QSB: Operating Principles for Optimal Functioning

Information

• NSF Award
• 0120288

Owner

• MEDICAL UNIVERSITY OF SOUTH CAROLINA

• Award Id

  0120288

• Award Effective Date

  9/1/2001 - 23 years ago

• Award Expiration Date

  2/28/2005 - 19 years ago

• Award Amount

  $ 438,315.00

• Award Instrument

  Continuing grant

The overall aim is to elucidate the operating and design principles of metabolic and genetic networks. Two complementary strategies will be merged. The first is a theoretical analysis of small, modular pathways, which form the building blocks of biochemical systems, and of composites of these modules. The analysis will elucidate the dynamic activation profiles of enzymes that yield optimal responses to demands like brief peak availability of a metabolite or sustained change in metabolite composition. The second strategy will entail reconstituting sphingolipid metabolism in E. coli and using this as an experimental model for studying fluxes and the effects of specific regulatory interventions. The system thus has the potential to provide an in vivo laboratory for studying de novo pathway design.

• Program Officer

  Fred G. Heineken

• Min Amd Letter Date

  8/15/2001 - 23 years ago

• Max Amd Letter Date

  6/11/2002 - 22 years ago

• ARRA Amount

• Name

  Medical University of South Carolina

• City

  CHARLESTON

• State

  SC

• Country

  United States

• Address

  171 ASHLEY AVE

• Postal Code

  294258908

• Phone Number

  8437923838

• First Name

  Eberhard

• Last Name

  Voit

• Email Address

  eberhard.voit@bme.gatech.edu

• Start Date

  8/15/2001 12:00:00 AM

• First Name

  Yusuf

• Last Name

  Hannun

• Email Address

  hannun@musc.edu

• Start Date

  8/15/2001 12:00:00 AM

• First Name

  David

• Last Name

  Perry

• Email Address

  perryd@musc.edu

• Start Date

  8/15/2001 12:00:00 AM

• Name

  Industrial Technology

• Code

  308000