Claims
- 1. A compound of structure (I) ##STR11## in which R.sup.1 and R.sup.4 are the same or different and are each hydrogen, C.sub.1-6 alkyl, halogen, trifluoromethyl, C.sub.1-6 alkoxy, C.sub.1-6 alkanoyl or C.sub.1-6 alkoxycarbonyl, RCF.sub.2 O, an ethoxy group substituted by 3 to 5 fluorine atoms; R.sup.2 and R.sup.3 together form a group --O(CR.sub.2).sub.m O-- where m is 1 or 2, and each group R is hydrogen or fluorine;
- n is 0 or 1;
- R.sup.5 and R.sup.6 are the same or different and are each hydrogen, C.sub.1-6 alkyl or C.sub.3-6 cycloalkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form an azetidino, pyrrolidino, piperidino, piperazino, N-C.sub.1-4 alkylpiperazino or morpholino group; and
- one of X and Y is a nitrogen atom, and the other is a group CR.sup.7 where R.sup.7 is hydrogen, C.sub.1-4 alkyl or NH.sub.2,
- or a pharmaceutically acceptable salt thereof.
- 2. A compound as claimed in claim 1 in which n is 1.
- 3. A compound as claimed in claim 1 in which R.sup.5 and R.sup.6 together with the nitrogen claim to which they are attached form a pyrrolidino, piperidino, piperazino, NC.sub.1-4 alkyl piperazino, or morpholino group.
- 4. A pharmaceutical composition comprising a compound as claimed in claim 1 in association with a pharmaceutically acceptable carrier.
- 5. A pharmaceutical composition comprising a compound as claimed in claim 2, in association with a pharmaceutically acceptable carrier.
- 6. A pharmaceutical composition as claimed in claim 5, in a form suitable for oral administration.
- 7. A pharmaceutical composition as claimed in claim 6, provided with an enteric coating.
- 8. A pharmaceutical composition as claimed in claim 4 in a form suitable for intravenous administration.
- 9. A method of inhibiting gastric acid secretion which comprises administering to a mammal in need thereof an effective amount of a compound as claimed in claim 1.
- 10. A method of treatment of gastrointerstinal diseases and other conditions caused or exacerbated by gastric acidity which comprises administering to a mammal in need thereof an effective amount of a compound as claimed in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8505615 |
Mar 1985 |
GBX |
|
8531605 |
Dec 1985 |
GBX |
|
Parent Case Info
This is a divisional of application Ser. No. 829,366 filed Feb. 14, 1986, now U.S. Pat. No. 4,777,172.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0178438 |
Apr 1986 |
EPX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
829366 |
Feb 1986 |
|