Claims
- 1. A compound having the structure:
- 2. The compound of claim 1, wherein any heterocyclic or heteroaryl ring, if present, is a piperazine, piperidine, pyrazine, pyridine, pyrrolidine, pyrazole, pyrimidine, thiophene, imidazole, azetidine, pyrrole, benzothiazole, benzodioxolane, dithiolane, oxathiine, imidazolidine, quinoline, isoquinoline, dihydro-1H-isoquinoline, dihydro-2H-pyridine, 1,3,4,9-tetrahydro-β-carboline, 2,8-diazaspiro[4.5]decane, 2,5-diazabicyclo[2.2.1]heptane, or [1,4]diazepane ring, dihydroisoquinoline, indole, isoindole, triazaspiro[4.5]decane, morpholine, furan or an isothiazole ring.
- 3. The compound of claim 1, having the structure:
- 4. The compound of claim 1, having the structure:
- 5. The compound of claim 4, wherein R1, R2 and N together form a substituted azetidine ring.
- 6. The compound of claim 4, wherein R1, R2 and N together form a substituted piperazine ring.
- 7. The compound of claim 1, having the structure:
- 8. The compound of claim 9, wherein R4 is H.
- 9. The compound of claim 8, wherein R3 is substituted or unsubstituted phenyl.
- 10. The compound of claim 9, wherein,
R1 is —(CH2)2NHC(═O)CH3; R2 is hydrogen or methyl; R4 is hydrogen or methyl; and R6 is substituted or unsubstituted phenyl or pytidine.
- 11. The compound of claim 10, wherein R2 is H.
- 12. The compound of claim 11, wherein R6 is substituted phenyl.
- 13. The compound of claim 1, having the structure:
- 14. The compound of claim 13, wherein R4 is H;
- 15. The compound of claim 14, wherein R3 is substituted or unsubstituted phenyl.
- 16. The compound of claim 15, wherein,
R1 is —(CH2)2NHC(═O)CH3; R2 is hydrogen or methyl; R4 is hydrogen or methyl; and R6 is substituted or unsubstituted cyclopentyl.
- 17. The compound of claim 16, wherein R2 is H.
- 18. The compound of claim 1, having the structure:
- 19. The compound of claim 18, wherein R4 is H.
- 20. The compound of claim 19, wherein R3 is substituted or unsubstituted phenyl;
- 21. The compound of claim 20, wherein,
R1 is —(CH2)2NHC(═O)CH3; R2 is hydrogen or methyl; R4 is hydrogen or methyl; and R6 is substituted or unsubstituted piperidine.
- 22. The compound of claim 21, wherein R2 is H.
- 23. The compound of claim 1, having the structure:
- 24. The compound of claim 23, wherein R3 is substituted or unsubstituted phenyl.
- 25. The compound of claim 24, wherein R4 is hydrogen.
- 26. The compound of claim 1, having the structure:
- 27. The compound of claim 26, wherein R8NR9 together form a substituted or unsubstituted azetidine, pyrrolidine, piperazine, piperidine, morpholine, azocane, dihydro-1H-isoquinoline, 1,2,3,6-tetrahydropyridine, dihydro-2H-pyridine, 1,3,4,9-tetrahydro-β-carboline, 1,3,8-triazaspiro[4.5]decane, 2,8-diazaspiro[4.5]decane, 2,5-diazabicyclo[2.2.1]heptane, 1,4-dioxa-8-azaspiro[4.5]decane, or [1.4]diazepane ring.
- 28. The compound of claim 27, wherein R8NR9 together form a substituted or unsubstituted azetidine, pyrrolidine, piperazine, piperidine or [1.4]diazepane ring.
- 29. The compound of claim 27, wherein the ring formed by R8NR9 is substituted with one or more aryl, heteroaryl, (C1-C30)alkylaryl, (C1-C30)alkylheteroaryl, (C1-C30)alkenylaryl, (C1-C30)alkenylheteroaryl, (C1-C30)alkynylaryl, or (C1-C30)allynylheteroaryl moiety, which itself can be substituted.
- 30. The compound of claim 26, wherein R3 is a substituted or unsubstituted phenyl.
- 31. The compound of claim 30, wherein
R1 is —(CH2)2NHC(═O)CH3; R2 is hydrogen or methyl; and R4 is hydrogen or methyl.
- 32. The compound of claim 1, having the structure:
- 33. The compound of claim 32, wherein R8 or R9 is a (C1-C30)alkyl substituted with one or more hydroxy, dihydroxy or amino moiety.
- 34. The compound of claim 32, wherein R8 or R9 is a substituted or unsubstituted pyrrolidine, piperidine, bicycle[2.2.1]heptane, 2-oxoazepan, indane, or cyclopropylbenzene ring.
- 35. The compound of claim 1, having the structure:
- 36. The compound of claim 35, wherein R10 is a substituted or unsubstituted piperidine ring.
- 37. The compound of claim 35, wherein R3 is a substituted or unsubstitited phenyl.
- 38. The compound of claim 37, wherein R4 is hydrogen.
- 39. The compound of claim 38, wherein R1 is —(CH2)2NHC(═O)CH3;
- 40. The compound of claim 39, wherein R2 is hydrogen.
- 41. The compound of claim 35, having the structure:
- 42. The compound of claim 1, having the structure:
- 43. The compound of claim 42, wherein R11NR12 together form a substituted or unsubstituted azetidine, pyrrolidine, piperazine, piperidine, morpholine, azocane, dihydro-1H-isoquinoline, 1,2,3,6-tetrahydropyridine, dihydro-2H-pyridine, 1,3,4,9-tetrahydro-β-carboline, 1,3,8-triazaspiro[4.5]decane, 2,8-diazaspiro[4.5]decane, 2,5-diazabicyclo[2.2.1]heptane, 1,4-dioxa-8-azaspiro[4.5]decane, or [1.4]diazepane ring.
- 44. The compound of claim 43, wherein R11NR12 together form a substituted or unsubstituted azetidine, pyrrolidine, piperazine, piperidine or [1.4]diazepane ring.
- 45. The compound of claim 43, wherein the ring formed by R11NR12 is substituted with one or more aryl, heteroaryl, (C1-C30)alkylaryl, (C1-C30)alkylheteroaryl, (C1-C30)alkenylaryl, (C1-C30)alkenylheteroaryl, (C1-C30)alkynylaryl, or (C1-C30)alkynylheteroaryl moieties, which itself can be substituted.
- 46. The compound of claim 42, wherein R3 is a substituted or unsubstituted phenyl.
- 47. The compound of claim 46, wherein R4 is hydrogen.
- 48. The compound of claim 47, wherein R1 is —(CH2)2NHC(═O)CH3.
- 49. The compound of claim 1, having the structure:
- 50. The compound of claim 49, wherein R11NR12 together form a substituted or unsubstituted azetidine, pyrroliaine, piperazine, piperidine, morpholine, azocane, dihydro-1H-isoquinoline, 1,2,3,6-tetrahydropyridine, dihydro-2H-pyridine, 1,3,4,9-tetrahydro-β-carboline, 1,3,8-triazaspiro[4.5]decane, 2,8-diazaspiro[4.5]decane, 2,5-diazabicyclo[2.2.1]heptane, 1,4-dioxa-8-azaspiro[4.5]decane, or [1.4]diazepane ring.
- 51. The compound of claim 50, wherein R11NR12 together form a substituted or unsubstituted azetidine, pyrrolidine, piperazine, piperidine or [1.4]diazepane ring.
- 52. The compound of claim 50, wherein the ring formed by R11NR12 is substituted with one or more aryl, heteroaryl, (C1-C30)alkylaryl, (C1-C30)alkylheteroaryl, (C1-C30)alkenylaryl, (C1-C30)alkenylheteroaryl, (C1-C30)alkynylaryl, or (C1-C30)alkynylheteroaryl moiety.
- 53. The compound of claim 49, wherein R3 is a substituted or unsubstituted phenyl.
- 54. The compound of claim 53, wherein R4 is hydrogen.
- 55. The compound of claim 54, wherein R1 is —(CH2)2NHC(═O)CH3.
- 56. A compound having the structure:
- 57. The compound of claim 56, wherein any alkyl is a straight chain (C1-C30)alkyl or a branched chain (C3-C30)alkyl.
- 58. The compound of claim 57, wherein any heterocyclic ring, if present, is a substituted or unsubstituted morpholine, pyrrolidine, piperazine, piperidine, azocane, dihydro-1H-isoquinoline, dihydro-2H-pyridine, 1,3,4,9-tetrahydro-β-carboline, 1,3,8-triazaspiro[4.5]decane, 2,8-diazaspiro[4.5]decane, 2,5-diazabicyclo[2.2.1]heptane, or [1,4]diazepane ring.
- 59. The compound of claim 7, wherein the compound is selected from the group consisting of:
N-{2-[6-(4-Fluorophenoxymethyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Methoxyphenoxymethyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-[2-(2-Phenyl-6-m-tolyloxymethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-{2-[6-(3-Bromophenoxymethyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; 3-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethoxy]-benzoic acid methyl ester; N-{2-[6-(4-Chlorophenoxymethyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; and N-{2-[6-(3-Methoxyphenoxymelhyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide.
- 60. The compound of claim 18, wherein the compound is selected from the group consisting of:
N-(2-{6-[1-(Benzenesulfonyl)piperidin-4-yloxymethyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}ethyl)acetamide; N-{2-[6-(1-Phenethylpiperidin-4-yloxymethyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]ethyl}acetamide; N-[2-{6-[1-(3-Phenylpropyl)piperidin-4-yloxymethyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}ethyl]acetamide; N-(2-{6-[1-(4-Bromobenzyl)piperidin-4-yloxymethyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}ethyl)acetamide; N-[2-(6-{1-[2-(2-Chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(3-Chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-(2-{6-[1-(3-Chlorobenzyl)piperidin-4-yloxymethyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}ethyl)acetamide; N-[2-(6-{1-[2-(4-Chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(2-Methoxyphenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(3-Methoxyphenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-4ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(4-Fluorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(2-Chloro-4-fluorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(2-Chloro-6-fluorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; N-[2-(6-{1-[2-(2-Trifluoromethylphenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide; and N-[2-(6-{1-[2-(2-Bromophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetamide.
- 61. The compound of claim 13, wherein the compound is N-(2-(6-{2-[Methyl-(3-phenylallyl)amino]ethoxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}ethyl]acetamide
- 62. The compound of claim 26, wherein the compound is selected from the group consisting of:
N-(2-{2-Phenyl-6-[4-(3-phenylallyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Hydroxy4-isopropylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{2-Phenyl-6-[4-(3-phenylpropyl)-piperazine-1-carhonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Phenethylpiperazine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; 2-{2-Phenyl-6-[4-(3-phenylpropyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-acetamide; N-[2-(6-{4-[2-(4-Chlorophenoxy)-ethyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-{2-[6-(4-Cyano-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{2-Phenyl-6-[4-(3-phenylprop-2-ynyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[cis-3,5-Dimethyl4-(3-phenylpropyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4,4-Diphenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(3,3-Diphenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Methoxy4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[trans-2,5-Dimethyl-4-(3-phenylpropyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(trans-2,5-Dimethylpiperazine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Benzyl-cis-3,5-dimethylpiperazine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(cis-3,5-Dimethyl4-phenethylpiperazine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(3-Methyl-3-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{2-Phenyl-6-[4-(5-trifluoromethylpyridin-2-yl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2′-Chlorobiphenyl-2-yl)-4-methoxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Chlorophenyl)4-methoxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Chlorophenyl)4-hydroxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2′-Chlorobiphenyl-2-yl)-4-hydroxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(4-Fluorophenyl)-4-methoxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-(4-phenylbutyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-(3-phenylpropyl)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[2-Phenyl-6-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(3-Cyclohexylpropyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(4-Methylpentyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-([1,4′]Bipiperidinyl-1′-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Cyclopentylpiperazine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Aminopiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Acetyl-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(2-Cyclohexylethyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[2-Phenyl-6-(4-phenylethynyl-3,6-dihydro-2H-pyridine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-tert-Butylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Phenethylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-[2-(6-{4-[3-(2-Cyanophenyl)-prop-2-ynyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(3-Cyanophenyl)-prop-2-ynyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(4-Cyanophenyl)-prop-2-ynyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid methyl ester; N-(2-{6-[4-(1-Hydroxyethyl)-4-phenylpiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-[2-(6-{4-[3-(4-Cyanophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid ethyl ester; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid amide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid methylamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid dimethylamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid benzylamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid ethylamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid diethylamide; N-(2-{6-[4-(Azetidine-1-carbonyl)-4-phenylpiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-phenyl-4-(pyrrolidine-1-carbonyl)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-phenyl-4-(piperidine-1-carbonyl)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(Morpholine-4-carbonyl)-4-phenylpiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid tert-butylamide; N-{2-[6-(4-Isopropyl-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{2-Phenyl-6-[4-(3-thiophen-2-yl-prop-2-ynyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid cyclobutylmethyl ester; N-(2-{6-[4-(4-Chlorophenyl)-4-methoxypiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-Methoxy-4-(3-trifluoromethylphenyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Isopropyl-4-methoxypiperidine-1-carbonyl)-2-pbenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Acetylamino-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-phenylpiperidine-4-carboxylic acid isopropyl ester; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-ethylaminopiperidine-4-carboxylic acid amide; N-(2-{6-[4-Methoxy-4-(3-methoxyphenyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; 1-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-pyrrolidin-1-ylpiperidine-4-carboxylic acid amide; N-(2-{6-[4-(2-Methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Amino-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Formyl-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Benzyl4-methoxypiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Methoxy-4-o-tolylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Methoxymethyl-4-phenylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-[2-(6-{4-[3-(2-Chlorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(3-Chlorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(4-Chlorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(2-Methoxyphenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(3-Methoxyphenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(4-Methoxyphenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(4-Chlorophenyl)-propionyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(3-Chlorophenyl)-propionyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(2-Chlorophenyl)propionyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[5-(4-Chlorophenyl)-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; 2-{4-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-piperazin-1-yl}-N-methyl-N-phenylacetamide; 4-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-piperazine-1-carboxylic acid benzyl ester; N-{2-[6-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4 .5]decane-8-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(Methylphenethylamino)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Phenethylaminopiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-[2-(6-{4-[2-(4-Chlorophenyl)-ethylamino]-piperidine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[2-(3H-Imidazol-4-yl)-ethylamino]-piperidine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-(2-{2-Phenyl-6-[4-(2-pyridin-4-ylethylamino)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-(2-pyridin-2-ylethylamino)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(4-Benzylaminopiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]-pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(Benzylmethylamino)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-[2-(2-Phenyl-6-{4-[(pyridin-4-ylmethyl)-amino]-piperidine-1-carbonyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-(2-{2-Phenyl-6-[4-(2-pyridin-3-ylethylamino)-piperidine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[2-Phenyl-6-((S)-2-phenylaminomethylpyrrolidine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-[2-(2-Phenyl-6-{4-[3-(4-trifluoromethylphenyl)-propyl]-piperazine-1-carbonyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(4-Fluorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-(2-{6-[4-(3-Benzo[1,3]dioxol-5-yl-propyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{2-Phenyl-6-[4-(3-p-tolylpropyl)-piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-[2-(6-{4-[3-(4-Bromophenyl)-propyl]-piperazine- -carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(3,4-Dichlorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-[2-(6-{4-[3-(2,4-Dichlorophenyl)-propyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-{2-[6-(4-Benzyl-[1,4]diazepane-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Phenethyl-[1,4]diazepane-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{2-Phenyl-6-[4-(3-phenylpropyl)-[1,4]diazepane-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(4-Acetylaminophenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Cyanophenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-[2-(6-{4-[4-(Acetylmethylamino)-phenyl]-piperazine-1-carbonyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-acetamide; N-(2-{6-[4-(2,6-Dimethylphenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Chlorophenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2,4-Dimethoxyphenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(5-Chloro-2-methoxyphenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(4-Chlorophenoxymethyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-{2-[6-(5-Benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-{2-[6-(4-Phenoxymethylpiperidine-1-carbonyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(4-Cyanophenoxymethyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(3-Cyanophenoxymethyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Nitrophenyl)-piperazine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; 2-{4-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-piperazin-1-yl}-benzoic acid methyl ester; N-{2-[2-Phenyl-6-(4-o-tolylpiperazine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-ethyl}-acetamide; N-(2-{6-[4-(3,4-Dichlorophenoxymethyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Cyanophenoxymethyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(2-Chlorophenyl)-4-cyanopiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; 2-{4-[4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-piperazin-1-yl}-benzamide;
N-(2-{6-[4-Cyano-4-(2-methoxyphenyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-(3-Chlorophenyl)-4-cyanopiperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; N-(2-{6-[4-Cyano4-(3-methoxyphenyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide; and N-(2-{6-[4-Cyano-4-(4-methoxyphenyl)-piperidine-1-carbonyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide.
- 63. The compound of claim 32, wherein the compound is selected from the group consisting of:
4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (3-phenoxyphenyl)-amide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (1-benzylpiperidin4-yl)-amide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (1-benzylpyrrolidin-3-yl)-amide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 4-[1,2,3]thiadiazol-4-yl-benzylamide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid benzylamide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-1-hydroxymethylethyl)-amide; 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (1-hydroxycyclohexylmethyl)-amide; and 4-(2-Acetylaminoethylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid [2-(4-phenoxyphenyl)-ethyl]-amide.
- 64. The compound of claim 42, wherein the compound is N-(2-{6-[3-(4-Benzylpiperazin-1-yl)-3-oxopropyl]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino}-ethyl)-acetamide.
- 65. A compound having the structure:
- 66. The compound of claim 65, wherein R3 is substituted or unsubstituted phenyl.
- 67. The compound of claim 66, wherein R20 is Cl.
- 68. The compound of claim 67, wherein R22 is SO2Ph.
- 69. The compound of claim 68, wherein R21 is H.
- 70. The compound of claim 69, wherein R21 is —C(═O)OH.
- 71. The compound of claim 67, wherein R20 is —NH(CH2)nNHC(═O)CH3 and R21 is —C(═O)OH.
- 72. The compound of claim 71, wherein R22 is H.
- 73. The compound of claim 71, wherein R22 is SO2Ph.
- 74. A method for treating a disease associated with the A2b adenosine receptor in a subject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compound of claim 1 so as to thereby treat the disease associated with the A2b adenosine receptor in the subject, wherein the disease associated with the A2b adenosine receptor is asthma, urticaria, scleroderm arthritis, myocardial infarction, myocardial reperfusion after ischemia, diabetic retinopathy, retinopathy of prematurity, diabetes, diarrhea, inflammatory bowel disease, proliferating tumor or is associated with mast cell degranulation, vasodilation, hypertension, hypersensitivity or the release of allergic mediators.
- 75. The method of claim 74, wherein the disease associated with the A2b adenosine receptor is diabetes.
- 76. The method of claim 74, wherein the disease associated with the A2b adenosine receptor is asthma.
- 77. The method of claim 74, wherein the disease associated with the A2b adenosine receptor is associated with mast cell degranulation.
- 78. The method of claim 74, wherein the disease associated with the A2b adenosine receptor is a proliferating tumor.
- 79. A method for treating a disease associated with the A2b adenosine receptor in a subject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compound of claim 1 so as to thereby treat the disease associated with the A2b adenosine receptor in the subject, wherein the disease associated with the A2b adenosine receptor is asthma, urticaria, scleroderm arthritis, myocardial infarction, myocardial reperfusion after ischemia, diabetic retinopathy, retinopathy of prematurity, diabetes, diarrhea, inflammatory bowel disease, proliferating tumor or is associated with mast cell degranulation, vasodilation, hypertension, hypersensitivity or the release of allergic mediators.
- 80. A pharmaceutical composition comprising the compound of claim 1, 3, 4, 7, 13, 18, 23, 26, 32, 35, 42 or 49 and a pharmaceutically acceptable carrier.
- 81. The pharmaceutical composition of claim 80, formulated for oral, topical, parenteral or nasal administration.
- 82. A process for the manufacture of a pharmaceutical composition comprising admixing the compound of claim 1, 3, 4, 7, 13, 18, 23, 26, 32, 35, 42 or 49 with a pharmaceutically acceptable carrier.
- 83. An article of manufacture comprising
packaging material; the pharmaceutical composition of claim 80; and instructions for use of the pharmaceutical composition in the treatment of a disease associated with the A2b adenosine receptor.
- 84. A process of manufacturing a compound having the structure:
- 85. The process of claim 84, wherein the reducing agent in step (a) is NaH and the solvent is dimethylformamide (DMF).
- 86. The process of claim 84, wherein the solvent in step (b) is tetrahydrofuran (THF).
- 87. The process of claim 84, wherein the solvent in step (c) is dimethyl sulfoxide (DMSO).
- 88. The process of claim 84, wherein the hydroxide base in step (d) is sodium hydroxide.
- 89. The process of claim 84, wherein the base in step (e) is triethylamine, the coupling agent is O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU), benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-Hydroxybenzotriazole, and the solvent is DMF.
- 90. The process of claim 84, wherein the order of the steps is (a), (b), (c), (e), then (d).
- 91. A compound produced by the process of claim 84.
- 92. Use of the compound of any one of claims 1-64 for manufacturing a medicament useful for treating a disease associated with the A2b adenosine receptor in a subject, wherein the disease associated with the A2b adenosine receptor is asthma, urticaria, scleroderm arthritis, myocardial infarction, myocardial reperfusion after ischemia, diabetic retinopathy, retinopathy of prematurity, diabetes, diarrhea, inflammatory bowel disease, proliferating tumor, or is associated with mast cell degranulation, vasodilation, hypertension, hypersensitivity or the release of allergic mediators.
- 93. The use of claim 92, wherein the disease associated with the A2b adenosine receptor is diabetes.
- 94. The use of claim 92, wherein the disease associated with the A2b adenosine receptor is asthma.
- 95. The use of claim 92, whereinr the disease associated with the A2b adenosine receptor is associated with mast cell degranulation.
- 96. The use of claim 92, wherein the disease associated with the A2b adenosine receptor is a proliferating tumor.
- 97. The compound of any one of claims 1, 2, 4-30, 32-46, 49-53, or 56-58, wherein any substituent, if present, is selected from halogen, hydroxyl, carbonyl, straight chain (C1-C30)alkyl, branched chain (C3-C30)alkyl, (C3-C10)cycloalkyl, straight chain(C1-C30)alkylcarbonyloxy, branched chain (C3-C30)alkylcarbonyloxy, arylcarbonyloxy, straight chain(C1-C30)alkoxycarbonyloxy, branched chain(C3-C30)alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, straight chain(C1-C30)alkylcarbonyl, branched chain (C3-C30)alkylcarbonyl, arylcarbonyl, straight chain (C1-C30)alkoxycarbonyl, branched chain (C3-C30)alkoxycarbonyl, aminocarbonyl, straight chain (C1-C30)alkylthiocarbonyl, branched chain (C3-C30)alkylthiocarbonyl, straight chain (C1-C30)alkylsulfonyl, branched chain (C3-C30)alkylsulfonyl, straight chain (C1-C30)alkoxyl, branched chain (C1-C30)alkoxyl, phosphate, phosphonato, cyano, amino, straight chain (C1-C30)alkylamino, branched chain (C3-C30)alkylamino, straight chain (C1-C30)dialkylamino, branched chain (C3-C30)dialkylamino, arylamino, diarylamino, straight chain (C1-C30)alkylarylamino, branched chain (C3-C30)alkylarylamino, acylamino, straight chain (C1-C30)alkylcarbonylamino, branched chain (C3-C30)alkylcarbonylamino, arylcarbonylamino, carbamoyl, ureido, amidino, imino, sulfhydryl, straight chain (C1-C30)alkylthio, branched chain (C3-C30)alkylthio, arylthio, thiocarboxylate, sulfates, sulfonato, sulfamoyl, sulfonamido, sulfonyl, benzenesulfonyl, nitro, trifluoromethyl, azido, 6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole, 3,4-dihydroxy-5-methoxytetrahydrofuran, 4-10 membered heterocyclyl, straight chain (C1-C30)alkylaryl, branched chain (C3-C30)alkylaryl, straight chain (C1-C30)alkylheteroaryl, branched chain (C3-C30)alkylheteroaryl, (C1-C30)alkenylaryl, (C1-C30)alkenylheteroaryl, (C1-C30)alkynylaryl, (C1-C30)alkynylheteroaryl or an aromatic or 5-6 membered heteroaromatic moiety,
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application No. 60/343,443, filed Dec. 20, 2001, the entire contents of which are hereby incorporated by reference.
[0002] Throughout this application, various publications are referenced by full citations. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art as known to those skilled therein as of the date of the invention described and claimed herein.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60343443 |
Dec 2001 |
US |