Claims
- 1. A sulfonamide compound of the formula (I) or a pharmacologically acceptable salt thereof: ##STR143## wherein: R.sup.1 represents a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, nitro group, phenoxy group, cyano group, acetyl group or amino group which may be protected,
- R.sup.2 and R.sup.3 may be the same or different from each other and each represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group, R.sup.4 and R.sup.7 may be the same or different from each other and each represent a hydrogen atom or a lower alkyl group,
- R.sup.5 and R.sup.6 may be the same or different from each other and each represent a hydrogen atom, halogen atom, lower alkoxy group or amino group which may be substituted,
- A represents a group of the formula: .dbd.N--,
- B represents a group of the formula: .dbd.N-- or ##STR144## in which R.sup.10 represents a hydrogen atom or lower alkyl group; E is selected from the group consisting of (a) ##STR145## in which Q represents an oxygen atom or a sulfur atom and R.sup.11 represents a hydrogen atom, lower alkyl group, amino group which may be substituted with a lower alkyl group, lower alkoxy group, 2-thienyl group, 2-furyl group or group of the formula: ##STR146## wherein D is .dbd.N-- or .dbd.CH-- and R.sup.12 and R.sup.13 are the same or different from each other and each being a hydrogen atom, halogen atom, nitro group, hydroxyl group which may be protected or lower alkyl group; or (b) an aromatic 6-membered cyclic group which may be substituted with 1 to 3 substituents G which may be the same or different from one another and which cyclic group may have 1 or 2 nitrogen atoms in the ring, wherein G is a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group which may be protected, carboxyl group which may be esterified or amidated, lower alkylthio group or phenoxy group.
- 2. A sulfonamide compound or a pharmacologically acceptable salt thereof according to claim 1, wherein R.sup.1 represents a lower alkoxy group.
- 3. A sulfonamide compound according to claim 1, wherein B is .dbd.N--.
- 4. A sulfonamide compound according to claim 3, wherein the compound is 2-N-(4-anilino-6-methoxy-5-pyrimidyl)-4-methoxybenzenesulfonamide.
- 5. A sulfonamide compound according to claim 3, wherein the compound is 4-(4-anilino-6-chloro-5-pyrimidyl)-4-methoxybenzenesulfonamide.
- 6. A sulfonamide compound according to claim 3, wherein the compound is N-4-(anilino-5-pyrimidyl)-4-methoxybenzenesulfonamide.
- 7. A sulfonamide compound according to claim 1, wherein the compound is N-(4,6-dianilino-5-pyrimidyl)-4-methoxybenzenesulfonamide.
- 8. A sulfonamide compound according to claim 1, wherein B is ##STR147##
- 9. A sulfonamide compound according to claim 8, wherein the compound is N-(4-anilino-3-pyridyl)-4-methoxybenzenesulfonamide.
Priority Claims (3)
Number |
Date |
Country |
Kind |
2-218710 |
Aug 1990 |
JPX |
|
3-38509 |
Mar 1991 |
JPX |
|
3-121041 |
May 1991 |
JPX |
|
Parent Case Info
This is a division of Ser. No. 08/231 272, filed Apr. 22, 1994, now U.S. Pat. No. 5,434,172, which is a division of Ser. No. 08/085,962, filed Jun. 30, 1993, now U.S. Pat. No. 5,332,751 which is a division of Ser. No. 07/923,345, filed Jul. 31, 1992, now U.S. Pat. No. 5,292,758, which is a division of Ser. No. 07/742,618, filed Aug. 8, 1991, now U.S. Pat. No. 5,250,549.
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, vol. 67, No. 13, Abstract 64346h, Sep. 25, 1967, p. 6060. |
Divisions (4)
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Number |
Date |
Country |
Parent |
231272 |
Apr 1994 |
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Parent |
85962 |
Jun 1993 |
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Parent |
923345 |
Jul 1992 |
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Parent |
742618 |
Aug 1991 |
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