Chemical Abstracts, vol. 101, No. 25, Dec. 17, 1994, Abstract No. 230466q, p. 765, col. R. and Heterocycles, vol. 22, No. 8, 1984, pp. 1789-1790, Ram Siya et al. |
J.F. Bunnett et al., "The Relative Reactivities of Methanol and Methoxide Ion in Addition to 4-Chlorobenzyne," The Journal of Organic Chemical Chemistry, vol. 34, No. 7, Jul. 1969, pp.2035-2163. |
Chae et al. (I), "Substituted 0.sup.6 --Benzyl Guanine Derivatives and Their Inactivation of Human 0.sup.6 --Alkylguanine-DNA Alkyl Transferase," J. Medicinal Chem., 37(3), 342-347 (1994). |
Martinez et al., "Potential Antitumor Agents. Some Sulfur-Substituted Derivatives of .alpha.- and .beta.-2'-Deoxythioguanosine," J. Medicinal Chem., 20(3), 341-344 (1977). |
Paul et al., "Inhibitors of Nucleoside Transport. A Structure-Activity Study Using Human Erythrocytes," J. Medicinal Chem.., 18(10), 968-973 (1975). |
Moschel et al. (V), "Structural Features of Substituted Purine Derivatives Compatible with Depletion of Human 0.sup.6 -Alkylguanine-DNA Alkyltransferase," J. Medicinal Chem., 35(23), 4486-4491 (1992). |
MacCoss et al., "Synthesis of the Chiral Acylonucleoside Antiherpetic Agent (S)-9- (2,3-Dihydroxy-1-Propoxymethyl)guanine," Tetrahedron Letters, 26(15), 1815-1818 (1985). |
Dolan et al.(I), "Depletion of Mammalian 0.sup.6 -Alklguanine-DNA Alkyltransferase Activity by 0.sup.6 -Benzylguanine Provides a Means to Evaluate the Role of This Protein in Protection Against Carcinogenic and Therapeutic Alkylating Agents," Proc. Nat. Acad. Sci. USA, 87, 5368-5372 (Jul. 1990). |
Dolan et al. (II), "Modulation of Mammalian 0.sup.6 -Alkylguanine-DNA Alkyltransferase in vivo by 0.sup.6 -Benzylguanine and its Effects on the Sensitivity of a Human Glimoa Tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea," Cancer Comm., 2(11), 371-377 (1990). |
Dolan et al. (III), "Metabolism of 0.sup.6 -Benzylguanine, an Inactivator of 0.sup.6 -Alkylguanine-DNA Alkyltranferase," Cancer Res., 54(19), 5123-5130 (Oct. 1, 1994). |
Chae et al. (II), 8-Substituted 0.sup.6 -Benzylguanine, Substituted 6(4)- (Benzyloxy)pyrimidine, and Related Derivatives as Inactivators of Human 0.sup.6 -Alky;guanine-DNA Alkyltransferase, J. Medicinal Chemistry, 38(2), 359-365 (1995). |
Friedman et al., "Activity of Temozolomide in the Treatment of Central Nervous System Tumor Xenografts," Cancer Res., 55, 2853-2857 (Jul. 1, 1995). |
Dolan et al. (IV), "Effect of 0.sup.6 -Alkylguanine Pretreatment on the Sensitivity of Human Colon Tumor Cells to the Cytotoxic Effects of Chloroethylating Agents," Cancer Res., 46, 4500-4504 (Sep. 1986). |
Dolan et al. (V), "Depletion of 0.sup.6 -Alkylguanine-DNA Alkyltransferase Activity in Mammalian Tissues and Human Tumor Xenografts in Nude Mice by Treatment with 0.sup.6 -Methylguanine," Cancer Chemotherapy and Pharmacology, 25, 103-108 (1989). |
Pegg et al., (I) "Mechanism of Inactivation of Human 0.sup.6 -Alkylguanine-DNA Alkyltransferase by 0.sup.6 -Benzylguanine," Biochemistry, 32(45), 11998-12006 (1993). |
Arris et al., "Probing the Active Site and Mechanism of Action of 0.sup.6 -Alkylguanine-DNA Alkyltransferase with Substrate Analogues (0.sup.6 -Substituted Guanines)," Anti-Cancer Drug Design, 9, 401-408 (1994). |
Marathi et al., "Anti-Neoplastic Activity of Sequenced Administration of )6- Benzylguanine, Streptozocin, and 1, 3-Bis(2-chloroethyl)-1-nitrosourea In Vitro and In Vivo," Biochemical Pharmacology, 48(11), 2127-2134 (1994). |
Wibley et al., "A Homology Model of the Three-Dimensional Structure of Human 0.sup.6 -Alkylguanine-DNA Alkyltransferase Based on the Crystal Structure of the C-terminal Domain of the Ada Protein from Escherichia coli,," Anti-Cancer Drug Design, 10, 75-95 (1995). |
Pegg et al., (II), "Increased Killing of Prostate, Breast, Colon, and Lung Tumor Cells by the Combination of Inactivators of 0.sup.6 -Alkylguanine-DNA Alkyltransferase and N, N'-Bis(2-chloroethyl)-N-nitrosourea," Biochemical Pharmacology, 50(8), 1141-1148 (1995). |
Berg et al., "Plasma and Cerebrospinal Fluid Pharmacokinetics of 0.sup.6 -Benzylguanine and Time Course of Peripheral Blood Mononuclear Cell 0.sup.6 -Alkylguanine-DNA Alkyltransferase Inhibition in the Nonhuman Primate," Cancer Res., 55, 4606-4610 (Oct. 15, 1995). |