Claims
- 1. A process for the preparation of a compound of formula (I) wherein:W represents —CH2— or a bond; Q represents Ar1 or Ar2; in the case where W represents —CH2—, Q represents an aryl group Ar1 wherein Ar1 represents naphthyl, phenyl, quinolyl, isoquinolyl, indolyl, benzofuranyl or benzothienyl; in the case where W represents a bond, Q represents an aryl group Ar2 wherein Ar2 represents acenaphthenyl, fluorenyl or indanyl; wherein the ring systems which Ar1 and Ar2 represent may all be optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, or trifluoromethyl; R10 represents X—A)p—Y; X represents S(O)n, C≡C, (CH2)2, CH═CH or CH2CH═CH; n represents 0, 1 or 2; A represents C1-6 alkylene; p is 0 or 1; Y represents COOH, provided that when X represents S(O)n, then p is 1; and R1 and R2 independently represent H or C1-5 alkyl; which process comprises, hydrolyzing a corresponding C1-5 alkyl ester compound and optionally converting the compound of formula (I) obtained to a pharmaceutically acceptable salt or solution.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9626643 |
Dec 1996 |
GB |
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Parent Case Info
This application is a continuation of application Ser. No. 09/011,780, filed Feb. 24, 1998, now U.S. Pat. No. 6,046,204, which is a National Stage of application of PCT/SE97/02157, filed Dec. 18, 1997, which claims priority from British priority patent application Serial No. 9626643.2, filed Dec. 21, 1996.
Foreign Referenced Citations (2)
Number |
Date |
Country |
9304047 |
Mar 1993 |
WO |
6917610 |
Jun 1996 |
WO |
Non-Patent Literature Citations (5)
Entry |
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Continuations (1)
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Number |
Date |
Country |
Parent |
09/011780 |
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US |
Child |
09/505862 |
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US |