Claims
- 1. A compound represented by the following formula (II) or (II′): wherein R represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, a cycloalkylalkyl group or a substituted or unsubstituted aralkyl group and l represents 0 or 1.
- 2. A process for the preparation of a pyrrolesulfonamide compound represented by the following formula (II) or (II′): wherein R represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, a cycloalkylalkyl group or a substituted or unsubstituted aralkyl group and l represents 0 or 1, which comprises:converting a pyrrole-3-sulfonic acid or a salt thereof, which is represented by the following formula (XIII): wherein M represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion or a quaternary ammonium ion, and p stands for 1 when M represents a hydrogen ion, an alkali metal ion or a quaternary ammonium ion or p stands for 2 when M represents an alkaline earth metal ion, into a compound represented by the following formula (XIV): wherein X″ represents a chlorine atom or a bromine atom; causing an α-aminoacetic acid, β-aminopropionic acid or derivative thereof, which is represented by the following formula (XV): RNH(CH2)lCH2COOR6 (XV) wherein R6 represents a hydrogen atom or a carboxyl-protecting group, and R and l have the same meanings as defined above, to act, thereby obtaining a compound represented by the following formula (XVI): wherein R represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, a cycloalkylalkyl group or a substituted or unsubstituted aralkyl group, R6 represents a hydrogen atom or a carboxyl-protecting group and l represents 0 or 1; and thensubjecting said compound to ring closure.
- 3. The compound of claim 1, which is represented by formula (II).
- 4. The compound of claim 1, which is represented by formula (II′).
- 5. The compound of claim 1, wherein R is a hydrogen atom.
- 6. The compound of claim 1, wherein R is a linear or branched alkyl group.
- 7. The compound of claim 1, wherein R is a cycloalkyl group.
- 8. The compound of claim 1, wherein R is a cycloalkylalkyl group.
- 9. The compound of claim 1, wherein R is a substituted or unsubstituted aralkyl group.
- 10. The compound of claim 1, wherein l is 0.
- 11. The compound of claim 1, wherein l is 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9-366757 |
Dec 1997 |
JP |
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CROSS-REFERENCE TO RELATED APPLICATIONS
The present application is a divisional of U.S. Ser. No. 09/939,829 filed Aug. 28, 2001, U.S. Pat. No. 6,583,296, which is a divisional of U.S. Ser. No. 09/367,842 filed Aug. 26, 1999, U.S. Pat. No. 6,331,623, which is a 371 application of PCT/JP98/05955 filed Dec. 25, 1998.
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Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, vol. 44, No. 3, Feb. 10, 1950; Abstract No. 1095i, Terent'Ev A P, et al., Sulfonation an sulfonic acids of acidophobic substances. VI. Sulfonation of alpha, alpha'—substituted pyrrole homologs. XP002098315 see abstract & Zhur. Obshchei Khim. (J. Gen. Chem.), vol. 19, 1949, pp. 1365-1369. |