Claims
- 1. A compound selected from those of formula (I) ##STR6## in which: R represents monocycloakyl bicycloalkyl, or polycycloalkyl having 3 to 15 carbon atoms, optionally having in its skeleton one or more heteroatoms chosen from nitrogen, oxygen and sulfur,
- X represents oxygen or sulfur,
- R.sub.1 represents straight- or branched-chain alkyl having 1 to 6 carbon atoms or monocycloakyl, bicycloalkyl, or polycycloalkyl having 3 to 15 carbon atoms, optionally containing on its skeleton one or more heteroatoms chosen from nitrogen, oxygen and sulfur,
- with the proviso that, when X is an oxygen atom and at the same time R is monocyclic or bicyclic alkyl or heteromonocycloalkyl, R.sub.1 cannot represent linear or branched alkyl or heteromonocycloalkyl, as well as its addition salts with a pharmaceutically-acceptable inorganic or organic acid, and, when R or R.sub.1 represents a radical comprising one or more centers of asymmetry, its isomers, enantiomers and diastereoisomers.
- 2. A compound as claimed in claim 1, wherein R and R.sub.1 represent cycloalkyl, bicycloalkyl, or polycycloalkyl having 3 to 15 carbon atoms, optionally interrupted by one or more nitrogen atoms, or an enantiomer or a diastereoisomer thereof.
- 3. Compound of claim 1 being N-(4-(cyclohexylamino)pyrid-3-yl)sulfonyl)-N'-cyclohexylurea or a salt thereof.
- 4. Compound of claim 1 being N-((4-(cycloheptylamino)pyrid-3-yl)sulfonyl)-N'-cyclohexylurea or a salt thereof.
- 5. Compound of claim 1 being N-((4-(cyclooctylamino)pyrid-3-yl)sulfonyl)-N'-cyclooctylurea or a salt thereof.
- 6. Compound of claim 1 being N-((4-(cycloheptylamino)pyrid-3-yl)sulfonyl)-N'-cyclohexylthiourea or a salt thereof.
- 7. Compound of claim 1 being N-((4-bicyclo[2.2.1]hept-l-ylamino)pyrid-3-yl)sulfonyl)-N'-isopropylthiourea or a salt thereof.
- 8. Compound of claim 1 being N-((4-(cyclooctylamino)pyrid-3-yl)sulfonyl)-N'-ethylthiourea or a salt thereof.
- 9. Compound of claim 1 being N-((4-(cyclododecylamino)pyrid-3-yl)sulfonyl)-N'-ethylurea or a salt thereof.
- 10. Compound of claim 1 being N-((4-(2-(aza-2-bicyclo[3.3.0]octyl)amino)pyrid-3-yl)sulfonyl)-N'-isopropylurea, a salt or a diastereoisomer thereof.
- 11. Compound of claim 1 being N-((4-(cycloheptylamino)pyrid-3-yl)sulfonyl)-N'-cycloheptylurea or a salt thereof.
- 12. A pharmaceutical composition containing as active principle a compound as claimed in claim 1 in combination with a pharmaceutically-acceptable carrier or diluent.
- 13. A pharmaceutical composition containing as active principle a compound as claimed in claim 11 in combination with a pharmaceutically-acceptable carrier or diluent.
- 14. A method for treating a living animal body afflicted with a circulatory ailment related to arterial hypertension or oedema comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for the alleviation of the said ailment.
- 15. A method for treating a living animal body afflicted with a circulatory ailment related to arterial hypertension or peripheral or cerebral oedema comprising the step of administering to the said living animal an amount of a compound of claim 11 which is effective for alleviation of the said ailment.
- 16. Method of claim 14 wherein the ailment is cerebral oedema.
- 17. Method of claim 15 wherein the ailment is cerebral oedema.
- 18. Compound of claim 1 which is N-((4-(cyclooctylamino)pyrid-3-yl)sulfonyl)-N'-cycloheptylurea or a salt thereof.
- 19. Compound of claim 1 which is N-((4-(cyclooctylamino)pyrid-3-yl)sulfonyl)-N'-cyclohexylurea or a salt thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
90 02659 |
Mar 1990 |
FRX |
|
92 00031 |
Jan 1992 |
FRX |
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Parent Case Info
The present application is a continuation-in-part of our prior-filed copending application Ser. No. 07/663,385, filed Mar. 1, 1991, now abandoned.
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Entry |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
663385 |
Mar 1991 |
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