Claims
- 1. A method for treating an animal or human living body afflicted with a condition requiring an antagonist of thromboxane A.sub.2 receptors or an inhibitor of thromboxane A.sub.2 -synthase comprising the step of administering to the living body an amount of a compound selected from those of formula (I): ##STR32## in which: R.sub.1 represents:
- linear or branched (C.sub.1 -C.sub.6)alkyl which is unsubstituted or substituted by a 2-pyridyl, 3-pyridyl or phenyl (which is itself optionally substituted by one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, phenylsu-fonyl (which is unsubstituted or substituted on the phenyl ring by one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, or trihalomethyl), naphthylsulfonyl, quinolylsulfonyl, or isoguinolylsulfonyl,
- R.sub.2 represents:
- hydrogen,
- phenyl which is unsubstituted or substituted by one or more halogen or linear or branched (C.sub.1-C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl, or trihalomethyl, 3-pyridyl or 2-pyridyl which is unsubstituted or substituted on the pyridine ring by one or more halogen or linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, or trihalomethyl,
- R.sub.3 represents one of the following groups: ##STR33## in which m is equal to 2, 3 or 4,
- n is equal to 4, 5, 6 or 7,
- and R represents hydrogen or a linear or branched (C.sub.1 -C.sub.6)alkyl,
- its enantiomers, diastereoisomers and epimers, or an addition salt thereof with a pharmaceutically-acceptable acid or base, which is effective for alleviation of said condition.
- 2. A method of claim 1 wherein the compound is selected from those, in which R.sub.1 represents a substituted or unsubstituted phenylsulfonyl group, its enantiomers, diastereoisomers and epimers, as well as its addition salts with a pharmaceutically-acceptable acid or base.
- 3. A method of claim 1 wherein the compound is selected from those in which R.sub.2 represents a hydroxyphenyl group, its enantiomers, diastereoisomers and epimers, as well as its addition salts with a pharmaceutically-acceptable acid or base.
- 4. A method of claim 1 wherein the compound is selected from those in which R.sub.1 represents naphthylsulfonyl, its enantiomers, diastereoisomers and epimers, as well as its addition salts with a pharmaceutically-acceptable acid or base.
- 5. A method of claim 1 wherein the compound is selected from those in which R.sub.1 represents isoquinolylsulfonyl, its enantiomers, diastereoisomers and epimers, as well as its addition salts with a pharmaceutically-acceptable acid or base.
- 6. A method of claim 1 wherein the compound selected from those (4Z)-6-[3.alpha.,4.alpha.)-1-(4-chlorophenylsulfonyl)-4-(2-hydroxyphenyl)pyrrolidin-3-yl]hex-4-enoic acid and its salts with a pharmaceutically-acceptable acid or base.
- 7. A method of claim 1 wherein the compound selected from (4Z)-6-[(3.alpha.,4.alpha.)-1-[(Isoquinol-5-yl)sulfonyl]-4-(2-hydroxyphenyl)pyrrolidin-3-yl]hex-4-enoic acid and its salts with a pharmaceutically-acceptable acid or base.
- 8. A method of claim 1 wherein the compound selected from (4Z)-6-[(3.alpha.,4.alpha.)-1-Naphth-1-ylsulfonyl)-4-(2-hydroxyphenyl)pyrrolidin-3-yl)]hex-4-enoic acid and its salts with a pharmaceutically-acceptable acid or base.
- 9. A method of claim 1 wherein the compound is in the form of a pharmaceutical composition containing the same along with a pharmaceutically-acceptable excipient or vehicle.
Priority Claims (1)
Number |
Date |
Country |
Kind |
92 01523 |
Feb 1992 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed applications Ser. No. 08/016,501, filed Feb. 11, 1993, now allowed.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5128366 |
Hirai et al. |
Jul 1992 |
|
Non-Patent Literature Citations (2)
Entry |
Becking et al, Tetrahedron Letters, vol. 29, No. 23, pp. 2797-2800, 1988. |
Chemical Abstracts, vol. 119, No. 15, Abstract 160,024q, Oct. 11, 1993. |
Divisions (1)
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Number |
Date |
Country |
Parent |
16501 |
Feb 1993 |
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