Claims
- 1. A 1,2-dithiole compound of the formula: ##STR4## wherein Het represents a heterocyclic radical selected from pyrimidin-2-yl, pyrimidin-4-yl and pyrimidin-5-yl, or a said heterocyclic radical substituted by a halogen atom or by an alkyl radical of 1 through 4 carbon atoms, an alkoxy radical of 1 through 4 carbon atoms, the mercapto radical, an alkylthio radical of 1 through 4 carbon atoms or a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical.
- 2. A 1,2-dithiole compound according to claim 1 wherein Het represents pyrimidin-2-yl, pyrimidin-4-yl or pyrimidin-5-yl, or a said heterocyclic radical substituted by a halogen atom, an alkyl radical of 1 through 4 carbon atoms, an alkoxy radical of 1 through 4 carbon atoms, an alkylthio radical of 1 through 4 carbon atoms or a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical.
- 3. A 1,2-dithiole compound according to claim 1 wherein the heterocyclic group Het is unsubstituted or is substituted by an alkyl radical of 1 through 4 carbon atoms or by a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical.
- 4. A 1,2-dithiole compound according to claim 1 wherein the heterocyclic group Het is unsubstituted or is substituted by methyl or dimethylamino.
- 5. The 1,2-dithiole compound according to claim 1 which is 5-(pyrimidin-4-yl)-1,2-dithiole-3-thione.
- 6. A pharmaceutical composition with anti-bilharzia activity which comprises an effective amount of a 1,2-dithiole compound as claimed in claim 1 in association with one or more compatible and pharmaceutically acceptable diluents or adjuvants.
Priority Claims (2)
Number |
Date |
Country |
Kind |
76 03603 |
Feb 1976 |
FRX |
|
76 36038 |
Nov 1976 |
FRX |
|
Parent Case Info
This is a division of application Ser. No. 766,967 filed Feb. 9, 1977, now U.S. Pat. No. 4,104,386.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1526768 |
Nov 1963 |
FRX |
Non-Patent Literature Citations (3)
Entry |
Bottcher et al., Chem. Ber. vol. 84, pp. 458-463 (1951). |
Le Grand et al., Bull. Soc. Chim. (France) pp. 79-83 (1955). |
The Chemistry of Heterocyclic Compounds, vol. 21, 1st Part, pp. 382-384 (1966). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
766967 |
Feb 1977 |
|