Claims
- 1. Compound of the formula: ##STR22## where X is S, S or SO.sub.2 ;
- m and n are either 0 or 1 and the sum of m and n is at least 1;
- the R's are the same or different and are H or CH.sub.3, and one of them can be C.sub.2 -C.sub.9 alkyl, phenyl, C.sub.7 -C.sub.10 phenylalkyl, furyl, thienyl, pyridyl, phenyl or C.sub.7 -C.sub.10 phenylalkyl substituted on adjacent ring carbon atoms with methylenedioxy, or phenyl or C.sub.7 -C.sub.10 phenylalkyl substituted on the ring with 1, 2 or 3 substituents individually selected from methoxy, ethoxy, bromine, chlorine, fluorine, trifluoromethyl and C.sub.1 -C.sub.4 alkyl; when X is S and m is 0 , one R on the group --RCR-- can be --OCH.sub.3 ; and when X is S and m is 1, the R on the group (CHR).sub.m can be --OCH.sub.3 ;
- R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.4 alkoxycarbonyl, trifluoroacetyl or substituted C.sub.1 -C.sub.4 alkyl where the substituent is C.sub.3 -C.sub.6 cycloalkyl, phenyl, phenyl substituted on adjacent carbon atoms with methylenedioxy, or phenyl substituted with 1, 2 or 3 substituents individually selected from methoxy, ethoxy, bromine, chlorine, fluorine, trifluoromethyl and C.sub.1 -C.sub.4 alkyl; and
- Z is H, Cl or CH.sub.3 ;
- and their pharmaceutically suitable salts.
- 2. Compound of claim 1: 2,3,8,9,10,11-hexahydro-1H-pyrido[3',4':4,5] pyrrolo[1,2,3-ef][1,5]benzothiazepine and its pharmaceutically suitable salts.
- 3. Compound of claim 1: 2,3,8,9,10,11-hexahdro-3-methyl-1H-pyrido[3',4':4,5] pyrrolo[1,2,3-ef][1,5]benzothiazepine and its pharmaceutically suitable salts.
- 4. Compound of claim 1: 9-cyclopropyl-2,3,8,9,10,11-hexahydro-1H-pyrido[3',4':4,5] pyrrolo[1,2,3-ef][1,5]benzothiazepine and its pharmaceutically suitable salts.
- 5. Compound of claim 1: 1,2,8,9,10,11-hexahydro-4H-pyrido[3', 4':4,5] pyrrolo[3,2,1-jk][4,1]benzothiazepine and its pharmaceutically suitable salts.
- 6. Compound of claim 1: 1,2,8,9,10,11-hexahydro-4H-pyrido[3',4':4,5] pyrrolo[3,2,1-jk][4,1]benzothiazepine and its pharmaceutically suitable salts.
- 7. Compound of claim 1: 2,3,8,9,10,11-hexahydro-3-pentyl-1H-pyrido[3',4':4,5] pyrrolo[1,2,3-ef][1,5]-benzothiazepine and its pharmaceutically suitable salts.
- 8. A method for inducing sedation in a warm-blooded animal which comprises administering to the animal an effective sedative amount of a compound of claim 1.
- 9. A pharmaceutical preparation suitable for use in warm-blooded animals consisting essentially of a pharmaceutically suitable vehicle and an effective sedative amount of the compound of claim 1.
CROSS REFERENCE TO RELATED APPLICATION
This is a division, of application Ser. No. 586,746, filed July 13, 1975, now U.S. Pat. No. 4,013,652 which in turn is a division of application Ser. No. 357,528, filed May 7, 1973, now U.S. Pat. No. 3,914,421, which is a continuation-in-part of Application Ser. No. 263,766, filed June 9, 1972, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3401166 |
Krapcho |
Sep 1968 |
|
3914421 |
Rajagopalan |
Oct 1975 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
586746 |
Jul 1975 |
|
Parent |
357528 |
May 1973 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
263766 |
Jun 1972 |
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