QUANTITATION OF ONCOGENE PRODUCTS IN CELLS AND TISSUE

Information

• Research Project
• 2093998

• ApplicationId

  2093998

• Core Project Number

  R44CA050843

• Full Project Number

  2R44CA050843-02A1

• Serial Number

  50843

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1991 - 33 years ago

• Project End Date

  9/30/1992 - 32 years ago

• Program Officer Name

• Budget Start Date

  9/30/1991 - 33 years ago

• Budget End Date

  9/30/1992 - 32 years ago

• Fiscal Year

  1991

• Support Year

  2

• Suffix

  A1

• Award Notice Date

  9/30/1991 - 33 years ago

Organizations

• CELL ANALYSIS SYSTEMS, INC.

DESCRIPTION: (Adpated from applicant's abstract) The objective of this project is to develop an assay for the quantitation of oncogene products in cancer cells and tissues. The main effort will be to quantitate the protein encoded by the HER-2/neu oncogene, P185(HER2), since it has been strongly implicated in the biological behavior of breast cancer, and may have prognostic significance. The techniques used will be those of high resolution digital image microscopy and immunohistochemical localization. Immunohistochemical techniques enable the assessment of protein status in tumor cells, specifically excluding other tissue components, and makes it possible to quantitate the protein in an objective manner. Image analysis combined with immunohistochemistry makes it possible to perform HER-2/neu protein level measurements on very small tissues such as derived from biopsy material or needle aspirates, and makes it possible to establish normal levels of expression versus overexpression of gene products.

IC Name

• Activity

  R44

• Administering IC

  CA

• Application Type

  2

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  394

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ET

• Study Section Name

  Experimental Therapeutics Subcommittee 2

• Organization Name

  CELL ANALYSIS SYSTEMS, INC.

• Organization Department

• Organization DUNS

• Organization City

  LOMBARD

• Organization State

  IL

• Organization Country

  UNITED STATES

• Organization Zip Code

  60148

• Organization District

  UNITED STATES