Claims
- 1. A compound of formula (I) or a salt thereof: ##STR5## wherein: P represents pyridyl; R.sup.1 is hydrogen, C.sub.1-6 alkyl, halogen, CF.sub.3, NR.sup.7 R.sup.8 or OR.sup.9 where R.sup.7, R.sup.8 and R.sup.9 are independently hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl;
- R.sup.2 is hydrogen or C.sub.1-6 alkyl;
- R.sup.3 is C.sub.1-6 alkyl;
- n is 0 to 3;
- m is 0 or 1; and
- R.sup.4 groups are independently C.sub.1-6 alkyl optionally substituted by one or more halogen atoms, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, C.sub.1-6 alkylthio, C.sub.3-6 cycloalkylthio, C.sub.3-6 cycloalkyl-C.sub.1-6 alkylthio, halogen, nitro, CF.sub.3, OCF.sub.3, SCF.sub.3, SO.sub.2 CF.sub.3, SO.sub.2 F, formyl, C.sub.2-6 alkanoyl, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, or OR.sup.9 where R.sup.7, R.sup.8 and R.sup.9 are as defined for R.sup.1, CO.sub.2 R.sup.10 where R.sup.10 is hydrogen or C.sub.1-6 alkyl or R.sup.4 is phenyl or thienyl optionally substituted by C.sub.1-6 alkyl, halogen, CF.sub.3, NR.sup.7 R.sup.8 or OR.sup.9.
- 2. A compound according to claim 1 in which R.sup.1 is hydrogen.
- 3. A compound according to claim 1 in which R.sup.2 is hydrogen and m is 0.
- 4. A compound according to claim 1 in which R.sup.4 is C.sub.1-6 alkyl or C.sub.1-6 alkylthio and n is 2.
- 5. A compound according to claim 1 which is:
- 5-Ethylthio-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-methyl-1-(3-pyridycarbamoyl)indoline,
- 6-Chloro-5-methyl-1-(3-pyridylcarbamoyl)indoline and 4-chloro-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 5-(N,N-Dimethylamino)-1-(3-pyridylcarbamoyl)indoline,
- 5-Iodo-1-(3-pyridylcarbamoyl)indoline,
- 5-Nitro-1-(3-pyridylcarbamoyl)indoline,
- 5-Methylthio-1-(3-pyridylcarbamoyl)indoline,
- 5-(2-Isoropyl)-1-(3-pyridylcarbamoyl)indoline,
- 4,6-Dichloro-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Fluoro-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Iodo-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 4-Iodo-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Bromo-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 4-Bromo-5-methyl-1-(3-pyridylcarbamoyl)indoline,
- 5-Phenyl-1-(3-pyridylcarbamoyl)indoline,
- 4,5-Dichloro-1-(3-pyridylcarbamoyl)indoline,
- 6,7-Dichloro-1-(3-pyridylcarbamoyl)indoline,
- 5-Chloro-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-1-(3-pyridylcarbamoyl)indoline,
- 5,6-Dichloro-1-(3-pyridylcarbamoyl)indoline,
- 5-(3-Thienyl)-1-(3-pyridylcarbamoyl)indoline,
- 5-Trifluoromethyl-1-(3-pyridylcarbamoyl)indoline,
- 5-Chloro-6-methyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-methyl-1-(4-pyridyl-carbamoyl)indoline,
- 6-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indoline,
- 4-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indoline,
- 5-Bromo-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-ethyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-propyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-tert-butyl-1-(3-pyridylcarbamoyl)indoline,
- 4-Chloro-5-tert-butyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-isopropyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-vinyl-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-ethylthio-1-(3-pyridylcarbamoyl)indoline,
- 6-Chloro-5-isopropylthio-1-(3-pyridylcarbamoyl)indoline,
- Methyl-6-chloro-1-(3-pyridylcarbamoyl)-indoline-5-carboxylate,
- 6-Chloro-5-iodo-1-(3-pyridylcarbamoyl)-indoline,
- 6-Chloro-5-methyl-1-(5-bromo-3-pyridylcarbamoyl)-indoline,
- 6-Bromo-5-propylthio-1-(3-pyridylcarbamoyl)indoline,
- 6-Bromo-5-ethylthio-1-(3-pyridylcarbamoyl)indoline,
- 6-Bromo-5-methylthio-1-(3-pyridylcarbamoyl)indoline,
- and pharmaceutically acceptable salts thereof.
- 6. A pharmaceutical composition which comprises a compound according to claim 1 and a pharmaceutically acceptable carrier or excipient.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9313913 |
Jul 1993 |
GBX |
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Parent Case Info
This is a continuation of application Ser. No. 08/454,811, filed as PCT/EP94/02148, Jun. 30, 1994, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4428881 |
Hedrich et al. |
Jan 1984 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 9205170 |
Apr 1992 |
WOX |
WO 9404533 |
Mar 1994 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Atwal et al., CA 121:230675, 1994. |
Continuations (1)
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Number |
Date |
Country |
Parent |
454811 |
May 1995 |
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