Claims
- 1. A pyrrole derivative of the formula: ##STR6## in which A forms with the pyrrole ring a 1-isoindoline ring system, Het denotes a 1, 8-naphthyridine ring system, which is unsubstituted or substituted with a halogen or a (1 to 4 C.) alkyl, (1 to 4 C.) alkyloxy, or (1 to 4 C.) alkylthio radical, Y denotes a CO, C=NOH or CHOH radical and R denotes a straight-or branched-chain alkenyl radical containing 3 to 10 carbon atoms or a straight or branched unsubstituted alkyl radical of 4 to 10 carbon atoms, or an alkyl radical which is substituted by alkyloxy, cyclohexyl or dialkylamino, or phenyl, or R denotes benzyl and, where they exist, "or a pharmaceutically acceptable salt thereof or an optical isomer thereof."
- 2. A pyrrole derivative according to claim 1 which is
- 2-(7-chloro-1, 8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone.
- 3. A pyrrole derivative according to claim 1 which is
- 2-(7-methoxy-1, 8-naphthyridin-2-yl)-3-(2-oxohexyl)-1-isoindolinone.
- 4. A pyrrole derivative according to claim 1 which is
- 2-(7-methoxy-1,8-naphthyridin-2-yl)-3-(5-methyl2-oxohexyl)-1-isoindolinone.
- 5. A pyrrole derivative according to claim 1 which is
- 2-(7-methoxy-1,8-naphthyridin-2-yl)-3-(6-methyl2-oxo-5-heptenyl)-1-isoindolinone.
- 6. A pyrrole derivative according to claim 1 which is
- 2-(7-methoxy-1,8-naphthyridin-2-yl)-3-(6-methyl-2-oxoheptyl)-1-isoindolinone.
- 7. A pyrrole derivative according to claim 1 which is
- 3-(3-cyclohexyl-2-oxopropyl)-2-(7-methoxy-1,8-naphthyridin-2-yl)-1-isoindolinone.
- 8. A pyrrole derivative according to claim 1 which is
- 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(3-isopropoxy-2-oxopropyl)-1-isoindolinone.
- 9. A pyrrole derivative according to claim 1 which is
- 2-(7-fluoro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone.
- 10. A pyrrole derivative according to claim 1 which is the dextrorotary isomer of 2-(7-chloro-1, 8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1isoindolinone.
- 11. Method of producing an anxiolytic, hypnotic, anticonvulsant, antiepileptic or muscle relaxant therapeutic effect in a subject in which such therapy is desirable which comprises administering to said subject an effective amount of a pyrrole derivative according to claim 1.
- 12. A pharmaceutical composition useful as an anxiolytic, hypnotic, anti-convulsant, antiepileptic or muscle relaxant, which contains, in combination with one or more diluents or adjuvants which are compatible and pharmaceutically acceptable, at least one pyrrole derivative of the formula: ##STR7## in which A forms with the pyrrole ring an isoindoline ring-system, Het denotes a naphthyridinyl radical, which is unsubstituted or substituted with a halogen or a (1 to 4 C.) alkyl, (1 to 4 C.) alkyloxy, or (1 to 4 C.) alkylthio radical, Y denotes a CO, C.dbd.NOH or CHOH radical and R denotes a straight-or branched-chain alkenyl radical containing 3 to 10 carbon atoms or a straight or branched unsubstituted alkyl radical of 4 to 10 carbon atoms, or an alkyl radical which is substituted by alkyloxy, cyclohexyl or dialkylamino, or phenyl, or R denotes benzyl and, where they exist, "or a pharmaceutically acceptable salt thereof or an optical isomer thereof."
Priority Claims (1)
Number |
Date |
Country |
Kind |
86 16795 |
Dec 1986 |
FRX |
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Parent Case Info
This Application is a continuation-in-Part of Application Ser. No. 126520 filed Nov. 30th 1987, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3884921 |
Cotrel et al. |
May 1975 |
|
4244966 |
Lippman et al. |
Jan 1981 |
|
4590189 |
Hiraga et al. |
May 1986 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
8403089 |
Aug 1984 |
WOX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
126520 |
Nov 1987 |
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