Claims
- 1. A compound of the formula ##STR6## wherein the R.sup.1 groups are, independently, hydrogen, hydroxyl, lower alkyl, hydroxyloweralkyl, loweralkoxy loweralkyl, loweralkoxy, halogen, formyl, phenyl, phenylloweralkyl, halophenyl or CH(OR.sup.4).sub.2, where R.sup.4 is alkyl of 1 to 4 carbon atoms or two R.sup.4 radicals are joined to form a lower alkylene chain; m is 1 or 2; A is a saturated alkylene radical having from 1 to 4 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms; S is sulfur; or an acid addition salt thereof, with the proviso that at least one of R.sup.1 is other than hydrogen.
- 2. A compound as claimed in claim 1 when A is CH.sub.2.
- 3. An anti-ulcer composition comprising an effective amount of a compound as claimed in claim 1, and a pharmaceutically acceptable carrier.
- 4. An anti-ulcer composition as claimed in claim 3, in unit dosage form.
- 5. A method of treating ulcers or hypersecretion in a mammal which comprises administering to said mammal in need of said treatment an effective antiulcer amount of a compound of the formula ##STR7## wherein the R.sup.1 groups are, independently, hydrogen, hydroxyl, lower alkyl, hydroxyloweralkyl, loweralkoxy loweralkyl, loweralkoxy, halogen, formyl, phenyl, phenylloweralkyl, halophenyl or CH(OR.sup.4).sub.2, where R.sup.4 is alkyl of 1 to 4 carbon atoms or two R.sup.4 radicals are joined to form a lower alkylene chain; m is 1 or 2; A is a saturated alkylene radical having from 1 to 4 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms; S is sulfur; or an acid addition salt thereof, with the proviso that A is linked to the 2 or 3 position of the pyridine ring.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7848813 |
Dec 1978 |
GBX |
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Parent Case Info
This application is a divisional of U.S. Ser. No. 350,442, filed Feb. 19, 1982, and now U.S. Pat. No. 4,440,773, issued Apr. 3, 1984, which is a continuation-in-part of U.S. Ser. No. 217,925, filed Dec. 18, 1980, and now U.S. Pat. No. 4,343,805, issued Aug. 10, 1982, which is a continuation of U.S. Ser. No. 98,421, filed Nov. 29, 1979, and now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
2761866 |
Goldberg et al. |
Sep 1956 |
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4038435 |
Winter et al. |
Jul 1977 |
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Non-Patent Literature Citations (1)
Entry |
Grassetti et al., J. Med. Chem. 8(6), 753-756, 1965. |
Divisions (1)
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Number |
Date |
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Parent |
350442 |
Feb 1982 |
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Continuations (1)
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Number |
Date |
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Parent |
98421 |
Nov 1979 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
217925 |
Dec 1980 |
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