Claims
- 1. A pyridine derivative of the formula (III): ##STR67## wherein R.sub.1 and R.sub.2 are the same or different and are a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkoxy group, hydroxy group, nitro group, cyano group, amino group, carbamoyl group, an acylamino group, a lower alkylamino group, a lower alkenylamino group or an aralkylamino group, X is an oxygen atom or --S(O)n--, wherein n is 0, 1 or 2; A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen atom, R.sub.5 and R.sub.6 are the same or different and are a hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogeno lower alkyl group, a halogeno lower alkenyl group, an optionally substituted aralkyl group or an optionally substituted aryl group, or R.sub.5 and R.sub.6 are joined to form a group of the formula: ##STR68## wherein R.sub.7 and R.sub.8 are the same or different and are a hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogeno lower alkyl group, a halogeno lower alkenyl group, an optionally substituted aralkyl group or an optionally substituted aryl group, or R.sub.7 and R.sub.8 are linked together to form a ring, B.sub.1 is ##STR69## or a salt or solvate thereof.
- 2. A pyridine derivative according to claim 1, wherein R.sub.1 and R.sub.2 are the same or different and are a hydrogen atom, amino group or an acylamino group, X is an oxygen or sulfur atom, A is a bivalent C.sub.1-6 hydrocarbon residue, R.sub.5 and R.sub.6 are the same or different and are a hydrogen atom or a lower alkyl, or R.sub.5 and R.sub.6 are joined to form a group of the formula: ##STR70## wherein R.sub.7 and R.sub.8 are the same or different and are a hydrogen atom, a lower alkyl group, an optionally substituted aralkyl group or an optionally substituted aryl group.
- 3. The pyridine derivative according to claim 1 which is 4-(5,5-dimethyloxazolidine-2,4-dione)methylthiopyridine.
- 4. A pharmaceutical composition which comprises a pharmaceutically effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
- 5. A method for providing anti-inflammatory activity which comprises administering an effective amount of the pharmaceutical composition of claim 4.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3-105691 |
May 1991 |
JPX |
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Parent Case Info
This application is a division of application Ser. No. 08/334,221 filed Nov. 4, 1994 now U.S. Pat. No. 5,457,106 which is a division application of Ser. No. 08/081,181, filed Jun. 24, 1993 now U.S. Pat. No. 5,389,658 which is a division of application Ser. No. 07/880,641 filed May 7, 1992 now U.S. Pat. No. 5,246,948.
US Referenced Citations (12)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2034712 |
Jun 1980 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, vol. 85, No. 14, Oct. 4, 1976, p. 325, Abstract 99178d. |
Chemical Abstracts, vol. 61, No. 1, Jul. 1, 1964, Abstract 638g. |
Divisions (3)
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Number |
Date |
Country |
Parent |
334221 |
Nov 1994 |
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Parent |
81181 |
Jun 1993 |
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Parent |
880641 |
May 1992 |
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