Claims
- 1. Pyrrolidineamide derivatives of acylamino acid of the general formula: ##STR60## wherein m is an integer of 1 to 3;
- n is 0, 1 or 2;
- R.sup.1 is phenyl, phenoxy, mono-substituted-phenyl or -phenoxy wherein the substituents on the substituted-phenyl or -phenoxy are selected from the group consisting of halogen, hydroxy, phenylalkyl having 7 to 10 carbon atoms, styryl, phenoxy, benzoyl and benzyloxy; a straight alkyl having 10 to 16 carbon atoms; or a straight alkenyl having 10 to 16 carbon atoms;
- R.sup.3 is H, NH.sub.2, OH, SCH.sub.3, carboxyl, a straight or branched (C.sub.3 -C.sub.5)alkyl, phenyl, benzyloxy, benzyloxyphenyl, indolyl, or imidazolyl.
- 2. A pharmaceutical composition for use in ameliorating cerebral insufficiency which comprises as an active ingredient a pharmaceutically effective amount of a compound of the general formula: ##STR61## wherein m is an integer of 1 to 3;
- n is 0, 1 or 2;
- R.sup.1 is phenyl, phenoxy, mono-substituted-phenyl or -phenoxy wherein the substituents on the substituted -phenyl or -phenoxy are selected from the group consisting of halogen, hydroxy, phenylalkyl having 7 to 10 carbon atoms, styryl, phenoxy, benzoyl and benzyloxy; a straight alkyl having 10 to 16 carbon atoms; or a straight alkenyl having 10 to 16 carbon atoms;
- R.sup.3 is H, NH.sub.2, OH, SCH.sub.3, carboxyl, a straight or branched (C.sub.3 -C.sub.5)alkyl, phenyl, benzyloxy, benzyloxyphenyl, indolyl, or imidazolyl, together with a pharmaceutical acceptable carrier.
- 3. A pharmaceutical composition according to claim 2 wherein said composition contains the active ingredient in an amount effective for ameliorating amnesia.
- 4. A pharmaceutical composition according to claim 2 wherein the active ingredient is contained in an amount of 10 to 2,000 mg in a daily dose.
Priority Claims (2)
Number |
Date |
Country |
Kind |
61-22756 |
Feb 1986 |
JPX |
|
61-43821 |
Feb 1986 |
JPX |
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Parent Case Info
This is a continuation of application Ser. No. 07/244,859, filed Sep. 15, 1988, now abandoned, which is a division of application Ser. No. 07/010,490, filed Feb. 3, 1987, now U.S. Pat. No. 4,826,870.
US Referenced Citations (6)
Foreign Referenced Citations (5)
Number |
Date |
Country |
0046707 |
Mar 1982 |
EPX |
0254545 |
Jan 1988 |
EPX |
60-172929 |
Sep 1985 |
JPX |
60-188317 |
Sep 1985 |
JPX |
1467927 |
Mar 1977 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Proceedings of the 1984 Annual Meeting of "The Agricultural Chemical Society" of Japan, pp. 752-754 (1984). |
Yoshimoto, et al., Agric. Biol. Chem., 42 (No. 12), pp. 2417-2419 (1978). |
Merck Index, p. 35, CA 195 and CA 196 (date not known). |
Divisions (1)
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Number |
Date |
Country |
Parent |
10490 |
Feb 1987 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
244859 |
Sep 1988 |
|