Claims
- 1. A process for the preparation of a pyrroloazepine derivative represented by the following formula (Ib): ##STR94## wherein A denotes a linear or branched C.sub.2-10 alkylene, alkenylene or alkynylene group, R means a hydrogen atom, a linear or branched C.sub.1-6 alkyl group or a C.sub.7-10 aralkyl group, R.sub.1 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y represents a group ##STR95## which R.sub.2 means a hydrogen atom or a cyano group, R.sub.3 and R'.sub.3 may be the same or different and individually denote a phenyl group or an aralkyl group, and B is an oxygen atom, sulfur atom, carbonyl group, hydroxymethylene group, sulfinyl group, sulfonyl group, or a cyclic or acyclic acetal group, and n stands for 0 or 1, which comprises:
- reacting a hydroxylamine, which is represented by the following formula (IX):
- NH.sub.2 OR.sub.1 (IX)
- wherein R.sub.1 has the same meaning as defined above, with a pyrroloazepine derivative represented by the following formula (Ia): ##STR96## wherein A, Y and R have the same meanings as defined above.
- 2. A process for the preparation of a pyrroloazepine derivative represented by the following formula (Ib): ##STR97## wherein A denotes a linear or branched C.sub.2-10 alkylene, alkenylene or alkynylene group, R means a hydrogen atom, a linear or branched C.sub.1-6 alkyl group or a C.sub.7-10 aralkyl group, R.sub.1 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y represents a group ##STR98## in which R.sub.2 means a hydrogen atom or a cyano group, R.sub.3 and R'.sub.3 may be the same or different and individually denote a phenyl group or an aralkyl group, and B is an oxygen atom, sulfur atom, carbonyl group, hydroxymethylene group, sulfinyl group, sulfonyl group, or a cyclic or acyclic acetal group, and n stands for 0 or 1, which comprises:
- causing a hydroxylamine, which is represented by the following formula (IX):
- NH.sub.2 OR.sub.1 (IX)
- wherein R.sub.1 has the same meaning as defined above to act on a compound represented by the following formula (III): ##STR99## wherein A and R have the same meanings as defined above and X means a halogen atom, methanesulfonyl group or a p-toluenesulfonyl group, thereby forming a compound represented by the following formula (X) : ##STR100## wherein A, R, R.sub.1 and X have the same meanings as defined above; and reacting the compound of the formula (X) with a nitrogen-containing cyclic compound represented by the following formula (IV):
- H--Y (IV)
- wherein Y has the same meaning as defined above.
Priority Claims (2)
Number |
Date |
Country |
Kind |
2-26137 |
Feb 1990 |
JPX |
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3-027739 |
Jan 1991 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 07/651,778, filed on Feb. 7, 1991, now U.S. Pat. No. 5,206,239.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3563979 |
Hester, Jr. |
Feb 1971 |
|
3573323 |
Hester, Jr. |
Mar 1971 |
|
3573324 |
Hester, Jr. |
Mar 1971 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
3903368 |
Aug 1990 |
DEX |
Divisions (1)
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Number |
Date |
Country |
Parent |
651778 |
Feb 1991 |
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