Claims
- 1. A compound of formula I whereinR1 is hydrogen, C1-C13 alkyl, C1-C13 alkyl substituted by one or more substituents selected from hydroxy, halogen or aryl, C2-C13 alkenyl, C2-C13 alkenyl substituted by one or more substituents selected from hydroxy, halogen or aryl, C2-C13 alkynyl, C2-C13 alkynyl substituted by one or more substituents selected from hydroxy, halogen or aryl, C1-C11 alkoxy, C1-C11 alkoxy substituted by one or more substituents selected from hydroxy, halogen or aryl; aryloxy or alkoxyalkyl, and R2 is aryloxy, or a pharmaceutically acceptable salt of an acidic compound of formula I wherein aryl, alone or in combination, means phenyl which is unsubstituted or substituted by one or more substitutents selected from C1-C13 alkyl, hydroxy, C1-C11 alkoxy or halogen.
- 2. A compound of claim 1, wherein R2 is in the para position.
- 3. A compound of claim 2, wherein R2 is phenoxy.
- 4. A compound of claim 3, wherein R1 is hydrogen, C1-C13 alkyl, C1-C13 alkyl substituted by one or more substituents selected from hydroxy, halogen or aryl, or C1-C11 alkoxy.
- 5. A compound of claim 3, wherein R1 is C1-C11 alkoxy substituted by one or more substituents selected from hydroxy, halogen or aryl; or alkylalkoxy.
- 6. A compound of claim 5, wherein R1 is benzyloxy.
- 7. The compound of claim 4, 5-methyl-5-(4-phenoxyphenyl) pyrimidine-2,4,6-trione.
- 8. A compound of claim 4, wherein R1 is C1-C13 alkyl.
- 9. The compound of claim 8, 5-hexyl-5-(4-phenoxyphenyl) pyrimidine-2,4,6-trione.
- 10. The compound of claim 6, 5-benzyloxymethyl-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione.
- 11. The compound of claim 4, wherein R1 is C1-C13 alkyl substituted by one or more substituents selected from hydroxy, halogen or aryl.
- 12. The compound of claim 8, 5-(2-hydroxyethyl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione.
PYRIMIDINE-2,4,6-TRIONES
This application claims priority under 35 U.S.C. § 119(e) of provisional application Ser. No. 60/119,903, filed Feb. 12, 1999.
Foreign Referenced Citations (4)
Number |
Date |
Country |
WO 9723465 |
Jul 1997 |
WO |
WO 9858915 |
Dec 1998 |
WO |
WO 9858925 |
Dec 1998 |
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WO9858925 |
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Non-Patent Literature Citations (1)
Entry |
Welch, A.R., et al., Arch. Biochem. Biophys. 1995, vol. 324, No. 1, Dec. 1, pp. 59-64. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/119903 |
Feb 1999 |
US |