Claims
- 1. A compound of the formula ##STR12## wherein R.sub.1 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy or ##STR13## and R.sub.2 and R.sub.4 are hydrogen or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 taken together are oxo groups with the proviso that at least one oxo group is present; R is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids and the lower alkyl esters, amides and mono or di lower alkyl amides thereof, hydroxy C.sub.2 to C.sub.7 alkyl and amino C.sub.2 to C.sub.7 alkyl or mono- or di-lower alkyl amino C.sub.2 to C.sub.7 alkyl; R.sub.5 is halogen or hydrogen and R.sub.6 is halogen with the proviso that when R.sub.1 or R.sub.3 is hydroxy, lower alkoxy or ##STR14## then R is lower alkyl or hydrogen; R.sub.7 is C.sub.1 to C.sub.6 alkyl, phenyl, or hydrogen the N-oxides and the pharmaceutically acceptable salts thereof.
- 2. A compound of the formula ##STR15## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, hydroxy or ##STR16## and R.sub.2 is hydrogen or R.sub.1 and R.sub.2 taken together are an oxo group; R is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids and the lower alkyl esters, amides and mono or di lower alkyl amides thereof, hydroxy C.sub.2 to C.sub.7 alkyl and amino C.sub.2 to C.sub.7 alkyl or mono- or di-lower alkylamino C.sub.2 to C.sub.7 alkyl; R.sub.5 is halogen or hydrogen and R.sub.6 is halogen with the proviso that when R.sub.1 or R.sub.3 is hydroxy, lower alkoxy or ##STR17## then R is lower alkyl or hydrogen; R.sub.7 is C.sub.1 to C.sub.6 alkyl, phenyl, or hydrogen and the pharmaceutically acceptable salts thereof.
- 3. A compound as claimed in claim 3 wherein R.sub.2 is hydrogen.
- 4. A compound of the formula ##STR18## wherein R.sub.1 is selected from the group consisting of hydrogen or lower alkyl; R is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids and the lower alkyl esters, amides and mono or di lower alkyl amides thereof, hydroxy C.sub.2 to C.sub.7 alkyl and amino C.sub.2 to C.sub.7 alkyl or mono- or di-lower alkyl amino C.sub.2 to C.sub.7 alkyl; R.sub.5 is halogen or hydrogen and R.sub.6 is halogen.
- 5. A compound of the formula ##STR19## wherein R" is selected from the group consisting of hydrogen or lower alkyl; R.sub.1 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, hydroxy or ##STR20## and R.sub.2 and R.sub.4 are hydrogen or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 taken together are oxo groups with the proviso that at least one oxo group is present; R.sub.5 is hydrogen or halogen and R.sub.6 is halogen; R.sub.7 is C.sub.1 to C.sub.6 alkyl, phenyl, or hydrogen.
- 6. A compound of the formula ##STR21## wherein R" and R.sub.11 are selected from the group consisting of hydrogen or lower alkyl and R.sub.5 and R.sub.6 are halogen.
- 7. A compound selected from the group consisting of
- 8-chloro-6-(2-fluorophenyl)-3,4-dihydropyrrolo[3,4-d][2]benzazepin-1(2H)-one,
- 8-chloro-6-(2-chlorophenyl)-3,4-dihydropyrrolo[3,4-d][2]benzazepin-1(2H)-one,
- 8-chloro-3,4-dihydro-6-phenylpyrrolo[3,4-d][2]benzazepin-1(2H)-one or
- 8-chloro-6-(2-chlorophenyl)-3,4-dihydro-2-methylpyrrolo[3,4-d][2]benzazepin-1(2H)-one.
- 8. A compound selected from the group consisting of
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1-hydroxypyrrolo[3,4-d][2]benzazepin-3(2H)-one,
- 8-chloro-6-(2-chlorophenyl)-3,4-dihydro-3-hydroxypyrrolo[3,4-d][2]benzazepin-1(2H)-one or
- 8-chloro-6-(2-chlorophenyl)pyrrolo[3,4-d][2]benzazepin-1,3-(2H,4H)-dione.
- 9. A compound selected from the group consisting of
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydropyrrolo[3,4-d][2]benzazepin-3(2H)-one-5-oxide or
- 8-chloro-6-(2-chlorophenyl)-3,4-dihydropyrrolo[3,4-d][2]benzazepin-1(2H)-one-5-oxide.
- 10. The compounds selected from the group consisting of:
- 8-chloro-6-(2-chlorophenyl)-1-ethyl-1,4-dihydropyrrolo[3,4-d][2]benzazepin-3(2H)-one,
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1-methyl-3-oxo-2H-pyrrolo[3,4-d][2]benzazepine-2-acetic acid methyl ester,
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1-methyl-3-oxo-2H-pyrrolo[3,4-d][2]benzazepine-2-acetamide and
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1-methylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 11. The compound:
- 8-chloro-6-(2-fluorophenyl)-1,4-dihydropyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 12. The compound:
- 8-chloro-1,4-dihydro-6-phenylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 13. The compound:
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1,2-dimethylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 14. The compound:
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-2-(2-hydroxyethyl)-1-methylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 15. The compound:
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydropyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 16. The compound:
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-1-methylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
- 17. The compound:
- 8-chloro-6-(2-chlorophenyl)-1,4-dihydro-2-methylpyrrolo[3,4-d][2]benzazepin-3(2H)-one.
Parent Case Info
This application is a continuation-in-part of Ser. No. 393,142, filed on June 28, 1982, now abandoned, which in turn is a continuation-in-part of Ser. No. 379,400, filed on May 18, 1982.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
45519 |
Feb 1982 |
EPX |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
393142 |
Jun 1982 |
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Parent |
379400 |
May 1982 |
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