Claims
- 1. A compound of the formula: ##STR5## wherein R.sup.1 is C.sub.1 -C.sub.15 alkyl, phenyl(lower)alkyl which may have 1 to 3 substituent(s) selected from the group consisting of cyano, hydroxy, halogen, lower alkyl, lower alkoxy, aryl, amino, di(lower)alkylamino and protected amino, or naphthyl(lower)alkyl,
- R.sup.2 is hydrogen or an acyl group, and
- R.sup.3 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxyaryl or protected carboxyaryl,
- or a pharmaceutically acceptable salt thereof.
- 2. A compound of claim 1, wherein
- R.sup.2 is hydrogen, ar(lower)alkoxycarbonyl, or arylsulfonyl which may have 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl, and
- R.sup.3 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxyphenyl or protected carboxyphenyl.
- 3. A compound of claim 2, wherein
- R.sup.1 is C.sub.1 -C.sub.12 alkyl, phenyl(lower)alkyl which may have 1 to 2 substituent(s) selected from the group consisting of cyano, hydroxy, halogen, lower alkyl, lower alkoxy, phenyl, amino, di(lower)alkylamino, and acylamino, or naphthyl(lower)alkyl,
- R.sup.2 is hydrogen, phenyl(lower)alkoxycarbonyl, or phenylsulfonyl which may have 1 to 2 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl, and
- R.sup.3 is carboxy(lower)alkyl, esterified carboxy(lower)alkyl, carboxyphenyl or esterified carboxyphenyl.
- 4. A compound of claim 3, wherein
- R.sup.1 is C.sub.1 -C.sub.12 alkyl, phenyl(lower)alkyl cyanophenyl(lower)alkyl, hydroxyphenyl(lower)alkyl, mono(or di)halophenyl(lower)alkyl, lower alkylphenyl(lower)alkyl, lower alkoxyphenyl(lower)alkyl, phenylphenyl(lower)alkyl, diphenyl(lower)alkyl, aminophenyl(lower)alkyl, di(lower alkyl)aminophenyl(lower)alkyl, lower alkanoylaminophenyl(lower)alkyl, or naphthyl(lower)alkyl,
- R.sup.2 is hydrogen, phenyl(lower)alkoxycarbonyl, or phenylsulfonyl which may have halogen, lower alkyl, lower alkoxy or mono(or di or tri)halo-lower alkyl, and
- R.sup.3 is carboxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl, carboxyphenyl or lower alkoxycarbonylphenyl.
- 5. A compound of claim 4, wherein
- R.sup.1 is C.sub.1 -C.sub.12 alkyl, phenyl(C.sub.1 -C.sub.5)alkyl, cyanophenyl(C.sub.1 -C.sub.5)alkyl, hydroxyphenyl(C.sub.1 -C.sub.5)alkyl, mono(or di)halophenyl(C.sub.1 -C.sub.5)alkyl, C.sub.1 -C.sub.4 alkylphenyl(C.sub.1 -C.sub.5)alkyl, C.sub.1 -C.sub.4 alkoxyphenyl(C.sub.1 -C.sub.5)alkyl, phenylphenyl(C.sub.1 -C.sub.5)alkyl, diphenyl(C.sub.1 -C.sub.5)alkyl, aminophenyl(C.sub.1 -C.sub.5)alkyl, di(C.sub.1 -C.sub.4 alkyl)amino-phenyl(C.sub.1 -C.sub.5)alkyl, C.sub.1 -C.sub.4 alkanoylaminophenyl(C.sub.1 -C.sub.5)alkyl, or naphthyl(C.sub.1 -C.sub.5)alkyl,
- R.sup.2 is hydrogen, phenyl(C.sub.1 -C.sub.4)alkoxycarbonyl, or phenylsulfonyl which may have halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or mono(or di or tri)halo-C.sub.1 -C.sub.4 alkyl, and
- R.sup.3 is carboxy(C.sub.1 -C.sub.4)alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl(C.sub.1 -C.sub.4)alkyl, carboxyphenyl or C.sub.1 -C.sub.4 alkoxycarbonylphenyl.
- 6. A pharmaceutical composition which comprises, as an active ingredient, a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.
- 7. A method for treating thrombotic diseases, asthma or nephritis, which comprises administering a compound of claim 1 or a pharmaceutically acceptable salt thereof to human being or animals.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8825454 |
Oct 1988 |
GBX |
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8908387 |
Apr 1989 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 07/421,399, filed on Oct. 13, 1989 now issued as U.S. Pat. No. 5,130,323 Jul. 14, 1992.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4210660 |
Takashima et al. |
Jul 1980 |
|
4785119 |
Hojo et al. |
Nov 1988 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0289911 |
Nov 1988 |
EPX |
61-257966 |
Nov 1986 |
JPX |
63-51370 |
Mar 1988 |
JPX |
Non-Patent Literature Citations (2)
Entry |
Frans M. Kaspersen et al: J.C.S. Perkin I, 1975, pp. 1617-1622, 1798-1802. |
Patrick E. Hanna et al: Journal of Medical Chemistry, 1973, vol. 16, No. 9, pp. 963-967. |
Divisions (1)
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Number |
Date |
Country |
Parent |
421399 |
Oct 1989 |
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