Claims
- 1. A metal salt complex having the structure ##SPC4##
- wherein
- R is
- a. hydrogen
- b. alkyl of 1 to 5 carbon atoms
- c. allyl
- d. CN
- e. CCl.sub.3 and
- f. 5-tetrazolyl
- M is a metal cation,
- X is an anion forming a compound with the cation M in which the compound has sufficient solubility to form a metal salt complex, and
- a is an integer corresponding to the valence of cation M and n is an integer which for the anion X satisfied the valence of the cation M.
- 2. A metal salt complex according to claim 1 where R is alkyl of 1 to 5 carbon atoms.
- 3. A metal salt complex according to claim 2 where R is methyl.
- 4. A metal salt complex according to claim 1 wherein (MX.sub.n) is zinc chloride.
- 5. A metal salt complex according to claim 4 wherein R is alkyl of 1 to 5 carbon atoms.
- 6. A metal salt complex according to claim 5 where R is Methyl.
- 7. A rodenticidal composition comprising a rodenticidally effective amount of a metal salt complex according to claim 1 and an edible carrier.
- 8. A method of exterminating pest rodents which comprises placing a rodenticidally-effective amount of a metal salt complex of claim 1 in the vicinity of a population of pest rodents in a place where the composition may be easily reached and ingested by the rodents.
Parent Case Info
This is a division of application Ser. No. 429,464 filed Dec. 28, 1973, now U.S. Pat. No. 3,929,808.
The present invention relates to 3-pyridylmethyl N-(4'-mercaptophenyl)carbamate and its mercapto derivatives and more particularly to their use and of compositions containing them for the control and extermination of pest rodents. This includes their salts and complexes.
The common rat, Rattus norvegicus, is vicious and constantly poses a serious threat to the health and well being of man. Rats and mice are destructive animals and a serious nuisance, causing millions of dollars damage annually to farms, agronomic crops, homes, food processing plants and many other businesses. Rats bite at least 14,000 (possibly up to 60,000) people every year, according to the U.S. Public Health Service, and are known carriers of over 35 contagious diseases including bubonic plague, trichinosis, typhus, rat bite fever, amoebic dysentery, tuberculosis, infectious jaundice and rabies. During the years from 1898 to 1923, almost 11 million deaths were caused by rat-borne plagues.
Use of rodenticides, fumigants, sprays and traps are the primary methods employed for the control of pest rodents. The term "pest rodents" refers not only to members of the order Rodentia but also to those of lagomorpha, which cause health hazards or economic loss unless kept in check. Rodenticides may be used in the form of a tracking powder or a bait or may be applied as a spray on the rodent's natural foodstuffs. The rodenticides used as a bait are of two classes: single- and multi-dose. Multi-dose rodenticides are usually selected over a single-dose rodenticides, as they have been safer in the past than the available single-dose rodenticides. The multi-dose rodenticides are anti-coagulants, including a number of different 4-hydroxy-coumarin and 1,3-indandione compounds. These multi-dose rodenticides consumed in small daily amounts have a lethal effect on rats and mice after liver stores of vitamin K have been depleted. Anti-coagulants are less effective on mice than rats, as mice are considered to be nibblers and may not consume an adequate amount of treated bait to have a lethal effect. A single-dose rodenticide which would be relatively safe to the person handling the material and to non-target species of animals and yet effective on a variety of pest rodents is highly desirable.
Many compounds are toxic to rodents. However, very few of these compounds are anywhere near suitable for use as a rodenticide because it is necessary for the pest rodent to consume voluntarily a sufficient amount of the poison even though sufficient untreated food may also be available. In bait rodenticides, feed acceptance is the key to excellence, and in all rodenticides safety and efficacy are highly important.
The 3-pyridylmethyl N-(4'-mercaptophenyl)carbamate and its derivatives of the present invention are so highly toxic to a wide variety of pest rodents that a single dose is sufficient; yet they are relatively safe for use in the presence of other species which may inadvertently ingest limited quantities of the rodenticide. Furthermore, rats and other pest rodents willingly consume the compounds in sufficiently lethal amounts when present in baits. Alternatively the compounds may be employed in compositions to be sprayed on natural foodstuffs. They may also be employed in a tracking powder, especially for use against mice, which habitually clean their paws by licking.
The basic compounds of the present invention have the formula: ##SPC1##
The compounds may be prepared by permitting equimolar amounts of 4-RS phenyl isocyanate and 3-pyridylcarbinol to react in the presence of an inert solvent, e.g., pyridine, an aromatic hydrocarbon or acetonitrile, in accordance with the following equation: ##SPC2##
The following typical examples describe variations in the preparation of 3-pyridylmethyl N-(4'-mercaptophenyl)carbamate and its various derivatives.
US Referenced Citations (3)
| Number |
Name |
Date |
Kind |
|
3284461 |
Wibert et al. |
Nov 1966 |
|
|
3428642 |
Debay et al. |
Feb 1969 |
|
|
3676457 |
Hubele et al. |
Jul 1972 |
|
Non-Patent Literature Citations (1)
| Entry |
| Novokov et al., Chem. Abstracts, vol. 70, (17) 77,728 W (Apr., 1969). |
Divisions (1)
|
Number |
Date |
Country |
| Parent |
429464 |
Dec 1973 |
|
Patent Grant
3966947
