Claims
- 1. Compound of the general formula (I) ##STR9## in which R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent C.sub.1-6 straight or branched chain alkyl or alkoxyalkyl group;
- R.sub.5 represents a C.sub.1-13 straight or branched chain alkyl group or a C.sub.5-8 cycloalkyl group may be substituted by a C.sub.1-3 alkyl group;
- R.sub.6 represents a hydrogen or halogen atom or a straight or branched C.sub.1-3 alkyl group; and
- R.sub.7 represents a C.sub.1-4 alkyl group optionally substituted by hydroxy or C.sub.1-3 alkoxy or trifluoromethyl or R.sub.7 represents a phenyl C.sub.1-2 alkyl group in which the phenyl portion is optionally substituted by 1 to 3 C.sub.1-3 alkyl or C.sub.1-3 alkoxy groups or halogen atoms.
- 2. Compounds as claimed in claim 1 in which R.sub.1 and R.sub.4 independently represent methyl or ethyl groups.
- 3. Compounds as claimed in claim 1 in which R.sub.2 and R.sub.3 independently represent a methyl or ethyl group.
- 4. Compounds as claimed in claim 1 in which R.sub.2 and R.sub.3 each represent an ethyl group.
- 5. Compounds as claimed in claim 1 in which R.sub.5 represents a C.sub.2-9 alkyl group.
- 6. Compounds as claimed in claim 5 in which R.sub.5 represents tert butyl.
- 7. Compounds as claimed in claim 1 in which R.sub.7 represents methyl, 2,2,2-trifluoroethyl, hydroxyethyl or phenethyl.
- 8. Compounds as claimed in claim 1 in which R.sub.7 represents methyl.
- 9. The compound
- 4-[2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl]-1,4-dihydro-2,6-dimethy-1-methyl-3,5-pyridine-dicarboxylic acid diethylester.
- 10. Compounds as claimed in claim 1 in which the hydrogen atom and the group R.sub.6 in the moiety --CH.dbd.CR.sub.6 CO.sub.2 R.sub.5 are trans with respect to each other.
- 11. Compounds as claimed in claim 1 in which R.sub.1 and R.sub.4 independently represent methyl or ethyl groups, R.sub.2 and R.sub.3 independently represent a methyl or ethyl group, R.sub.5 represents a C.sub.2 -C.sub.9 alkyl group, R.sub.6 represents a hydrogen atom, and R.sub.7 represents methyl, 2,2,2-trifluoroethyl, hydroxyethyl, or phenethyl group.
- 12. Compounds as claimed in claim 11 in which R.sub.5 represents a tert butyl group.
- 13. Compounds as claimed in claim 11 in which R.sub.2 and R.sub.3 each represent an ethyl group.
- 14. Compounds as claimed in claim 11 in which R.sub.7 represents a methyl group.
- 15. Compounds as claimed in claim 11 in which the hydrogen atom and the group R.sub.6 in the moiety --CH.dbd.CR.sub.6 CO.sub.2 R.sub.5 are trans with respect to each other.
- 16. Compounds as claimed in claim 11 in which R.sub.1 and R.sub.4 each represent a methyl group, R.sub.2 and R.sub.3 each represent an ethyl group, R.sub.5 represents a tert butyl group, and R.sub.7 represents methyl or 2,2,2-trifluoroethyl group, and in which the hydrogen atom and the group R.sub.6 in the moiety --CH.dbd.CR.sub.6 CO.sub.2 R.sub.5 are trans with respect to each other.
- 17. Compound of the general formula (I) ##STR10## in which R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent C.sub.1-6 straight or branched chain alkyl or alkoxyalkyl group;
- R.sub.5 represents a C.sub.1-13 straight or branched chain alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl group;
- R.sub.6 represents a hydrogen; and
- R.sub.7 represents a C.sub.1-4 alkyl group optionally substituted by hydroxy or C.sub.1-3 alkoxy or trifluoromethyl or R.sub.7 represents a phenyl C.sub.1-2 alkyl group in which the phenyl portion is optionally substituted by 1 to 3 C.sub.1-3 alkyl or C.sub.1-3 alkoxy groups or halogen atoms.
- 18. Pharmaceutical compositions comprising a compound as claimed in claim 1 in association with a pharmaceutically acceptable carrier or diluent.
- 19. Compositions as claimed in claim 18 in a form suitable for oral, sub lingual, transdermal, parenteral or rectal administration, or for administration by inhalation or insufflation.
Priority Claims (1)
Number |
Date |
Country |
Kind |
19486 A/86 |
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ITX |
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Parent Case Info
This is a divisional of co-pending application Ser. No. 07/016,590 filed 02/19/87 now U.S. Pat. No. 4,806,533.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4492703 |
Goldmann et al. |
Jan 1985 |
|
4801599 |
Semeraro et al. |
Jan 1989 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
16590 |
Feb 1987 |
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