Claims
- 1. A compound having the formula ##STR12## wherein: R is hydrogen or lower-alkyl;
- R' is selected from the group consisting of hydrogen, fluoro and --SR'", where R'" is phenyl, benzyl or lower-alkyl;
- R" is selected from the group consisting of hydrogen, fluoro and --SR'", with the proviso that when R" is hydrogen, R' is also hydrogen, where in the definitions of R and R'", lower-alkyl, each occurrence, has from 1 to 6 carbon atoms;
- Z is 2,6-dimethyl-4-pyridinyl;
- a pharmaceutically acceptable acid-addition salt thereof; or an alkali metal or a pharmaceutically acceptable amine salt of a compound where R is hydrogen.
- 2. A compound according to claim 1 wherein R is hydrogen and R' and R" are hydrogen or fluoro.
- 3. 1-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, according to claim 2.
- 4. 1-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, according to claim 2.
- 5. 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid, according to claim 2.
- 6. 1-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6,8-difluoro-1,4-dihydro-5-(phenylthio)-3-quinolinecarboxylic acid, according to claim 1.
- 7. 1-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-1,4-dihydro-8-(benzylthio)-3-quinolinecarboxylic acid, according to claim 1.
- 8. A composition for combating bacteria, which comprises an antibacterially effective amount of a compound according to claim 1 where R is hydrogen together with one or more pharmaceutically acceptable excipients or diluents.
- 9. A method for combating bacteria, which comprises contacting the locus of said bacteria with a composition according to claim 8.
- 10. A method for combating a bacterial infection in a mammalian host which comprises administering to said host an antibacterially effective amount of a composition according to claim 8.
- 11. A composition for combating bacteria, which comprises an antibacterially effective amount of the compound according to claim 4 together with one or more pharmaceutically acceptable excipients or diluents.
- 12. A method for combating bacteria, which comprises contacting the locus of said bacteria with a composition according to claim 11.
- 13. A method for combating a bacterial infection in a mammalian host which comprises administering to said host an antibacterially effective amount of a composition according to claim 11.
Parent Case Info
This application is a continuation-in-part of copending application Ser. No. 219,124, filed July 15, 1988, now abandoned, which is in turn a continuation-in-part of application Ser. No. 094,359, filed Sept. 8, 1987, now abandoned.
US Referenced Citations (8)
Foreign Referenced Citations (3)
Number |
Date |
Country |
179239 |
Apr 1986 |
EPX |
309789 |
Apr 1989 |
EPX |
166678 |
Aug 1985 |
JPX |
Non-Patent Literature Citations (1)
Entry |
Wise et al, Antimicrobial Agents and Chemotherapy, 23, pp. 559-564 (1983). |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
219124 |
Jul 1988 |
|
Parent |
94359 |
Sep 1987 |
|