Claims
- 1. A pharmaceutical composition comprising a compound according to formula I
- 2. A composition according to claim 1 wherein in the formula I
Y is oxygen, and
G and G′, together with the bond linking them, are C═C.
- 3. The composition according to claim 2 wherein the meaning of V is pyridyl.
- 4. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and the meaning of Z is selected from,
a) halogen, alkyl, alkoxy, OH, NO2 or NH2; b) halogen, alkyl, alkoxy, NO2 or NH2; c) fluoro, chloro, bromo, iodo, C1-4-alkyl, C1-4alkoxy, trifluoromethyl, NO2 or NH2; d) fluoro, chloro, bromo, iodo, C1-4-alkyl, methoxy, trifluoromethyl, NO2 or NH2; e) fluoro, chloro, bromo, C1-4-alkyl, C14 alkoxy, trifluoromethyl, NO2 or NH2; f) fluoro, chloro, bromo, C1-4-alkyl, methoxy, trifluoromethyl, NO2 or NH2; g) fluoro, chloro, bromo, iodo, C1-4 alkyl; h) fluoro, chloro, bromo, iodo, methyl or ethyl; i) fluoro, chloro, bromo, C1-4 alkyl; and j) fluoro, chloro, bromo, methyl or ethyl.
- 5. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and t is selected from,
a) 1,2 or 3; and b) 1 or 2.
- 6. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and the meaning of R1 is selected from,
a) alkyl, cycloalkyl, cycloalkenyl, or substituted heterocycle; b) C1-10 alkyl, C3-10 cycloalkyl, C6-8 cycloalkenyl, or substituted heterocycle; c) C1-8 alkyl, C3-10cycloalkyl, C6-8 cycloalkenyl, or substituted heterocycle; and d) furyl or thienyl, optionally substituted by one or more alkyl or halogen.
- 7. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and R2 is hydrogen.
- 8. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and R3 is —C(O)R3a wherein the meaning of R3a is selected from,
a) alkyl, optionally substituted aryl or heterocycle; b) C1-5-alkyl, optionally substituted phenyl, benzyl, phenethyl, or thienyl; and c) methyl.
- 9. A composition according to claim 1 wherein in the formula I
Y is oxygen, G and G′, together with the bond linking them, are C═C, and R4 is hydroxy.
- 10. A composition according to claim 1 wherein the compound of formula I is 4-acetyl-5-(4-bromophenyl)-1-(5-bromopyridin-2-yl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one.
- 11. A composition according to claim 1 wherein the compound of formula I is in the form of its (−)-enantiomer.
- 12. A composition according to claim 1 wherein the compound of formula I is in the form of its (R)-enantiomer.
- 13. A compound of formula I
- 14. A compound of formula
- 15. A compound of formula I
- 16. A compound of formula
- 17. A compound of formula
- 18. A compound of formula
- 19. A compound of formula
Parent Case Info
[0001] This is a continuation-in-part of application Ser. No. 09/970,140, filed Oct. 3, 2001, and claims the benefit of U.S. Provisional Application No. 60/400,807, filed Aug. 1, 2002.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60400807 |
Aug 2002 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
10255494 |
Sep 2002 |
US |
Child |
10750247 |
Dec 2003 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09970140 |
Oct 2001 |
US |
Child |
10255494 |
Sep 2002 |
US |