples of lower alkylthioalkyl group include methylthiomethyl, ethylthiomethyl, methylthioethyl, ethylthioethyl and the like.
Halogen atom includes chlorine, bromine, fluorine and iodine atom.
Examples of aralkyl group include benzyl, 3-phenylpropyl, 4-phenylbutyl and the like.
Examples of aryloxy group include phenyloxy, naphtyloxy and the like.
5- or 6-Membered heterocyclic group includes 5- or 6-membered one containing one to three hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom. The examples of the 5-membered heterocyclic group are furyl, tetrahydrofuryl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isooxazolyl or pyrazolyl and the 6-membered heterocyclic group are pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl. These heterocyclic groups may be substituted by alkyl as methyl or ethyl, halogen atom or phenyl. When the heterocyclic group is substituted by phenyl, it may form a condensed ring combining the two adjacent carbon atoms in the heterocyclic group with phenyl group. Examples of the condensed ring are benzothiazolyl, benzofuryl, quinazolinyl or quinoxalinyl group.
Examples of substituent of phenyl group and aralkyl group which may be substituted freely include halogen atom, lower alkyl, lower alkoxy, trihaloalkyl, nitro, cyano and the like, and as numbers of the substituents one or two is preferable.
The compound of the formula (I) in this invention may form an addition salt with an acid such as hydrochloric acid, sulfuric acid, phosphoric acid, methanesulfonic acid, p-toluenesulfonic acid or trifluoroacetic acid when sufficiently basic, and also form a salt with an inorganic base when it contains a carboxylic group. Such salts are also included in this invention.

The compound of the formula (I) in this invention may be prepared by any of the following methods.
(Method A) ##STR3## [R, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 of the formula (II) are the same as those in the formula (I)]
This method comprises reacting a 3-aminoacrylic acid anilide derivative (II) or its tautomer with 2,2,6-trimethyl-4H-1,3-dioxin-4-one in an appropriate solvent (e.g., toluene or xylene) under heating at a temperature of e.g., 100.degree.-140.degree. C. 2-Ethyl-2,6-dimethyl-4H-1,3-dioxin-4-one is also useful in place of 2,2,6-trimethyl-4H-1,3-dioxin-4-one. Also, in this method, 3-aminoacrylic acid anilide derivative (II) is not necessarily required to be in its isolated form but may be in the form of the crude reaction mixture of an amine of the formula (III) with a compound of the formula (IV) ##STR4## [R, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 in the formula (III) and (IV) are the same as those in the formula (I).]
For the practical purpose it is convenient to use the crude reaction mixture as such
(Method B) ##STR5## [R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 in the formula (III) and (V) are the same as those in the formula (I).]
This method comprises reacting a 4-pyrone compound (V) corresponding to the formula (I), i.e., 4-oxo-N-phenyl-4H-pyran-3-carboxamide with ammonia or an amine of the formula (III) or a salt thereof in an appropriate solvent (e.g., ethanol or water) at a temperature from room temperature to about 60.degree. C. The amount of ammonia or the amine employed is equimolecular or more to the 4-pyrone compound or a large excess if needed. When the amine is used as its available salt, it is required to convert to its free form by addition of an organic or an inorganic base in an amount needed for neutralization or more.
(Method C) ##STR6## [R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 in the formula (VI) and (VII) are the same meaning as defined in the formula (I).]
This method comprises reacting a carboxylic acid corresponding to the formula (I), i.e., 1,4-dihydro-4oxo-3-pyridinecarboxylic acid derivative (VI) with an aniline derivative (VII) in the presence of a condensing agent for dehydration. It is advantageous to use as the condensing agent for dehydration 1-substituted-2-halopyridinium salt and a tertiary amine according to the method described in e.g., Japanese Patent Unexamined Publication No. Sho 52(1977)-57,102. (Method C') ##STR7## [R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 in the formula (VIII) and (VII) are the same meaning as defined in the formula (I), and X is halogen atom.]
This method comprises reacting an acid halide (VIII) prepared easily by the reaction of (VI) and halogenating agent such as thionyl chloride with an aniline derivative (VII) in the presence of a base.
(Method D) ##STR8## [R, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.7 of the formula (IX) are the same as those in the formula (I).]
This method comprises reacting a 1,4-dihydro-4-oxo-3-pyridinecarboxamide derivative (IX) with a halogenating reagent. It is especially advantageous to use as the halogenating reagent, N-chlorosuccinimide or N-bromosuccinimide in an appropriate chlorinated hydrocarbon solvent (e.g., dichloromethane, chloroform, tetrachloromethane, trichloroethylene or tetrachloroethane) in the presence or absence of free-radical initiator.
The reaction may be also conducted by dissolving the compound (IX) in a halogenated hydrocarbon as mentioned above, and blowing or dropping into the resultant solution bromine or chlorine in gaseous or liquid state.
In the above halogenation of the compound (IX), it may additionally give the substitution at phenyl group which is bonded at the amide nitrogen atom.
(Method E)
This method in conducted by treating a compound of the formula (I) (R.sub.6 is halogen atom) with an alkali metal halide which concerns an exchange of halogen atom (R.sub.6) in the formula (I). It is useful to synthesize a compound of the formula (I) in which R.sub.6 is fluorine atom and which it is difficult to produce by direct introduction.
(Method F) ##STR9## [R, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 in the formula (II), (X), (XI) and (XII) are the same as those in the formula (I).]
This method comprises reacting an 3-aminoacrylic acid anilide derivative (II) with acid halide (X) in the presence of a base to yield a compound of the formula (XI), and then reacting this compound (XI) with a N,N-dimethylamide dimethylketal derivative (XII). It is possible to use an ester of formic acid instead of (XII) in the case that R.sub.7 is hydrogen atom. This method is useful to synthesize a compound of the formula (I) in which R.sub.6 is aryl group.
For herbicidal applications, the compounds of the present invention are generally formulated into herbicidal compositions. These compositions can be solids such as dusts, granules, or wettable powders; or they can be liquids such as solutions, aerosols, or emulsifiable concentrates.
For example, solid compositions such as dusts, wettable powders or granules can be prepared by blending the active compound with a solid inert carrier such as the kaolinites, bentonites, clays, talcs, silicas and the like. Liquids compositions such as solutions or emulsifiable concentrates can be prepared by dissolving the active compound with a liquid inert solvent such as xylene, ethanol, acetone, dimethylformamide, some vegetable oils, water and so on.
Surface active agents for wetting, dispersing or emulsifying are generally used with the herbicidal compositions as above defined. For example; polyoxyethylene-alkyl ethers, polyoxyethylene-sorbitan fatty acid esters, and other nonionic types; alkyl and alkylarlyl sulfonates and sulfates and their sodium salts and other anionic types or other types of surface active agents.
For pre-emergence applications these herbicidal compositions are usually applied either as sprays, dusts, or granules in the area in which suppression of vegetation is desied. For post-emergence applications control of established plant growth, sprays or dusts are most commonly used. These formulations may contain 10-80% for wettable powders, 1-10% for granules, or 10-50% for emulsifiable concentrates by weight of active ingredient. Dosage of these herbicidal compositions for pre-emergence or postemergence applications is generally 0.1-2 Kg by weight of active ingredient.
This invention is illustrated further by examples hereinafter. Also, growth-inhibitory activities on plants of the compounds of the invention are shown in reference examples.
Furthermore, related specific compounds in addition to the compounds shown in the examples are as follows;
1. 1-butyl-2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
2. 2-ethyl-1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide
3. 2-ethyl-1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
4. 1-(4-chlorophenylmethyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
5. 1-cyclohexylmethyl-2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
6. 2-ethyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
7. 2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
8. 2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
9. 2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
10. 1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-2-propyl-3-pyridinecarboxamide,
11. 1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide
12. 1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
13. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
14. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
15. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
16. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
17. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
18. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
19. 1,2-dibutyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide
20. 2-butyl-1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide
21. 2-butyl-1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
22. 2-butyl-1-(4-chlorophenylmetyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
23. 2-butyl-cyclohexylmetyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
24. 2-butyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
25. 2-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
26. 2-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
27. 2-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
28. 1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-1-pentyl-3-pyridinecarboxamide,
29. 1-butyl-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl)-3-pyridinecarboxamide,
30. 1-hexyl-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl)-3-pyridinecarboxamide,
31. 1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-2-(2-methylpropyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
32. 1-(4-chlorophenylmethyl0-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
33. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
34. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
35. 1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
36. 1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
37. 1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
38. 1-butyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide
39. 1,4-dihydro-6-methyl-4-oxo-1,2-dipentyl-N-phenyl-3-pyridinecarboxamide,
40. 1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide
41. 1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
42. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
43. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
44. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
45. 1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
46. 1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
47. 1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
48. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N,2-diphenyl-3pyridinecarboxamide,
49. 1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
50. 1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
51. 1-butyl-2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
52. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide,
53. 2-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
54. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-phenylmethyl-3-pyridinecarboxamide,
55. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl3-pyridinecarboxamide,
56. 2-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
57. 2-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
58. 2-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
59. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
60. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
61. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
62. 2-(3-chlorophenyl)-1-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
64. 2-(3-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
65. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
66. 2-(3-chlorophenyl)-1-(4chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
67. 2-(3-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
68. 2-(3-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
69. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
70. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
71. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
72. 1-butyl-1,4-dihydro-6-methyl-2-(2-methyphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
73. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide,
74. 1-hexyl-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
75. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-1-furylmethyl-3-pyridinecarboxamide,
76. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
77. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
78. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
79. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
80. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
81. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
82. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
83. 1-butyl-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
84. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide,
85. 1-hexyl-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
86. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-1-phenylmethyl-3-pyridinecarboxamide,
87. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
88. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-3-pyridinecarboxamide,
89. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
90. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
91. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
92. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
93. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
95. 2-(2-furyl)-1,4-dihydro-6-4-oxo-1-pentyl-N-phenyl-3-pyridinecarboxamide,
96. 1-hexyl-2-(2furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
97. 2-(2-furyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
98. 1-(4-chlorophenylmethyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
99. 1-cyclohexylmethyl-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
100. 2-(2-furyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
101. 2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
102. 2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
103. 2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
104. 1-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
105. 1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
106. 1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
107. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-phenylmethyl-2-(2-pyridyl)-3-pyridinecarboxamide,
108. 1,4- dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
109. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
110. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
111. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-3-pyridinecarboxamide,
112. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
113. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
114. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(2-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
115. 1-butyl-1,4-dihydro-6-methyl4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
116. 1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
117. 1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridine-carboxamide,
118. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-(phenylmethyl)-2-(3-pyridyl)-3-pyridinecarboxamide,
119. 1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
120. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
121. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
122. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
123. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
124. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
125. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(3-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
126. 1-butyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
127. 1,4-dihydro-6-methyl-4-oxo-1-pentyl-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
128. 1-hexyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
129. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-1-phenylmethyl-2-(4-pyridyl)-3-pyridinecarboxamide,
130. 1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
131. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
132. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-3- pyridinecarboxamide,3-pyridinecarboxamide,
133. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
134. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
135. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
136. 1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-(4-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
137. 1-butyl-2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
138. 2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
139. 2-ethyl-1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
140. 2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
141. 2-ethyl-1,4- dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
142. 1-(4-chlorophenylmethyl)-2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
143. 1-cyclohexylmethyl-2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
144. 2-ethyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
145. 2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
146. 2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
147. 2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
148. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
149. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-2-propyl-3-pyridinecarboxamide,
150. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
151. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
152. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
153. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
154. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
155. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
156. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
157. 1,2-dibutyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
158. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-propyl-3-pyridinecarboxamide,
159. 2-butyl-1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
160. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
161. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
162. 2-butyl-1-(4-methylphenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
163. 2-butyl-1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
164. 2-butyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
165. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
166. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
167. 2-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
168. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
169. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-1-pentyl-4-oxo-3-pyridinecarboxamide,
170. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
171. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
172. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
173. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
174. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
175. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
176. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
177. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
178. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(2-methylpropyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
179. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
180. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1,2-dipentyl-3-pyridinecarboxamide,
181. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
182. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-1-phenylmethyl-3-pyridinecarboxamide,
183. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
184. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
185. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
186. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
187. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
188. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
189. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-pentyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
190. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-2-phenyl-3-pyridinecarboxamide,
191. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
192. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
193. 1cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
194. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
195. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
196. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
197. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
198. 1-butyl-2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
199. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
200. 2-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
201. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
202. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
203. 2-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
204. 2-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
205. 2-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
206. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
207. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
208. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
209. 1-butyl-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
210. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
211. 2-(3-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
212. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
213. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
214. 2-(3-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
215. 2-(3-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
216. 2-(3-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
217. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
218. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
219. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
220. 1-butyl-1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
221. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
222. 1-hexyl-1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
223. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
224. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
225. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
226. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
227. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
228. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
229. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
230. 1,4-dihydro-6-methyl-N,2-bis(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
231. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
232. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
233. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
234. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
235. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
236. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
237. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
238. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
239. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
240. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
241. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
242. 1-butyl-2(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
243. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
244. 2-(2-furyl)-1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
245. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
246. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
247. 1-(4-chlorophenylmethyl)-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
248. 1-cyclohexylmethyl-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
249. 2-(2-furyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
250. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
251. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
252. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
253. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
254. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-2-(2-pyridyl)-3-pyridinecarboxamide,
255. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
256. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-2-(2-pyridyl)-3-pyridinecarboxamide,
257. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
258. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
259. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
260. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
261. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
262. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
263. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
264. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
265. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-2-(3-pyridyl)-3-pyridinecarboxamide,
266. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
267. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-2-(3-pyridyl)-3-pyridinecarboxamide,
268. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
269. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
270. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
271. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
272. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
273. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
274. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(3-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
275. 1-butyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
276. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-pentyl-2-(4-pyridyl)-3-pyridinecarboxamide,
277. 1-hexyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
278. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-2-(4-pyridyl)-3-pyridinecarboxamide,
279. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
280. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
281. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
282. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
283. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
284. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
285. 1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
286. 1-butyl-N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
287. N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl4-oxo-1-pentyl-3-pyridinecarboxamide,
288. N-(2-chlorophenyl)-2-ethyl-1-hexyl-1,4-dihydro-6-methyl4-oxo-3-pyridinecarboxamide,
289. N-(2-chlorophenyl)-2-ehtyl-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
290. N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
291. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
292. N-(2-chlorophenyl)-1-cyclohexylmethyl-2-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
293. N-(2-chlorophenyl)-2-ethyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
294. N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
295. N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
296. N-(2-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
297. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
298. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-2-propyl-3-pyridinecarboxamide,
299. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
300. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-2-propyl-3-pyridinecarboxamide,
301. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
302. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
303. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
304. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
305. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
306. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
307. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
308. 1,2-dibuyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
309. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
310. 2-butyl-N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
311. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
312. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
313. 2-butyl-N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
314. 2-butyl-N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
315. 2-butyl-N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
316. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
317. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
318. 2-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
319. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
320. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
321. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
322. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
323. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
324. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
325. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
326. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
327. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
328. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
329. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylpropyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
330. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
331. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1,2-dipentyl-3-pyridinecarboxamide,
332. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
333. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-1-phenylmethyl-3-pyridinecarboxamide,
334. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
335. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
336. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
337. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
338. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
339. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
340. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
341. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-2-phenyl-3-pyridinecarboxamide,
342. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
343. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-1-phenylmethyl3-pyridinecarboxamide,
344. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
345. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
346. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
347. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
348. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
349. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
350. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
351. 1-butyl-N,2-bis(2-chlorophenyl)1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
352. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
353. N,2-bis(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
354. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
355. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
356. N,2-bis(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
357. N,2-bis(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
358. N,2-bis(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
359. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
360. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
361. N,2-bis(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
362. 1-butyl-N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
363. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
364. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
365. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
366. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
367. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
368. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
369. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
370. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
371. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
372. N-(2-chlorophenyl)-2-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
373. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
374. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
375. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
376. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
377. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
378. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
379. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
380. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
381. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
382. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
383. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
384. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
385. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
386. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
387. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
388. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
389. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
390. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
391. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
392. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
393. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
394. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
395. 1-butyl-N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
396. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide, 397. N-(2-chlorophenyl)-2-(2-furyl)-1-hexyl-1,4-dihydro-6-methyl-4oxo--3-pyridinecarboxamide,
398. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
399. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
400. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
401. N-(2-chlorophenyl)-1-cyclohexylmethyl-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
402. N-(2-chlorophenyl)-2-(2-furyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
403. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
404. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
405. N-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
406. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
407. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4oxo-1-pentyl-2-(2-pyridyl)-3-pyridinecarboxamide,
408. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
409. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-2-(2-pyridyl)-3-pyridinecarboxamide,
410. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
411. N-(2-chlorophenyl)-1-(4chlorophenylmethyl)-1,4-dihydro-6methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
412. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
413. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
414. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
415. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
416. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
417. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
418. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-2-(3-pyridyl)-3-pyridinecarboxamide,
419. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
420. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-2-(3-pyridyl)-3-pyridinecarboxamide,
421. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
422. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
423. N-(2-chlorophenyl)-1-cyclohexymethyl-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
424. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
425. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
426. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
427. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
428. 1-butyl-N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
429. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-2-(4-pyridyl)-3-pyridinecarboxamide,
430. N-(2-chlorophenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
431. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenylmethyl-2-(4-pyridyl)-3-pyridinecarboxamide,
432. N-(2-chlorophenyl)-1.4-dihydro-6-methyl-1-(4-methylphenylmethyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
433. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
434. N-(2-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
435. N-(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
436. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
437. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
438. N-(2-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
439. 2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
440. 2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-methylphenylmethyl)-3-pyridinecarboxamide,
441. 1-(4-chlorophenylmethyl)-2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
442. 1-cyclohexylmethyl-2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl-4-oxo-3-pyridinecarboxamide,
443. 2-ethyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
444. 2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
445. 2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
446. 2-ethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
447. 1,4-dihydro-6methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-2-propyl-3-pyridinecarboxamide,
448. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
449. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
450. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
451. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
452. 1,4-dihydro-6-methyl-N-(2,3-dimethylpheny;)-4-oxo-2-propyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
453. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-propyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
454. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-propyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
455. 2-butyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
456. 2-butyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
457. 2-butyl-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
458. 2-butyl-1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
459. 2-butyl-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
460. 2-butyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
461. 2-butyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
462. 2-butyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
463. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
464. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
465. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
466. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
467. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-3-pyridinecarboxamide,
468. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
469. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
470. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-2-(2-methylpropyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
471. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-1-phenylmethyl-3-pyridinecarboxamide,
472. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
473. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
474. 1-cyclohexymethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
475. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-3-pyridinecarboxamide,
476. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
477. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
478. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-pentyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
479. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
480. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
481. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
482. 1-(2-furylmethyl)1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
483. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(2-pyridylmethyl)-3-pyridinecarboxamide,
484. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-phenyl-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
485. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-phenyl-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
486. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
487. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
488. 2-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
489. 2-(2-chlorophenyl)-1-cyclohexymethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
490. 2(2-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
491. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
492. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
493. 2-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
494. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
495. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
496. 2-(3-chlorophenyl)-1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
497. 2-(3-chlorophenyl)-1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
498. 2-(3-chlorophenyl)-1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
499. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
500. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
501. 2-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
502. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
503. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
504. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
505. 1cyclohexylmethyl-1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
506. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
507. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
508. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
509. 1,4-dihydro-6-methyl-2-(2-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-pyridelmethyl)-3-pyridinecarboxamide,
510. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
511. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-1(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
512. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
513. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-2(3-methylphenyl)-N-(2,3-dimethylmethyl)-4-oxo-3-pyridinecarboxamide,
514. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
515 1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethyplhenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
516. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
517. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
518. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
519. 2-(2furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
520. 1-(4-chlorophenylmethyl)-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
521. 1-cyclohexylmethyl-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
522. 2-(2-furyl)-1-(2furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
523. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
524. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
525. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
526. 1,4-dihydro-6-methyl-N-(s,3-dimethylphenyl)-4-oxo-1-phenylmethyl-2-(2-pyridyl)-3-pyridinecarboxamide,
527. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
528. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
529. 1-cylcohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)--4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
530. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
531. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(2-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
532. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(2-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
533. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(2ppyridyl)-1-(4-pyridylmethyl)-3-pyridinecarboxamide,
534. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenylmethyl-2-(3-pyridyl)-3-pyridinecarboxamide,
535. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)1-(4methylphenylmethyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
536. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(3ppyridyl)-3-pyridinecarboxamide,
537. 1-cyclohexymethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
538. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
539. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(3-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
540. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(3-pyridyl)-1-(3-pyridylmethyl)-3-pyridinecarboxamide,
541. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridylmethyl)-3-pyridinecarboxamide,
542. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
543. 1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-1(4-methylphenylmethyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
544. 1-(4-chlorophenylmethyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
545. 1-cyclohexylmethyl-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
546. 1-(2-furylmethyl)-1,4-dihydro-6-methyl-N-(2,3dimethylphenyl)-4-oxo-2-(4-puridyl)-3-pyridinecarboxamide,
547. 1,4dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-1-(2-pyridylmethyl)-3-pyridinecarboxamide,
548. 1,4dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-1(3-pyridylmethyl)-3-pyridinecarboxamide,
549. 1,4dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-2-(4-pyridyl)-1(4-pyridylmethyl)-3-pyridinecarboxamide,
550. 1-butyl-2-ethyl-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
551. 2-ethyl-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
552. 2-ethyl-1-hexyl-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)4-oxo-3-pyridinecarboxamide,
553. 2-ethyl-1,4dihydro-1(3-methoxypropyl)-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
554. 2-ethyl-1,4dihydro-1-(2-methoxyethyl)-6-methyl-N-(2,6dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
555. 1-(ethoxyethyl)-2-ethyl-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
556. 1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1,2-diphenyl-3-pyridinecarboxamide,
557. 1-(2-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
558. 1-(3-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
559. 1-(4-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
660. 1,4dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
561. 1,4dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
562. 1,4dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
563. 2-(2-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6 -dimethylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
564. 1,2-bis(2-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
565. 2-(2-chlorophenyl)-1(3-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
566. 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
567. 2-(3-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
568. 1-(2-chlorophenyl)-2(3-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
569. 2-(2-chlorophenyl)-1(3-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
570. 2-(3-chlorophenyl)-1-(4-chlorophenyl)-1,4dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
571. 2-(2-chlorophenyl)-1,4dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
572. 2-(2-chlorophenyl)-1,4dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
573. 2-(2-chlorophenyl)-1,4dihydro-6-methyl-1(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
574. 2-(3-chlorophenyl)-1,4dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
575. 2-(3-chlorophenyl)-8-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
576. 2-(3-chlorophenyl)-1,4dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
577. 1,4dihydro-6-methyl-2(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
578. 1-(2-chlorophenyl)-1,4dihydro-6-methyl-2-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
579. 1-(3-chlorophenyl)-1,4dihydro-6-methyl-2-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
580. 1-(4-chlorophenyl)-1,4dihydro-6-methyl-2-(2-methylphenyl)-N-(2,6-dimethylphenyl)-6-oxo-3-pyridinecarboxamide,
581. 1,4dihydro-6-methyl-1,2-bis(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
582. 1,4dihydro-6-methyl-2-(2-methylphenyl)-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
583. 1,4dihydro-6-methyl-2-(2-methylphenyl)-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
584. 1,4dihydro-6-methyl-2-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
585. 1-(1-chlorophenyl)-1,4dihydro-6-methyl-2-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
586. 1-(3-chlorophenyl)-1,4dihydro-6-methyl-2-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
587. 1-(4-chlorophenyl)-1,4dihydro-6-methyl-2-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
588. 1,4-dihydro-6-methyl-1-(2-methylphenyl)-2-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4oxo-3-pyridinecarboxamide,
589. 1,4-dihydro-6-methyl-1,2-bis(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
590. 1,4-dihydro-6-methyl-2-(3-methylphenyl)-1(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
591. 2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,3-dimethylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
592. 1-(2-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
593. 1-(3-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
594. 1-(4-chlorophenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)4-oxo-3-pyridinecarboxamide,
595. 2-(2-furyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
596. 2-(2-furyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
597. 2-(2-furyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
598. 1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenyl-(2-pyridyl)-3-pyridinecarboxamide,
599. 1-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
600. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
601. 1-(4-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
602. 1,4-dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
603. 1,4-dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-pyridyl)-3-pyridinecarboxamide,
604. 1,4-dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
605. 1,4-dihydro-6-methyl-N-(2,6-dimethyphenyl)-4-oxo-1-phenyl-2(3-pyridyl)-3-pyridinecarboxamide,
606. 1-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
607. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2(3-pyridyl)-3-pyridinecarboxamide,
608. 1-(4-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
609.1,4-dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
610. 1,4-dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
611. 1,4-dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
612. 1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenyl-2(4-pyridyl)-3-pyridinecarboxamide,
613. 1-(2-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pryridyl)-3-pyridinecarboxamide,
614. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
615. 1-(4-chlorophenyl)-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
616. 1,4-dihydro-6-methyl-1-(2-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
617. 1,4-dihydro-6-methyl-1-(3-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
618. 1,4-dihydro-6-methyl-1-(4-methylphenyl)-N-(2,6-dimethylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
619. 5-bromo-1-butyl-2-ethyl-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-44-oxo-3-pyridinecarboxamide,
620. 5-bromo-2-ethyl-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
621. 5-bromo-2-ethyl-1-hexyl-1,4-dihydro-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
622. 5-bromo-2-ethyl-1,4-dihydro-1-(3-methoxypropyl)-6-methyl-N-(2,6-dimethylphenyl)-4oxo-3-pyridinecarboxamide,
623. 5-bromo-2-ethyl-1,4-dihydro-1(2-methoxyethyl)-6-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
624. 2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
625. 2-ethyl-N-(2,6-diethylphenyl)-1-hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
626. 5-bromo-2-ethyl-N-(2,6-diethylmethyl)-1,4-dihydro-1-(2-methoxyethyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
627. 2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1-(3-methoxypropyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
628. 2ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1-(2-methoxyethyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
629. 1-(2-ethoxyethyl)-2ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
630. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
631. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
632. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
6.33 N-(2,6diethylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2phenyl-3-pyridinecarboxamide,
634. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1(4-methylphenyl)-4-2phenyl-3-pyridinecarboxamide,
635. 2-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridinecarboxamide,
636. 1,2-bis(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
637. 2-(2-chlorophenyl)-1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
638. 2-(2-chlorophenyl)-1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
639. 2-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
640. 2-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
641. 2-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
642. 2-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridinecarboxamide,
643. 1-(2-chlorophenyl)-2-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
644. 1,2-bis(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
645. 2-(3-chlorophenyl)-1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
646. 2-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
647. 2-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
648. 2-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
649. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2(2-methylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
650. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
651. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
652. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
653. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
654. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2(2-methylphenyl)-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
655. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2(2-methylphenyl)-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
656. N-(2,6-diethylphenyl)-1,4-dihydro-6methyl-2-(3-methylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
657. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
658. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
659. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
660. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
661. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1,2-bis(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
662. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-2-(4-methylphenyl)-4-oxo- 3-pyridinecarboxamide,
663. N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
664. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
665. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4oxo-3-pyridinecarboxamide,
666. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-2-(2-furyl)-8,6-methyl-4-oxo-3-pyridinecarboxamide,
667. N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
668. N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
669. N-(2,6-diethylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
670. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-2(2-pyridyl)-3-pyridinecarboxamide,
671. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
672. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
673. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
674. N-(2,6-diethelphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
675. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1(3-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
676. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2(2pyridyl)-3-pyridinecarboxamide,
677. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
678. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
679. 1(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
680. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
681. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-4-oxo-2(3-pyridyl)-3-pyridinecarboxamide,
682. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2(3-pyridyl)-3-pyridinecarboxamide,
683. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
684. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
685. 1-(2-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
686. 1-(3-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
687. 1-(4-chlorophenyl)-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
688. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
689. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
690. N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
691. 5-bromo-1-(2-ethoxyethyl)-2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
692. 5-bromo-2-ethyl-N-(2,6-diethelphenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
693. 5-bromo-2-ethyl-N-(2,6-diethylphenyl)-1-hesyl-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
694. 5-bromo-2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
695. 1-butyl-2-ethyl-Np(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
696. 2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
697. 2-ethyl-N-(2-ethyl-6-methylphenyl)-1hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
698. 2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-1-(3-methoxypropyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
699. 2-ethyl-N-(2-ethyl-6methylphenyl)-1,4-dihydro-1(2-methoxyethyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
700. 1-(2-ethoxyethyl)-2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
701. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-N,1-diphenyl-3-pyridinecarboxamide,
702. 1-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
703. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
705. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
706. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
707. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
708. 2-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridinecarboxamide,
709. 1,2-bis(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
710. 2-(2-chlorophenyl)-1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
711. 2-(2-chlorophenyl)-1(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
712. 2-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
713. 2(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
714. 2-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
715. 2-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridinecarboxamide,
716. 1-(2-chlorophenyl)-2-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
717. 1,2-bis(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
718. 2-(3-chlorophenyl)-1-(4-chlorophenyl)-N-(2ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
719. 2-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
720. 2-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-=b 6-methyl-1(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
721. 2-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
722. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
723. 1-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl-4-oxo-3-pyridinecarboxamide,
724. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
725. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
726. N-(2-ethyl-6-methylphenyl)-8,6-methyl-1,2-bis(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
727. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2(2-methylphenyl)-1-(3-methylphenyl)4-oxo-3-pyridinecarboxamide,
728. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2(2-methylphenyl)-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
729. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6methyl-2(3-methylphenyl)-4-oxo-1-phenyl-3-pyridinecarboxamide,
730. 1-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
731. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
732. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)1,4-dihydro-6-methyl-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
733. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-2-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
734. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1,2-bis(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
735. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-2-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
736. N-(2-ethyl-6methylphenyl)-2(2-furyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridinecarboxamide,
737. 1(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-0x0-3-pyridinecarboxamide,
738. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
739. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-2-(2-furyl)1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
740. N-(2-ethyl-6methylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl)-1-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
741. N-(2-ethyl-6-methylphenyl)-2(2-furyl)-1,4-dihydro-6-methyl)-1-(3-methylphenyl)-4-oxo-3-pyridinecarboxamide,
742. N-(2-ethyl-6-methylphenyl)-2-(2-furyl)-1,4-dihydro-6-methyl)-1-(4-methylphenyl)-4-oxo-3-pyridinecarboxamide,
743. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-(2-pyridyl)-3-pyridinecarboxamide,
744. 1-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
745. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
746. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
747. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1(2-methylphenyl)-4-oxo-2(2-pyridyl)-3-pyridinecarboxamide,
748. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1(3-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
749. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(4-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
750. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-2-(3-pyridyl)-3-pyridinecarboxamide,
751. 1-(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
752. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
753. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(3-pridyl)-3-pyridinecarboxamide,
754. N-(2-ethyl-6-methelphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-2-(2-pyridyl)-3-pyridinecarboxamide,
755. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
756. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1(4-methylphenyl)-4-oxo-2-(3-pyridyl)-3-pyridinecarboxamide,
757. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-phenyl-2-(4-pyridyl)-3-pyridinecarboxamide,
758. 1(2-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
759. 1-(3-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
760. 1-(4-chlorophenyl)-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
761. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(2-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
762. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-1-(3-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
763. N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6methyl-1-(4-methylphenyl)-4-oxo-2-(4-pyridyl)-3-pyridinecarboxamide,
764. 5-bromo-1-butyl-2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
765. 5-bromo-2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-6-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
766. 5-bromo-2-ethyl-N-(2-ethyl-6-methylphenyl)1-hexyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
767. 5-bromo-2-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-1-(3-methoxypropyl)-6-methyl-4-oxo-3-pyridinecarboxamide,
768. 5-bromo-2-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-1-(2-methoxyethyl)-6-methyl-4oxo-3-pyridinecarboxamide,
769. 6-ethyl-1,4-dihydro-2-methyl-1(4-methylphenylmethyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
770. 1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-2-methyl-4oxo-N-phenyl-3-pyridinecarboxamide,
771. 1-cyclohexylmethyl-6-methyl-1,4-dihydro-2-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
772. 6-ethyl-1,4-dihydro-2-methyl-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
773. 6-ethyl-1,4-dihydro-2-methyl-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
774. 1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-2-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
775. 1-cyclohexylmethyl-6-ethyl-1,4-dihydro-2-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
776. N-(2-chlorophenyl)-6ethyl-1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
777. N-(2-chlorophenyl)-6-ethyl-1,4-dihydro-2-methyl-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
778. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
779. N-(2-chlorophenyl)-1-cyclohexylmethyl-6-ethyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
780. 6-ethyl-1,4-dihydro-4-oxo-N-phenyl-1-phenylmethyl-2-propyl-3-pyridinecarboxamide,
781. 6-ethyl-1,4-dihydro-1-(4-methylphenylmethyl)-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
782. 1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
783. 1-cyclohexylmethyl-6-ethyl-1,4-dihydro-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
784. 6-ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-2-propyl-3-pyridinecarboxamide,
785. 6-ethyl-1,4-dihydro-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
786. 1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
787. 1cyclohexylmethyl-6-ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
788. N-(2-chlorophenyl)-6-ethyl-1,4-dihydro-4-oxo-1-phenylmethyl-2-propyl-3-pyridinecarboxamide,
789. N-(2-chlorophenyl)-6-ethyl-1,4-dihydro-1-(4-methylphenylmethyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
790. N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-4-oxo-2-propyl-3-pyridinecarboxamide,
791. N-(2-chlorophenyl)-1-clorohexylmethyl-6-ethyl-1,4-dihydro-4-oxo-2-propyl-3-pyridinecarboxamide,
792. 2-butyl-6-ethyl-1,4-dihydro-4-oxo-N-phenyl-1-phenylmethyl-3-pyridinecarboxamide,
793. 2-butyl-6-ethyl-1,4-dihydro-1(4-methylphenylmethyl)-4-oxo-N-phenyl-3-pyridinecarboxamide,
794. 2-butyl-1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-4-oxo-N--phenyl-3-pyridinecarboxamide,
795. 2-butyl-1-cyclohexylmethyl-6-ethyl-1,4-dihydro-4-oxo-N-phenyl-3-pyridinecarboxamide,
796. 2-butyl-6-ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
797/ 2-butyl-6-ethyl-1,4-dihydro-N-(2-methylphenyl)-1-(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
798. 2-butyl-1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
799. 2-butyl-1-cyclohexylmethyl-6ethyl-1,4-dihydro-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
800. 2-butyl-N-(2-chlorophenyl)-6-ethyl-1,4-dihydro-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
801. 2-butyl-N-(2-chlorophenyl)-6-ethyl-1,4-dihydro-1(4-methylphenylmethyl)-4-oxo-3-pyridinecarboxamide,
802. 2-butyl-N-(2-chlorophenyl)-1-(4-chlorophenylmethyl)-6-ethyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide,
803. 2-butyl-N-(2-chlorophenyl)-1-cyclohexylmethyl-6-ethyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide,
804. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
805. 6-ethyl-N-(2,6-diethylphenyl)-1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
806. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
807. 5-bromo-6-ethyl-N-(2,6diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
808. 5-bromo-6ethyl-N-(2,6-diethylphenyl)-1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
809. 5-bromo-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
810. 1-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
811. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
812. 6-ethyl-N-(2,6-diethylphenyl)-1-hexyl-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
813. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
814. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-(2-phenylmethyl)-3-pyridinecarboxamide,
815. 1-butyl-5,6-diethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
816. 5,6-diethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
817. 5,6-diethyl-N-(2,6-diethylphenyl)-1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
818. 5,6-diethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
819. 5,6-diethyl-N-(2,6 -diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-(1-phenylmethyl)-3-pyridinecarboxamide,
820. 1-butyl-6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
821. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
822. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
823. 6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
824. 6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-1(2-phenylethyl)-3-pyridinecarboxamide,
825. 5-bromo-1-butyl-6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
826. 5-bromo-6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
827. 5-bromo-6-ethyl-N-(2-ethyl-6-methylphenyl)1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
838. 5-bromo-6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
829. 5-bromo-6-ethyl-N-(2-ethyl-6-methylphenyl)1,4-dihydro-2-methyl-4-oxo-1-(2-phenylethyl)-3-pyridinecarboxamide,
830. 1-butyl-6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
831. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
832. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1-hexyl-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
833. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
834. 6-ethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
835. 1-butyl-5,6-diethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
836. 5,6-diethyl-N-(2-ethyl-6methylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
837. 5,6-diethyl-N-(2-ethyl-6-methylphenyl)-1-hexyl-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
838. 5,6-diethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
839. 5,6-diethyl-N-(2-ethyl-6-methylphenyl)-1,4-dihydro-2-methyl-4-oxo-1-(2-phenylethyl)-3-pyridinecarboxamide,
840. 1-butyl-6-ethyl-N-(2,6-dimethylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide,
841. 6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
842. 6-ethyl-1-hexyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
843. 6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
844. 6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1(2-phenylethyl)-3-pyridinecarboxamide,
845. 5-bromo-1-butyl-6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
846. 5-bromo-6-ethyl-1,4-dihydro-2methyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
847. 5-bromo-6-ethyl-1-hexyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
848. 5-bromo-6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethelphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
849. 5-bromo-6-ethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-(2-phenylethyl)-3-pyridinecarboxamide,
850. 1-butyl-6-ethyl-1,4-dihydro-2,5-dimethyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
851. 6-ethyl-1,4-dihydro-2,5-dimethyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
852. 6-ethyl-1-hexyl-1,4-dihydro-2,5-dimethyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
853. 6-ethyl-1,4-dihydro-2,5-dimethyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
854. 6-ethyl-1,4-dihydro-2,5-dimethyl-N-(2,6-dimethylphenyl)-4-oxo-1(2-phenylethyl)-3-pyridinecarboxamide,
855. 1-butyl-5,6-diethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
856. 5,6-diethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-pentyl-3-pyridinecarboxamide,
857. 5,6-diethyl-1-hexyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-3-pyridinecarboxamide,
858. 5,6-diethyl-1,4-dihydro-2-methyl-N-(2,6-dimethylphenyl)-4-oxo-1-phenylmethyl-3-pyridinecarboxamide,
859. 5,6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
860. 5-ethyl-N-(2,6-diethylphenyl)-8,1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
861. N-(4-bromo-2,6-diethylphenyl)-5-ethyl-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
862. 2-butyl-5-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
863. 5-bromo-1-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
864. 5-bromo-N-(4-bromo-2,6-diethylphenyl)-1-ethyl-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
865. 5-bromo-2-butyl-N-(2,6-diethylphenyl)-1-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
866. 5-bromo-N-(4-bromo-2,6-diethylphenyl)-2-butyl-1-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
867. 1-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-5,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
868. N-(4-bromo-2,6-diethylphenyl)-1-ethyl-1,4-dihydro-5,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
869. 2-butyl-1-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-5,6-dimethyl-4-oxo-3-pyridinecarboxamide,
870. N-(4-bromo-2,6-diethylphenyl)-2-butyl-1-ethyl-1,4-dihydro-5,6-dimethyl-4-oxo-3-pyridinecarboxamide,
871. 5-bromo-N-(2,6-diethylphenyl)-6-ethyl-1,4-dihydro-1-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
872. 5-bromo-2-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1-methyl-4-oxo-3-pyridinecarboxamide,
873. 5-bromo-N-(4-bromo-2,6-diethylphenyl)-6-ethyl-1,4-dihydro-1,2-dimethyl-4-oxo-3-pyridinecarboxamide,
874. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1,5-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
875. N-(4-bromo-2,6-diethylphenyl)-6-ethyl-1,4-dihydro-1,5-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
876. 2-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-1,5-dimethyl-4-oxo-3-pyridinecarboxamide,
877. N-(4-bromo-2,6-diethylphenyl)-2-butyl-6-ethyl-1,4-dihydro-1,5-dimethyl-4-oxo-3-pyridinecarboxamide,
878. 5-chloro-N-(2,6diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
879. N-(4-bromo-2,6-diethylphenyl)5-chloro-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
880. 2-butyl-5-chloro-N-(2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
881. N-(4-bromo-2,6-diethylphenyl)-2-butyl-5-chloro-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
882. 5-bromo-N-(4-chloro-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
883. N-(4-chloro-2,6-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
884. 5-bromo-2-butyl-N-(4-chloro-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
885. 2-butyl-N-(4-chloro-2,6-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
886. 5-bromo-N-(2,6-diethyl-4-methylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
887. N-(2,6-diethyl-4-methylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
888. 5-bromo-2-butyl-N-(2,6-diethyl-4-methylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
889. 2-butyl-N-(2,6-diethyl-4-methylphenyl)1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
890. N-(4-bromo-2,6-diethylphenyl)-2-ethyl-1,4-dihydro-5,6-dimethyl-4-oxo-1-propyl-3-pyridinecarboxamide,
891. N-(4-bromo-2,6-diethylphenyl)-6-methyl-1,4-dihydro-2,5-dimethyl-4-oxo-1-propyl-3-pyridinecarboxamide,
892. 2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-5,6-dimethyl-4-oxo-1-propyl-3-pyridinecarboxamide,
893. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-propyl-3-pyridinecarboxamide,
894. N-(4-bromo-2,6-diethylphenyl)-2-ethyl-1,4-dihydro-5,6-dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
895. N-(4-bromo-2,6-diethylphenyl)-6-ethyl-1,4-dihydro-2,5-dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
896. 2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-5,6-dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
897. 6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-1-pentyl-3-pyridinecarboxamide,
898. N-(4-bromo-2,6-diethylphenyl)-1-butyl-2-ethyl-1,4-dihydro-5,6-dimethyl-4-oxo-3-pyridinecarboxamide,
899. N-(4-bromo-2,6-diethylphenyl)-1-butyl-6-ethyl-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
900. 1-butyl-2-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-5,6-dimethyl-4-oxo-3-pyridinecarboxamide,
901. 1-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,5-dimethyl-4-oxo-3-pyridinecarboxamide,
902. 1-(3-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
903. 1-(3-bromophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
904. 2-ethyl-1-(3-fluorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
905. 2-ethyl-1,4-dihydro-1-(3-iodophenyl)-6-methyl-4oxo-N-phenyl-3-pyridinecarboxamide,
906. 2-ethyl-1-(3-trifluoromethylphenyl)-1,4-dihydro-6-methyl4-oxo-N-phenyl-3-pyridinecarboxamide,
907. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
908. 1-(3-bromophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
909. 1-(3-fluorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
910. 1,4-dihydro-1-(3-iodophenyl)-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
911. 1-(3-trifluoromethylphenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-2-propyl-3-pyridinecarboxamide,
912. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl3-pyridinecarboxamide,
913. 1-(3-bromophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
914. 1-(3-fluorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
915. 1,4-dihydro-1-(3-iodophenyl)-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
916. 1(3-trifluoromethylphenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-N-phenyl-3-pyridinecarboxamide,
917. 2-butyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
918. 2-butyl-1(2,5-dichlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
919. 2-butyl-1(2,6-dichlorophenyl)1,4-dihydro-6-methyl-4-oxo-N-phenyl-3-pyridinecarboxamide,
920. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide,
921. 1-(3-bromophenyl)-1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide,
922. 1-(3-fluorophenyl)-1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide,
923. 1,4-dihydro-1-(3-iodophenyl)-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide,
924. 1-(3-trifluoromethylphenyl)-1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide,
925. 1-(3-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
926. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-propyl-3-pyridinecarboxamide,
927. 2-butyl-1-(3-chloropheynl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-3-pyridinecarboxamide,
928. 1-(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo2-pentyl-3-pyridinecarboxamide,
929. 1(3-chlorophenyl)-1,4-dihydro-6-methyl-N-(2-methylphenyl)-4-oxo-2-phenyl-3-pyridinecarboxamide,
930. N-(2-chlorophenyl)-1-(3-chlorophenyl)-2-ethyl-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
931. N-(2-chlorophenyl)-1(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-propyl-3-pyridinecarboxamide,
932. 2-butyl-N-(2-chlorophenyl)-1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxamide,
933. N-(2-chlorophenyl)-1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-pentyl-3-pyridinecarboxamide,
934. N-(2-chlorophenyl)-1-(3-chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-2-phenyl-3-pyridinecarboxamide,
935. 5-bromo-N-(2,6-diethylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
936. 5-bromo-N-(2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
937. 5-bromo-N-(2,6-diethyl-4methylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
938. 5-bromo-N-(2,6-diethyl-4-methylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
939. 5-bromo-2-butyl-N-(2,4,6-triethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
940. 5-bromo-N-(2,4,,6-triethylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
941. 5-bromo-N-(2,4,6-triethylphenyl)-1,4-dihydro-1.6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
942. 5-bromo-N-(2,6-diethyl-4-propylphenyl)1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
943. 5bromo-2-butyl-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
944. 5-bromo-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
945. 5-bromo-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
946. 5-bromo-N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
947. 5-bromo-2-butyl-N-(2,6-diethyl-4(1-methylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
948. 5-bromo-N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-2-methoxymethyl-1,4-dimethyl-4-oxo-3-pyridinecarboxamide,
949. 5-bromo-N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
950. 5-bromo-N-(2,6diethyl-4-(1,1-dimethylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
951. 5-bromo-2-butyl-N-(2,6-diethyl-4-(1,1-dimethylethyl)phenyl)1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
952. 5bromo-N-(b 2,6-diethyl-4-(1,1-dimethylethyl)phenyl)-1,4-dihydro-2-methoxymethyl-1,6dimethyl-4-oxo-3-pyridinecarboxamide,
953. 5-bromo-N-(2,6-diethyl-4(1,1dimethylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-2methylthiomethyl-4-oxo-3-pyridinecarboxamide,
954. 5-bromo-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
955. 5-bromo-2-butyl-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
956. 5-bromo-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
957. 5-bromo-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
958. 5-bromo-N-(4-bromo-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
959. 5-bromo-N-(bromo-2,6-diethylphenyl)-2-butyl-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
960. 5-bromo-2-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
961. 5-bromo-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
962. 5-bromo-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
963. 5-bromo-2-butyl-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
964. 5-bromo-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
965. 5-bromo-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl)-4-oxo-3-pyridinecarboxamide,
966. 5-bromo-2-butyl-N-(2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
967. 5-bromo-N-(2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
968. 5-bromo-N-(b 2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
969. 5-bromo-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
970. 5-bromo-2-butyl-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
971. 5-bromo-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-2-methoxyphenyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
972. 5-bromo-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
973. N-(4-amino-2,6-diethylphenyl)-5-bromo-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
974. N-(4-amino-2,6-diethylphenyl)-5-bromo-2-butyl-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
975. N-(4-amino-2,6-diethylphenyl)-5-bromo-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo3-pyridinecarboxamide,
976. N-(4-amino-2,6-diethylphenyl)-5-bromo-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
977. 5-bromo-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
978. 5-bromo-2-butyl-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
979. 5-bromo-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
980. 5-bromo-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4oxo-3-pyridinecarboxamide,
981. 5-bromo-N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
982. 5-bromo-2-butyl-N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
983. 5-bromo-N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
984. 5-bromo-N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
985. 5-bromo-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4oxo-2-propyl-3-pyridinecarboxamide,
986. 5-bromo-2-butyl-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
987. 5-bromo-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-2-methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
988. 5-bromo-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
989. 5-bromo-N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
990. 5-bromo-2-butyl-N-(2,6-ethoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
991. 5-bromo-N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro--2methoxymethyl-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
992. 5-bromo-N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-2-methylthiomethyl-4-oxo-3-pyridinecarboxamide,
993. 5-bromo-N-(2,6-diethyl-4-hydroxyphenyl)1,4-dihydro-1,6-dimethyl-4oxo-2-propyl-3-pyridinecarboxamide,
994. 2-butyl-N-(2,4,6-triethylphenyl)-1,4-dihydro-1,5,6trimethyl-4-oxo-3-pyridinecarboxamide,
995. N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
996. 2-butyl-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
997. N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
998. 2-butyl-N-(2,6-diethyl-4-(1-methylethyl)phenyl)1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
999. N-(2,6-diethyl-4-(1,1-dimethylethyl)phenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1000. 2-butyl-N-(2,6-diethyl-4(1,1-dimethylethyl)phenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1001. N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1002. 2-butyl-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1003. 2-butyl-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1004. N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1005. 2-butyl-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1006. N-(2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-1,5,6trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1007. 2-butyl-N-(2,6-dimethyl-4-methoxyphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1008.N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1009. 2-butyl-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1010. N-(4-amino-2,6-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1011. N-(4-amino-2,6-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1012. N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1013. 2-butyl-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1014. N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-[1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1015. 2-butyl-N-(4-cyano-2,6-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1016. N-(2,6-diethyl-4-diethylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1017. 2-butyl-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1018. N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1019. 2-butyl-N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro-1,5,6-trimethyl-4-oxo-3-pyridinecarboxamide,
1020. 5-ethyl-N-(2,6-diethyl-4-methylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1021. 2-butyl-5-ethyl-N-(2,6-diethyl-6-methylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1022. 5-ethyl-N-(2,4,6-triethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1023. 2-butyl-5-ethyl-N-(2,4,6-triethylphenyl)-1,4-dihydro-1,6-dimethyl--oxo-3-pyridinecarboxamide,
1024. 5-ethyl-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1025. 2-butyl-5-ethyl-N-(2,6-diethyl-4-propylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1026. 5-ethyl-N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1027. 2-butyl-5-ethyl-N-(2,6-diethyl-4-(1-methylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1028. 5-ethyl-N-(2,6-diethyl-4-(1,1-dimethylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1029. 2-butyl-5-ethyl-N-(2,6-diethyl-4-(1,1-dimethylethyl)phenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1030. 5-ethyl-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1031. 2-butyl-5-ethyl-N-(2,6-diethyl-4-trifluoromethylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1032. 5-ethyl-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1033. 2-butyl-5-ethyl-N-(2,6-diethyl-4-iodophenyl)-1,4-dihydro--1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1034. 5-ethyl-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1035. 2-butyl-5-ethyl-N-(2,6-diethyl-4-hydroxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1036. 5-ethyl-N-(2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1037. 2-butyl-5-ethyl-N-(2,6-diethyl-4-methoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1038. 5-ethyl-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1039. 2-butyl-5-ethyl-N-(2,6-diethyl-4-phenoxyphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1040. N-(4-amino-2,6-diethylphenyl)-5-ethyl-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1041. N-(4-amino-2,6-diethylphenyl)-2-butyl-5-ethyl-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1042. 5-ethyl-N-(2,6-diethyl-4-nitrophenyl)-1,4-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1043. 2-butyl-5-ethyl-N-(2,6-diethyl-4-nitrophenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1044. N-(4-amino-2,6-diethylphenyl)-5-ethyl-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1045. 2-butyl-N-(4-cyano-2,6-diethylphenyl)-5-ethyl-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
1046. 5-ethyl-n-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1047. 2-butyl-5-ethyl-N-(2,6-diethyl-4-methoxycarbonylphenyl)-1,4-dihydro-1,6dimethyl-4-oxo-3-pyridinecarboxamide,
1048. 5-ethyl-N-(2,6-diethyl-4ethoxycarbonylphenyl)-1,4-dihydro-1,6dimethyl-4-oxo-2-propyl-3-pyridinecarboxamide,
1049. 2-butyl-5-ethyl-N-(2,6-diethyl-4-ethoxycarbonylphenyl)-1,4-dihydro-1,6-dimethyl-4-oxo-3-pyridinecarboxamide,
EXAMPLE 1
1-butyl-1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-3-pyridinecarboxamide
A mixture of 4.42 g (18.47 mmol) of .alpha.-benzoylacetanilide, 1.89 g (25.84 mmol) of n-butylamine, one drop of acetic acid and 25 ml of toluene was refluxed for 1.5 hours, while the resulted water and excess of butylamine were removed through a Dean-Stark's water separator, together with about 12 ml of toluene. While heating, to the mixture was dropwise added a solution of 7.2 g (46.18 mmol) of 2-ethyl-2,6-dimethyl-4H-1,3-dioxin-4-one in 16 ml of toluene within about 30 minutes and after the resulted mixture was refluxed for forty minutes, it was cooled to room temperature. The crystals precipitated was separated by filtration and dried under vacuo to afford 3.72 g of the title compound having mp. 189.5.degree.-193.degree. C.
EXAMPLE 2
1,4-dihydro-6-methyl-4-oxo-N,2-diphenyl-1-pentyl-3-pyridinecarboxamide
1 g (3.23 mmol) of 6-methyl-4-oxo-N,2-diphenyl-4-H-pyran-3-carboxamide and 590 mg (6.78 mmol) of benzylamine were dissolved in 10 ml of ethanol, and the resulted mixture was stirred over night at room temperature. Ethanol was removed under vacuo. The crystal residue was recrystallized from ethylacetate to afford 700 mg of the title compound having mp. 164.degree.-165.5.degree. C.
EXAMPLE 3
5-bromo-1-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide
To a mixture of 700 mg (1.90 mmol) of 1-butyl-6-ethyl-N-(2,6-diethylphenyl)-1,4-dihydro-2-methyl-4-oxo-3-pyridinecarboxamide, 14 ml of methylene chloride and 1.2 g (7.40 mmol) of sodium carbonate was added a solution of 303 mg (1.90 mmol) of bromine in 5 ml of methylene chloride under vigorous stirring. After the completion of addition the mixture was stirred for 6 hours. The insoluble product in methylene chloride was filtered off and the filtrate was concentrated in vacuo to give a crystalline residue. The residue was recrystallized from benzene and cyclohexane to afford 615 mg of the title compound having mp. 132.5.degree.-133.5.degree. C.
EXAMPLE 4
1,4-dihydro-2-methyl-4-oxo-N,5-diphenyl-1-phenylmethyl -3-pyridinecarboxamide
To a mixture of 2.66 g (10 mmol) of 3-benzylaminocrotonanilide, 0.87 g (11 mmol) of pyridine and 30 ml of methylene chloride was added a mixture of 1.45 ml (11 mmol) of phenylacetylchloride and 5 ml of methylene chloride under ice cooling. After the mixture was stirred for 2.5 hours under ice cooling, it was poured into ice water and extracted. The organic layer was dried and concentrated in an usual manner and the residue was crystallized form benzene and diethylether to afford 1.81 g of 2-phenylacetyl-3-phenylmethylamino-2-butenoylanilide. A mixture of 1.60 g (4.16 mmol) of 2-phenylacetyl-3-phenylmethylamino-2-butenoylanilide, 2.23 g of N,N-dimethylformamide dimethylacetal, 0.2 ml of triethylamine and 5 ml of benzene was refluxed for 80 minutes under nitrogen atmosphere. The reaction mixture was concentrated under vacuo to give an oily residue, which was purified by column chromatography and crystallization from ethylacetate to afford 0.70 g of the title compound.
The following Table 1 and Table 2 show physical properties of the compounds associated with this invention. Numbers in the column "Evaluation" in Table 2 were obtained as follows:
A carrier was prepared by mixing 50 parts (by weight) of talc, 25 parts of bentonite, 2 parts of Solpole-9047 (Toho Chemical Co., Ltd, Japan) and 3 parts of Solpole-5039 (Toho Chemical Co., Ltd, Japan). 50 parts of a test compound and 200 parts of the carrier were mixed to obtain 20% wettable powder, followed by dispersing the powder in distilled water to make a dispersion of the definite concentrations.
Seeds of Oryza sativa L., Echinochloa crus-galli L., and Raphanus sativus L. were germinated in a laboratory dish, to which the dispersion was added. After breeding for 7 days in a thermostatic box kept at 25.degree. C. under illumination of fluorescent tubes, growth of plant was observed. In the column of "Evaluation" of Table 2, the designation 1 denotes no influence, 2 denotes 25% growth inhibition, 3 denotes 50% growth inhibition, 4 denotes 75% growth inhibition and 5 denotes 100% growth inhibition.
TABLE 1__________________________________________________________________________Example Melting MolecularNO. R R.sub.2 R.sub.3 R.sub.4 R.sub.5 R.sub.6 R.sub.7 point (.degree.C.) formula Method__________________________________________________________________________1 phenylmethyl C.sub.2 H.sub.5 H H H H CH.sub.3 155-157 C.sub.22 H.sub.22 N.sub.2 O.sub.2 A2 4-methyl " " " " " " 153-154 C.sub.23 H.sub.24 N.sub.2 O.sub.2 A phenylmethyl3 butyl n-C.sub.3 H.sub.7 " " " " " 116-117 C.sub.20 H.sub.26 N.sub.2 O.sub.2 A4 phenylmethyl " " " " " " 150-152 C.sub.23 H.sub.24 N.sub.2 O.sub.2 A5 2-phenylethyl " " " " " " 132-133 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A6 phenylmethyl n-C.sub.4 H.sub.9 " " " " " 132-134 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A7 4-methyl " " " " " " C.sub.25 H.sub.28 N.sub.2 O.sub.2 A phenylmethyl8 phenylmethyl iso-C.sub.4 H.sub.9 " " " " " 112.5-114 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A9 " n-C.sub.5 H.sub.11 " " " " " 114-115.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A10 " n-C.sub.7 H.sub.15 " " " " " 86-88 C.sub.27 H.sub.32 N.sub.2 O.sub.2 A11 " n-C.sub.9 H.sub.19 " " " " " C.sub.29 H.sub.36 N.sub.2 O.sub.2 A12 " phenylmethyl " " " " " 190.5-193 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A13 4-methyl phenylmethyl H H H H CH.sub.3 188-189 C.sub.28 H.sub.26 N.sub.2 O.sub.2 A phenylmethyl14 H phenyl " " " " " 277-279 C.sub.19 H.sub.16 N.sub.2 O.sub.2 B15 methyl " " " " " " 215-217 C.sub.20 H.sub.18 N.sub.2 O.sub.2 B16 ethyl " " " " " " 207-209 C.sub.21 H.sub.20 N.sub.2 O.sub.2 B17 propyl " " " " " " 180-183 C.sub.22 H.sub.22 N.sub.2 O.sub.2 B18 butyl " " " " " " 189.5-193 C.sub.23 H.sub.24 N.sub.2 O.sub.2 A19 pentyl " " " " " " 170.5-173 C.sub.24 H.sub.26 N.sub.2 O.sub. B20 hexyl " " " " " " 137-138.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A21 octyl " " " " " " C.sub.27 H.sub.32 N.sub.2 O.sub.2 A22 3- " " " " " " 203-204.5 C.sub.23 H.sub.24 N.sub.2 O.sub.3 A methoxypropyl23 2- " " " " " " 191-192 C.sub.22 H.sub.22 N.sub.2 O.sub.3 A methoxyethyl24 phenyl " " " " " " more than C.sub.25 H.sub.20 N.sub.2 O.sub.2 A 300.degree. C.25 phenylmethyl phenyl H H H H CH.sub.3 185.5-187.5 C.sub.26 H.sub.22 N.sub.2 O.sub.2 A26 4-methyl " " " " " " 191.5-193 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A phenylmethyl27 4-chloro " " " " " " 198-200 C.sub.26 H.sub.21 ClN.sub.2 O.sub.2 A phenylmethyl28 2-phenylethyl " " " " " " 168-171 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A29 2-furylmethyl " " " " " " C.sub.24 H.sub.20 N.sub.2 O.sub. A30 2- " " " " " " 209-211 C.sub.25 H.sub.21 N.sub.3 O.sub.2 A pyridylmethyl31 phenylmethyl 3-chloro " " " " " 227-229 C.sub.26 H.sub.21 ClN.sub.2 O.sub.2 A phenyl32 " 4-chloro " " " " " 222.5-228 C.sub.26 H.sub.21 ClN.sub.2 O.sub.2 A phenyl33 " 4-methyl " " " " " 172-175 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A phenyl34 " 2-furyl " " " " " C.sub.24 H.sub.20 N.sub.2 O.sub.3 A35 " n-C.sub.3 H.sub.7 2-CH.sub.3 " " " " 139-140.5 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A36 4-chloro " " " " " " 124-125 C.sub.24 H.sub.25 ClN.sub.2 O.sub.2 A phenylmethyl37 2-phenylethyl n-C.sub.3 H.sub.7 2-CH.sub.3 H H H CH.sub.3 132.5-134.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A38 butyl phenyl " " " " " 166.5-168.0 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A39 phenylmethyl " " " " " " 231-233 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A40 4-chloro " " " " " " 106-109 C.sub.27 H.sub.23 ClN.sub.2 O.sub.2 A phenylmethyl41 butyl " 2-Cl " " " " 174-175 C.sub.23 H.sub.23 ClN.sub.2 O.sub.2 A42 " " 2-CH.sub.3 3-CH.sub.3 " " " 221-224 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A43 phenylmethyl " " " " " " 214-216 C.sub.28 H.sub.26 N.sub.2 O.sub.2 A44 2-phenylethyl " " " " " " 215-217.5 C.sub.29 H.sub.28 N.sub.2 O.sub.2 A45 butyl " 2-CH.sub.3 6-CH.sub.3 " " " 166-168.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A46 phenylmethyl " " " " " " C.sub.28 H.sub.26 N.sub.2 O.sub.2 A47 butyl H 2-C.sub. 2 H.sub.5 6-C.sub.2 H.sub.5 " " " 151-152.5 C.sub.21 H.sub.28 N.sub.2 O.sub.2 C'48 " C.sub.2 H.sub.5 " " " " " C.sub.23 H.sub.32 N.sub.2 O.sub.2 A49 phenylmethyl C.sub.2 H.sub.5 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 H H CH.sub.3 C.sub.26 H.sub.30 N.sub.2 O.sub.2 A50 2-phenylethyl " " " " " " C.sub.27 H.sub.32 N.sub.2 O.sub.2 A51 propyl n-C.sub.3 H.sub.7 " " " " " C.sub.23 H.sub.32 N.sub.2 O.sub.2 A52 butyl " " " " " " C.sub.24 H.sub.34 N.sub.2 O.sub.2 A53 phenylmethyl " " " " " " 152-154 C.sub.27 H.sub.32 N.sub.2 O.sub.2 A54 butyl n-C.sub.4 H.sub.9 " " " " " C.sub.25 H.sub.36 N.sub.2 O.sub.2 A55 " iso-C.sub.4 H.sub.9 " " " " " C.sub.25 H.sub.36 N.sub.2 O.sub.2 A56 " phenylmethyl " " " " " C.sub.28 H.sub.34 N.sub.2 O.sub.2 A57 " phenyl " " " " " 152-153 C.sub.27 H.sub.32 N.sub.2 O.sub.2 A58 phenyl " " " " " " more than C.sub.29 H.sub.28 N.sub.2 O.sub.2 A 300.degree. C.59 phenylmethyl " " " " " " 100-103 C.sub.30 H.sub.30 N.sub.2 O.sub.2 A60 2-phenylmethyl phenyl " " " " " 196-197.5 C.sub.31 H.sub.32 N.sub.2 O.sub.2 A61 2-methylphenyl phenyl 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 H H CH.sub.3 162.5-163.5 C.sub.30 H.sub.30 N.sub.2 O.sub.2 A62 phenyl 4- " " " " " 297-299 C.sub.30 H.sub.30 N.sub.2 O.sub.2 A methylphenyl63 butyl C.sub.2 H.sub.5 " " " Br " C.sub.23 H.sub.31 BrN.sub.2 O.sub.2 D64 phenylmethyl CH.sub.3 H H " H C.sub.2 H.sub.5 135-137 C.sub.22 H.sub.22 N.sub.2 O.sub.2 B65 " " " " " " n-C.sub.3 H.sub.7 112-113 C.sub.23 H.sub.24 N.sub.2 O.sub.2 B66 butyl " " " " " phenyl 181-183 C.sub.23 H.sub.24 N.sub.2 O.sub.2 B67 phenylmethyl " " " " " " 104-106 C.sub.26 H.sub.22 N.sub.2 O.sub.2 B68 " " " " " " CF.sub.3 78-80 C.sub.21 H.sub.17 F.sub.3 N.sub.2 O.sub.2 B69 butyl " 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " " C.sub.2 H.sub.5 112.5-114.5 C.sub.23 H.sub.32 N.sub.2 O.sub.2 B70 phenylmethyl " " " " " " 133.5-135 C.sub.26 H.sub.30 N.sub.2 O.sub.2 B71 2-phenylethyl " " " " " " 109-111 C.sub.27 H.sub.32 N.sub.2 O.sub.2 B72 butyl " " " " Br " 132.5-133.5 C.sub.23 H.sub.31 BrN.sub.2 O.sub.2 D73 2- CH.sub.3 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 H Br C.sub.2 H.sub.5 126-129.5 C.sub.27 H.sub.31 BrN.sub.2 O.sub.2 D phenylethyl74 butyl " " " " H n-C.sub.3 H.sub.7 C.sub.24 H.sub.34 N.sub.2 O.sub.2 B75 2-phenylethyl " " " " " " C.sub.28 H.sub.34 N.sub.2 O.sub. B76 " " " " " " CF.sub.3 179-180 C.sub.26 H.sub.27 F.sub.3 N.sub.2 O.sub.2 B77 butyl " " " " " n-C.sub.4 H.sub.9 C.sub.25 H.sub.36 N.sub.2 O.sub.2 B78 2-phenylethyl " " " " " " C.sub.29 H.sub.36 N.sub.2 O.sub.2 B79 butyl " " " phenyl " H 180-182 C.sub.27 H.sub.32 N.sub.2 O.sub.2 F80 2-phenylethyl " " " H --(CH.sub.2)4-- 188-190 C.sub.29 H.sub.34 N.sub.2 O.sub.2 B81 phenylmethyl " H H " phenyl H 166-168 C.sub.26 H.sub.22 N.sub.2 O.sub.2 F82 cyclohexyl- C.sub.2 H.sub.5 " " " H CH.sub.3 C.sub.22 H.sub.28 N.sub.2 O.sub.2 A methyl83 4-methyl- n-C.sub. 3 H.sub.7 " " " " " 181-183 C.sub.24 H.sub.26 N.sub.2 O.sub.2 A phenylmethyl84 cyclohexyl- " " " " " " C.sub.23 H.sub.30 N.sub.2 O.sub.2 A methyl85 cyclohexyl- n-C.sub.4 H.sub.9 H H H H CH.sub.3 C.sub.24 H.sub.32 N.sub.2 O.sub.2 A methyl86 4-methyl- iso-C.sub.4 H.sub.9 " " " " " C.sub.25 H.sub.28 N.sub.2 O.sub.2 A phenylmethyl87 cyclohexyl- " " " " " " C.sub.24 H.sub.32 N.sub.2 O.sub.2 A methyl88 4-methyl- n-C.sub.5 H.sub.11 " " " " " 151-152.5 C.sub.26 H.sub.30 N.sub.2 O.sub.2 A phenylmethyl89 phenylmethyl C.sub.2 H.sub.5 2-CH.sub.3 " " " " C.sub.23 H.sub.24 N.sub.2 O.sub.2 A90 4-chloro- " " " " " " C.sub.23 H.sub.23 ClN.sub.2 O.sub.2 A phenylmethyl91 phenylmethyl nC.sub.4 H.sub.9 " " " " " 161-163.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A92 4-chloro- " " " " " " C.sub.25 H.sub.27 ClN.sub.2 O.sub.2 A phenylmethyl93 phenylmethyl nC.sub.5 H.sub.11 " " " " " 111.5-113 C.sub.26 H.sub.30 N.sub.2 O.sub.2 A94 4-chloro- " " " " " " 155-156.5 C.sub.26 H.sub.29 ClN.sub.2 O.sub.2 A phenylmethyl95 phenylmethyl C.sub.2 H.sub.5 2-Cl " " " " 174.5-177 C.sub.22 H.sub.21 ClN.sub.2 O.sub.2 A96 phenylmethyl nC.sub.3 H.sub.7 " " " " " 171-171.5 C.sub.22 H.sub.23 ClN.sub.2 O.sub.2 A97 phenylmethyl nC.sub.4 H.sub.9 2-Cl H H H CH.sub.3 121-123 C.sub.24 H.sub.25 ClN.sub.2 O.sub.2 A98 phenylmethyl nC.sub.3 H.sub.7 2-CH.sub.3 3-CH.sub.3 " " " 126-128 C.sub.25 H.sub.28 N.sub.2 O.sub.2 A99 phenylmethyl methoxy- H H " " " C.sub.22 H.sub.22 N.sub.2 O.sub.3 A methyl100 phenylmethyl 2-methyl- " " " " " 173-174 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A phenyl101 phenylmethyl 3-methyl- " " " " " 202.5-204.5 C.sub.27 H.sub.24 N.sub.2 O.sub.2 A phenyl102 phenylmethyl 2-chloro- " " " " " 194-196 C.sub.26 H.sub.21 ClN.sub.2 O.sub.2 A phenyl103 phenylmethyl 2-furyl " " " " " C.sub.24 H.sub.20 N.sub.2 O.sub.3 A104 methyl nC.sub.4 H.sub.9 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " " " 95.5-96 C.sub.22 H.sub.30 N.sub.2 O.sub.2 B105 methyl " " " " Br " 180-180.5 C.sub.22 H.sub.29 BrN.sub.2 O.sub. D106 methyl " " " " CH.sub.3 CH.sub.3 114.5-115.5 C.sub.23 H.sub.32 N.sub.2 O.sub.2 B107 methyl " " " 4-Br H " 170.5-171.0 C.sub.22 H.sub.29 BrN.sub.2 O.sub.2 B108 methyl " " " " Br " 179.5-180 C.sub.22 H.sub.28 Br.sub.2 N.sub.2 D.sub.2109 methyl nC.sub.4 H.sub.9 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 4-Br CH.sub.3 CH.sub.3 139.0-140.0 C.sub.23 H.sub.31 BrN.sub.2 O.sub.2 B110 methyl nC.sub.3 H.sub.7 " " H " " 148-150.5 C.sub.26 H.sub.30 N.sub.2 O.sub.2 B111 methyl " " " 4-Br " " 156.0-156.5 C.sub.26 H.sub.29 BrN.sub.2 O.sub.2 B112 methyl nC.sub.5 H.sub.11 " " H H " 98-98.5 C.sub.24 H.sub.34 N.sub.2 O.sub.2 B113 3-chlorophenyl nC.sub.4 H.sub.9 H H " " " 210-211 C.sub.23 H.sub. 23 ClN.sub.2 O.sub.2 B114 3-bromophenyl " " " " " " 204-205 C.sub.23 H.sub.23 BrN.sub.2 O.sub.2 B115 3,5-bistri- " " " " " " 248-249 C.sub.25 H.sub.22 F.sub.6 N.sub.2 O.sub.2 B fluoromethyl- phenyl116 3-trifluoro " " " " " " 175-176 C.sub.24 H.sub.23 F.sub.3 N.sub.2 O.sub.2 B methylphenyl117 3-methylphenyl " " " " " " 110.5-111 C.sub.24 H.sub.26 N.sub.2 O.sub.2 B118 3-iodophenyl " " " " " " 211.5-216.5 C.sub.23 H.sub.23 IN.sub.2 O.sub.2 B119 3-fluorophenyl " " " " " " 185.5-187 C.sub.23 H.sub.23 FN.sub.2 O.sub.2 B120 3-ethylphenyl " " " " " " 142-142.5 C.sub.25 H.sub.28 N.sub.2 O.sub.2 B121 3,5-dichloro- nC.sub.4 H.sub.9 H H H H CH.sub.3 218-218.5 C.sub.23 H.sub.22 Cl.sub.2 N.sub.2 B.sub.2 phenyl122 3-methoxyphenyl n-C.sub.4 H.sub.9 " " " " " 140-142 C.sub.24 H.sub.26 N.sub.2 O.sub.3 B123 2,3-dichloro- " " " " " " 178-180 C.sub.23 H.sub.22 ClN.sub.2 O.sub.2 B phenyl124 3,4-dichloro- " " " " " " 199.5-200.0 C.sub.23 H.sub.22 Cl.sub.2 N.sub.2 B.sub.2 phenyl125 3-chlorophenyl " 2-CH.sub.3 3-CH.sub.3 " " " 123-124 C.sub.25 H.sub.27 ClN.sub.2 O.sub.2 B126 3-chlorophenyl " 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " " " 178-178.5 C.sub.27 H.sub.31 ClN.sub.2 O.sub.2 B127 3-chlorophenyl phenyl " " " " " 242-243 C.sub.29 H.sub.27 ClN.sub.2 O.sub.2 B128 H nC.sub.4 H.sub.9 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 H H CH.sub.3 oil C.sub.21 H.sub.28 N.sub.2 O.sub.2 B129 H 3-bromo- H H " " " 286.5-289 C.sub.19 H.sub.15 BrN.sub.2 O.sub.2 B phenyl130 methyl nC.sub.3 H.sub.7 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " " " 99.5-100.5 C.sub.21 H.sub.28 N.sub.2 O.sub.2 B131 methyl " " " 4-Br " " 159.0-160.0 C.sub.21 H.sub.27 BrN.sub.2 O.sub.2 B132 methyl " " " 4-I " " C.sub.21 H.sub.27 IN.sub.2 O.sub.2 B133 methyl nC.sub.3 H.sub.7 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 4-OCH.sub.3 H CH.sub.3 C.sub.22 H.sub.30 N.sub.2 O.sub.3 B134 methyl " " " 4-C.sub.2 H.sub.5 " " C.sub.23 H.sub.32 N.sub.2 O.sub.2 B135 methyl 3-chloro- H H H " " 191.0-192.5 C.sub.20 H.sub.17 ClN.sub.2 O.sub.2 B phenyl136 ethyl nC.sub.4 H.sub.9 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 4-Br " " 143.5-145 C.sub.23 H.sub.31 BrN.sub.2 O.sub.2 B137 H " " " H Br CH.sub.3 163-166 C.sub.21 H.sub.27 BrN.sub.2 O.sub.2 D138 methyl nC.sub.3 H.sub.7 " " " " " 183-184.5 C.sub.21 H.sub.27 BrN.sub.2 O.sub.2 D139 methyl " " " 4-Br " " 204-205 C.sub.21 H.sub.26 Br.sub.2 N.sub.2 D.sub.2140 methyl " " " 4-C.sub.2 H.sub.5 " " 169-173.5 C.sub.23 H.sub.31 BrN.sub.2 O.sub.2 D141 ethyl nC.sub.4 H.sub.9 " " 4-Br " " 210-210.5 C.sub.23 H.sub.30 Br.sub.2 N.sub.2 D.sub.2142 methyl nC.sub.3 H.sub.7 " " 4-C.sub.2 H.sub.5 CH.sub.3 " C.sub.24 H.sub.34 N.sub.2 O.sub.2 B143 methyl " " " 4-I " " C.sub.22 H.sub.29 IN.sub.2 O.sub.2 B144 methyl nC.sub.4 H.sub.9 " " 4-Br C.sub.2 H.sub.5 " oil C.sub.24 H.sub.33 BrN.sub.2 O.sub.2 B145 methyl nC.sub.3 H.sub.7 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 H H C.sub.2 H.sub.5 C.sub.22 H.sub.30 N.sub.2 O.sub.2 B146 methyl nC.sub.4 H.sub.9 " " 4-Br CH.sub.3 " C.sub.24 H.sub.33 BrN.sub.2 O.sub.2 B147 phenyl " H H H H CH.sub.3 213.0-214.0 C.sub.23 H.sub.24 N.sub.2 O.sub.2 B148 2-methylphenyl " " " " " " 183.0-185.0 C.sub.24 H.sub.26 N.sub.2 O.sub.2 B149 2-chlorophenyl " " " " " " 153.0-154.0 C.sub.23 H.sub.23 ClN.sub.2 O.sub.2 B150 methyl phenyl 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " CH.sub.3 " C.sub.25 H.sub.28 N.sub.2 O.sub.2 B151 3-cyanophenyl nC.sub.4 H.sub.9 H H " H " 207.5-209.5 C.sub.24 H.sub.23 N.sub.3 O.sub.2 B152 3-nitrophenyl " " " " " " 184.5-186 C.sub.23 H.sub.23 N.sub.3 O.sub.4 B153 4-chlorophenyl " " " " " " 192.0-192.5 C.sub.23 H.sub.23 ClN.sub.2 O.sub.2 B154 4-methylphenyl " " " " " " 163.5-165.0 C.sub.24 H.sub.26 N.sub.2 O.sub.2 B155 3-chloro-2- " " " " " " 163.0-164.0 C.sub.24 H.sub.25 ClN.sub.2 O.sub.2 B methylphenyl156 3-chloro-4- " " " " " " C.sub.24 H.sub.25 ClN.sub.2 O.sub.2 B methylphenyl157 5-chloro-2- nC.sub.4 H.sub.9 H H H H CH.sub.3 C.sub.24 H.sub.25 ClN.sub.2 O.sub.2 B methylphenyl158 3-pyridyl " " " " " " C.sub.22 H.sub.23 N.sub.3 O.sub.2 B159 3-bromophenyl " 2-CH.sub.3 3-CH.sub.3 " " " 157.5-158.0 C.sub.25 H.sub.27 BrN.sub. B O.sub.2160 3-methylphenyl " " " " " " 165.0-166.5 C.sub.26 H.sub.30 N.sub.2 O.sub.2 B161 3-trifluoro- " " " " " " 157.5-158.0 C.sub.26 H.sub.27 F.sub.3 N.sub.2 O.sub.2 B methylphenyl162 3-bromophenyl " 2-C.sub.2 H.sub.5 6-C.sub.2 H.sub.5 " " " 136.5-137.5 C.sub.27 H.sub.31 BrN.sub.2 O.sub.2 B163 3-trifluoro- " " " " " " C.sub.28 H.sub.31 F.sub.3 N.sub.2 O.sub.2 B methylphenyl164 methyl n-C.sub.3 H.sub.7 " " " Br C.sub.2 H.sub.5 C.sub.22 H.sub.29 BrN.sub.2 O.sub.2 D165 methyl " " " 4-OCH.sub.3 " CH.sub.3 C.sub.22 H.sub.29 BrN.sub.2 O.sub.3 D166 methyl " " " I " " C.sub.21 H.sub.26 BrIN.sub.2 O.sub.2 D__________________________________________________________________________
TABLE 2__________________________________________________________________________ EvaluationExample IR NMR Conc. PlantsNo. .nu. value (cm.sup.-1) Method Chemical shift .delta. value Solvent (ppm) X Y Z__________________________________________________________________________1 1617, KBr 1.40 (3H,t), 2.26 (3H,s), CDCl.sub.3 20 4 4 1 1663 3.40 (2H,q), 5.22 (2H,s), 100 4 4 2 6.43 (1H,s), 6.70-7.75(10H,m), 12.76(1H,br)2 1600, KBr 1.37 (3H,t), 2.26 (3H,s), " 20 4 4 1 1638, 2.32 (3H,s), 3.25 (2H,q), 100 4 4 1 1664 5.18 (2H,s), 6.43 (1H,s), 6.60-7.75 (9H,m), 12.83 (1H,br)3 1630, KBr 1.04 (6H,t), 0.7-2.0 (6h,m), " 20 3 4 3 1675 2.31 (3H,s), 3.27 (2H,t), 100 3 4 3 3.87 (2H,t), 6.31 (1H,s), 6.90-7.60 (5H,m), 12.60 (1H,br)4 1627, KBr 0.98 (3H,t), 1.80 (2H,six), " 20 4 4 1 1667 2.24 (3H,s), 3.18 (2H,t), 100 4 4 1 5.16 (2H,s), 6.40 (1H,s), 6.70-7.70 (10H,m), 12.75 (1H,br)5 1625, KBr 1.07 (3H,t), 1.63 (2H,six), " 20 3 4 1 1673 2.31 (3H,s), 2.91 (2H,t), 100 3 4 1 3.36 (2H,t), 4.10 (2H,t), 6.32 (1H,s), 6.90-7.70 (10H,m), 12.69 (1H,br)6 1630, KBr 0.89 (3H,t), 1.00-2.00 (4H,m), CDCl.sub.3 20 4 4 1 1675 2.25 (3H,s), 3.22 (2H,t), 100 4 4 2 5.19 (2H,s), 6.41 (1H,s), 6.70-7.70 (10H,m), 12.70 (1H,br)7 1640, KBr 0.92 (3H,t), 1.10-2.20 (4H,m), " 20 4 4 1 1665 2.24 (3H,s), 2.30 (3H,s), 100 4 4 1 3.25 (2H,t), 5.15 (2H,s), 6.41 (1H,s), 6.70-7.75 (9H,m), 12.74 (1H,br)8 1620, KBr 0.95 (6H,d), 2.90 (1H,m), " 20 4 4 1 1660 2.23 (3H,s), 3.46 (2H,d), 100 4 4 1 5.20 (2H,s), 6.41 (1H,s), 6.70-7.70 (10H,m), 12.42 (1H,br)9 1627, KBr 0.87 (3H,t,), 1.00-2.10 (6H,m), " 20 4 4 1 1670 2.22 (3H,s), 3.23 (2H,t), 100 4 4 1 5.16 (2H,s), 6.40 (1H,s), 6.70-7.70 (10H,m), 12.63 (1H,br)10 1637, KBr 0.83 (3H,t), 1.00-2.00 (10H,m), " 20 3 4 1 1663 2.22 (3H,s), 3.20 (2H,t), 100 4 4 1 5.14 (2H,s), 6.36 (1H,s), 6.70-7.75 (10H,m), 12.70 (1H,br)11 1600, Neat 0.86 (3H,t), 0.90-2.00 (14H,m), CDCl.sub.3 20 3 4 1 1630, 2.24 (3H,s), 3.20 (2H,t), 100 3 4 1 1670 5.18 (2H,s), 6.40 (1H,s), 6.70-7.70 (10H,m), 12.65 (1H,br)12 1623, KBr 2.23 (3H,s), 4.70 (2H,s), " 20 1 4 1 1660 5.00 (2H,s), 6.47 (1H,s), 100 1 4 1 6.60-7.65 (15H,m), 12.83 (1H,br)13 1627, KBr 2.20 (3H,s), 2.31 (3H,s), " 20 2 4 1 1657 4.73 (2H,s), 5.00 (2H,s), 100 2 4 1 6.50 (1H,s), 6.65-7.70 (15H,m), 12.83 (1H,br)14 1610, KBr 20 1 3 1 1640, 100 2 4 1 166015 1625, KBr 2.36 (3H,s), 3.14 (3H,s), CDCl.sub.3 20 2 3 3 1663 6.51 (1H,s), 100 2 4 5 6.85-7.60 (10H,m), 12.53 (1H,br)16 1617, KBr 1.06 (3H,t), 2.42 (3H,s), CDCl.sub.3 20 1 4 1 1663 3.68 (2H,q), 6.51 (1H,s), 100 4 4 1 6.90-7.60 (10H,m), 12.45 (1H,br)17 1617, KBr 0.59 (3H,t), 1.45 (2H,six), " 20 4 4 1 1677 2.40 (3H,s), 3.48 (2H,t), 100 4 4 1 6.48 (1H,s), 6.80-7.65 (10H,m), 12.50 (1H,br)18 1600, KBr 0.66 (3H,t), 0.50-1.80 (4H,m), " 20 3 4 1 1617, 2.40 (3H,s), 3.58 (2H,t), 100 3 4 2 1680 6.51 (1H,s), 6.60- 7.65 (10H,m), 12.49 (1H,br)19 1617, KBr 0.71 (3H,t), 0.50-1.70 (6H,m), " 20 4 4 1 1675 2.38 (3H,s), 3.50 (2H,t), 100 4 4 3 6.32 (1H,s), 6.80-7.50 (10H,m), 12.53 (1H,br)20 1617, KBr 0.77 (3H,t), 0.50-1.80 (8H,m), " 20 4 4 1 1675 2.41 (3H,s), 3.57 (2H,t), 100 4 4 1 6.51 (1H,s), 6.85-7.60 (10H,m), 12.57 (1H,br)21 1600, KBr 0.58 (3H,t), 0.40-1.60 (12H,m), CDCl.sub.3 20 4 4 1 1620, 2.38 (3H,s), 3.66 (2H,t), 100 4 4 1 1680 6.43 (1H,s), 6.80-7.50 (10H,m), 12.07 (1H,br)22 1617, KBr 1.67 (2H,m), 2.40 (3H,s), " 20 3 4 1 1677 3.00 (2H,t), 3.12 (3H,s), 100 3 5 1 3.70 (2H,t), 6.48 (1H,s), 6.80-7.60 (10H,m), 12.46 (1H,br)23 1623, KBr 2.44 (3H,s), 3.12 (3H,s), " 20 4 4 1 1670 3.22 (2H,t), 3.85 (2H,t), 100 4 4 1 6.48 (1H,s), 6.80-7.60 (10H,m), 12.35 (1H,br)24 1623, KBr 20 1 4 1 1675 100 1 4 125 1620, KBr 2.27 (3H,s), 4.89 (2H,s) CDCl.sub.3 20 4 4 1 1675 6.59 (1H,s), 6.55-7.60 (15H,m), 100 4 4 1 12.46 (1H,br)26 1620, KBr 2.25 (3H,s), 2.28 (3H,s), CDCl.sub.3 20 4 4 1 1673 4.79 (2H,s), 6.55 (1H,s), 100 4 4 1 6.50-7.60 (14H,m), 12.48 (1H,br)27 1625, KBr 2.25 (3H,s), 4.80 (2H,s), " 20 4 4 1 1665 6.58 (1H,s), 100 4 4 1 6.55-7.60 (14H,m), 12.38 (1H,br)28 1613, KBr 2.42 (3H,s), 2.68 (2H,t), " 20 1 4 1 1673 3.80 (2H,t), 6.52 (1H,t), 100 3 4 1 6.50-7.60 (15H,m), 12.43 (1H,br)29 1623, KBr 2.43 (3H,s), 4.78 (2H,s), " 20 4 4 1 1673 5.75 (1H,m), 6.20 (1H,dd), 100 4 4 1 6.50 (1H,s), 6.80-7.55 (11H,m), 12.35 (1H,br)30 1617, KBr 2.30 (3H,s), 4.91 (2H,s), " 20 4 4 1 1667 6.58 (1H,s), 100 4 4 1 6.50-8.45 (14H,m), 12.53 (1H,br)31 1615, KBr 2.30 (3H,s), 4.82 (2H,s), CDCl.sub.3 20 4 4 1 1665 6.59 (1H,s), 100 4 4 1 6.60-7.60 (14H,m), 12.60 (1H,br)32 1623, KBr 2.26 (3H,s), 4.82 (2H,s), " 1670 6.57 (1H,s), 6.55-7.60 (14H,m), 12.55 (1H,br)33 1623, KBr 2.22 (3H,s), 2.30 (3H,s) " 20 3 4 1 1673 4.82 (2H,s), 6.52 (1H,s), 100 3 4 1 6.55-7.60 (14H,m), 12.39 (1H,br)34 1625, Neat 2.23 (3H,s), 4.86 (2H,s) " 20 4 4 1 1675 6.18 (1H,m), 6.35 (1H,dd), 100 4 4 3 6.57 (1H,s), 6.70-7.70 (11H,m), 12.30 (1H,br)35 1623, KBr 1.00 (3H,t), 1.75 (2H,six), " 20 4 4 1 1660 2.24 (3H,s), 2.40 (3H,s), 100 4 4 1 3.20 (2H,t), 5.17 (2H,s), 6.39 (1H,s), 5.17 (2H,s), 12.43 (1H,br)36 1630, KBr 1.00 (3H,t), 1.75 (2H,six) CDCl.sub.3 20 4 4 1 1675 2.21 (3H,s), 2.39 (3H,s), 100 4 4 2 3.20 (2H,t), 5.11 (2H,s), 6.38 (1H,s), 6.70-8.05 (8H,m). 12.50 (1H,br)37 1627, KBr 1.06 (3H,t), 1.75 (2H,six), " 20 4 4 2 1653 2.30 (3H,s), 2.37 (3H,s) 100 4 4 2 2.90 (2H,t), 3.40 (2H,t), 4.08 (2H,t), 6.30 (1H,s), 6.80-8.00 (9H,m), 12.50 (1H,br)38 1610, KBr 0.66 (3H,t), 0.50-1.80( 4H,m), " 20 4 4 1 1675 2.32 (3H,s), 2.39 (3H,s), 100 4 4 3 3.50 (2H,t), 6.51 (1H,s), 6.80-7.90 (9H,m), 12.25 (1H,br)39 1623, KBr 2.27 (3H,s), 2.36 (3H,s), " 20 4 4 1 1667 4.83 (2H,s), 6.57 (1H,s), 100 4 4 2 6.55-7.84 (14H,m), 12.28 (1H,br)40 1623, KBr 2.27 (3H,s), 2.35 (3H,s), " 20 3 4 1 1673 4.81 (2H,s), 6.57 (1H,s), 100 4 4 2 6.55-7.85 (13H,m), 12.21 (1H,br)41 1623, KBr 0.65 (3H,t), 0.40-1.80 (4H,m), CDCl.sub.3 20 4 4 1 1680 2.41 (3H,t), 3.52 (2H,t), 100 4 4 1 6.50 (1H,t), 6.70-8.17 (9H,m), 12.90 (1H,br)42 1607, KBr 0.65 (3H,t), 0.40-1.80 (4H,m) CDCl.sub.3 20 4 4 1 1680 2.12 (3H,t), 2.21 (3H,t), + 100 4 4 1 2.43 (3H,t), 3.62 (2H,t), DMSO-d.sup.6 6.46 (1H,t), 6.70-7.50 (8H,t), 11.63 (1H,br)43 1605, KBr 2.20 (6H,t), 2.23 (3H,t), CDCl.sub.3 20 4 4 1 1617, 4.81 (2H,s), 6.53 (1H,t), 100 4 4 1 1677 6.50-7.60 (13H,m), 12.05 (1H,m)44 1603, KBr 2.20 (6H,ms), 2.42 (3H,t), " 20 1 2 1 1625 2.66 (2H,t), 3.80 (2H,t) 100 1 3 1 1675 6.50 (1H,t), 6.50-7.60 (13H,m), 12.00 (1H,br)45 1620, KBr 0.67 (3H,t), 0.40-1.80 (4H,m), " 20 3 4 5 1675 2.20 (6H,t), 2.40 (3H,t), 100 3 4 5 3.60 (2H,t), 6.49 (1H,t), 6.87-7.20 (8H,m), 11.13 (1H,br)46 1625, KBr 2.10 (6H,s), 2.24 (3H,s), CDCl.sub.3 20 4 4 1 1650 4.84 (2H,s), 6.60 (1H,s), 100 4 4 1 6.60-7.30 (13H,m), 11.05 (1H,br)47 1630, KBr 1.06 (3H,t), 1.18 (6H,t), " 20 1 2 4 1675 0.75-2.10 (4H,m), 2.35 (3H,s), 100 1 2 4 2.63 (4H,q), 3.89 (2H,t), 6.43 (1H,s), 7.25 (3H,s), 8.44 (1H,s), 11.80 (1H,br)48 1630, Neat 1.20 (6H,t), 0.70-2.00 (10H,m), " 20 3 3 5 1660 Neat 2.40 (3H,s), 2.65 (4H,q), 100 5 4 5 3.35 (2H,q), 3.90 (2H,t), 6.37 (1H,s), 7.03 (3H,s), 11.80 (1H,br)49 1630, Neat 1.20 (6H,t), 1.33 (3H,t), " 20 1 2 3 1660 2.27 (3H,s), 2.70 (4H,q), 100 3 4 5 3.30 (2H,q), 5.23 (2H,s), 6.49 (1H,s), 6.80-7.50 (8H,m), 11.81 (1H,br)50 1630, Neat 1.19 (6H,t), 1.21 (3H,t), " 20 5 5 5 1650 2.35 (3H,s), 2.66 (4H,q), 100 5 5 5 2.95 (2H,t), 3.37 (2H,q), 4.15 (2H,t), 6.39 (1H,s), 7.00-7.40 (8H,m), 11.70 (1H,br)51 1625, KBr 1.18 (6H,t), 0.80-2.10 (10H,m), CDCl.sub.3 20 1 1 3 1660 2.37 (3H,s), 2.67 (4H,q), 100 4 4 4 3.30 (H,t), 3.85 (2H,t), 6.39 (1H,s), 7.03 (3H,s), 11.80 (1H,br)52 1627, Neat 1.17 (6H,t), 0.60-2.00 (12H,m), " 20 2 3 5 1650, 2.37 (3H,s), 2.65 (4H,q), 100 4 4 5 1663 3.20 (2H,t), 3.90 (2H,t), 6.37(1H,s), 7.03 (3H,s), 11.82 (1H,br)53 1630, KBr 0.95 (3H,t), 1.19 (6H,t), " 20 3 4 1 1665 1.70 (2H,six), 2.26 (3H,s), 100 3 4 4 2.70 (4H,q), 3.23 (2H,t), 5.18 (2H,s), 6.44 (1H,s), 6.80-7.50 (8H,m), 11.80 (1H,br)54 1630, Neat 1.18 (6H,t), 0.60-2.00 (14H,m), " 20 2 1 4 1665 2.38 (3H,s), 2.65 (4H,q), 100 4 4 4 3.23 (2H,t), 3.92 (2H,t), 6.39 (1H,s), 7.03 (3H,s), 11.78 (1H,br)55 1647 Neat 0.98 (6H,d), 1.17 (6H,t), " 20 1 2 4 0.50-2.00 (8H,m), 2.39 (3H,s), 100 5 5 4 2.65 (4H,q), 3.22 (2H,d), 3.95 (2H,t), 6.38 (1H,s), 7.02 (3H,s), 12.05 (1H,s),56 1630, Neat 0.91 (3H,t), 1.10 (6H,t), CDCl.sub.3 20 3 4 5 1660 0.70-2.00 (4H,m), 2.36 (3H,s), 100 5 4 5 2.55 (4H,q), 3.80 (2H,t), 4.93 (2H,s), 6.46 (2H,s), 7.00-7.35 (8H,m), 12.70 (1H,br)57 1620, KBr 0.59 (3H,t), 1.10 (6H,t), " 20 2 4 4 1667 0.50-1.80 (4H,m), 2.43 (3H,s), 100 4 4 4 2.50 (4H,q), 3.62 (2H,t), 6.53 (1H,s), 7.00-7.50 (8H,m), 11.06 (1H,br)58 1623, KBr 20 4 4 1 1673 100 4 4 159 1625, KBr 1.10 (6H,t), 2.29 (3H,s), CDCl.sub.3 20 4 4 1 1667 2.50 (4H,q), 4.91 (2H,s), 100 4 4 3 6.60 (1H,s), 6.60-7.40 (13H,m), 10.98 (1H,br)60 1620, KBr 1.10 (6H,t), 2.44 (3H,s), " 20 1 1 1 1660 2.50 (4H,q), 2.67 (2H,t), 100 1 2 1 3.83 (2H,t), 6.50 (1H,s), 6.50-7.40 (13H,m), 11.02 (1H,br)61 1600, KBr 1.10 (6H,t), 1.90 (3H,s), CDCl.sub.3 20 3 4 3 1620, 2.02 (3H,s), 2.52 (4H,q), 100 3 4 4 1665 6.59 (1H,s), 6.80-7.10 (12H,m), 11.02 (1H,br)62 1620, KBr 20 2 3 1 1673 100 3 4 163 1660 Neat 1.18 (6H,t), 0.80- 2.00 (10H,m), CDCl.sub.3 20 4 5 5 2.65 (4H,q), 2.74 (3H,s), 100 5 5 5 3.32 (2H,q), 4.06 (2H,t), 7.10 (3H,s), 11.20 (1H,br)64 1625, KBr 1.19 (3H,t), 2.51 (2H,q), " 20 4 4 2 1660 2.82 (3H,s), 5.16 (2H,s), 100 4 4 2 6.43 (1H,s), 6.70-7.75 (10H,m), 12.68 (1H,br)65 1600, KBr 0.93 (3H,t), 1.65 (2H,six), " 20 3 3 1 1620, 2.45 (2H,t), 2.87 (3H,s), 100 3 3 1 1673 5.25 (2H,s), 6.40 (1H,s), 6.70-7.75 (10H,m), 12.70 (1H,br)66 1600, KBr 0.62 (3H,t), 0.50-1.80 (4H,m), CDCl.sub.3 20 1630, 2.95 (3H,s), 3.85 (2H,t), 100 1665 6.36 (1H,s), 6.90-7.75 (10H,m), 12.60 (1H,br)67 1600, KBr 2.85 (3H,s), 5.09 (2H,s), " 20 1 1 1 1615, 6.47 (1H,s), 6.64-7.75 (15H,m), 100 2 1 2 1665 12.53 (1H,br)68 1607, KBr 2.76 (3H,s), 5.30 (2H,s), " 20 2 4 1 1630, 6.47 (1H,s), 100 3 4 1 1680 6.72-7.75 (10H,m), 11.62 (1H,br)69 1620. KBr 1.19 (6H,t), 0.80-2.00 (10H,m), " 20 4 4 5 1650 2.65 (6H,q), 2.90 (3H,s), 100 5 5 5 3.93 (2H,t), 6.42 (1H,s), 7.06 (3H,s), 11.71 (1H,br)70 1625, KBr 1.18 (6H,t), 1.22 (3H,t), " 20 1 1 4 1660 2.55 (2H,q), 2.65 (4H,q), 100 3 4 4 2.79 (3H,s), 5.20 (2H,s), 6.49 (1H,s), 6.80-7.50 (8H,m), 11.80 (1H,br)71 1627, KBr 1.19 (6H,t), 1.27 (3H,t), CDCl.sub.3 20 4 5 5 1650 KBr 2.63 (2H,q), 2.65 (4H,q), 100 5 5 5 2.92 (3H,s), 2.90 (2H,t), 4.18 (2H,t), 6.42 (1H,s), 7.00-7.30 (8H,m), 11.75 (1H,br)72 1605, KBr 1.18 (6H,t), 0.80-2.00 (10H,m), " 20 1 2 5 1650 2.65 (4H,q), 2.84 (3H,s), 100 4 4 5 3.08 (2H,q), 4.00 (2H,t), 7.06 (3H,s), 11.05 (1H,br)73 1615, KBr 1.16 (6H,t), 1.27 (3H,t), " 20 4 5 5 1645, 2.65 (4H,q), 2.85 (3H,s), 100 5 5 5 1665 3.00 (2H,t), 3.05 (2H,q), 4.22 (2H,t), 6.95-7.30 (8H,m), 10.89 (1H,br)74 1630, KBr 1.18 (6H,t), 0.80-2.00 (12H,m) " 20 2 3 5 1660 2.60 (2H,t), 2.65 (4H,q), 100 5 5 5 2.86 (3H,s), 3.90 (2H,t), 6.38 (1H,s), 7.02 (3H,s), 11.72 (1H,br)75 1625, KBr 1.00 (3H,t), 1.19 (6H,t), 1.20- " 20 1 1 3 1660 1.70 (2H,m), 2.52 (2H,t), 2.63 100 2 3 4 (4H,q), 2.89( 3H,s), 2.95 (2H,t), 4.11 (2H,t), 6.38 (1H,s), 6.95-7.30 (8H,m), 11.57 (1H,br)76 1630, KBr 1.18 (6H,t), 2.63 (4H,q), CDCl.sub.3 20 4 4 3 1653 2.96 (3H,s), 3.00 (2H,t), 100 5 5 3 4.23 (2H,t), 6.97 (1H,s), 6.95-7.30 (8H,m), 10.88 (1H,br)77 1630, KBr 1.20 (6H,t), 0.80-2.00 (14H,m), " 20 1 1 3 1660 2.60 (2H,t), 2.65 (4H,q), 2.86 (3H,s), 3.93 (2H,t), 6.40 (1H,s), 7.05 (3H,s), 11.73 (1H,br)78 1625, KBr 1.20 (6H,t), 0.80-1.80 (7H,m), " 20 1 2 4 1660 2.60 (2H,t), 2.67 (4H,q), 100 2 2 4 2.93 (3H,s), 2.97 (2H,t) 4.15 (2H,t), 6.41 (1H,s), 7.00-7.40 (8H,m), 11.61 (1H,br)79 1655 KBr 1.17 (6H,t), 0.80-2.00 (7H,m), " 20 1 2 1 2.65 (4H,q), 2.83 (3H,s), 100 2 2 1 3.92 (2H,t), 7.02 (3H,s), 7.10-7.60 (6H,m), 11.57 (1H,br)80 1620, KBr 1.19 (6H,t), 1.70 (4H,m), " 20 1 3 4 1650 2.62 (4H,m), 2.67 (4H,q), 100 2 3 4 2.93 (3H,s), 2.95 (2H,t), 4.20 (2H,t), 7.00-7.40 (8H,m), 11.72 (1H,br)81 1630, KBr 2.79 (3H,s), 5.10 (2H,s), CDCl.sub.3 20 1 1 1 1650, 6.80-7.70 (16H,m), 100 1 2 1 1670 12.60 (1H,br)82 0.80-2.00 (13H,m), 1.28 (3H,s), " 20 4 4 1 2.36 (3H,ms), 3.80 (2H,d), 100 4 4 1 6.35 (1H,s), 6.80-7.80 (5H,m), 12.66 (1H,br)83 1630, KBr 20 4 4 1 1673 100 4 4 184 0.70-2.10(18H,m), 2.36 (3H,s), CDCl.sub.3 20 4 4 2 3.78 (2H,d), 6.36 (1H,s), 100 4 4 2 6.80-7.75 (5H,m), 12.57 (1H,br)85 1625, Neat 0.50-2.10 (20H,m), 2.34 (3H,s), " 20 3 4 1 1670 3.75 (2H,d), 6.30 (1H,s), 100 4 4 1 6.80-7.70 (5H,m), 12.60 (1H,br)86 1630, Neat 0.97 (6H,d), 1.70-2.30 (3H,m), CDCl.sub.3 20 4 4 1 1663 2.25 (3H,s), 2.31 (3H,s), 100 4 4 1 3.50 (2H,d), 5.65 (2H,d), 6.40 (1H,s), 6.70-7.70 (9H,m), 12.45 (1H,br)87 1623, Neat 0.60-2.30 (14H,m), 0.95 (6H,d), " 20 4 4 2 1663 2.32 (3H,s), 3.82 (2H,d), 100 4 4 2 6.33 (1H,s), 6.80-7.70 (5H,m), 12.38 (1H,br)88 1600, KBr 20 4 4 1 1645, 100 3 4 1 166789 1630, KBr 20 4 4 4 1667 100 4 4 490 1633, Neat 20 4 4 1 1667 100 4 4 391 1613, KBr 20 4 4 1 1627, 100 4 4 1 166792 1633, Neat 0.70-2.00 (7H,m), 2.22 (3H,s), CDCl.sub.3 20 4 4 1 1667 2.39 (3H,s), 3.20 (2H,t), 100 4 4 1 5.13 (2H,s), 6.40 (1H,s), 6.70-8.07 (8H,m), 12.47 (1H,br)93 1610, KBr 0.60-2.00 (9H,m), 2.26 (3H,s), " 20 4 4 1 1627, 2.41 (3H,s), 3.26 (2H,t), 100 4 4 1 1657 5.19 (2H,s), 6.41 (1H,s), 6.70-8.05(9H,m), 12.54 (1H,br)94 1630, Neat 20 1 4 1 1670 100 1 4 195 1633, KBr 1.37 (3H,t), 2.26 (3H,s), CDCl.sub.3 20 4 4 1 1675 3.22 (2H,q), 5.13 (2H,s), 100 4 4 2 6.44 (1H,s), 6.70-8.43 (9H,m), 13.22 (1H,br)96 1.00 (3H,t), 1.77 (2H,m), CDCl.sub.3 20 4 4 1 2.26 (3H,s), 3.20 (2H,t), 100 4 4 1 5.20 (2H,s), 6.43 (1H,s), 6.70-8.33 (9H,m), 13.18 (1H,br)97 1637, KBr 0.70-2.00 (7H,m), 2.26 (3H,s), " 20 4 4 1 1680 3.18 (2H,t), 5.16 (2H,s), 100 4 4 1 6.39 (1H,s), 6.70-8.40 (9H,m), 13.18 (1H,br)98 1605, KBr 20 4 4 1 1630, 100 4 4 3 167399 1630, Neat 2.25 (3H,s), 3.41 (3H,s), CDCl.sub.3 20 4 4 1 1670 5.01 (2H,s), 5.45 (2H,s), 100 4 4 1 6.50 (1H,s), 6.70-7.77 (10H,m), 12.45(1H,br)100 2.05 (3H,s), 2.30 (3H,s), " 20 3 4 1 4.83 (2H,d), 6.31 (1H,s), 100 3 4 1 6.60-7.60 (14H,m), 12.50 (1H,br)101 1600, KBr 2.16 (3H,s), 2.25 (3H,s), CDCl.sub.3 20 4 4 1 1623, 4.79 (2H,d), 6.53 (1H,s), 100 4 4 1 1670 6.50-7.60 (14H,m), 12.40 (1H,br)102 1627, KBr 2.32 (3H,s), 4.66 (1H,d), " 20 4 4 1 1677 5.05 (1H,d), 6.63 (1H,s), 100 4 4 1 6.60-7.60 (14H,m), 12.67 (1H,br)103 1625, Neat 20 4 4 1 1680 100 4 4 3104 1630, KBr 0.80-2.00 (7H,m), 1.18 (6H,t), CDCl.sub.3 20 5 5 5 1657, 2.36 (3H,s), 2.65 (4H,q), 100 5 5 5 1637 3.38 (2H,t), 3.60 (3H,s), 6.42 (1H,s), 7.08 (3H,s), 11.80 (1H,br)105 1667 KBr 20 4 5 5 100 4 5 5106 1620, KBr 0.70-2.00 (7H,m), 1.18 (6H,t), CDCl.sub. 3 20 4 5 5 1655 2.17 (3H,s), 2.30 (3H,s), 100 5 5 5 2.67 (4H,q), 3.40 (2H,t), 3.61 (3H,s), 7.08 (3H,s), 11.85 (1H,br)107 1640, KBr 0.70-2.00 (7H,m), 1.16 (6H,t), " 20 5 5 5 1667 2.36 (3H,s), 2.61 (4H,q), 100 5 5 5 3.34 (2H,t), 3.57 (3H,s), 6.38 (1H,s), 7.16 (2H,s), 11.99 (1H,br)108 1625, KBr 0.70-2.00 (7H,m), 1.18 (6H,t), " 20 5 5 5 1660 2.36 (3H,s), 2.62 (4H,q), 100 5 5 5 3.35 (2H,t), 3.57 (3H,s), 7.16 (2H,s), 11.75 (1H,br)109 0.70-2.00 (7H,m), 1.16 (6H,t), " 20 5 5 5 2.16 (3H,s), 2.40 (3H,s), 100 5 5 5 2.63 (4H,q), 3.33 (2H,t) 3.61 (3H,s), 7.16 (2H,s), 12.07 (1H,br)110 1620, KBr 1.03 (3H,t), 1.20 (6H,t), " 20 5 5 5 1650 1.73 (2H,m), 2.17 (3H,s), 100 5 5 5 2.40 (3H,s), 2.63 (4H,q), 3.27 (2H,t), 3.62 (3H,s), 7.11 (3H,s), 11.83 (1H,br)111 1625, KBr 1.17 (6H,t), 0.70-2.00 (5H,m), CDCl.sub.3 20 5 5 5 1655 2.16 (3H,s), 2.40 (3H,s), 100 5 5 5 2.62 (4H,q), 3.31 (2H,t), 3.61 (3H,s), 7.19 (2H,s), 12.04 (1H,br)112 1620, KBr 0.70-2.00 (9H,m), 1.18 (6H,t), " 20 4 4 4 1657 2.17 (3H,s), 2.30 (3H,s), 100 5 4 4 2.67 (4H,a), 3.40 (2H,t), 3.61 (3H,s), 7.00 (3H,s), 11.85 (1H,br)113 1630, KBr 0.60-1.90 (7H,m), 1.89 (3H,s), " 20 4 4 1 1677 4.01 (2H,t), 6.41 (1H,s), 100 4 4 1 6.90-7.70 (9H,m), 12.73 (1H,br)114 1600, KBr 20 4 4 1 1637, 100 4 5 1 1667115 1635, KBr 0.50-1.90 (7H,m), 1.78 (3H,s), CDCl.sub.3 20 3 5 1 1687 2.95 (2H,t), 6.44 (1H,s), 100 4 5 1 7.00-8.10 (8H,m), 12.60 (1H,br)116 1600, KBr 0.40-2.10 (7H,m), 1.81 (3H,s), CDCl.sub.3 20 4 4 1 1635, 2.89 (2H,t), 6.41 (1H,s), 100 4 4 1 1680 6.80-8.00 (9H,m), 12.78 (1H,br)117 1603, KBr 0.40-2.00 (7H,m), 1.78 (3H,s), " 20 4 3 1 1640, .234 (3H,s), 3.00 (2H,t), 100 4 3 1 1670 6.35 (1H,s), 6.70-7.90 (9H,m), 13.11 (1H,br)118 1600, KBr 0.35-2.00 (7H,m), 1.87 (3H,s), " 20 1 4 1 1635, 3.00 (2H,t), 6.37 (1H,s), 100 1 4 1 1675 6.70-8.00 (9H,m), 12.90 (1H,br)119 1600, KBr 0.40-2.00 (7H,m), 1.85 (3H,s), " 20 4 4 1 1640, 3.03 (2H,t), 6.38 (1H,s), 100 4 4 1 1685 6.75-7.80 (9H,m), 12.82 (1H,br)120 1605, KBr 0.40-2.20 (7H,m), 1.24 (3H,t), " 20 4 4 1 1640, 1.84 (3H,s), 2.69 (2H,q), 100 4 4 1 1675 3.05 (2H,t), 6.39 (1H,s), 6.70-7.85 (9H,m), 13.07 (1H,br)121 1600, KBr 0.50-2.00 (7H,m), 1.88 (3H,s), CDCl.sub.3 20 1 4 1 1637, 3.00 (2H,t), 6.37 (1H,s), 100 1 4 1 1695 6.75-7.80 (8H,m), 12.72 (1H,br)122 1600, KBr 0.40-2.00 (7H,m), 1.91 (3H,s), " 20 4 4 1 1633, 3.08 (2H,t), 3.82 (3H,s), 100 4 4 1 1673 6.42 (1H,s), 6.60-7.80 (9H,m), 12.90 (1H,br)123 1603, KBr 0.40-2.00 (7H,m), 2.00-2.70 (1H, " 20 4 4 1 1640, m), 1.85 (3H,s), 3.10-3.90 100 4 4 1 1675 (1H,m), 6.46 (1H,s), 6.80-7.85 (8H,m), 12.73 (1H,br)124 1600, KBr 0.50-2.00 (7H,m), 1.85 (3H,s), " 20 4 4 1 1635, 3.00 (2H,t), 6.36 (1H,s), 100 4 4 1 1680 6.70-7.80 (8H,m), 12.75 (1H,br)125 1610, KBr 0.50-1.80 (7H,m), 1.87 (3H,s), " 20 4 4 1 1640, 2.29 (6H,s), 3.03 (2H,t), 100 4 4 2 1673 6.43 (1H,s), 6.40-7.83 (7H,m), 12.40 (1H,br)126 1637, KBr 0.50-1.90 (7H,m), 1.20 (6H,t), CDCl.sub.3 20 1 4 1 1660 1.89 (3H,s), 2.70 (4H,q), 100 1 4 1 3.05 (2H,t), 6.45 (1H,s), 7.00-7.55 (7H,m), 12.00 (1H,br)127 1633, KBr 1.12 (6H,t), 2.03 (3H,s), " 20 4 4 1 1663 2.54 (4H,q), 6.61 (1H,s), 100 4 4 1 6.60-7.50 (12H,m), 11.00 (1H,br)128 0.50-1.93 (7H,m), 1.16 (6H,t), " 20 1 4 5 2.10 (3H,s), 2.62 (4H,q), 100 4 4 5 2.90-3.35 (2H,m), 6.23 (1H,s), 7.06 (3H,s), 11.44 (1H,br), 12.23 (1H,s)129 1653, KBr 2.31 (3H,s), 6.23 (1H,s), CDCl.sub.3 20 1 1 1 1683 6.80-7.70 (9H,m), -DMSO-d.sup.6 100 1 1 1 10.90-12.00 (1H,br), 12.53 (1H,br)130 1633, KBr 1.03 (3H,t), 1.19 (6H,t), CDCl.sub.3 20 5 5 5 1637 1.67 (2H,six), 2.30 (3H,s), 100 5 5 5 2.66 (4H,q), 3.30 (2H,t), 3.49 (3H,s), 6.33 (1H,s), 7.05 (3H,s), 11.90 (1H,br)131 1637, KBr 1.03 (3H,t), 1.16 (6H,t), CDCl.sub.3 20 5 5 5 1663 1.67 (2H,six), 2.32 (3H,s), 100 5 5 5 2.62 (4H,q), 3.30 (2H,t), 3.53 (3H,s), 6.35 (1H,s), 7.16 (2H,s), 12.05 (1H,br)132 1.01 (3H,t), 1.16 (6H,t), " 20 5 5 5 1.70 (2H,six), 2.34 (3H,s), 100 5 5 5 2.57 (4H,q), 3.30 (2H,t), 3.57 (3H,s), 6.38 (1H,s), 7.35 (2H,s), 12.00 (1H,br)133 1.04 (3H,t), 1.18 (6H,t), 1.70 " 20 5 5 5 (2H,six), 2.36 (3H,s), 2.63 100 5 5 5 (4H,q), 3.32 (2H,t), 3.58 (3H,s), 3.77 (3H,s), 6.40 (1H,s), 6.64 (2H,s), 11.47 (1H,br)134 1.18 (6H,t), 1.22 (3H,t), " 20 4 5 5 0.80-2.10 (5H,m), 2.35 (3H,s), 100 5 5 5 2.62 (6H,q), 3.32 (2H,t), 3.56 (3H,s), 6.37 (1H,s), 6.87 (2H,s), 11.60 (1H,br)135 1600, KBr 2.32 (3H,s), 3.11 (3H,s), " 20 1 3 2 1633, 6.47 (1H,s), 6.70-7.70 (9H,m), 100 1 3 5 1675 12.75 (1H,br)136 1633, KBr 1.18 (6H,t), 1.38 (3H,t), CDCl.sub.3 20 5 5 5 1667 0.70-2.00 (7h,m), 2.40 (3H,s), 100 5 5 5 2.64 (4H,q), 3.10-3.70 (2H,m), 4.02 (2H,q), 6.41 (1H,s), 7.20 (2H,s), 12.08 (1H,br)137 KBr 1.16 (6H,t), 0.45-2.00 (7H,m), " 20 1 3 5 1657 2.44 (3H,s), 2.63 (4H,q), 100 1 5 5 2.80-3.40 (2H,m), 7.09 (3H,s), 11.75 (2H,br)138 1613, KBr 1.03 (3H,t), 1.18 (6H,t), " 20 5 5 5 1660 1.70 (2H,six), 2.70 (3H,s), 100 5 5 5 2.68 (4H,q), 3.28 (2H,t), 3.68 (3H,s), 7.11 (3H,s), 11.07 (1H,br)139 1610, KBr 1.03 (3H,t), 1.16 (6H,t), " 20 5 5 5 1660 1.70 (2H,six), 2.62 (4H,q), 100 5 5 5 2.69 (3H,s), 3.27 (2H,t), 3.67 (3H,s), 7.17 (2H,s), 11.27 (1H,br)140 1600, KBr 1.03 (3H,t), 1.18 (6H,t), 1.23 " 20 4 5 5 1667 (3H,t), 1.70 (2H,six), 2.61 100 5 5 5 (2H,q), 2.66 (4H,q), 2.68 (3H,s), 3.27 (2H,t), 3.67 (3H,s), 6.93 (2H,s), 10.86 (1H,br)141 1607, KBr 1.17 (6H,t), 1.43 (3H,t), CDCl.sub.3 20 5 5 5 1663 0.60-2.00 (7H,m), 2.63 (4H,q), 100 5 5 5 2.75 (3H,s), 3.00-3.60 (2H,m), 4.14 (2H,q), 7.19 (2H,s), 11.35 (1H,br)142 1.03 (3H,t), 1.18 (6H,t), " 20 4 5 5 1.23 (3H,t), 1.70 (2H,six), 100 5 5 5 2.17 (3H,s), 2.40 (3H,s), 2.60 (2H,q), 2.65 (4H,q), 3.32 (2H,t), 3.61 (3H,s), 6.91 (2H,s), 11.62 (1H,br)143 1620, KBr 1.03 (3H,t), 1.16 (6H,t), " 20 4 5 5 1660 1.70 (2H,six), 2.16 (3H,s), 100 4 5 5 2.40 (3H,s), 2.60 (4H,q), 3.32 (2H,t), 3.62 (3H,s), 7.38 (2H,s), 12.05 (1H,br)144 1617, KBr 1.17 (6H,t), 1.23 (3H,t), " 20 5 5 5 1650 0.70-2.20 (7H,m), 2.39 (3H,s), 100 5 5 5 2.63 (4H,q), 2.67 (2H,q), 3.33 (2H,t), 3.61 (3H,s), 7.20 (2H,s), 12.16 (1H,br)145 1633, Neat 1.03 (3H,t), 1.19 (6H,t), " 20 3 5 5 1663 1.28 (3H,t), 1.70 (2H,six), 100 4 5 5 2.67 (6H,q), 3.40 (2H,t), 3.59 (3H,s), 6.46 (1H,s), 7.10 (3H,s), 11.82 (1H,br)146 1617, KBr 1.18 (6H,t), 1.25 (3H,t), CDCl.sub.3 20 3 4 5 1667 0.70-2.00 (7H,m), 2.17 (3H,s) 100 4 5 5 2.65 (4H,q), 2.81 (2H,q), 3.10-3.60 (2H,m), 3.67 (3H,s), 7.19 (2H,s), 12.08 (1H,br)147 1625, KBr 0.40-1.20 (7H,m), 1.83 (3H,s), " 20 4 4 1 1690 3.02 (2H,t), 6.41 (1H,s), 100 4 4 1 6.80-7.90 (10H,m), 13.02 (1H,br)148 1633, KBr 0.35-2.00 (7H,m), 1.73 (3H,s), " 20 4 4 1 1677 1.93 (3H,s), 2.00-2.50 (1H,m), 100 4 4 1 3.25-3.95 (1H,m), 6.43 (1H,s), 6.70-7.85 (9H,m), 13.13 (1H,br)149 1603, KBr 0.40-2.00 (7H,m), 1.84 (3H,s), " 20 4 4 1 1640, 2.00-3.90 (2H,m), 6.40 (1H,s), 100 4 4 1 1673 6.80-8.00 (9H,m), 12.87 (1H,br)150 1.10 (6H,t), 2.24 (3H,s), " 20 4 5 5 2.41 (3H,s), 2.51 (4H,q), 100 5 5 5 3.23 (3H,s), 6.85-7.55 (8H,m), 11.23 (1H,br)151 1633, KBr 0.40-2.00 (7H,m), 1.81 (3H,s), CDCl.sub.3 20 4 4 1 1680, 2.97 (2H,t), 6.43 (1H,s), 100 4 4 1 2280 6.80-8.00 (9H,m), 12.63 (1H,br)152 1600, KBr 0.40-2.00 (7H,m), 1.87 (3H,s), CDCl.sub.3 20 4 3 1 1637, 2.97 (2H,t), 6.44 (1H,s), -DMSO-d.sup.6 100 4 4 1 1680 6.80-8.70 (9H,m), 12.60 (1H,br)153 1633, KBr 0.40-2.00 (7H,m), 1.82 (3H,s), CDCl.sub.3 20 1 4 1 1685 3.01 (2H,t), 6.37 (1H,s), 100 1 4 1 6.80-7.85 (9H,m), 12.82 (1H,br)154 1600, KBr 0.40-2.00 (7H,m), 1.86 (3H,s), CDCl.sub.3 20 4 4 1 1633, 2.41 (3H,s), 2.83 (2H,t), -DMSO-d.sup.6 100 4 4 1 1675 6.33 (1H,s), 6.80-8.00 (9H,m), 12.56 (1H,br)155 1600, KBr 0.40-2.00 (7H,m), 1.80 (3H,s), CDCl.sub.3 20 4 4 1 1637, 2.05 (3H,s), 2.00-2.60 (1H,m), 100 4 4 1 1673 3.25-3.90 (1H,m), 6.46 (1H,s), 6.80-7.80 (8H,m) 12.90 (1H,br)156 0.40-2.00 (7H,m), 1.86 (3H,s), CDCl.sub.3 20 4 4 1 2.45 (3H,s), 3.03 (2H,t), 100 4 4 1 6.40 (1H,s), 6.80-7.85 (8H,s), 12.85 (1H,br)157 0.30-2.50 (7H,m), 1.81 (3H,s), " 20 4 3 1 1.98 (3H,s), 1.90-2.50 (1H,m), 100 4 3 1 3.20-4.10 (1H,m), 6.49 (1H,s), 6.75-7.90 (8H,m), 12.87 (1H,s)158 0.40-2.00 (7H,m), 1.79 (3H,s), " 20 1 4 1 2.50-3.40 (2H,m), 6.42 (1H,s), 100 4 4 1 6.80-8.90 (9H,m), 12.70 (1H,s),159 1613, KBr 0.40-2.00 (7H,m), 1.88 (3H,s), " 20 4 4 1 1637, 2.31 (6H,s), 3.03 (2H,t), 100 4 4 1 1683 6.42 (1H,s), 6.75-7.90 (7H,m), 12.41 (1H,br)160 1605, KBr 0.40-2.00 (7H,m), 1.88 (3H,s), " 20 4 4 1 1637, 2.29 (6H,s), 2.41 (3H,s), 100 4 4 2 1673 3.05 (2H,t), 6.42 (1H,s), 6.70-7.90 (7H,m), 12.56 (1H,br)161 1613, KBr 0.40-2.00 (7H,m), 1.86 (3H,s), CDCl.sub.3 20 4 4 1 1640, 2.30 (6H,s), 2.50-3.50 (2H,m), 100 4 4 2 1680 6.44 (1H,s), 6.70-8.00 (7H,m), 12.38 (1H,br)162 1635, KBr 0.40-2.00 (7H,m), 1.22 (6H,t), " 20 3 4 2 1667 1.91 (3H,s), 2.69 (4H,q), 100 4 4 2 2.50-3.50 (2H,m), 6.47 (1H,s), 6.80-8.00 (7H,m), 11.93 (1H,br)163 1633, KBr 0.40-2.00 (7H,m), 1.19 (3H,s), " 20 1 2 1 1655 1.87 (3H,s), 2.65 (4H,q), 100 4 5 3 2.20-4.10 (2H,m), 6.47 (1H,s), 6.80-7.90 (7H,m), 11.85 (1H,br)164 1.03 (3H,t), 1.16 (6H,t), " 20 5 5 5 1.29 (3H,t), 1.70 (2H,six), 100 5 5 5 2.63 (4H,q), 3.07 (2H,q), 3.27 (2H,t), 3.72 (3H,s), 7.06 (3H,s), 10.95 (1H,br)165 1.04 (3H,t), 1.18 (6H,t), " 20 5 5 5 1.70 (2H,six), 2.64 (4H,q) 100 5 5 5 2.76 (3H,s), 3.34 (2H,t), 3.68 (3H,s), 3.77 (3H,s), 6.64 (2H,s), 10.64 (1H,br)166 1.01 (3H,t), 1.18 (6H,t), CDCl.sub.3 20 5 5 5 1.70 (2H,six), 2.74 (3H,s), 100 5 5 5 2.61 (4H,q), 3.32 (2H,t), 3.76 (3H,s), 7.39 (2H,s), 11.13 (1H,br)__________________________________________________________________________ X: Oryza sativa L. Y: Echinochloa crusgalli L. Z: Raphanus sativus L.

Pyridine-3-carboxamide derivatives

Information

Patent Number

Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

US Classifications

Field of Search

US

International Classifications

Abstract

Description

Claims

Priority Claims (1)

US Referenced Citations (1)

Non-Patent Literature Citations (5)

Entry
Chem. Abstracts, vol. 85, No. 3, Abst. 85:21037n, Jul. 19, 1976.
Chem. Abstracts, vol. 88, No. 3, Abst. No. 88:22565g, Jan. 16, 1978.
Chem. Abstracts, vol. 96, No. 7, Abst. No. 96:52,150a, Feb. 15, 1982.
Chem. Abstracts, vol. 97, No. 7, Abst. No. 97:55,701n, Aug. 16, 1982.
Chem. Abstracts, vol. 97, Chemical Substance Index, Prod-Z, p. 5780CS (1982).