Claims
- 1. A peptide mimetic compound having the following chemical structure: ##STR7## wherein x=4 to 8,
- y=0 to 4,
- W=CH.sub.2 --CH.sub.2 or CH.dbd.CH,
- Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,
- R=C.sub.1-6 alkyl,
- Ar=a pyridyl group, and
- Asp=aspartic acid residue.
- 2. A peptide mimetic compound of claim 1 in which the pyridyl group is 2-(4-pyridyl)ethyl amide.
- 3. A peptide mimetic compound of claim 1 in which the pyridyl group is 3-(3-pyridyl)alanine,
- 4. 8-Guanidinooctanoyl-Asp-2-(4-pyridyl)ethyl amide.
- 5. 8-Guanidinooctanoyl-Asp-3-(3-pyridyl)alanine.
- 6. The method of inhibiting platelet aggregation in a warm blooded mammal comprising administering to said mammal an effective amount of a peptide mimetic compound of claim 1 in a pharmaceutically acceptable carrier.
- 7. The method of inhibiting formation of a thrombus in a warm blooded mammal comprising administering to said mammal an effective amount of a peptide mimetic compound of claim 1 in a pharmaceutically acceptable carrier.
- 8. A pharmaceutical composition which comprises a peptide mimetic compound of claim 1 in an amount effective for inhibiting platelet aggregation with a pharmaceutically acceptable carrier.
CROSS REFERENCE TO RELATED APPLICATIONS
This is a division of application Ser. No. 07/513,532, filed Apr. 23, 1990 now U.S. Pat. No. 5,037,808 which is a continuation-in-part of application Ser. No. 07/395,614, filed Aug. 8, 1989, which in turn is a division of application Ser. No. 07/221,703, filed July 20, 1988, now U.S. Pat. No. 4,879,313.
US Referenced Citations (7)
Number |
Name |
Date |
Kind |
4517686 |
Ruoslahti et al. |
May 1985 |
|
4578079 |
Ruoslahti et al. |
Mar 1986 |
|
4589881 |
Pierschbacher et al. |
May 1986 |
|
4614517 |
Ruoslahti et al. |
Sep 1986 |
|
4661111 |
Ruoslahti et al. |
Apr 1987 |
|
4683291 |
Zimmerman et al. |
Jul 1987 |
|
4879237 |
Rouslahti et al. |
Nov 1989 |
|
Non-Patent Literature Citations (5)
Entry |
Kloczewiak et al., Biochem. 23, 1767-1774 (1984). |
Plow et al, Proc. Natl. Acad. Sci. 82, 8057-8061 (1984). |
Ruggeri et al, Ibid. 83, 5708-5712 (1986). |
Ginsberg et al, J. Biol. Chem. 260(7), 3931-3936 (1985). |
Haverstick et al., Blood 66(4) 946-952 (1985). |
Divisions (2)
|
Number |
Date |
Country |
Parent |
513532 |
Apr 1990 |
|
Parent |
221703 |
Jul 1988 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
395614 |
Aug 1989 |
|