Claims
- 1. A compound of the formula ##STR24## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or alkynyl, hydroxymethyl, the group ##STR25## wherein R.sub.11 is hydrogen, hydroxy, alkoxy, amino and mono- or di-lower alkylamino; and R.sub.3 is selected from the group consisting of hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or alkynyl, hydroxymethyl, the group ##STR26## wherein R.sub.11 is hydrogen, hydroxy, trihalomethyl, alkoxy, amino and mono- or di-lower alkylamino; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or alkynyl, the group ##STR27## lower alkyl, a radical of the formula --C.sub.1 to C.sub.6 lower alkyl --COR.sub.21 wherein R.sub.21 is hydroxy, lower alkoxy, amino or mono- or di-lower alkyl substituted amino, hydroxy C.sub.2 to C.sub.7 alkyl and amino or mono- or di-lower alkyl amino C.sub.2 to C.sub.7 alkyl; R.sub.4 is selected from the group consisting of hydrogen, acyloxy ##STR28## wherein R is C.sub.1 to C.sub.6 alkyl, halo alkyl, phenyl or hydrogen, straight chain lower alkoxy and hydroxy; R.sub.5 is halogen or hydrogen; R.sub.6 is halogen with the proviso that if one of R.sub.1 or R.sub.3 is hydroxymethyl or the group ##STR29## wherein R.sub.11 is as above then the remaining substituent is selected from the group consisting of hydrogen, lower alkyl and C.sub.3 to C.sub.7 alkenyl or alkynyl, and R.sub.2 is hydrogen and the further proviso that (A) when R.sub.4 is acyloxy then R.sub.1 and R.sub.3 are hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or C.sub.3 to C.sub.7 alkynyl, and R.sub.2 is the group ##STR30## lower alkoxy, (B) when R.sub.4 is hydroxy then R.sub.1 and R.sub.3 are hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or C.sub.3 to C.sub.7 alkynyl, and R.sub.2 is hydrogen or (C) when R.sub.4 is alkoxy then R.sub.1 and R.sub.3 are hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or C.sub.3 to C.sub.7 alkynyl,
- and the pharmaceutically acceptable salts thereof.
- 2. A compound of the formula ##STR31## wherein R.sub.1 " and R.sub.3 " are selected from the group consisting of hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or C.sub.3 to C.sub.7 alkynyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, C.sub.3 to C.sub.7 alkenyl or C.sub.3 to C.sub.7 alkynyl, the group ##STR32## lower alkyl, a radical of the formula --C.sub.1 to C.sub.6 lower alkyl --COR.sub.21 wherein R.sub.21 is hydroxy, lower alkoxy, amino or mono- or di-lower alkyl substituted amino, hydroxy C.sub.2 to C.sub.7 alkyl and amino or mono- or di-lower alkylamino C.sub.2 to C.sub.7 alkyl; R.sub.5 is halogen or hydrogen and R.sub.6 is halogen
- and the pharmaceutically acceptable salts thereof.
- 3. The compound of claim 1 wherein R.sub.1 is hydrogen or lower alkyl; R.sub.3 is hydrogen; R.sub.4 is hydrogen and R.sub.5 and R.sub.6 are halogen.
- 4. The compound of claim 3 wherein R.sub.5 is chloro or fluoro and R.sub.6 is chloro.
- 5. The compound of claim 1 wherein R.sub.1 is lower alkyl, i.e., a C.sub.1 to C.sub.7 straight or branched chain hydrocarbon.
- 6. The compound: 8-Chloro-6-(2-chlorophenyl)-2H,4H-pyrrolo[3,4-d][2]benzazepine.
- 7. The compound: 8-Chloro-6-(2-fluorophenyl)-2H,4H-pyrrolo[3,4-d][2]benzazepine.
- 8. The compound: 8-Chloro-6-(2-chlorophenyl)-1-methyl-2H,4H-pyrrolo[3,4-d][2]benzazepine.
- 9. The compound: 8-Chloro-6-(2-chlorophenyl)-2-methyl-2H,4H-pyrrolo[3,4-d][2]benzazepine.
- 10. The compound: 8-Chloro-6-(2-fluorophenyl)-2H-4H-pyrrolo[3,4-d][2]benzazepine-2-ethanol.
- 11. The compound: 8-Chloro-6-(2-chlorophenyl)-2H,4H-pyrrolo[3,4-d][2]benzazepine-2-carboxylic acid methyl ester.
RELATED APPLICATIONS
This is a continuation-in-part application of copending U.S. patent application Ser. No. 175,555, filed Aug. 5, 1980.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4022801 |
Gschwend |
May 1977 |
|
4169150 |
Hara et al. |
Sep 1979 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
175555 |
Aug 1980 |
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