Claims
- 1. A method for determining the level of an analyte in blood from a solution formed from a dried blood fluid specimen, said blood fluid specimen being a plasma or serum specimen, comprising:
in either order, measuring the analyte level in said solution and measuring the level of a normalizing analyte; and determining the analyte level in the blood from which said blood fluid specimen was collected based on said analyte level in said solution and on said level of said normalizing analyte in said solution.
- 2. The method according to claim 1, said analyte being ALT.
- 3. The method according to claim 1, said analyte being a cholesterol.
- 4. The method according to claim 1, said analyte being PSA.
- 5. The method according to claim 1, said normalizing analyte being sodium.
- 6. The method according to claim 1, said normalizing analyte being chloride.
- 7. The method according to claim 1, said normalizing analyte being osmolality.
- 8. The method according to claim 1, further comprising measuring the level of a second normalizing analyte in said solution wherein the level of analyte in the blood from which said blood fluid specimen was collected is determined based on the level of said analyte and said second normalizing analyte in said solution.
- 9. The method according to claim 8, wherein a first blood analyte level is determined based on the levels in solution of said analyte and said normalizing analyte; a second blood analyte level is determined based on the levels in solution of said analyte and said second normalizing analyte; and the level of analyte in the blood from which said blood fluid specimen was collected is determined by calculating the mean average of said first and second blood analyte levels.
- 10. The method according to claim 9, wherein said first and second normalizing analytes are dissimilar and are each selected from the group consisting of sodium, chloride, and osmolality.
- 11. The method according to claim 1, comprising:
receiving a first electrical signal corresponding to the level of analyte in said solution; receiving a second electrical signal corresponding to the level of normalizing analyte in said solution; and determining the level of analyte in the blood from which said blood fluid specimen was collected based on said first and second electrical signals.
- 12. The method according to claim 11, each of said first and second electrical signals being analog signals.
- 13. The method according to claim 1, comprising:
determining the level of analyte in said solution; and calculating the level of analyte in the blood from which said blood fluid specimen was collected by multiplying said level of analyte in said solution by a correction factor, said correction factor being determined as a function of the level of normalizing analyte in said solution.
- 14. A method for determining the concentration of an analyte in blood from a solution formed from a dried blood fluid specimen, comprising:
in either order, measuring the analyte level in said solution and measuring the level of a normalizing analyte; and determining the analyte level in the blood from which said blood fluid specimen was collected based on said analyte level in said solution and on said level of said normalizing analyte in said solution; said normalizing analyte being selected from the group consisting of sodium, chloride, and osmolality.
- 15. The method according to claim 14, said analyte being ALT.
- 16. The method according to claim 14, said analyte being a cholesterol.
- 17. The method according to claim 14, said analyte being PSA.
- 18. The method according to claim 16, said normalizing analyte being sodium.
- 19. The method according to claim 16, said normalizing analyte being chloride.
- 20. The method according to claim 16, said normalizing analyte being osmolality.
- 21. The method according to claim 14, further comprising measuring the level of a second normalizing analyte in said solution wherein the level of analyte in the blood from which said blood fluid specimen was collected is determined based on the level of said analyte and said second normalizing analyte in said solution.
- 22. The method according to claim 21, wherein a first blood analyte level is determined based on the levels in solutions of said analyte and said normalizing analyte; a second blood analyte level is determined based on the levels in solution of said analyte and said second normalizing analyte; and the level of analyte in the blood from which said blood fluid specimen was collected is determined by calculating the mean average of said first and second blood analyte levels.
- 23. The method according to claim 14, comprising:
receiving a first electrical signal corresponding to the level of analyte in said solution; receiving a second electrical signal corresponding to the level of normalizing analyte in said solution; and determining the level of analyte in the blood from which said blood fluid specimen was collected based on said first and second electrical signals.
- 24. The method according to claim 23, each of said first and second electrical signals being analog signals.
- 25. The method according to claim 14, comprising:
determining the level of analyte in said solution; and calculating the level of analyte in the blood from which said blood fluid specimen was collected by multiplying said level of analyte in said solution by a correction factor, said correction factor being determined as a function of the level of normalizing analyte in said solution.
- 26. The method according to claim 14, said blood fluid specimen being a dried whole blood sample.
- 27. The method according to claim 14, said blood fluid specimen being a dried serum sample.
- 28. A method for determining the concentration of an analyte from a solution formed from a dried blood fluid specimen, comprising:
in any order, measuring the level of an analyte in said solution, measuring the level of a first normalizing analyte in said solution, and measuring the level of a second normalizing analyte in said solution; determining the analyte level in the blood from which said blood fluid specimen was collected based on said analyte level in said solution, the level of said first normalizing analyte in said solution, and the level of said second normalizing analyte in said solution.
- 29. The method according to claim 28, said analyte being ALT.
- 30. The method according to claim 28, said analyte being a cholesterol.
- 31. A method according to claim 28, said analyte being PSA.
- 32. The method according to claim 28, further comprising measuring the level of a second normalizing analyte in said solution wherein the level of analyte in the blood from which said blood fluid specimen was collected is determined based on the level of said analyte and said second normalizing analyte in said solution.
- 33. The method according to claim 28, comprising:
receiving a first electrical signal corresponding to the level of analyte in said solution; receiving a second electrical signal corresponding to the level of the first normalizing analyte in said solution; and determining the level of analyte in the blood from which said blood fluid specimen was collected based on said first and second electrical signals.
- 34. The method according to claim 33, each of said first and second electrical signals being analog signals.
- 35. The method according to claim 28, comprising:
determining the level of analyte in said solution; and calculating the level of analyte in the blood from which said blood fluid specimen was collected by multiplying said level of analyte in said solution by a correction factor, said correction factor being determined as a function of the level of normalizing analyte in said solution.
- 36. A method for reporting a test result, comprising:
receiving an incoming inquiry from a user; prompting said user for a test number; retrieving a test result from a database of test numbers and test results; and reporting said test results to said user, said test results comprising an analyte level having been determined according to claim 1.
- 37. A method for reporting a test result, comprising:
receiving an incoming inquiry from a user; prompting said user for a test number; retrieving a test result from a database of test numbers and test results; and reporting said test results to said user, said test results comprising an analyte level having been determined according to claim 14.
- 38. A method for reporting a test result, comprising:
receiving an incoming inquiry from a user; prompting said user for a test number; retrieving a test result from a database of test numbers and test results; and reporting said test results to said user, said test results comprising an analyte level having been determined according to claim 28.
- 39. A method for preparing a database of test results, comprising:
receiving a test number; receiving a test result; and storing said test result and said test number in a database record, said test result comprising an analyte level having been determined according to claim 1.
- 40. A method for preparing a database of test results, comprising:
receiving a test number; receiving a test result; and storing said test result and said test number in a database record, said test result comprising an analyte level having been determined according to claim 14.
- 41. A method for preparing a database of test results, comprising:
receiving a test number; receiving a test result; and storing said test result and said test number in a database record, said test result comprising an analyte level having been determined according to claim 28.
- 42. A method for preparing a database for use in determining an analyte level in blood based upon measurements of the analyte in a solution formed from a blood fluid specimen and based upon the measurement of first and second normalizing analytes in said solution, comprising:
providing a plurality of blood samples each having a known blood analyte level; for each of said blood samples, preparing a blood fluid specimen thereby yielding a plurality of blood fluid specimens; for each of said blood fluid specimens, forming a solution; for each of said solutions, measuring the levels of said analyte, a first normalizing analyte, and a second normalizing analyte in said solution; and recording in a database record the known blood analyte level, the level of analyte measured in said solution, the level of first normalizing analyte measured in said solution and the level of said second normalizing analyte measured in said solution.
- 43. The method according to claim 43, said analyte being ALT.
- 44. The method according to claim 43, said analyte being a cholesterol.
- 45. The method according to claim 43, said analyte being PSA.
- 46. The method according to claim 43, said first normalizing analyte being sodium.
- 47. The method according to claim 43, said first normalizing analyte being chloride.
- 48. The method according to claim 43, said first normalizing analyte being osmolality.
- 49. The method according to claim 43, said blood fluid specimen being a dried whole blood sample.
- 50. The method according to claim 43, said blood fluid specimen being a dried serum sample.
- 51. The method according to claim 43, wherein each of said plurality of blood fluid specimens is formed before the first of said database records is prepared.
- 52. The method according to claim 43, further comprising:
after preparing a plurality of database records, deriving an algorithm from said database for calculating blood analyte levels from a solution analyte level, a first normalizing analyte level, and a second normalizing solution analyte level in a solution prepared from a blood fluid specimen.
- 53. The method according to claim 53, said algorithm being first order with respect to said solution analyte level.
- 54. The method according to claim 53, said algorithm being first order with respect to said solution analyte level, said first normalizing analyte level, and said second normalizing analyte level.
- 55. The method according to claim 43, said database comprising a computer file disposed in computer readable form on a computer readable medium.
- 56. A computer readable medium containing the computer file prepared in accordance with the method of claim 56.
- 57. A method for determining the concentration of an analyte in a body fluid specimen from a solution formed from an modified specimen, comprising:
in any order, measuring the level of an analyte in said solution, measuring the level of a first normalizing analyte in said solution, and measuring the level of a second normalizing analyte in said solution; determining the analyte level in the specimen from which said modified specimen was collected based on said analyte level in said solution, the level of said first normalizing analyte in said solution, and the level of said second normalizing analyte in said solution.
- 58. A method according to claim 1, said blood fluid specimen comprising a dried whole blood specimen.
- 59. A method according to claim 28, said blood fluid specimen comprising a dried blood serum specimen.
- 60. A fluid collector comprising:
an absorbent substrate coated with a saccharide polymer, said substrate permitting at least substantial separation of serum from red blood cells via differential wicking.
- 61. A fluid collector according to claim 60, said saccharide comprising xylose.
- 62. A kit comprising a device for obtaining blood in combination with the fluid collector of claim 60.
- 63. A fluid collection device comprising a superstrate and the fluid collector of claim 60, said fluid collector being generally fixed with respect to said superstrate, said fluid collector having an aperture defining a blood receiving opening and permitting access to said fluid collector.
- 64. A fluid collection device according to claim 63, said fluid collector having a first end and a second end, said aperture permitting access to said first end of said fluid collector, said superstrate having a second aperture relatively proximal said second end of said fluid collector.
- 65. A method for determining the level of an analyte in a fluid based on measurement of said analyte in a modified fluid specimen to be analyzed, comprising in any appropriate order:
providing a plurality of fluid specimens having a known measurable analyte level; preparing a modified fluid specimen from each of said fluid specimens; in either order, measuring the level of said analyte and at least one normalizing analyte in each of said modified fluid specimens thereby generating a data set; using said data set, deriving an algorithm for determining the level of analyte as a function of analyte level measured in a modified specimen and normalizing analyte measured in a modified specimen; determining the levels of said analyte and said normalizing analyte in said modified fluid specimen to be analyzed; and calculating the level of said analyte in the fluid from which said modified specimen was obtained based on said algorithm.
- 66. A method according to claim 65, said fluid specimen comprising a blood fraction.
- 67. A method according to claim 66, said fluid specimen comprising blood serum.
- 68. A method according to claim 65, said modified fluid specimen comprising a dried blood serum specimen.
- 69. A method according to claim 65, said analyte being ALT.
- 70. A method according to claim 65, said being cholesterol.
- 71. A method according to claim 65, said being PSA.
- 72. A method according to claim 65, said normalizing analyte being sodium.
- 73. A method according to claim 65, said normalizing analyte being cholesterol.
- 74. A method according to claim 65, further comprising:
measuring the level of a second normalizing analyte in said fluid specimens having a known or measurable analyte level, said algorithm being a function also of the second normalizing analyte level; and measuring the level of said second normalizing analyte in said modified fluid specimen to be analyzed.
RELATED APPLICATION
[0001] This application claims priority to prior application serial No. 60/374,629 filed Apr. 23, 2002. The prior application is hereby incorporated by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60374629 |
Apr 2002 |
US |