Claims
- 1. A compound of the formula: ##STR5## wherein R.sup.1 is thienyl(lower)alkyl, furyl(lower)alkyl or pyrrolyl(lower)alkyl,
- R.sup.2 is hydrogen or an acyl group, and
- R.sup.3 is carboxyl(lower)alkyl,
- protected carboxyl(lower)alkyl,
- carboxyaryl or protected carboxyaryl, and
- a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1, wherein R.sup.2 is hydrogen, phenyl(lower)alkoxycarbonyl, or phenylsulfonyl which may have 1 to 2 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono (or di or tri)halo(lower)alkyl, and
- R.sup.3 is carboxy(lower)alkyl, esterified carboxy(lower)alkyl, carboxyphenyl or esterified carboxyphenyl.
- 3. The compound of claim 1, wherein R.sup.3 is carboxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl, carboxyphenyl or lower alkoxycarbonylphenyl.
- 4. A pharmaceutical composition, which comprises:
- as an active ingredient, a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier.
- 5. A method for treating thrombotic diseases, asthma, or nephritis, which comprises:
- administering a compound of claim 1 or a pharmaceutically acceptable salt thereof too a human being or animals in need thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8825454 |
Oct 1988 |
GBX |
|
8908387 |
Apr 1989 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 07/843,196, filed on Feb. 28, 1992, now U.S. Pat. No. 5,264,453 which is a DIV of Ser. No. 07/421,399, filed on Oct. 13, 1989 now U.S. Pat. No. 5,130,323.
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Number |
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Jul 1980 |
|
4785119 |
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Nov 1988 |
|
4916152 |
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Apr 1990 |
|
5130323 |
Setoi et al. |
Jul 1992 |
|
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Number |
Date |
Country |
0289911 |
Nov 1988 |
EPX |
61-257966 |
Nov 1986 |
JPX |
63-51370 |
Mar 1988 |
JPX |
Non-Patent Literature Citations (6)
Entry |
Frans M. Kaspersen et al: J. C. S. Perkin I 1975, pp. 1617-1622. |
Frans M. Kaspersen et al: J. C. S. Perkin I 1975, pp. 1798-1802. |
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Divisions (2)
|
Number |
Date |
Country |
Parent |
843196 |
Feb 1992 |
|
Parent |
421399 |
Oct 1989 |
|