Claims
- 1. A compound selected from the group consisting of ##STR34## and the pharmaceutically-acceptable cationic salts thereof wherein R is selected from the group consisting of methyl, ethyl, acetyl and COR.degree. wherein
- R.sup.o is selected from the group consisting of hydroxy, alkoxy having 1 to 4 carbon atoms, hydroxyalkoxy having 2 to 4 carbon atoms, amino and hydroxyamino;
- each of R.sub.2, R.sub.3 and R.sub.4 is selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halo, benzyloxy, hydroxy, thiol, alkanoyloxy having 1 to 4 carbon atoms, benzylthio, benzoyloxy, benzylsulfinyl, methylthio and methylsulfinyl and
- R.sub.2 and R.sub.3 , and R.sub.3 and R.sub.4 when taken together are selected from the group consisting of methylenedioxy and ethylenedioxy.
- 2. A compound according to claim 1 wherein each of R.sub.2, R.sub.3 and R.sub.4 is hydrogen; and R is COR.sup.O wherein R.sup.O is said alkoxy.
- 3. A compound according to claim 1 wherein R.sub.2 is hydrogen; each of R.sub.3, and R.sub.4 is said alkoxy; and R is COR.sup.O wherein R.sup.O is said alkoxy.
- 4. A compound according to claim 1 wherein R.sub.2 is hydrogen; each of R.sub.3 and R.sub.4 is said alkyl; and R is COR.sup.O wherein R.sup.O is said alkoxy.
- 5. A compound according to claim 2 wherein R.sup.O is ethoxy.
- 6. A compound according to claim 3 wherein R.sup. is ethoxy; and each of R.sub.3 and R.sub.4 is methoxy.
- 7. A compound according to claim 4 wherein R.sup.O is ethoxy; and each of R.sub.3 and R.sub.4 is methyl.
- 8. The method of controlling allergic symptoms in a mammalian subject which comprises adminstering to the subject an allergy symptom controlling amount of a compound selected from the group consisting of ##STR35## and the pharmaceutically-acceptable cationic salts thereof wherein R is selected from the group consisting of methyl, ethyl, acetyl, and -COR.sup.O wherein R.sup.O is selected from the group consisting of hydroxy, alkoxy having 1 to 4 carbon atoms. hydroxyalkoxy having 2 to 4 carbon atoms, amino and hydroxyamino;
- each of R.sub.2, R.sub.3 and R.sub.4 is selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halo, benzyloxy, hydroxy, thiol, alkanoyloxy having 1 to 4 carbon atoms, benzylthio, benzylsulfinyl, benzoyloxy, methylthio, and methylsulfinyl and
- R.sub.2 and R.sub.3, and R.sub.3 and R.sub.4 when taken together are selected from the group consisting of methylenedioxy and ethylenedioxy.
- 9. The method of claim 8 wherein each of R.sub.2, R.sub.3 and R.sub.4 is hydrogen and R is COR.sup.O wherein R.sup.O is said alkoxy.
- 10. The method of claim 8 wherein R.sub.2 is hydrogen, each of R.sub.3 and R.sub.4 is said alkyl; and R is COR.sup.O wherein R.sup.O is said alkoxy.
- 11. The method of claim 10 wherein each of R.sub.3 and R.sub.4 is methyl; and R.sup.O is ethoxy.
- 12. A pharmaceutical composition active as an antiallergy agent comprising a compound selected from the group consisting of ##STR36## and the pharmaceutically-acceptable cationic salts thereof wherein R is selected from the group consisting of methyl, ethyl, acetyl and COR.sup.O wherein R.sup.O is selected from the group consisting of hydroxy, alkoxy having 1 to 4 carbon atoms, hydroxyalkoxy having 2 to 4 carbon atoms and hydroxyamino;
- each of R.sub.2, R.sub.3 and R.sub.4 is selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halo, benzyloxy, hydroxy, thiol, alkanoyloxy having 1 to 4 carbon atoms, bezylthio, benzoyloxy, benzylsulfinyl, methythio, and methylsulfinyl;
- R.sub.2 and R.sub.3, and R.sub.3 and R.sub.4 when taken together are selected from the group consisting of methylenedioxy and ethylenedioxy;
- and a pharmaceutical carrier, said antiallergy agent being present in an amount of from about 0.5% to about 95% by weight of the carrier.
- 13. A pharmaceutical composition as claimed in claim 12 in a form suitable for administration by inhalation.
- 14. A pharmaceutical composition as claimed in claim 12 comprising a solution or suspension of the antiallergy agent in water.
- 15. A pharmaceutical composition as claimed in claim 12 comprising a suspension of the antiallergy agent in a liquefied propellant.
- 16. A pharmaceutical composition as claimed in claim 12 comprising the solid antiallergy agent and a solid diluent.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 786,185 filed Apr. 11, 1977 which in turn is a division of application Ser. No. 667,515 filed Mar. 16, 1976 and now U.S. Pat. No. 4,044,134 which, in turn, is a division of application Ser. No. 485,945 filed July 5, 1974 and now U.S. Pat. No. 3,974,161 which, in turn, is a continuation-in-part of application Ser. No. 444,138 filed Feb. 20, 1974 and now abandoned which, in turn, is a continuation-in-part of application Ser. No. 351,025 filed Apr. 13, l973 and now abandoned.
US Referenced Citations (4)
Divisions (3)
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Number |
Date |
Country |
Parent |
786185 |
Apr 1977 |
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Parent |
667515 |
Mar 1976 |
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Parent |
485945 |
Jul 1974 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
444138 |
Feb 1974 |
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Parent |
351025 |
Apr 1973 |
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